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P19663

- TYPH_LACRH

UniProt

P19663 - TYPH_LACRH

Protein

Thymidine phosphorylase

Gene

deoA

Organism
Lactobacillus rhamnosus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

    GO - Molecular functioni

    1. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro
    2. thymidine phosphorylase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine phosphorylase (EC:2.4.2.4)
    Alternative name(s):
    TdRPase
    Gene namesi
    Name:deoA
    OrganismiLactobacillus rhamnosus
    Taxonomic identifieri47715 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›23›23Thymidine phosphorylasePRO_0000059077Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00044. Gp_dh_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P19663-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKIGINEFG RIGRLAFRRI YEL                                23
    Length:23
    Mass (Da):2,752
    Last modified:February 1, 1991 - v1
    Checksum:i8705C9C4D82C1AD7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei23 – 231

    Sequence databases

    PIRiS11384.

    Cross-referencesi

    Sequence databases

    PIRi S11384.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00044. Gp_dh_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification and characterization of uridine and thymidine phosphorylase from Lactobacillus casei."
      Avraham Y., Grossowicz N., Yashphe J.
      Biochim. Biophys. Acta 1040:287-293(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, SUBUNIT.
      Strain: ATCC 7469 / DSM 20021 / NCDO 243 / NCIB 6375.

    Entry informationi

    Entry nameiTYPH_LACRH
    AccessioniPrimary (citable) accession number: P19663
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3