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P19663 (TYPH_LACRH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
OrganismLactobacillus rhamnosus
Taxonomic identifier47715 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length23 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Subunit structure

Homodimer. Ref.1

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›23›23Thymidine phosphorylase
PRO_0000059077

Experimental info

Non-terminal residue231

Sequences

Sequence LengthMass (Da)Tools
P19663 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 8705C9C4D82C1AD7

FASTA232,752
        10         20 
MVKIGINEFG RIGRLAFRRI YEL 

« Hide

References

[1]"Purification and characterization of uridine and thymidine phosphorylase from Lactobacillus casei."
Avraham Y., Grossowicz N., Yashphe J.
Biochim. Biophys. Acta 1040:287-293(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, SUBUNIT.
Strain: ATCC 7469 / DSM 20021 / NCDO 243 / NCIB 6375.

Cross-references

Sequence databases

PIRS11384.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00044. Gp_dh_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_LACRH
AccessionPrimary (citable) accession number: P19663
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families