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Protein

Phosducin

Gene

PDC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin
Short name:
PHD
Alternative name(s):
33 kDa phototransducing protein
Protein MEKA
Gene namesi
Name:PDC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001637481 – 245PhosducinAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73Phosphoserine; by PKA1 Publication1

Post-translational modificationi

Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19632.
PRIDEiP19632.

PTM databases

iPTMnetiP19632.

Interactioni

Subunit structurei

Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.By similarity

Protein-protein interaction databases

IntActiP19632. 2 interactors.
STRINGi9913.ENSBTAP00000005468.

Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 35Combined sources15
Helixi74 – 80Combined sources7
Helixi87 – 105Combined sources19
Beta strandi113 – 116Combined sources4
Helixi120 – 128Combined sources9
Beta strandi135 – 141Combined sources7
Helixi148 – 161Combined sources14
Beta strandi165 – 171Combined sources7
Helixi172 – 175Combined sources4
Turni183 – 185Combined sources3
Beta strandi187 – 193Combined sources7
Beta strandi196 – 201Combined sources6
Helixi204 – 207Combined sources4
Helixi214 – 222Combined sources9
Turni223 – 225Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A0RX-ray2.80P1-245[»]
ProteinModelPortaliP19632.
SMRiP19632.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19632.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 245Thioredoxin foldBy similarityAdd BLAST135

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3171. Eukaryota.
ENOG4110DRD. LUCA.
HOGENOMiHOG000232010.
HOVERGENiHBG003456.
InParanoidiP19632.

Family and domain databases

Gene3Di1.10.168.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR001200. Phosducin.
IPR023196. Phosducin_N_dom.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
PRINTSiPR00677. PHOSDUCIN.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

P19632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKAKSQSLE EDFEGQASHT GPKGVINDWR KFKLESEDSD SVAHSKKEIL
60 70 80 90 100
RQMSSPQSRD DKDSKERFSR KMSVQEYELI HKDKEDENCL RKYRRQCMQD
110 120 130 140 150
MHQKLSFGPR YGFVYELESG EQFLETIEKE QKITTIVVHI YEDGIKGCDA
160 170 180 190 200
LNSSLICLAA EYPMVKFCKI KASNTGAGDR FSSDVLPTLL VYKGGELLSN
210 220 230 240
FISVTEQLAE EFFTGDVESF LNEYGLLPEK EMHVLEQTNM EEDME
Length:245
Mass (Da):28,231
Last modified:May 1, 1991 - v2
Checksum:i5CA621610401D550
GO

Sequence cautioni

The sequence AAA62716 differs from that shown. Reason: Frameshift at position 231.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44H → P in AAA30349 (PubMed:2210381).Curated1
Sequence conflicti238 – 239TN → SK in AAA30349 (PubMed:2210381).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58170 mRNA. Translation: AAA62716.1. Frameshift.
M33529 mRNA. Translation: AAA30349.1.
PIRiA38379.
UniGeneiBt.12783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58170 mRNA. Translation: AAA62716.1. Frameshift.
M33529 mRNA. Translation: AAA30349.1.
PIRiA38379.
UniGeneiBt.12783.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A0RX-ray2.80P1-245[»]
ProteinModelPortaliP19632.
SMRiP19632.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP19632. 2 interactors.
STRINGi9913.ENSBTAP00000005468.

PTM databases

iPTMnetiP19632.

Proteomic databases

PaxDbiP19632.
PRIDEiP19632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3171. Eukaryota.
ENOG4110DRD. LUCA.
HOGENOMiHOG000232010.
HOVERGENiHBG003456.
InParanoidiP19632.

Miscellaneous databases

EvolutionaryTraceiP19632.

Family and domain databases

Gene3Di1.10.168.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR001200. Phosducin.
IPR023196. Phosducin_N_dom.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
PRINTSiPR00677. PHOSDUCIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHOS_BOVIN
AccessioniPrimary (citable) accession number: P19632
Secondary accession number(s): P20940, Q28160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 1, 1991
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.