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P19596 (FGF1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 1

Short name=FGF-1
Alternative name(s):
Acidic fibroblast growth factor
Short name=aFGF
Endothelial cell growth factor
Short name=ECGF
Heparin-binding growth factor 1
Short name=HBGF-1

Cleaved into the following chain:

  1. Endothelial cell growth factor alpha
Gene names
Name:FGF1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length155 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro By similarity.

Subcellular location

Secreted By similarity. Cytoplasm By similarity. Cytoplasmcell cortex By similarity. Cytoplasmcytosol By similarity. Nucleus By similarity. Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13 By similarity. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery By similarity.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Biological processAngiogenesis
Differentiation
   Cellular componentCytoplasm
Nucleus
Secreted
   LigandHeparin-binding
   Molecular functionDevelopmental protein
Growth factor
Mitogen
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

branch elongation involved in ureteric bud branching

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to heat

Inferred from electronic annotation. Source: Ensembl

epicardial cell to mesenchymal cell transition

Traceable author statement PubMed 20299672. Source: DFLAT

fibroblast growth factor receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

lung development

Inferred from electronic annotation. Source: Ensembl

mesonephric epithelium development

Inferred from sequence or structural similarity. Source: UniProtKB

organ induction

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell division

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cholesterol biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of intracellular signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcell cortex

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular region

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular space

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionS100 protein binding

Inferred from sequence or structural similarity. Source: UniProtKB

fibroblast growth factor receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

growth factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

heparin binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 1515
PRO_0000008920
Chain16 – 155140Fibroblast growth factor 1
PRO_0000008921
Chain22 – 155134Endothelial cell growth factor alpha
PRO_0000008922

Regions

Region127 – 14317Heparin-binding By similarity

Sites

Binding site331Heparin By similarity

Sequences

Sequence LengthMass (Da)Tools
P19596 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 8EDB70545E2B4365

FASTA15517,322
        10         20         30         40         50         60 
MAEGEITTFT ALTERFGLPL GNYKKPKLLY CSNGGHFLRI LPDGKVDGTR DRSDQHIQLQ 

        70         80         90        100        110        120 
LSAEDVGEVY IKSTASGQYL AMDTNGLLYG SQLPGEECLF LERLEENHYN TYISKKHADK 

       130        140        150 
NWFVGLKKNG NSKLGPRTHY GQKAILFLPL PVSAD 

« Hide

References

[1]"Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development."
Schnurch H., Risau W.
Development 111:1143-1154(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]Martin G.R., Han J.K.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor."
Risau W., Gautschi-Sova P., Boehlen P.
EMBO J. 7:959-962(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-48.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S63263 mRNA. Translation: AAB19629.1.
S63261 Genomic DNA. Translation: AAD13942.1.
U31863 mRNA. Translation: AAA80310.1.
PIRA60130.
RefSeqNP_990511.1. NM_205180.1.
UniGeneGga.648.

3D structure databases

ProteinModelPortalP19596.
SMRP19596. Positions 5-155.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000011866.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000011880; ENSGALP00000011866; ENSGALG00000007343.
GeneID396094.
KEGGgga:396094.

Organism-specific databases

CTD2246.

Phylogenomic databases

eggNOGNOG246422.
GeneTreeENSGT00730000110923.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidP19596.
KOK04358.
OMANGLLYGS.
OrthoDBEOG7992S1.
PhylomeDBP19596.
TreeFamTF317805.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF65. PTHR11486:SF65. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816152.
PROP19596.

Entry information

Entry nameFGF1_CHICK
AccessionPrimary (citable) accession number: P19596
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families