Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-1-acid glycoprotein 2

Gene

ORM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.1 Publication

GO - Biological processi

  • acute-phase response Source: ProtInc
  • platelet degranulation Source: Reactome
  • regulation of immune system process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Acute phase, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-33633-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein 2
Short name:
AGP 2
Alternative name(s):
Orosomucoid-2
Short name:
OMD 2
Gene namesi
Name:ORM2
Synonyms:AGP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8499. ORM2.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • platelet alpha granule lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5005.
OpenTargetsiENSG00000228278.
PharmGKBiPA32818.

Chemistry databases

ChEMBLiCHEMBL5958.
DrugBankiDB00477. Chlorpromazine.
DB00497. Oxycodone.
DB01041. Thalidomide.

Polymorphism and mutation databases

BioMutaiORM2.
DMDMi231458.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001786119 – 201Alpha-1-acid glycoprotein 2Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi23 ↔ 165
Glycosylationi33N-linked (GlcNAc...) (complex)8 Publications1
Glycosylationi56N-linked (GlcNAc...)4 Publications1
Glycosylationi72N-linked (GlcNAc...)3 Publications1
Disulfide bondi90 ↔ 183
Glycosylationi93N-linked (GlcNAc...)5 Publications1
GlycosylationiCAR_000171103N-linked (GlcNAc...)3 Publications1

Post-translational modificationi

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).8 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP19652.
MaxQBiP19652.
PaxDbiP19652.
PeptideAtlasiP19652.
PRIDEiP19652.

2D gel databases

DOSAC-COBS-2DPAGEP19652.
SWISS-2DPAGEP19652.

PTM databases

iPTMnetiP19652.
PhosphoSitePlusiP19652.
UniCarbKBiP19652.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Inductioni

Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.

Gene expression databases

BgeeiENSG00000228278.
GenevisibleiP19652. HS.

Organism-specific databases

HPAiHPA046438.
HPA057726.

Interactioni

Protein-protein interaction databases

BioGridi111047. 5 interactors.
IntActiP19652. 3 interactors.
STRINGi9606.ENSP00000394936.

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni20 – 23Combined sources4
Helixi24 – 26Combined sources3
Helixi33 – 39Combined sources7
Beta strandi41 – 51Combined sources11
Helixi53 – 60Combined sources8
Beta strandi62 – 72Combined sources11
Turni73 – 76Combined sources4
Beta strandi77 – 86Combined sources10
Beta strandi89 – 100Combined sources12
Turni101 – 104Combined sources4
Beta strandi105 – 110Combined sources6
Beta strandi113 – 120Combined sources8
Beta strandi127 – 133Combined sources7
Turni137 – 139Combined sources3
Beta strandi141 – 150Combined sources10
Helixi153 – 165Combined sources13
Helixi170 – 172Combined sources3
Helixi178 – 180Combined sources3
Helixi184 – 191Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3APUX-ray2.10A/B19-201[»]
3APVX-ray2.15A/B19-201[»]
3APWX-ray2.20A/B19-201[»]
3APXX-ray2.20A19-201[»]
ProteinModelPortaliP19652.
SMRiP19652.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19652.

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.1 Publication

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
GeneTreeiENSGT00390000012130.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP19652.
KOiK17308.
OMAiPGSHEDE.
OrthoDBiEOG091G0NAQ.
PhylomeDBiP19652.
TreeFamiTF343791.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF
60 70 80 90 100
RNEEYNKSVQ EIQATFFYFT PNKTEDTIFL REYQTRQNQC FYNSSYLNVQ
110 120 130 140 150
RENGTVSRYE GGREHVAHLL FLRDTKTLMF GSYLDDEKNW GLSFYADKPE
160 170 180 190 200
TTKEQLGEFY EALDCLCIPR SDVMYTDWKK DKCEPLEKQH EKERKQEEGE

S
Length:201
Mass (Da):23,603
Last modified:April 1, 1993 - v2
Checksum:i49167ABCC22933B9
GO

Sequence cautioni

The sequence CAA29873 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA29874 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32T → I in CAG33211 (Ref. 4) Curated1
Sequence conflicti102E → D in BAG35159 (PubMed:14702039).Curated1
Sequence conflicti125T → I in BAG35159 (PubMed:14702039).Curated1
Sequence conflicti162A → V in BAG35159 (PubMed:14702039).Curated1
Sequence conflicti189Q → H in BAG35159 (PubMed:14702039).Curated1

