P19663 (TYPH_LACRH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Name:

deoA

Organism

Lactobacillus rhamnosus

Taxonomic identifier

47715 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	23 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
Subunit structure	Homodimer. Ref.1
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›23	›23	Thymidine phosphorylase		PRO_0000059077
Experimental info
	Non-terminal residue	23	1

Sequences

	Sequence		Length	Mass (Da)
	P19663 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 8705C9C4D82C1AD7	FASTA	23	2,752
	10 20 MVKIGINEFG RIGRLAFRRI YEL

References

[1]

"Purification and characterization of uridine and thymidine phosphorylase from Lactobacillus casei." Avraham Y., Grossowicz N., Yashphe J. Biochim. Biophys. Acta 1040:287-293(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, SUBUNIT. Strain: ATCC 7469 / DSM 20021 / NCDO 243 / NCIB 6375.

Cross-references

Sequence databases
PIR	S11384.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR020828. GlycerAld_3-P_DH_NAD(P)-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF00044. Gp_dh_N. 1 hit. [Graphical view]
PROSITE	PS00647. THYMID_PHOSPHORYLASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_LACRH

Accession

Primary (citable) accession number: P19663

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program