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Protein

Glutathione S-transferase Mu 3

Gene

Gstm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • cellular response to drug Source: MGI
  • cellular response to organic cyclic compound Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_317599. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 3 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 3
Glutathione S-transferase GT9.3
Gene namesi
Name:Gstm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106026. Gstm3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 218217Glutathione S-transferase Mu 3PRO_0000185828Add
BLAST

Proteomic databases

MaxQBiP19639.
PaxDbiP19639.
PRIDEiP19639.

Expressioni

Gene expression databases

BgeeiP19639.
CleanExiMM_GSTM3.
GenevestigatoriP19639.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

MINTiMINT-1869606.
STRINGi10090.ENSMUSP00000102289.

Structurei

3D structure databases

ProteinModelPortaliP19639.
SMRiP19639. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8887GST N-terminalAdd
BLAST
Domaini90 – 208119GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 82Glutathione bindingBy similarity
Regioni46 – 505Glutathione bindingBy similarity
Regioni59 – 602Glutathione bindingBy similarity
Regioni72 – 732Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG300089.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiP19639.
KOiK00799.
OMAiYEEKRYV.
OrthoDBiEOG7KH9M3.
PhylomeDBiP19639.
TreeFamiTF353040.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMTLGYWNT RGLTHSIRLL LEYTDSSYEE KRYVMGDAPN FDRSQWLSEK
60 70 80 90 100
FNLGLDFPNL PYLIDGSHKV TQSNAILRYL GRKHNLCGET EEERIRVDTL
110 120 130 140 150
ENQVMDTRIQ LMIVCCSPDF EKQKPEFLKA IPEKMKLYSE FLGKRPWFAG
160 170 180 190 200
DKVTYVDFLA YDILDQYRMF EPKCLDAFPN LRDFLARFEG LKKISAYMKS
210
SRFLPRPVFT KIAQWGTD
Length:218
Mass (Da):25,702
Last modified:January 23, 2007 - v2
Checksum:iF4989897BE817868
GO

Sequence cautioni

The sequence AAA37748.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044927 mRNA. Translation: AAH44927.1.
J03953 mRNA. Translation: AAA37748.1. Different initiation.
CCDSiCCDS17744.1.
PIRiB28946.
E37520.
RefSeqiNP_034489.1. NM_010359.2.
UniGeneiMm.440885.

Genome annotation databases

EnsembliENSMUST00000004136; ENSMUSP00000004136; ENSMUSG00000004038.
GeneIDi14864.
KEGGimmu:14864.
UCSCiuc008qxv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044927 mRNA. Translation: AAH44927.1.
J03953 mRNA. Translation: AAA37748.1. Different initiation.
CCDSiCCDS17744.1.
PIRiB28946.
E37520.
RefSeqiNP_034489.1. NM_010359.2.
UniGeneiMm.440885.

3D structure databases

ProteinModelPortaliP19639.
SMRiP19639. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1869606.
STRINGi10090.ENSMUSP00000102289.

Proteomic databases

MaxQBiP19639.
PaxDbiP19639.
PRIDEiP19639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004136; ENSMUSP00000004136; ENSMUSG00000004038.
GeneIDi14864.
KEGGimmu:14864.
UCSCiuc008qxv.2. mouse.

Organism-specific databases

CTDi2947.
MGIiMGI:106026. Gstm3.

Phylogenomic databases

eggNOGiNOG300089.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiP19639.
KOiK00799.
OMAiYEEKRYV.
OrthoDBiEOG7KH9M3.
PhylomeDBiP19639.
TreeFamiTF353040.

Enzyme and pathway databases

ReactomeiREACT_317599. Glutathione conjugation.

Miscellaneous databases

NextBioi287113.
PROiP19639.
SOURCEiSearch...

Gene expression databases

BgeeiP19639.
CleanExiMM_GSTM3.
GenevestigatoriP19639.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole."
    Pearson W.R., Reinhart J., Sisk S.C., Anderson K.S., Adler P.N.
    J. Biol. Chem. 263:13324-13332(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  3. "Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA."
    Pearson W.R., Windle J.J., Morrow J.F., Benson A.M., Talalay P.
    J. Biol. Chem. 258:2052-2062(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-41.
  4. "Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties."
    Mannervik B., Alin P., Guthenberg C., Jensson H., Tahir M.K., Warholm M., Joernvall H.
    Proc. Natl. Acad. Sci. U.S.A. 82:7202-7206(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-26.

Entry informationi

Entry nameiGSTM4_MOUSE
AccessioniPrimary (citable) accession number: P19639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.