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P19662 (UDP_LACRH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uridine phosphorylase

EC=2.4.2.3
Alternative name(s):
UDRPase
Gene names
Name:udp
OrganismLactobacillus rhamnosus
Taxonomic identifier47715 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length23 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activity

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.

Subunit structure

Homotetramer.

Sequence similarities

Belongs to the PNP/UDP phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›23›23Uridine phosphorylase
PRO_0000063189

Experimental info

Sequence uncertainty11R or S
Sequence uncertainty71E or T
Non-terminal residue231

Sequences

Sequence LengthMass (Da)Tools
P19662 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 918B2E2F32F35A17

FASTA232,630
        10         20 
RLKVIPEKLK DVKLVCTDVF GDN 

« Hide

References

[1]"Purification and characterization of uridine and thymidine phosphorylase from Lactobacillus casei."
Avraham Y., Grossowicz N., Yashphe J.
Biochim. Biophys. Acta 1040:287-293(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Strain: ATCC 7469 / DSM 20021 / NCDO 243 / NCIB 6375.

Cross-references

Sequence databases

PIRS11383.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00574; UER00633.

Family and domain databases

InterProIPR000888. dTDP_sugar_isom.
[Graphical view]
ProDomPD001462. dTDP_sugar_isom. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameUDP_LACRH
AccessionPrimary (citable) accession number: P19662
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways