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P19639

- GSTM4_MOUSE

UniProt

P19639 - GSTM4_MOUSE

Protein

Glutathione S-transferase Mu 3

Gene

Gstm3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: MGI
    2. protein homodimerization activity Source: MGI

    GO - Biological processi

    1. cellular response to drug Source: MGI
    2. cellular response to organic cyclic compound Source: MGI

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_215316. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase Mu 3 (EC:2.5.1.18)
    Alternative name(s):
    GST class-mu 3
    Glutathione S-transferase GT9.3
    Gene namesi
    Name:Gstm3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:106026. Gstm3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 218217Glutathione S-transferase Mu 3PRO_0000185828Add
    BLAST

    Proteomic databases

    MaxQBiP19639.
    PaxDbiP19639.
    PRIDEiP19639.

    Expressioni

    Gene expression databases

    BgeeiP19639.
    CleanExiMM_GSTM3.
    GenevestigatoriP19639.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    MINTiMINT-1869606.
    STRINGi10090.ENSMUSP00000102289.

    Structurei

    3D structure databases

    ProteinModelPortaliP19639.
    SMRiP19639. Positions 2-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8887GST N-terminalAdd
    BLAST
    Domaini90 – 208119GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni7 – 82Glutathione bindingBy similarity
    Regioni46 – 505Glutathione bindingBy similarity
    Regioni59 – 602Glutathione bindingBy similarity
    Regioni72 – 732Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Mu family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG300089.
    GeneTreeiENSGT00550000074559.
    HOGENOMiHOG000115735.
    HOVERGENiHBG106842.
    InParanoidiP19639.
    KOiK00799.
    OMAiLENQVME.
    OrthoDBiEOG7KH9M3.
    PhylomeDBiP19639.
    TreeFamiTF353040.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01267. GSTRNSFRASEM.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19639-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPMTLGYWNT RGLTHSIRLL LEYTDSSYEE KRYVMGDAPN FDRSQWLSEK    50
    FNLGLDFPNL PYLIDGSHKV TQSNAILRYL GRKHNLCGET EEERIRVDTL 100
    ENQVMDTRIQ LMIVCCSPDF EKQKPEFLKA IPEKMKLYSE FLGKRPWFAG 150
    DKVTYVDFLA YDILDQYRMF EPKCLDAFPN LRDFLARFEG LKKISAYMKS 200
    SRFLPRPVFT KIAQWGTD 218
    Length:218
    Mass (Da):25,702
    Last modified:January 23, 2007 - v2
    Checksum:iF4989897BE817868
    GO

    Sequence cautioni

    The sequence AAA37748.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC044927 mRNA. Translation: AAH44927.1.
    J03953 mRNA. Translation: AAA37748.1. Different initiation.
    CCDSiCCDS17744.1.
    PIRiB28946.
    E37520.
    RefSeqiNP_034489.1. NM_010359.2.
    UniGeneiMm.440885.

    Genome annotation databases

    EnsembliENSMUST00000004136; ENSMUSP00000004136; ENSMUSG00000004038.
    ENSMUST00000106678; ENSMUSP00000102289; ENSMUSG00000004038.
    GeneIDi14864.
    KEGGimmu:14864.
    UCSCiuc008qxv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC044927 mRNA. Translation: AAH44927.1 .
    J03953 mRNA. Translation: AAA37748.1 . Different initiation.
    CCDSi CCDS17744.1.
    PIRi B28946.
    E37520.
    RefSeqi NP_034489.1. NM_010359.2.
    UniGenei Mm.440885.

    3D structure databases

    ProteinModelPortali P19639.
    SMRi P19639. Positions 2-215.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1869606.
    STRINGi 10090.ENSMUSP00000102289.

    Proteomic databases

    MaxQBi P19639.
    PaxDbi P19639.
    PRIDEi P19639.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004136 ; ENSMUSP00000004136 ; ENSMUSG00000004038 .
    ENSMUST00000106678 ; ENSMUSP00000102289 ; ENSMUSG00000004038 .
    GeneIDi 14864.
    KEGGi mmu:14864.
    UCSCi uc008qxv.2. mouse.

    Organism-specific databases

    CTDi 2947.
    MGIi MGI:106026. Gstm3.

    Phylogenomic databases

    eggNOGi NOG300089.
    GeneTreei ENSGT00550000074559.
    HOGENOMi HOG000115735.
    HOVERGENi HBG106842.
    InParanoidi P19639.
    KOi K00799.
    OMAi LENQVME.
    OrthoDBi EOG7KH9M3.
    PhylomeDBi P19639.
    TreeFami TF353040.

    Enzyme and pathway databases

    Reactomei REACT_215316. Glutathione conjugation.

    Miscellaneous databases

    NextBioi 287113.
    PROi P19639.
    SOURCEi Search...

    Gene expression databases

    Bgeei P19639.
    CleanExi MM_GSTM3.
    Genevestigatori P19639.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01267. GSTRNSFRASEM.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole."
      Pearson W.R., Reinhart J., Sisk S.C., Anderson K.S., Adler P.N.
      J. Biol. Chem. 263:13324-13332(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    3. "Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA."
      Pearson W.R., Windle J.J., Morrow J.F., Benson A.M., Talalay P.
      J. Biol. Chem. 258:2052-2062(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-41.
    4. "Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties."
      Mannervik B., Alin P., Guthenberg C., Jensson H., Tahir M.K., Warholm M., Joernvall H.
      Proc. Natl. Acad. Sci. U.S.A. 82:7202-7206(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-26.

    Entry informationi

    Entry nameiGSTM4_MOUSE
    AccessioniPrimary (citable) accession number: P19639
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3