Reviewed, UniProtKB/Swiss-Prot P19640 (RNAS1_ODOVI)

Names and origin

Protein names

Recommended name:
    Ribonuclease pancreatic
    EC=3.1.27.5
Alternative name(s):
    RNase 1
    RNase A

Gene names

Name:	RNASE1
Synonyms:	RNS1

Organism

Odocoileus virginianus virginianus (Virginia white-tailed deer)

Taxonomic identifier

9875 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Cervidae › Odocoileinae › Odocoileus

Protein attributes

Sequence length	30 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA By similarity.
Catalytic activity	Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
Subunit structure	Monomer By similarity.
Subcellular location	Secreted.
Tissue specificity	Pancreas.
Sequence similarities	Belongs to the pancreatic ribonuclease family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro pancreatic ribonuclease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›30	›30	Ribonuclease pancreatic		PRO_0000057207
Sites
	Active site	12	1	Proton acceptor
	Binding site	7	1	Substrate By similarity
	Binding site	10	1	Substrate By similarity
Natural variations
	Natural variant	3	1	T → S
Experimental info
	Non-terminal residue	30	1

Sequences

	Sequence		Length	Mass (Da)
	P19640-1 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 9184E7C816394D20	FASTA	30	3,376
	10 20 30 KETAAAKFER QHMDPAPAAA XXQNYCNQMM

References

[1]	"Evolution of ribonuclease in relation to polypeptide folding mechanisms." Barnard E.A., Cohen M.S., Gold M.H., Kim J.K. Nature 240:395-398(1972) [PubMed: 4564316] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Pancreas.

Cross-references

Sequence databases
PIR	A05004.
3D structure databases
HSSP	HSSP built from PDB template 2RNS based on UniProtKB P00656.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P19640.
Family and domain databases
InterPro	IPR001427. RNaseA. [Graphical view]
PANTHER	PTHR11437. RNaseA. 1 hit.
Pfam	PF00074. RnaseA. 1 hit. [Graphical view]
ProDom	PD000535. RNaseA. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00127. RNASE_PANCREATIC. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNAS1_ODOVI

Accession

Primary (citable) accession number: P19640

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)