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P19596

- FGF1_CHICK

UniProt

P19596 - FGF1_CHICK

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Protein
Fibroblast growth factor 1
Gene
FGF1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331Heparin By similarity

GO - Molecular functioni

  1. S100 protein binding Source: UniProtKB
  2. fibroblast growth factor receptor binding Source: UniProtKB
  3. growth factor activity Source: UniProtKB
  4. heparin binding Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. branch elongation involved in ureteric bud branching Source: UniProtKB
  3. cellular response to heat Source: Ensembl
  4. epicardial cell to mesenchymal cell transition Source: DFLAT
  5. fibroblast growth factor receptor signaling pathway Source: UniProtKB
  6. lung development Source: Ensembl
  7. mesonephric epithelium development Source: UniProtKB
  8. organ induction Source: Ensembl
  9. positive regulation of angiogenesis Source: UniProtKB
  10. positive regulation of cell division Source: UniProtKB
  11. positive regulation of cell migration Source: UniProtKB
  12. positive regulation of cell proliferation Source: UniProtKB
  13. positive regulation of cholesterol biosynthetic process Source: UniProtKB
  14. positive regulation of epithelial cell proliferation Source: Ensembl
  15. positive regulation of intracellular signal transduction Source: UniProtKB
  16. positive regulation of protein phosphorylation Source: Ensembl
  17. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_197153. Negative regulation of FGFR signaling.
REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198103. Signaling by activated point mutants of FGFR1.
REACT_198105. Activated point mutants of FGFR2.
REACT_198138. Signaling by FGFR mutants.
REACT_198173. Signaling by activated point mutants of FGFR3.
REACT_198174. Signaling by FGFR3 mutants.
REACT_202388. FGFR1b ligand binding and activation.
REACT_202481. FGFR2b ligand binding and activation.
REACT_205965. FGFR4 ligand binding and activation.
REACT_207556. PI-3K cascade.
REACT_212391. FGFR3b ligand binding and activation.
REACT_216625. FGFR3c ligand binding and activation.
REACT_224574. FGFR1c ligand binding and activation.
REACT_224844. FGFR2c ligand binding and activation.
REACT_94545. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 1
Short name:
FGF-1
Alternative name(s):
Acidic fibroblast growth factor
Short name:
aFGF
Endothelial cell growth factor
Short name:
ECGF
Heparin-binding growth factor 1
Short name:
HBGF-1
Cleaved into the following chain:
Gene namesi
Name:FGF1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 13

Subcellular locationi

Secreted By similarity. Cytoplasm By similarity. Cytoplasmcell cortex By similarity. Cytoplasmcytosol By similarity. Nucleus By similarity
Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13 By similarity. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery By similarity.

GO - Cellular componenti

  1. cell cortex Source: UniProtKB-SubCell
  2. cytosol Source: UniProtKB
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: UniProtKB
  5. nucleus Source: UniProtKB-SubCell
  6. proteinaceous extracellular matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1515
PRO_0000008920Add
BLAST
Chaini16 – 155140Fibroblast growth factor 1
PRO_0000008921Add
BLAST
Chaini22 – 155134Endothelial cell growth factor alpha
PRO_0000008922Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011866.

Structurei

3D structure databases

ProteinModelPortaliP19596.
SMRiP19596. Positions 5-155.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 14317Heparin-binding By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG246422.
GeneTreeiENSGT00730000110923.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP19596.
KOiK04358.
OMAiNGLLYGS.
OrthoDBiEOG7992S1.
PhylomeDBiP19596.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF65. PTHR11486:SF65. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19596-1 [UniParc]FASTAAdd to Basket

« Hide

MAEGEITTFT ALTERFGLPL GNYKKPKLLY CSNGGHFLRI LPDGKVDGTR    50
DRSDQHIQLQ LSAEDVGEVY IKSTASGQYL AMDTNGLLYG SQLPGEECLF 100
LERLEENHYN TYISKKHADK NWFVGLKKNG NSKLGPRTHY GQKAILFLPL 150
PVSAD 155
Length:155
Mass (Da):17,322
Last modified:February 1, 1996 - v2
Checksum:i8EDB70545E2B4365
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S63263 mRNA. Translation: AAB19629.1.
S63261 Genomic DNA. Translation: AAD13942.1.
U31863 mRNA. Translation: AAA80310.1.
PIRiA60130.
RefSeqiNP_990511.1. NM_205180.1.
UniGeneiGga.648.

Genome annotation databases

EnsembliENSGALT00000011880; ENSGALP00000011866; ENSGALG00000007343.
GeneIDi396094.
KEGGigga:396094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S63263 mRNA. Translation: AAB19629.1 .
S63261 Genomic DNA. Translation: AAD13942.1 .
U31863 mRNA. Translation: AAA80310.1 .
PIRi A60130.
RefSeqi NP_990511.1. NM_205180.1.
UniGenei Gga.648.

3D structure databases

ProteinModelPortali P19596.
SMRi P19596. Positions 5-155.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000011866.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000011880 ; ENSGALP00000011866 ; ENSGALG00000007343 .
GeneIDi 396094.
KEGGi gga:396094.

Organism-specific databases

CTDi 2246.

Phylogenomic databases

eggNOGi NOG246422.
GeneTreei ENSGT00730000110923.
HOGENOMi HOG000236341.
HOVERGENi HBG007580.
InParanoidi P19596.
KOi K04358.
OMAi NGLLYGS.
OrthoDBi EOG7992S1.
PhylomeDBi P19596.
TreeFami TF317805.

Enzyme and pathway databases

Reactomei REACT_197153. Negative regulation of FGFR signaling.
REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198103. Signaling by activated point mutants of FGFR1.
REACT_198105. Activated point mutants of FGFR2.
REACT_198138. Signaling by FGFR mutants.
REACT_198173. Signaling by activated point mutants of FGFR3.
REACT_198174. Signaling by FGFR3 mutants.
REACT_202388. FGFR1b ligand binding and activation.
REACT_202481. FGFR2b ligand binding and activation.
REACT_205965. FGFR4 ligand binding and activation.
REACT_207556. PI-3K cascade.
REACT_212391. FGFR3b ligand binding and activation.
REACT_216625. FGFR3c ligand binding and activation.
REACT_224574. FGFR1c ligand binding and activation.
REACT_224844. FGFR2c ligand binding and activation.
REACT_94545. SHC-mediated cascade.

Miscellaneous databases

NextBioi 20816152.
PROi P19596.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF65. PTHR11486:SF65. 1 hit.
Pfami PF00167. FGF. 1 hit.
[Graphical view ]
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development."
    Schnurch H., Risau W.
    Development 111:1143-1154(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. Martin G.R., Han J.K.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor."
    Risau W., Gautschi-Sova P., Boehlen P.
    EMBO J. 7:959-962(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-48.

Entry informationi

Entry nameiFGF1_CHICK
AccessioniPrimary (citable) accession number: P19596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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