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P19620

- ANXA2_PIG

UniProt

P19620 - ANXA2_PIG

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Protein
Annexin A2
Gene
ANXA2, ANX2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

GO - Molecular functioni

  1. S100 protein binding Source: UniProt
  2. calcium ion binding Source: InterPro
  3. calcium-dependent phospholipid binding Source: UniProtKB-KW
  4. phospholipase inhibitor activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A2
Alternative name(s):
Annexin II
Annexin-2
Calpactin I heavy chain
Calpactin-1 heavy chain
Chromobindin-8
Lipocortin II
Placental anticoagulant protein IV
Short name:
PAP-IV
Protein I
p36
Gene namesi
Name:ANXA2
Synonyms:ANX2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Secretedextracellular spaceextracellular matrixbasement membrane. Melanosome By similarity
Note: In the lamina beneath the plasma membrane.

GO - Cellular componenti

  1. basement membrane Source: UniProtKB-SubCell
  2. melanosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 339338Annexin A2
PRO_0000067472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei24 – 241Phosphotyrosine; by SRC By similarity
Modified residuei26 – 261Phosphoserine; by PKC By similarity
Modified residuei49 – 491N6-acetyllysine By similarity
Modified residuei152 – 1521N6-acetyllysine By similarity
Modified residuei199 – 1991Phosphotyrosine By similarity
Modified residuei227 – 2271N6-acetyllysine By similarity

Post-translational modificationi

ISGylated By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP19620.
PRIDEiP19620.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF By similarity. Interacts with COCH By similarity.

Protein-protein interaction databases

MINTiMINT-1214816.
STRINGi9823.ENSSSCP00000004935.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 10261Annexin 1
Add
BLAST
Repeati114 – 17461Annexin 2
Add
BLAST
Repeati199 – 25961Annexin 3
Add
BLAST
Repeati274 – 33461Annexin 4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 2423S100A10-binding site
Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.
Contains 4 annexin repeats.

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG259189.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
KOiK17092.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19620-1 [UniParc]FASTAAdd to Basket

« Hide

MSTVHEILCK LSLEGDHSTP ASAYGSVKAY TNFDAERDAL NIETAIKTKG    50
VDEVTIVNIL TNRSNEQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL 100
GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM 150
YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD 200
AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG 250
DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIX IMVSRSEVDM 300
LKIRSEFKRK YGKSLYNYIQ QDTKGDYQKA LLYLCGGDD 339
Length:339
Mass (Da):38,534
Last modified:May 29, 2007 - v4
Checksum:iFAC554639119900D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231C → P AA sequence 1 Publication
Sequence conflicti229 – 2291F → S AA sequence 1 Publication
Sequence conflicti230 – 2301E → S AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY706383 mRNA. Translation: AAU85387.1.
PIRiS01128.
RefSeqiNP_001005726.1. NM_001005726.1.
UniGeneiSsc.12241.

Genome annotation databases

GeneIDi406192.
KEGGissc:406192.

Cross-referencesi

Web resourcesi

Protein Spotlight

Red velvet - Issue 86 of September 2007

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY706383 mRNA. Translation: AAU85387.1 .
PIRi S01128.
RefSeqi NP_001005726.1. NM_001005726.1.
UniGenei Ssc.12241.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1214816.
STRINGi 9823.ENSSSCP00000004935.

Proteomic databases

PaxDbi P19620.
PRIDEi P19620.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 406192.
KEGGi ssc:406192.

Organism-specific databases

CTDi 302.

Phylogenomic databases

eggNOGi NOG259189.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
KOi K17092.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view ]
PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of metaphase II-specific gene transcripts in porcine oocytes and their expression in early stage embryos."
    Cui X.S., Song H., Kim N.H.
    Reprod. Fertil. Dev. 17:625-631(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Annexin A2 / p11 interaction: new insights into annexin A2 tetramer structure by chemical cross-linking, high-resolution mass spectrometry, and computational modeling."
    Schulz D.M., Kalkhof S., Schmidt A., Ihling C., Stingl C., Mechtler K., Zschoernig O., Sinz A.
    Proteins 69:254-269(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-339, ACETYLATION AT SER-2.
  3. "A discontinuous epitope on p36, the major substrate of src tyrosine-protein-kinase, brings the phosphorylation site into the neighbourhood of a consensus sequence for Ca2+/lipid-binding proteins."
    Johnsson N., Johnsson K., Weber K.
    FEBS Lett. 236:201-204(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-70.
  4. "p36, the major cytoplasmic substrate of src tyrosine protein kinase, binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix."
    Johnsson N., Marriott G., Weber K.
    EMBO J. 7:2435-2442(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-30.
  5. "Binding sites for calcium, lipid and p11 on p36, the substrate of retroviral tyrosine-specific protein kinases."
    Johnsson N., Vandekerckhove J., Van Damme J., Weber K.
    FEBS Lett. 198:361-364(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 213-234.

Entry informationi

Entry nameiANXA2_PIG
AccessioniPrimary (citable) accession number: P19620
Secondary accession number(s): Q5Y2C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 29, 2007
Last modified: April 16, 2014
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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