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Protein

Glutathione S-transferase Mu 3

Gene

Gstm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • cellular response to drug Source: MGI
  • cellular response to organic cyclic compound Source: MGI
  • metabolic process Source: InterPro

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-MMU-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 3 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 3
Glutathione S-transferase GT9.3
Gene namesi
Name:Gstm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106026. Gstm3.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001858282 – 218Glutathione S-transferase Mu 3Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP19639.
PaxDbiP19639.
PeptideAtlasiP19639.
PRIDEiP19639.

PTM databases

iPTMnetiP19639.
PhosphoSitePlusiP19639.

Expressioni

Gene expression databases

BgeeiENSMUSG00000004038.
CleanExiMM_GSTM3.
GenevisibleiP19639. MM.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-1869606.
STRINGi10090.ENSMUSP00000004136.

Structurei

3D structure databases

ProteinModelPortaliP19639.
SMRiP19639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 88GST N-terminalAdd BLAST87
Domaini90 – 208GST C-terminalAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Glutathione bindingBy similarity2
Regioni46 – 50Glutathione bindingBy similarity5
Regioni59 – 60Glutathione bindingBy similarity2
Regioni72 – 73Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated

Phylogenomic databases

eggNOGiENOG410IN5J. Eukaryota.
ENOG4110YU0. LUCA.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiP19639.
KOiK00799.
OMAiFARICYS.
OrthoDBiEOG091G0K2E.
PhylomeDBiP19639.
TreeFamiTF353040.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMTLGYWNT RGLTHSIRLL LEYTDSSYEE KRYVMGDAPN FDRSQWLSEK
60 70 80 90 100
FNLGLDFPNL PYLIDGSHKV TQSNAILRYL GRKHNLCGET EEERIRVDTL
110 120 130 140 150
ENQVMDTRIQ LMIVCCSPDF EKQKPEFLKA IPEKMKLYSE FLGKRPWFAG
160 170 180 190 200
DKVTYVDFLA YDILDQYRMF EPKCLDAFPN LRDFLARFEG LKKISAYMKS
210
SRFLPRPVFT KIAQWGTD
Length:218
Mass (Da):25,702
Last modified:January 23, 2007 - v2
Checksum:iF4989897BE817868
GO

Sequence cautioni

The sequence AAA37748 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044927 mRNA. Translation: AAH44927.1.
J03953 mRNA. Translation: AAA37748.1. Different initiation.
CCDSiCCDS17744.1.
PIRiB28946.
E37520.
RefSeqiNP_034489.1. NM_010359.2.
UniGeneiMm.440885.

Genome annotation databases

EnsembliENSMUST00000004136; ENSMUSP00000004136; ENSMUSG00000004038.
GeneIDi14864.
KEGGimmu:14864.
UCSCiuc008qxv.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiGSTM3_MOUSE
AccessioniPrimary (citable) accession number: P19639
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families