Polymorphismi

Many different variants of ORM2 are known.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01466738R → Q.Corresponds to variant rs147969317dbSNPEnsembl.1
Natural variantiVAR_05017299V → A.Corresponds to variant rs2636889dbSNPEnsembl.1
Natural variantiVAR_050173141G → R.Corresponds to variant rs12685968dbSNPEnsembl.1
Natural variantiVAR_050174167C → R.Corresponds to variant rs1126777dbSNPEnsembl.1
Natural variantiVAR_050175174M → V.Corresponds to variant rs2636890dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06675 Genomic DNA. Translation: CAA29874.1. Sequence problems.
X05780 Genomic DNA. No translation available.
X06674
, X06676, X06677, X06678, X06679, X06680 Genomic DNA. Translation: CAA29873.2. Sequence problems.
X05784 Genomic DNA. No translation available.
M21540 Genomic DNA. Translation: AAA51549.1.
AK312226 mRNA. Translation: BAG35159.1.
CR456930 mRNA. Translation: CAG33211.1.
AL356796 Genomic DNA. Translation: CAI16860.1.
CH471090 Genomic DNA. Translation: EAW87417.1.
BC015964 mRNA. Translation: AAH15964.1.
BC056239 mRNA. Translation: AAH56239.1.
CCDSiCCDS6804.1.
PIRiJT0326. OMHU2.
RefSeqiNP_000599.1. NM_000608.2.
UniGeneiHs.719954.

Genome annotation databases

EnsembliENST00000431067; ENSP00000394936; ENSG00000228278.
GeneIDi5005.
KEGGihsa:5005.
UCSCiuc004bil.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06675 Genomic DNA. Translation: CAA29874.1. Sequence problems.
X05780 Genomic DNA. No translation available.
X06674
, X06676, X06677, X06678, X06679, X06680 Genomic DNA. Translation: CAA29873.2. Sequence problems.
X05784 Genomic DNA. No translation available.
M21540 Genomic DNA. Translation: AAA51549.1.
AK312226 mRNA. Translation: BAG35159.1.
CR456930 mRNA. Translation: CAG33211.1.
AL356796 Genomic DNA. Translation: CAI16860.1.
CH471090 Genomic DNA. Translation: EAW87417.1.
BC015964 mRNA. Translation: AAH15964.1.
BC056239 mRNA. Translation: AAH56239.1.
CCDSiCCDS6804.1.
PIRiJT0326. OMHU2.
RefSeqiNP_000599.1. NM_000608.2.
UniGeneiHs.719954.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3APUX-ray2.10A/B19-201[»]
3APVX-ray2.15A/B19-201[»]
3APWX-ray2.20A/B19-201[»]
3APXX-ray2.20A19-201[»]
ProteinModelPortaliP19652.
SMRiP19652.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111047. 5 interactors.
IntActiP19652. 3 interactors.
STRINGi9606.ENSP00000394936.

Chemistry databases

ChEMBLiCHEMBL5958.
DrugBankiDB00477. Chlorpromazine.
DB00497. Oxycodone.
DB01041. Thalidomide.

PTM databases

iPTMnetiP19652.
PhosphoSitePlusiP19652.
UniCarbKBiP19652.

Polymorphism and mutation databases

BioMutaiORM2.
DMDMi231458.

2D gel databases

DOSAC-COBS-2DPAGEP19652.
SWISS-2DPAGEP19652.

Proteomic databases

EPDiP19652.
MaxQBiP19652.
PaxDbiP19652.
PeptideAtlasiP19652.
PRIDEiP19652.

Protocols and materials databases

DNASUi5005.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431067; ENSP00000394936; ENSG00000228278.
GeneIDi5005.
KEGGihsa:5005.
UCSCiuc004bil.4. human.

Organism-specific databases

CTDi5005.
DisGeNETi5005.
GeneCardsiORM2.
HGNCiHGNC:8499. ORM2.
HPAiHPA046438.
HPA057726.
MIMi138610. gene.
neXtProtiNX_P19652.
OpenTargetsiENSG00000228278.
PharmGKBiPA32818.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
GeneTreeiENSGT00390000012130.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP19652.
KOiK17308.
OMAiPGSHEDE.
OrthoDBiEOG091G0NAQ.
PhylomeDBiP19652.
TreeFamiTF343791.

Enzyme and pathway databases

BioCyciZFISH:G66-33633-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiP19652.
GenomeRNAii5005.
PROiP19652.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000228278.
GenevisibleiP19652. HS.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA1AG2_HUMAN
AccessioniPrimary (citable) accession number: P19652
Secondary accession number(s): B2R5L2
, Q16571, Q5T538, Q6IB74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 1, 1993
Last modified: November 30, 2016
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.