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Protein

Amine oxidase [flavin-containing] B

Gene

Maob

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei156Important for catalytic activityBy similarity1
Sitei365Important for catalytic activityBy similarity1
Sitei382Important for catalytic activityBy similarity1

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: RGD
  • primary amine oxidase activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • negative regulation of serotonin secretion Source: RGD
  • neurotransmitter catabolic process Source: RGD
  • positive regulation of dopamine metabolic process Source: RGD
  • response to aluminum ion Source: RGD
  • response to corticosterone Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to selenium ion Source: RGD
  • response to steroid hormone Source: RGD
  • response to toxic substance Source: RGD

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.4.3.4 5301
ReactomeiR-RNO-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
SABIO-RKiP19643

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] B (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type B
Short name:
MAO-B
Gene namesi
Name:Maob
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi3041 Maob

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 489CytoplasmicBy similarityAdd BLAST488
Transmembranei490 – 516Helical; Anchor for type IV membrane proteinBy similarityAdd BLAST27
Topological domaini517 – 520Mitochondrial intermembraneBy similarity4

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi139L → H: No change in substrate affinity. 1
Mutagenesisi199I → F: Increased affinity for serotonin and tyramine. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2993
GuidetoPHARMACOLOGYi2490

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000998632 – 520Amine oxidase [flavin-containing] BAdd BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei52N6-acetyllysineBy similarity1
Modified residuei397S-8alpha-FAD cysteineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP19643
PRIDEiP19643

PTM databases

iPTMnetiP19643
PhosphoSitePlusiP19643

Expressioni

Gene expression databases

BgeeiENSRNOG00000029778
GenevisibleiP19643 RN

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi247778, 1 interactor
STRINGi10116.ENSRNOP00000043466

Chemistry databases

BindingDBiP19643

Structurei

3D structure databases

ProteinModelPortaliP19643
SMRiP19643
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 52Arg/Lys-rich (basic)Add BLAST17

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
GeneTreeiENSGT00730000110903
HOGENOMiHOG000221615
HOVERGENiHBG004255
InParanoidiP19643
KOiK00274
OMAiPWKAPLA
OrthoDBiEOG091G0G7P
PhylomeDBiP19643

Family and domain databases

Gene3Di3.50.50.60, 4 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PRINTSiPR00757 AMINEOXDASEF
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKCDVIVV GGGISGMAAA KLLHDCGLSV VVLEARDRVG GRTYTIRNKN
60 70 80 90 100
VKYVDLGGSY VGPTQNRILR LAKELGLETY KVNEVERLIH FVKGKSYAFR
110 120 130 140 150
GPFPPVWNPI TYLDYNNLWR TMDEMGQEIP SDAPWKAPLA EEWDYMTMKE
160 170 180 190 200
LLDKICWTNS TKQIATLFVN LCVTAETHEV SALWFLWYVK QCGGTTRIIS
210 220 230 240 250
TTNGGQERKF IGGSGQVSER IKDILGDRVK LERPVIHIDQ TGENVVVKTL
260 270 280 290 300
NHEIYEAKYV ISAIPPVLGM KIHHSPPLPI LRNQLITRVP LGSVIKCMVY
310 320 330 340 350
YKEPFWRKKD FCGTMVIEGE EAPIAYTLDD TKPDGSCAAI MGFILAHKAR
360 370 380 390 400
KLVRLTKEER LRKLCELYAK VLNSQEALQP VHYEEKNWCE EQYSGGCYTA
410 420 430 440 450
YFPPGILTQY GRVLRQPVGK IFFAGTETAS HWSGYMEGAV EAGERAAREI
460 470 480 490 500
LHAIGKIPED EIWQPEPESV DVPARPITNT FLERHLPSVP GLLKLLGLTT
510 520
ILSATALGFL AHKKGLFVRF
Length:520
Mass (Da):58,459
Last modified:January 23, 2007 - v3
Checksum:iF2C230BC6CDE5840
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38R → C in AAA41566 (PubMed:2974701).Curated1
Sequence conflicti335 – 336GS → AG in AAA41566 (PubMed:2974701).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23601 mRNA Translation: AAA41566.1
BC089814 mRNA Translation: AAH89814.1
PIRiA31870
RefSeqiNP_037330.1, NM_013198.1
UniGeneiRn.6656

Genome annotation databases

EnsembliENSRNOT00000044009; ENSRNOP00000043466; ENSRNOG00000029778
GeneIDi25750
KEGGirno:25750
UCSCiRGD:3041 rat

Similar proteinsi

Entry informationi

Entry nameiAOFB_RAT
AccessioniPrimary (citable) accession number: P19643
Secondary accession number(s): Q5EBB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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