SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P19643

- AOFB_RAT

UniProt

P19643 - AOFB_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Amine oxidase [flavin-containing] B

Gene
Maob
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561Important for catalytic activity By similarity
Sitei365 – 3651Important for catalytic activity By similarity
Sitei382 – 3821Important for catalytic activity By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: RGD
  2. primary amine oxidase activity Source: RGD
  3. protein homodimerization activity Source: RGD

GO - Biological processi

  1. negative regulation of serotonin secretion Source: RGD
  2. neurotransmitter catabolic process Source: RGD
  3. positive regulation of dopamine metabolic process Source: RGD
  4. response to aluminum ion Source: RGD
  5. response to corticosterone Source: RGD
  6. response to drug Source: RGD
  7. response to ethanol Source: RGD
  8. response to lipopolysaccharide Source: RGD
  9. response to selenium ion Source: RGD
  10. response to steroid hormone Source: RGD
  11. response to toxic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.4.3.4. 5301.
SABIO-RKP19643.

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] B (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type B
Short name:
MAO-B
Gene namesi
Name:Maob
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3041. Maob.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 489488Cytoplasmic By similarityAdd
BLAST
Transmembranei490 – 51627Helical; Anchor for type IV membrane protein; By similarityAdd
BLAST
Topological domaini517 – 5204Mitochondrial intermembrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Ensembl
  3. mitochondrial outer membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi139 – 1391L → H: No change in substrate affinity.
Mutagenesisi199 – 1991I → F: Increased affinity for serotonin and tyramine. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 520519Amine oxidase [flavin-containing] BPRO_0000099863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei52 – 521N6-acetyllysine By similarity
Modified residuei397 – 3971S-8alpha-FAD cysteine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP19643.
PRIDEiP19643.

Expressioni

Gene expression databases

GenevestigatoriP19643.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP19643.
SMRiP19643. Positions 3-501.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 5217Arg/Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiP19643.
KOiK00274.
PhylomeDBiP19643.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19643-1 [UniParc]FASTAAdd to Basket

« Hide

MSNKCDVIVV GGGISGMAAA KLLHDCGLSV VVLEARDRVG GRTYTIRNKN    50
VKYVDLGGSY VGPTQNRILR LAKELGLETY KVNEVERLIH FVKGKSYAFR 100
GPFPPVWNPI TYLDYNNLWR TMDEMGQEIP SDAPWKAPLA EEWDYMTMKE 150
LLDKICWTNS TKQIATLFVN LCVTAETHEV SALWFLWYVK QCGGTTRIIS 200
TTNGGQERKF IGGSGQVSER IKDILGDRVK LERPVIHIDQ TGENVVVKTL 250
NHEIYEAKYV ISAIPPVLGM KIHHSPPLPI LRNQLITRVP LGSVIKCMVY 300
YKEPFWRKKD FCGTMVIEGE EAPIAYTLDD TKPDGSCAAI MGFILAHKAR 350
KLVRLTKEER LRKLCELYAK VLNSQEALQP VHYEEKNWCE EQYSGGCYTA 400
YFPPGILTQY GRVLRQPVGK IFFAGTETAS HWSGYMEGAV EAGERAAREI 450
LHAIGKIPED EIWQPEPESV DVPARPITNT FLERHLPSVP GLLKLLGLTT 500
ILSATALGFL AHKKGLFVRF 520
Length:520
Mass (Da):58,459
Last modified:January 23, 2007 - v3
Checksum:iF2C230BC6CDE5840
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381R → C in AAA41566. 1 Publication
Sequence conflicti335 – 3362GS → AG in AAA41566. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23601 mRNA. Translation: AAA41566.1.
BC089814 mRNA. Translation: AAH89814.1.
PIRiA31870.
RefSeqiNP_037330.1. NM_013198.1.
UniGeneiRn.6656.

Genome annotation databases

GeneIDi25750.
KEGGirno:25750.
UCSCiRGD:3041. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23601 mRNA. Translation: AAA41566.1 .
BC089814 mRNA. Translation: AAH89814.1 .
PIRi A31870.
RefSeqi NP_037330.1. NM_013198.1.
UniGenei Rn.6656.

3D structure databases

ProteinModelPortali P19643.
SMRi P19643. Positions 3-501.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P19643.
ChEMBLi CHEMBL2993.
GuidetoPHARMACOLOGYi 2490.

Proteomic databases

PaxDbi P19643.
PRIDEi P19643.

Protocols and materials databases

DNASUi 25750.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25750.
KEGGi rno:25750.
UCSCi RGD:3041. rat.

Organism-specific databases

CTDi 4129.
RGDi 3041. Maob.

Phylogenomic databases

eggNOGi COG1231.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi P19643.
KOi K00274.
PhylomeDBi P19643.

Enzyme and pathway databases

BRENDAi 1.4.3.4. 5301.
SABIO-RK P19643.

Miscellaneous databases

NextBioi 607939.
PROi P19643.

Gene expression databases

Genevestigatori P19643.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a cDNA for rat liver monoamine oxidase B."
    Ito A., Kuwahara T., Inadome S., Sagara Y.
    Biochem. Biophys. Res. Commun. 157:970-976(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. "A key amino acid responsible for substrate selectivity of monoamine oxidase A and B."
    Tsugeno Y., Ito A.
    J. Biol. Chem. 272:14033-14036(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ILE-199.

Entry informationi

Entry nameiAOFB_RAT
AccessioniPrimary (citable) accession number: P19643
Secondary accession number(s): Q5EBB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi