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Protein

Ethanolamine ammonia-lyase light chain

Gene

eutC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Ethanolamine = acetaldehyde + NH3.

Cofactori

Pathwayi: ethanolamine degradation

This protein is involved in the pathway ethanolamine degradation, which is part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the pathway ethanolamine degradation and in Amine and polyamine degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

BioCyciEcoCyc:EUTC-MONOMER.
ECOL316407:JW2433-MONOMER.
MetaCyc:EUTC-MONOMER.
BRENDAi4.3.1.7. 2026.
UniPathwayiUPA00560.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine ammonia-lyase light chain (EC:4.3.1.7)
Alternative name(s):
Ethanolamine ammonia-lyase small subunit
Gene namesi
Name:eutC
Ordered Locus Names:b2440, JW2433
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG50007. eutC.

Subcellular locationi

GO - Cellular componenti

  • ethanolamine ammonia-lyase complex Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059881 – 295Ethanolamine ammonia-lyase light chainAdd BLAST295

Proteomic databases

PaxDbiP19636.
PRIDEiP19636.

Interactioni

Subunit structurei

Heterodimer of a small and a large subunit.

Protein-protein interaction databases

BioGridi4260577. 11 interactors.
IntActiP19636. 30 interactors.
STRINGi511145.b2440.

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi50 – 54Combined sources5
Helixi64 – 72Combined sources9
Helixi89 – 107Combined sources19
Helixi112 – 117Combined sources6
Beta strandi121 – 126Combined sources6
Helixi130 – 135Combined sources6
Helixi137 – 140Combined sources4
Helixi145 – 154Combined sources10
Beta strandi160 – 166Combined sources7
Helixi172 – 175Combined sources4
Helixi178 – 190Combined sources13
Turni191 – 193Combined sources3
Beta strandi200 – 203Combined sources4
Helixi209 – 217Combined sources9
Beta strandi220 – 227Combined sources8
Beta strandi238 – 245Combined sources8
Turni248 – 250Combined sources3
Helixi253 – 255Combined sources3
Beta strandi256 – 263Combined sources8
Helixi269 – 286Combined sources18
Helixi290 – 292Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ABOX-ray2.10B/D1-295[»]
3ABQX-ray2.05B/D1-295[»]
3ABRX-ray2.10B/D1-295[»]
3ABSX-ray2.25B/D1-295[»]
3ANYX-ray2.10B/D44-295[»]
3AO0X-ray2.25B/D44-295[»]
ProteinModelPortaliP19636.
SMRiP19636.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19636.

Family & Domainsi

Sequence similaritiesi

Belongs to the EutC family.Curated

Phylogenomic databases

eggNOGiENOG4107FQ9. Bacteria.
COG4302. LUCA.
HOGENOMiHOG000253991.
InParanoidiP19636.
KOiK03736.
OMAiCKDKDEY.
PhylomeDBiP19636.

Family and domain databases

HAMAPiMF_00601. EutC. 1 hit.
InterProiIPR009246. EutC.
[Graphical view]
PfamiPF05985. EutC. 1 hit.
[Graphical view]
PIRSFiPIRSF018982. EutC. 1 hit.

Sequencei

Sequence statusi: Complete.

P19636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQKQIEEIV RSVMASMGQA APAPSEAKCA TTNCAAPVTS ESCALDLGSA
60 70 80 90 100
EAKAWIGVEN PHRADVLTEL RRSTVARVCT GRAGPRPRTQ ALLRFLADHS
110 120 130 140 150
RSKDTVLKEV PEEWVKAQGL LEVRSEISDK NLYLTRPDMG RRLCAEAVEA
160 170 180 190 200
LKAQCVANPD VQVVISDGLS TDAITVNYEE ILPPLMAGLK QAGLKVGTPF
210 220 230 240 250
FVRYGRVKIE DQIGEILGAK VVILLVGERP GLGQSESLSC YAVYSPRMAT
260 270 280 290
TVEADRTCIS NIHQGGTPPV EAAAVIVDLA KRMLEQKASG INMTR
Length:295
Mass (Da):31,782
Last modified:November 1, 1997 - v2
Checksum:iC7E87143B8E050E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75493.1.
AP009048 Genomic DNA. Translation: BAA16322.1.
PIRiG65018.
RefSeqiNP_416935.1. NC_000913.3.
WP_000372316.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75493; AAC75493; b2440.
BAA16322; BAA16322; BAA16322.
GeneIDi946925.
KEGGiecj:JW2433.
eco:b2440.
PATRICi32120265. VBIEscCol129921_2535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75493.1.
AP009048 Genomic DNA. Translation: BAA16322.1.
PIRiG65018.
RefSeqiNP_416935.1. NC_000913.3.
WP_000372316.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ABOX-ray2.10B/D1-295[»]
3ABQX-ray2.05B/D1-295[»]
3ABRX-ray2.10B/D1-295[»]
3ABSX-ray2.25B/D1-295[»]
3ANYX-ray2.10B/D44-295[»]
3AO0X-ray2.25B/D44-295[»]
ProteinModelPortaliP19636.
SMRiP19636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260577. 11 interactors.
IntActiP19636. 30 interactors.
STRINGi511145.b2440.

Proteomic databases

PaxDbiP19636.
PRIDEiP19636.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75493; AAC75493; b2440.
BAA16322; BAA16322; BAA16322.
GeneIDi946925.
KEGGiecj:JW2433.
eco:b2440.
PATRICi32120265. VBIEscCol129921_2535.

Organism-specific databases

EchoBASEiEB4300.
EcoGeneiEG50007. eutC.

Phylogenomic databases

eggNOGiENOG4107FQ9. Bacteria.
COG4302. LUCA.
HOGENOMiHOG000253991.
InParanoidiP19636.
KOiK03736.
OMAiCKDKDEY.
PhylomeDBiP19636.

Enzyme and pathway databases

UniPathwayiUPA00560.
BioCyciEcoCyc:EUTC-MONOMER.
ECOL316407:JW2433-MONOMER.
MetaCyc:EUTC-MONOMER.
BRENDAi4.3.1.7. 2026.

Miscellaneous databases

EvolutionaryTraceiP19636.
PROiP19636.

Family and domain databases

HAMAPiMF_00601. EutC. 1 hit.
InterProiIPR009246. EutC.
[Graphical view]
PfamiPF05985. EutC. 1 hit.
[Graphical view]
PIRSFiPIRSF018982. EutC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEUTC_ECOLI
AccessioniPrimary (citable) accession number: P19636
Secondary accession number(s): P78273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.