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Protein

Cathelicidin-3

Gene

CATHL3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelicidin-3
Alternative name(s):
Bactenecin-7
Short name:
Bac7
PR-59
Gene namesi
Name:CATHL3
Synonyms:BAC7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Propeptidei30 – 1301011 PublicationPRO_0000004709Add
BLAST
Peptidei131 – 18959Cathelicidin-3PRO_0000004710Add
BLAST
Propeptidei190 – 1901Removed; partialPRO_0000004711

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301Pyrrolidone carboxylic acid
Disulfide bondi85 ↔ 96
Disulfide bondi107 ↔ 124

Post-translational modificationi

Elastase is responsible for its maturation.

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP19661.
PeptideAtlasiP19661.
PRIDEiP19661.

Expressioni

Tissue specificityi

Large granules of neutrophils.

Gene expression databases

BgeeiENSBTAG00000031599.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000034498.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JWCX-ray1.80C/D131-146[»]
4JWDX-ray1.95C/D173-186[»]
5F8KX-ray2.801y/2y131-146[»]
5HAUX-ray3.001x/2x131-165[»]
ProteinModelPortaliP19661.
SMRiP19661. Positions 30-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000203349.
HOVERGENiHBG006116.
InParanoidiP19661.
OMAiRPLPFPR.
OrthoDBiEOG091G0XQS.
TreeFamiTF338457.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQRASLSL GRWSLWLLLL GLVLPSASAQ ALSYREAVLR AVDRINERSS
60 70 80 90 100
EANLYRLLEL DPPPKDVEDR GARKPTSFTV KETVCPRTSP QPPEQCDFKE
110 120 130 140 150
NGLVKQCVGT ITLDQSDDLF DLNCNELQSV RRIRPRPPRL PRPRPRPLPF
160 170 180 190
PRPGPRPIPR PLPFPRPGPR PIPRPLPFPR PGPRPIPRPL
Length:190
Mass (Da):21,567
Last modified:November 1, 1995 - v2
Checksum:i8CD07D7AA30A731C
GO

Mass spectrometryi

Molecular mass is 18395±1 Da from positions 30 - 190. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42977 mRNA. Translation: AAA87359.1.
Y09471 Genomic DNA. Translation: CAA70616.1.
BC134776 mRNA. Translation: AAI34777.1.
BC142014 mRNA. Translation: AAI42015.1.
PIRiA36589.
RefSeqiNP_776426.1. NM_174001.2.
UniGeneiBt.527.

Genome annotation databases

EnsembliENSBTAT00000034610; ENSBTAP00000034498; ENSBTAG00000031599.
GeneIDi281037.
KEGGibta:281037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42977 mRNA. Translation: AAA87359.1.
Y09471 Genomic DNA. Translation: CAA70616.1.
BC134776 mRNA. Translation: AAI34777.1.
BC142014 mRNA. Translation: AAI42015.1.
PIRiA36589.
RefSeqiNP_776426.1. NM_174001.2.
UniGeneiBt.527.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JWCX-ray1.80C/D131-146[»]
4JWDX-ray1.95C/D173-186[»]
5F8KX-ray2.801y/2y131-146[»]
5HAUX-ray3.001x/2x131-165[»]
ProteinModelPortaliP19661.
SMRiP19661. Positions 30-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000034498.

Proteomic databases

PaxDbiP19661.
PeptideAtlasiP19661.
PRIDEiP19661.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000034610; ENSBTAP00000034498; ENSBTAG00000031599.
GeneIDi281037.
KEGGibta:281037.

Organism-specific databases

CTDi281037.

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000203349.
HOVERGENiHBG006116.
InParanoidiP19661.
OMAiRPLPFPR.
OrthoDBiEOG091G0XQS.
TreeFamiTF338457.

Gene expression databases

BgeeiENSBTAG00000031599.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTHL3_BOVIN
AccessioniPrimary (citable) accession number: P19661
Secondary accession number(s): A5PJ95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.