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Protein

Alpha-1-acid glycoprotein 2

Gene

ORM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.1 Publication

GO - Biological processi

  • acute-phase response Source: ProtInc
  • neutrophil degranulation Source: Reactome
  • platelet degranulation Source: Reactome
  • positive regulation of interleukin-1 beta secretion Source: UniProtKB
  • positive regulation of interleukin-1 secretion Source: UniProtKB
  • positive regulation of tumor necrosis factor secretion Source: UniProtKB
  • regulation of immune system process Source: InterPro

Keywordsi

Biological processAcute phase, Transport

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein 2
Short name:
AGP 2
Alternative name(s):
Orosomucoid-2
Short name:
OMD 2
Gene namesi
Name:ORM2
Synonyms:AGP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000228278.3.
HGNCiHGNC:8499. ORM2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5005.
OpenTargetsiENSG00000228278.
PharmGKBiPA32818.

Chemistry databases

ChEMBLiCHEMBL5958.
DrugBankiDB00477. Chlorpromazine.
DB00497. Oxycodone.
DB01041. Thalidomide.

Polymorphism and mutation databases

BioMutaiORM2.
DMDMi231458.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001786119 – 201Alpha-1-acid glycoprotein 2Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi23 ↔ 165
Glycosylationi33N-linked (GlcNAc...) (complex) asparagine8 Publications1
Glycosylationi56N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi72N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi90 ↔ 183
Glycosylationi93N-linked (GlcNAc...) asparagine5 Publications1
GlycosylationiCAR_000171103N-linked (GlcNAc...) asparagine3 Publications1

Post-translational modificationi

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).8 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP19652.
MaxQBiP19652.
PaxDbiP19652.
PeptideAtlasiP19652.
PRIDEiP19652.

2D gel databases

DOSAC-COBS-2DPAGEiP19652.
SWISS-2DPAGEiP19652.

PTM databases

iPTMnetiP19652.
PhosphoSitePlusiP19652.
UniCarbKBiP19652.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Inductioni

Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.

Gene expression databases

BgeeiENSG00000228278.
GenevisibleiP19652. HS.

Organism-specific databases

HPAiHPA046438.
HPA047725.
HPA057726.

Interactioni

Protein-protein interaction databases

BioGridi111047. 5 interactors.
IntActiP19652. 3 interactors.
STRINGi9606.ENSP00000394936.

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni20 – 23Combined sources4
Helixi24 – 26Combined sources3
Helixi33 – 39Combined sources7
Beta strandi41 – 51Combined sources11
Helixi53 – 60Combined sources8
Beta strandi62 – 72Combined sources11
Turni73 – 76Combined sources4
Beta strandi77 – 86Combined sources10
Beta strandi89 – 100Combined sources12
Turni101 – 104Combined sources4
Beta strandi105 – 110Combined sources6
Beta strandi113 – 120Combined sources8
Beta strandi127 – 133Combined sources7
Turni137 – 139Combined sources3
Beta strandi141 – 150Combined sources10
Helixi153 – 165Combined sources13
Helixi170 – 172Combined sources3
Helixi178 – 180Combined sources3
Helixi184 – 191Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3APUX-ray2.10A/B19-201[»]
3APVX-ray2.15A/B19-201[»]
3APWX-ray2.20A/B19-201[»]
3APXX-ray2.20A19-201[»]
ProteinModelPortaliP19652.
SMRiP19652.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19652.

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.1 Publication

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
GeneTreeiENSGT00390000012130.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP19652.
KOiK17308.
OMAiPGSHEDE.
OrthoDBiEOG091G0NAQ.
PhylomeDBiP19652.
TreeFamiTF343791.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR001500. A1A_glycop.
IPR012674. Calycin.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF
60 70 80 90 100
RNEEYNKSVQ EIQATFFYFT PNKTEDTIFL REYQTRQNQC FYNSSYLNVQ
110 120 130 140 150
RENGTVSRYE GGREHVAHLL FLRDTKTLMF GSYLDDEKNW GLSFYADKPE
160 170 180 190 200
TTKEQLGEFY EALDCLCIPR SDVMYTDWKK DKCEPLEKQH EKERKQEEGE

S
Length:201
Mass (Da):23,603
Last modified:April 1, 1993 - v2
Checksum:i49167ABCC22933B9
GO

Sequence cautioni

The sequence CAA29873 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA29874 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32T → I in CAG33211 (Ref. 4) Curated1
Sequence conflicti102E → D in BAG35159 (PubMed:14702039).Curated1
Sequence conflicti125T → I in BAG35159 (PubMed:14702039).Curated1
Sequence conflicti162A → V in BAG35159 (PubMed:14702039).Curated1
Sequence conflicti189Q → H in BAG35159 (PubMed:14702039).Curated1

Polymorphismi

Many different variants of ORM2 are known.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01466738R → Q. Corresponds to variant dbSNP:rs147969317Ensembl.1
Natural variantiVAR_05017299V → A. Corresponds to variant dbSNP:rs2636889Ensembl.1
Natural variantiVAR_050173141G → R. Corresponds to variant dbSNP:rs12685968Ensembl.1
Natural variantiVAR_050174167C → R. Corresponds to variant dbSNP:rs1126777Ensembl.1
Natural variantiVAR_050175174M → V. Corresponds to variant dbSNP:rs2636890Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06675 Genomic DNA. Translation: CAA29874.1. Sequence problems.
X05780 Genomic DNA. No translation available.
X06674
, X06676, X06677, X06678, X06679, X06680 Genomic DNA. Translation: CAA29873.2. Sequence problems.
X05784 Genomic DNA. No translation available.
M21540 Genomic DNA. Translation: AAA51549.1.
AK312226 mRNA. Translation: BAG35159.1.
CR456930 mRNA. Translation: CAG33211.1.
AL356796 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87417.1.
BC015964 mRNA. Translation: AAH15964.1.
BC056239 mRNA. Translation: AAH56239.1.
CCDSiCCDS6804.1.
PIRiJT0326. OMHU2.
RefSeqiNP_000599.1. NM_000608.2.
UniGeneiHs.719954.

Genome annotation databases

EnsembliENST00000431067; ENSP00000394936; ENSG00000228278.
GeneIDi5005.
KEGGihsa:5005.
UCSCiuc004bil.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiA1AG2_HUMAN
AccessioniPrimary (citable) accession number: P19652
Secondary accession number(s): B2R5L2
, Q16571, Q5T538, Q6IB74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 1, 1993
Last modified: September 27, 2017
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families