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Protein

Exocyst complex component EXO70

Gene

EXO70

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in the assembly of the exocyst.1 Publication

Miscellaneous

Present with 4280 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • GTP-Rho binding Source: SGD
  • phosphatidylinositol-4,5-bisphosphate binding Source: SGD

GO - Biological processi

  • exocyst assembly Source: SGD
  • exocyst localization Source: SGD
  • exocytosis Source: SGD
  • Golgi to plasma membrane transport Source: SGD
  • protein transport Source: UniProtKB-KW
  • Rho protein signal transduction Source: SGD
  • vesicle tethering involved in exocytosis Source: SGD

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31542-MONOMER

Protein family/group databases

TCDBi1.F.2.1.1 the octameric exocyst (exocyst) family

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component EXO70
Alternative name(s):
Exocyst complex protein of 70 kDa
Gene namesi
Name:EXO70
Ordered Locus Names:YJL085W
ORF Names:J0932
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL085W
SGDiS000003621 EXO70

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189751 – 623Exocyst complex component EXO70Add BLAST623

Proteomic databases

MaxQBiP19658
PaxDbiP19658
PRIDEiP19658

Interactioni

Subunit structurei

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84. Interacts with RHO3.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • GTP-Rho binding Source: SGD

Protein-protein interaction databases

BioGridi33671, 503 interactors
DIPiDIP-2934N
IntActiP19658, 11 interactors
MINTiP19658
STRINGi4932.YJL085W

Structurei

Secondary structure

1623
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi69 – 71Combined sources3
Helixi74 – 89Combined sources16
Helixi92 – 95Combined sources4
Helixi97 – 115Combined sources19
Beta strandi116 – 119Combined sources4
Turni122 – 124Combined sources3
Helixi125 – 153Combined sources29
Helixi161 – 167Combined sources7
Helixi176 – 191Combined sources16
Helixi195 – 214Combined sources20
Turni215 – 217Combined sources3
Helixi218 – 221Combined sources4
Helixi239 – 260Combined sources22
Helixi268 – 292Combined sources25
Helixi298 – 301Combined sources4
Helixi304 – 318Combined sources15
Turni319 – 321Combined sources3
Helixi327 – 358Combined sources32
Helixi370 – 382Combined sources13
Helixi383 – 385Combined sources3
Helixi386 – 392Combined sources7
Turni393 – 395Combined sources3
Helixi398 – 400Combined sources3
Helixi408 – 410Combined sources3
Helixi423 – 450Combined sources28
Helixi469 – 488Combined sources20
Helixi492 – 495Combined sources4
Turni496 – 498Combined sources3
Helixi499 – 532Combined sources34
Beta strandi535 – 537Combined sources3
Helixi542 – 563Combined sources22
Helixi571 – 596Combined sources26
Helixi597 – 599Combined sources3
Beta strandi600 – 602Combined sources3
Helixi603 – 605Combined sources3
Helixi611 – 622Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B1EX-ray2.00A63-623[»]
2B7MX-ray3.50A/B/C/D63-623[»]
2PFVX-ray2.10A63-623[»]
5YFPelectron microscopy4.40G1-623[»]
ProteinModelPortaliP19658
SMRiP19658
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19658

Family & Domainsi

Sequence similaritiesi

Belongs to the EXO70 family.Curated

Phylogenomic databases

HOGENOMiHOG000000807
InParanoidiP19658
KOiK07195
OMAiERFSNFN
OrthoDBiEOG092C0ZIR

Family and domain databases

InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR004140 Exo70
PANTHERiPTHR12542 PTHR12542, 1 hit
PfamiView protein in Pfam
PF03081 Exo70, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit

Sequencei

Sequence statusi: Complete.

P19658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAEIDIDEA DVLVLSQELQ KTSKLTFEIN KSLKKIAATS NQSSQLFTPI
60 70 80 90 100
LARNNVLTTL QRNIESTLNS VASVKDLANE ASKYEIILQK GINQVGLKQY
110 120 130 140 150
TQVVHKLDDM LEDIQSGQAN REENSEFHGI LTHLEQLIKR SEAQLRVYFI
160 170 180 190 200
SILNSIKPFD PQINITKKMP FPYYEDQQLG ALSWILDYFH GNSEGSIIQD
210 220 230 240 250
ILVGERSKLI LKCMAFLEPF AKEISTAKNA PYEKGSSGMN SYTEALLGFI
260 270 280 290 300
ANEKSLVDDL YSQYTESKPH VLSQILSPLI SAYAKLFGAN LKIVRSNLEN
310 320 330 340 350
FGFFSFELVE SINDVKKSLR GKELQNYNLL QDCTQEVRQV TQSLFRDAID
360 370 380 390 400
RIIKKANSIS TIPSNNGVTE ATVDTMSRLR KFSEYKNGCL GAMDNITREN
410 420 430 440 450
WLPSNYKEKE YTLQNEALNW EDHNVLLSCF ISDCIDTLAV NLERKAQIAL
460 470 480 490 500
MPNQEPDVAN PNSSKNKHKQ RIGFFILMNL TLVEQIVEKS ELNLMLAGEG
510 520 530 540 550
HSRLERLKKR YISYMVSDWR DLTANLMDSV FIDSSGKKSK DKEQIKEKFR
560 570 580 590 600
KFNEGFEDLV SKTKQYKLSD PSLKVTLKSE IISLVMPMYE RFYSRYKDSF
610 620
KNPRKHIKYT PDELTTVLNQ LVR
Length:623
Mass (Da):71,294
Last modified:February 1, 1991 - v1
Checksum:i277D89176FC2837D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti497A → S in AAU09750 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08787 Genomic DNA Translation: CAA70039.1
Y00473 Genomic DNA Translation: CAA68535.1
X83502 Genomic DNA Translation: CAA58485.1
Z49362 Genomic DNA Translation: CAA89380.1
AY723833 Genomic DNA Translation: AAU09750.1
J03546 Genomic DNA Translation: AAA66919.1
BK006943 Genomic DNA Translation: DAA08714.1
PIRiA27300
RefSeqiNP_012450.1, NM_001181518.1

Genome annotation databases

EnsemblFungiiYJL085W; YJL085W; YJL085W
GeneIDi853359
KEGGisce:YJL085W

Similar proteinsi

Entry informationi

Entry nameiEXO70_YEAST
AccessioniPrimary (citable) accession number: P19658
Secondary accession number(s): D6VW98, E9P961
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health