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Protein

Amine oxidase [flavin-containing] B

Gene

Maob

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei156Important for catalytic activityBy similarity1
Sitei365Important for catalytic activityBy similarity1
Sitei382Important for catalytic activityBy similarity1

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: RGD
  • primary amine oxidase activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • negative regulation of serotonin secretion Source: RGD
  • neurotransmitter catabolic process Source: RGD
  • positive regulation of dopamine metabolic process Source: RGD
  • response to aluminum ion Source: RGD
  • response to corticosterone Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to selenium ion Source: RGD
  • response to steroid hormone Source: RGD
  • response to toxic substance Source: RGD
  • substantia nigra development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.4.3.4. 5301.
ReactomeiR-RNO-141333. Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB.
SABIO-RKP19643.

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] B (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type B
Short name:
MAO-B
Gene namesi
Name:Maob
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi3041. Maob.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 489CytoplasmicBy similarityAdd BLAST488
Transmembranei490 – 516Helical; Anchor for type IV membrane proteinBy similarityAdd BLAST27
Topological domaini517 – 520Mitochondrial intermembraneBy similarity4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi139L → H: No change in substrate affinity. 1
Mutagenesisi199I → F: Increased affinity for serotonin and tyramine. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2993.
GuidetoPHARMACOLOGYi2490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000998632 – 520Amine oxidase [flavin-containing] BAdd BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei52N6-acetyllysineBy similarity1
Modified residuei397S-8alpha-FAD cysteineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP19643.
PRIDEiP19643.

PTM databases

iPTMnetiP19643.
PhosphoSitePlusiP19643.

Expressioni

Gene expression databases

BgeeiENSRNOG00000029778.
ExpressionAtlasiP19643. baseline and differential.
GenevisibleiP19643. RN.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043466.

Chemistry databases

BindingDBiP19643.

Structurei

3D structure databases

ProteinModelPortaliP19643.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 52Arg/Lys-rich (basic)Add BLAST17

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
ENOG410XSNC. LUCA.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiP19643.
KOiK00274.
OMAiTETASHW.
OrthoDBiEOG091G0G7P.
PhylomeDBiP19643.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKCDVIVV GGGISGMAAA KLLHDCGLSV VVLEARDRVG GRTYTIRNKN
60 70 80 90 100
VKYVDLGGSY VGPTQNRILR LAKELGLETY KVNEVERLIH FVKGKSYAFR
110 120 130 140 150
GPFPPVWNPI TYLDYNNLWR TMDEMGQEIP SDAPWKAPLA EEWDYMTMKE
160 170 180 190 200
LLDKICWTNS TKQIATLFVN LCVTAETHEV SALWFLWYVK QCGGTTRIIS
210 220 230 240 250
TTNGGQERKF IGGSGQVSER IKDILGDRVK LERPVIHIDQ TGENVVVKTL
260 270 280 290 300
NHEIYEAKYV ISAIPPVLGM KIHHSPPLPI LRNQLITRVP LGSVIKCMVY
310 320 330 340 350
YKEPFWRKKD FCGTMVIEGE EAPIAYTLDD TKPDGSCAAI MGFILAHKAR
360 370 380 390 400
KLVRLTKEER LRKLCELYAK VLNSQEALQP VHYEEKNWCE EQYSGGCYTA
410 420 430 440 450
YFPPGILTQY GRVLRQPVGK IFFAGTETAS HWSGYMEGAV EAGERAAREI
460 470 480 490 500
LHAIGKIPED EIWQPEPESV DVPARPITNT FLERHLPSVP GLLKLLGLTT
510 520
ILSATALGFL AHKKGLFVRF
Length:520
Mass (Da):58,459
Last modified:January 23, 2007 - v3
Checksum:iF2C230BC6CDE5840
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38R → C in AAA41566 (PubMed:2974701).Curated1
Sequence conflicti335 – 336GS → AG in AAA41566 (PubMed:2974701).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23601 mRNA. Translation: AAA41566.1.
BC089814 mRNA. Translation: AAH89814.1.
PIRiA31870.
RefSeqiNP_037330.1. NM_013198.1.
UniGeneiRn.6656.

Genome annotation databases

EnsembliENSRNOT00000044009; ENSRNOP00000043466; ENSRNOG00000029778.
GeneIDi25750.
KEGGirno:25750.
UCSCiRGD:3041. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23601 mRNA. Translation: AAA41566.1.
BC089814 mRNA. Translation: AAH89814.1.
PIRiA31870.
RefSeqiNP_037330.1. NM_013198.1.
UniGeneiRn.6656.

3D structure databases

ProteinModelPortaliP19643.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043466.

Chemistry databases

BindingDBiP19643.
ChEMBLiCHEMBL2993.
GuidetoPHARMACOLOGYi2490.

PTM databases

iPTMnetiP19643.
PhosphoSitePlusiP19643.

Proteomic databases

PaxDbiP19643.
PRIDEiP19643.

Protocols and materials databases

DNASUi25750.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044009; ENSRNOP00000043466; ENSRNOG00000029778.
GeneIDi25750.
KEGGirno:25750.
UCSCiRGD:3041. rat.

Organism-specific databases

CTDi4129.
RGDi3041. Maob.

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
ENOG410XSNC. LUCA.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiP19643.
KOiK00274.
OMAiTETASHW.
OrthoDBiEOG091G0G7P.
PhylomeDBiP19643.

Enzyme and pathway databases

BRENDAi1.4.3.4. 5301.
ReactomeiR-RNO-141333. Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB.
SABIO-RKP19643.

Miscellaneous databases

PROiP19643.

Gene expression databases

BgeeiENSRNOG00000029778.
ExpressionAtlasiP19643. baseline and differential.
GenevisibleiP19643. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiAOFB_RAT
AccessioniPrimary (citable) accession number: P19643
Secondary accession number(s): Q5EBB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.