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P19639

- GSTM4_MOUSE

UniProt

P19639 - GSTM4_MOUSE

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Protein
Glutathione S-transferase Mu 3
Gene
Gstm3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: MGI
  2. protein homodimerization activity Source: MGI

GO - Biological processi

  1. cellular response to drug Source: MGI
  2. cellular response to organic cyclic compound Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 3 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 3
Glutathione S-transferase GT9.3
Gene namesi
Name:Gstm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:106026. Gstm3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 218217Glutathione S-transferase Mu 3
PRO_0000185828Add
BLAST

Proteomic databases

MaxQBiP19639.
PaxDbiP19639.
PRIDEiP19639.

Expressioni

Gene expression databases

BgeeiP19639.
CleanExiMM_GSTM3.
GenevestigatoriP19639.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

MINTiMINT-1869606.
STRINGi10090.ENSMUSP00000102289.

Structurei

3D structure databases

ProteinModelPortaliP19639.
SMRiP19639. Positions 2-215.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8887GST N-terminal
Add
BLAST
Domaini90 – 208119GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 82Glutathione binding By similarity
Regioni46 – 505Glutathione binding By similarity
Regioni59 – 602Glutathione binding By similarity
Regioni72 – 732Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.

Phylogenomic databases

eggNOGiNOG300089.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiP19639.
KOiK00799.
OMAiLENQVME.
OrthoDBiEOG7KH9M3.
PhylomeDBiP19639.
TreeFamiTF353040.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19639-1 [UniParc]FASTAAdd to Basket

« Hide

MPMTLGYWNT RGLTHSIRLL LEYTDSSYEE KRYVMGDAPN FDRSQWLSEK    50
FNLGLDFPNL PYLIDGSHKV TQSNAILRYL GRKHNLCGET EEERIRVDTL 100
ENQVMDTRIQ LMIVCCSPDF EKQKPEFLKA IPEKMKLYSE FLGKRPWFAG 150
DKVTYVDFLA YDILDQYRMF EPKCLDAFPN LRDFLARFEG LKKISAYMKS 200
SRFLPRPVFT KIAQWGTD 218
Length:218
Mass (Da):25,702
Last modified:January 23, 2007 - v2
Checksum:iF4989897BE817868
GO

Sequence cautioni

The sequence AAA37748.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044927 mRNA. Translation: AAH44927.1.
J03953 mRNA. Translation: AAA37748.1. Different initiation.
CCDSiCCDS17744.1.
PIRiB28946.
E37520.
RefSeqiNP_034489.1. NM_010359.2.
UniGeneiMm.440885.

Genome annotation databases

EnsembliENSMUST00000004136; ENSMUSP00000004136; ENSMUSG00000004038.
ENSMUST00000106678; ENSMUSP00000102289; ENSMUSG00000004038.
GeneIDi14864.
KEGGimmu:14864.
UCSCiuc008qxv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044927 mRNA. Translation: AAH44927.1 .
J03953 mRNA. Translation: AAA37748.1 . Different initiation.
CCDSi CCDS17744.1.
PIRi B28946.
E37520.
RefSeqi NP_034489.1. NM_010359.2.
UniGenei Mm.440885.

3D structure databases

ProteinModelPortali P19639.
SMRi P19639. Positions 2-215.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1869606.
STRINGi 10090.ENSMUSP00000102289.

Proteomic databases

MaxQBi P19639.
PaxDbi P19639.
PRIDEi P19639.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004136 ; ENSMUSP00000004136 ; ENSMUSG00000004038 .
ENSMUST00000106678 ; ENSMUSP00000102289 ; ENSMUSG00000004038 .
GeneIDi 14864.
KEGGi mmu:14864.
UCSCi uc008qxv.2. mouse.

Organism-specific databases

CTDi 2947.
MGIi MGI:106026. Gstm3.

Phylogenomic databases

eggNOGi NOG300089.
GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115735.
HOVERGENi HBG106842.
InParanoidi P19639.
KOi K00799.
OMAi LENQVME.
OrthoDBi EOG7KH9M3.
PhylomeDBi P19639.
TreeFami TF353040.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

NextBioi 287113.
PROi P19639.
SOURCEi Search...

Gene expression databases

Bgeei P19639.
CleanExi MM_GSTM3.
Genevestigatori P19639.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01267. GSTRNSFRASEM.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole."
    Pearson W.R., Reinhart J., Sisk S.C., Anderson K.S., Adler P.N.
    J. Biol. Chem. 263:13324-13332(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  3. "Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA."
    Pearson W.R., Windle J.J., Morrow J.F., Benson A.M., Talalay P.
    J. Biol. Chem. 258:2052-2062(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-41.
  4. "Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties."
    Mannervik B., Alin P., Guthenberg C., Jensson H., Tahir M.K., Warholm M., Joernvall H.
    Proc. Natl. Acad. Sci. U.S.A. 82:7202-7206(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-26.

Entry informationi

Entry nameiGSTM4_MOUSE
AccessioniPrimary (citable) accession number: P19639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3