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Protein

Fibroblast growth factor 1

Gene

FGF1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331HeparinBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-GGA-109704. PI3K Cascade.
R-GGA-1257604. PIP3 activates AKT signaling.
R-GGA-190322. FGFR4 ligand binding and activation.
R-GGA-190370. FGFR1b ligand binding and activation.
R-GGA-190371. FGFR3b ligand binding and activation.
R-GGA-190372. FGFR3c ligand binding and activation.
R-GGA-190373. FGFR1c ligand binding and activation.
R-GGA-190375. FGFR2c ligand binding and activation.
R-GGA-190377. FGFR2b ligand binding and activation.
R-GGA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-GGA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-GGA-5654227. Phospholipase C-mediated cascade, FGFR3.
R-GGA-5654228. Phospholipase C-mediated cascade, FGFR4.
R-GGA-5654687. Downstream signaling of activated FGFR1.
R-GGA-5654688. SHC-mediated cascade:FGFR1.
R-GGA-5654689. PI-3K cascade:FGFR1.
R-GGA-5654693. FRS-mediated FGFR1 signaling.
R-GGA-5654695. PI-3K cascade:FGFR2.
R-GGA-5654699. SHC-mediated cascade:FGFR2.
R-GGA-5654700. FRS-mediated FGFR2 signaling.
R-GGA-5654704. SHC-mediated cascade:FGFR3.
R-GGA-5654706. FRS-mediated FGFR3 signaling.
R-GGA-5654710. PI-3K cascade:FGFR3.
R-GGA-5654712. FRS-mediated FGFR4 signaling.
R-GGA-5654719. SHC-mediated cascade:FGFR4.
R-GGA-5654720. PI-3K cascade:FGFR4.
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5654732. Negative regulation of FGFR3 signaling.
R-GGA-5654733. Negative regulation of FGFR4 signaling.
R-GGA-5673001. RAF/MAP kinase cascade.
R-GGA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 1
Short name:
FGF-1
Alternative name(s):
Acidic fibroblast growth factor
Short name:
aFGF
Endothelial cell growth factor
Short name:
ECGF
Heparin-binding growth factor 1
Short name:
HBGF-1
Cleaved into the following chain:
Gene namesi
Name:FGF1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

  • Secreted By similarity
  • Cytoplasm By similarity
  • Cytoplasmcell cortex By similarity
  • Cytoplasmcytosol By similarity
  • Nucleus By similarity

  • Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1515PRO_0000008920Add
BLAST
Chaini16 – 155140Fibroblast growth factor 1PRO_0000008921Add
BLAST
Chaini22 – 155134Endothelial cell growth factor alphaPRO_0000008922Add
BLAST

Proteomic databases

PaxDbiP19596.

Expressioni

Gene expression databases

BgeeiENSGALG00000007343.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011866.

Structurei

3D structure databases

ProteinModelPortaliP19596.
SMRiP19596. Positions 5-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 14317Heparin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00730000110923.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP19596.
KOiK18496.
OMAiLGPRTHY.
OrthoDBiEOG091G0NAY.
PhylomeDBiP19596.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF86. PTHR11486:SF86. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGEITTFT ALTERFGLPL GNYKKPKLLY CSNGGHFLRI LPDGKVDGTR
60 70 80 90 100
DRSDQHIQLQ LSAEDVGEVY IKSTASGQYL AMDTNGLLYG SQLPGEECLF
110 120 130 140 150
LERLEENHYN TYISKKHADK NWFVGLKKNG NSKLGPRTHY GQKAILFLPL

PVSAD
Length:155
Mass (Da):17,322
Last modified:February 1, 1996 - v2
Checksum:i8EDB70545E2B4365
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63263 mRNA. Translation: AAB19629.1.
S63261 Genomic DNA. Translation: AAD13942.1.
U31863 mRNA. Translation: AAA80310.1.
PIRiA60130.
RefSeqiNP_990511.1. NM_205180.1.
XP_015149495.1. XM_015294009.1.
XP_015149496.1. XM_015294010.1.
UniGeneiGga.5059.
Gga.51519.
Gga.648.

Genome annotation databases

EnsembliENSGALT00000011880; ENSGALP00000011866; ENSGALG00000007343.
GeneIDi396094.
KEGGigga:396094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63263 mRNA. Translation: AAB19629.1.
S63261 Genomic DNA. Translation: AAD13942.1.
U31863 mRNA. Translation: AAA80310.1.
PIRiA60130.
RefSeqiNP_990511.1. NM_205180.1.
XP_015149495.1. XM_015294009.1.
XP_015149496.1. XM_015294010.1.
UniGeneiGga.5059.
Gga.51519.
Gga.648.

3D structure databases

ProteinModelPortaliP19596.
SMRiP19596. Positions 5-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011866.

Proteomic databases

PaxDbiP19596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000011880; ENSGALP00000011866; ENSGALG00000007343.
GeneIDi396094.
KEGGigga:396094.

Organism-specific databases

CTDi2246.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00730000110923.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP19596.
KOiK18496.
OMAiLGPRTHY.
OrthoDBiEOG091G0NAY.
PhylomeDBiP19596.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiR-GGA-109704. PI3K Cascade.
R-GGA-1257604. PIP3 activates AKT signaling.
R-GGA-190322. FGFR4 ligand binding and activation.
R-GGA-190370. FGFR1b ligand binding and activation.
R-GGA-190371. FGFR3b ligand binding and activation.
R-GGA-190372. FGFR3c ligand binding and activation.
R-GGA-190373. FGFR1c ligand binding and activation.
R-GGA-190375. FGFR2c ligand binding and activation.
R-GGA-190377. FGFR2b ligand binding and activation.
R-GGA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-GGA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-GGA-5654227. Phospholipase C-mediated cascade, FGFR3.
R-GGA-5654228. Phospholipase C-mediated cascade, FGFR4.
R-GGA-5654687. Downstream signaling of activated FGFR1.
R-GGA-5654688. SHC-mediated cascade:FGFR1.
R-GGA-5654689. PI-3K cascade:FGFR1.
R-GGA-5654693. FRS-mediated FGFR1 signaling.
R-GGA-5654695. PI-3K cascade:FGFR2.
R-GGA-5654699. SHC-mediated cascade:FGFR2.
R-GGA-5654700. FRS-mediated FGFR2 signaling.
R-GGA-5654704. SHC-mediated cascade:FGFR3.
R-GGA-5654706. FRS-mediated FGFR3 signaling.
R-GGA-5654710. PI-3K cascade:FGFR3.
R-GGA-5654712. FRS-mediated FGFR4 signaling.
R-GGA-5654719. SHC-mediated cascade:FGFR4.
R-GGA-5654720. PI-3K cascade:FGFR4.
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5654732. Negative regulation of FGFR3 signaling.
R-GGA-5654733. Negative regulation of FGFR4 signaling.
R-GGA-5673001. RAF/MAP kinase cascade.
R-GGA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

PROiP19596.

Gene expression databases

BgeeiENSGALG00000007343.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF86. PTHR11486:SF86. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF1_CHICK
AccessioniPrimary (citable) accession number: P19596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.