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P19620

- ANXA2_PIG

UniProt

P19620 - ANXA2_PIG

Protein

Annexin A2

Gene

ANXA2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 4 (29 May 2007)
      Previous versions | rss
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    Functioni

    Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. phospholipase inhibitor activity Source: InterPro
    4. S100 protein binding Source: UniProt

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A2
    Alternative name(s):
    Annexin II
    Annexin-2
    Calpactin I heavy chain
    Calpactin-1 heavy chain
    Chromobindin-8
    Lipocortin II
    Placental anticoagulant protein IV
    Short name:
    PAP-IV
    Protein I
    p36
    Gene namesi
    Name:ANXA2
    Synonyms:ANX2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Secretedextracellular spaceextracellular matrixbasement membrane. Melanosome By similarity
    Note: In the lamina beneath the plasma membrane.

    GO - Cellular componenti

    1. basement membrane Source: UniProtKB-SubCell
    2. melanosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Basement membrane, Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 339338Annexin A2PRO_0000067472Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei24 – 241Phosphotyrosine; by SRCBy similarity
    Modified residuei26 – 261Phosphoserine; by PKCBy similarity
    Modified residuei49 – 491N6-acetyllysineBy similarity
    Modified residuei152 – 1521N6-acetyllysineBy similarity
    Modified residuei199 – 1991PhosphotyrosineBy similarity
    Modified residuei227 – 2271N6-acetyllysineBy similarity

    Post-translational modificationi

    ISGylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP19620.
    PRIDEiP19620.

    Interactioni

    Subunit structurei

    Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF By similarity. Interacts with COCH By similarity.By similarity

    Protein-protein interaction databases

    MINTiMINT-1214816.
    STRINGi9823.ENSSSCP00000004935.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 10261Annexin 1Add
    BLAST
    Repeati114 – 17461Annexin 2Add
    BLAST
    Repeati199 – 25961Annexin 3Add
    BLAST
    Repeati274 – 33461Annexin 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 2423S100A10-binding siteAdd
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG259189.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    KOiK17092.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view]
    PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19620-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVHEILCK LSLEGDHSTP ASAYGSVKAY TNFDAERDAL NIETAIKTKG    50
    VDEVTIVNIL TNRSNEQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL 100
    GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM 150
    YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD 200
    AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG 250
    DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIX IMVSRSEVDM 300
    LKIRSEFKRK YGKSLYNYIQ QDTKGDYQKA LLYLCGGDD 339
    Length:339
    Mass (Da):38,534
    Last modified:May 29, 2007 - v4
    Checksum:iFAC554639119900D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti223 – 2231C → P AA sequence (PubMed:2937654)Curated
    Sequence conflicti229 – 2291F → S AA sequence (PubMed:17607745)Curated
    Sequence conflicti230 – 2301E → S AA sequence (PubMed:2937654)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY706383 mRNA. Translation: AAU85387.1.
    PIRiS01128.
    RefSeqiNP_001005726.1. NM_001005726.1.
    UniGeneiSsc.12241.

    Genome annotation databases

    GeneIDi406192.
    KEGGissc:406192.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Red velvet - Issue 86 of September 2007

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY706383 mRNA. Translation: AAU85387.1 .
    PIRi S01128.
    RefSeqi NP_001005726.1. NM_001005726.1.
    UniGenei Ssc.12241.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1214816.
    STRINGi 9823.ENSSSCP00000004935.

    Proteomic databases

    PaxDbi P19620.
    PRIDEi P19620.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 406192.
    KEGGi ssc:406192.

    Organism-specific databases

    CTDi 302.

    Phylogenomic databases

    eggNOGi NOG259189.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    KOi K17092.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view ]
    PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of metaphase II-specific gene transcripts in porcine oocytes and their expression in early stage embryos."
      Cui X.S., Song H., Kim N.H.
      Reprod. Fertil. Dev. 17:625-631(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Annexin A2 / p11 interaction: new insights into annexin A2 tetramer structure by chemical cross-linking, high-resolution mass spectrometry, and computational modeling."
      Schulz D.M., Kalkhof S., Schmidt A., Ihling C., Stingl C., Mechtler K., Zschoernig O., Sinz A.
      Proteins 69:254-269(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-339, ACETYLATION AT SER-2.
    3. "A discontinuous epitope on p36, the major substrate of src tyrosine-protein-kinase, brings the phosphorylation site into the neighbourhood of a consensus sequence for Ca2+/lipid-binding proteins."
      Johnsson N., Johnsson K., Weber K.
      FEBS Lett. 236:201-204(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-70.
    4. "p36, the major cytoplasmic substrate of src tyrosine protein kinase, binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix."
      Johnsson N., Marriott G., Weber K.
      EMBO J. 7:2435-2442(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-30.
    5. "Binding sites for calcium, lipid and p11 on p36, the substrate of retroviral tyrosine-specific protein kinases."
      Johnsson N., Vandekerckhove J., Van Damme J., Weber K.
      FEBS Lett. 198:361-364(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 213-234.

    Entry informationi

    Entry nameiANXA2_PIG
    AccessioniPrimary (citable) accession number: P19620
    Secondary accession number(s): Q5Y2C7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3