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Protein

Fibroblast growth factor 1

Gene

FGF1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331HeparinBy similarity

GO - Molecular functioni

  1. fibroblast growth factor receptor binding Source: UniProtKB
  2. growth factor activity Source: UniProtKB
  3. heparin binding Source: UniProtKB
  4. S100 protein binding Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. branch elongation involved in ureteric bud branching Source: UniProtKB
  3. cellular response to heat Source: Ensembl
  4. epicardial cell to mesenchymal cell transition Source: DFLAT
  5. fibroblast growth factor receptor signaling pathway Source: UniProtKB
  6. lung development Source: Ensembl
  7. mesonephric epithelium development Source: UniProtKB
  8. organ induction Source: Ensembl
  9. positive regulation of angiogenesis Source: UniProtKB
  10. positive regulation of cell division Source: UniProtKB
  11. positive regulation of cell migration Source: UniProtKB
  12. positive regulation of cell proliferation Source: UniProtKB
  13. positive regulation of cholesterol biosynthetic process Source: UniProtKB
  14. positive regulation of epithelial cell proliferation Source: Ensembl
  15. positive regulation of intracellular signal transduction Source: UniProtKB
  16. positive regulation of protein phosphorylation Source: Ensembl
  17. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_284939. PIP3 activates AKT signaling.
REACT_290454. FGFR3c ligand binding and activation.
REACT_297795. FRS2-mediated cascade.
REACT_301570. FGFR2c ligand binding and activation.
REACT_303797. Signaling by activated point mutants of FGFR1.
REACT_309205. SHC-mediated cascade.
REACT_310443. FGFR1c ligand binding and activation.
REACT_317212. Negative regulation of FGFR signaling.
REACT_321666. Activated point mutants of FGFR2.
REACT_322908. FGFR3b ligand binding and activation.
REACT_329873. Signaling by activated point mutants of FGFR3.
REACT_330475. Signaling by FGFR3 mutants.
REACT_332547. Phospholipase C-mediated cascade.
REACT_333432. FGFR1b ligand binding and activation.
REACT_338659. FGFR2b ligand binding and activation.
REACT_343900. Constitutive PI3K/AKT Signaling in Cancer.
REACT_344129. PI3K Cascade.
REACT_344411. PI-3K cascade.
REACT_347570. FGFR4 ligand binding and activation.
REACT_351988. Signaling by FGFR mutants.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 1
Short name:
FGF-1
Alternative name(s):
Acidic fibroblast growth factor
Short name:
aFGF
Endothelial cell growth factor
Short name:
ECGF
Heparin-binding growth factor 1
Short name:
HBGF-1
Cleaved into the following chain:
Gene namesi
Name:FGF1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 13

Subcellular locationi

Secreted By similarity. Cytoplasm By similarity. Cytoplasmcell cortex By similarity. Cytoplasmcytosol By similarity. Nucleus By similarity
Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery (By similarity).By similarity

GO - Cellular componenti

  1. cell cortex Source: UniProtKB-SubCell
  2. cytosol Source: UniProtKB
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: UniProtKB
  5. nucleus Source: UniProtKB-SubCell
  6. proteinaceous extracellular matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1515PRO_0000008920Add
BLAST
Chaini16 – 155140Fibroblast growth factor 1PRO_0000008921Add
BLAST
Chaini22 – 155134Endothelial cell growth factor alphaPRO_0000008922Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011866.

Structurei

3D structure databases

ProteinModelPortaliP19596.
SMRiP19596. Positions 5-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 14317Heparin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG246422.
GeneTreeiENSGT00730000110923.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP19596.
KOiK18496.
OMAiLGPRTHY.
OrthoDBiEOG7992S1.
PhylomeDBiP19596.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF65. PTHR11486:SF65. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGEITTFT ALTERFGLPL GNYKKPKLLY CSNGGHFLRI LPDGKVDGTR
60 70 80 90 100
DRSDQHIQLQ LSAEDVGEVY IKSTASGQYL AMDTNGLLYG SQLPGEECLF
110 120 130 140 150
LERLEENHYN TYISKKHADK NWFVGLKKNG NSKLGPRTHY GQKAILFLPL

PVSAD
Length:155
Mass (Da):17,322
Last modified:February 1, 1996 - v2
Checksum:i8EDB70545E2B4365
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63263 mRNA. Translation: AAB19629.1.
S63261 Genomic DNA. Translation: AAD13942.1.
U31863 mRNA. Translation: AAA80310.1.
PIRiA60130.
RefSeqiNP_990511.1. NM_205180.1.
UniGeneiGga.648.

Genome annotation databases

EnsembliENSGALT00000011880; ENSGALP00000011866; ENSGALG00000007343.
GeneIDi396094.
KEGGigga:396094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63263 mRNA. Translation: AAB19629.1.
S63261 Genomic DNA. Translation: AAD13942.1.
U31863 mRNA. Translation: AAA80310.1.
PIRiA60130.
RefSeqiNP_990511.1. NM_205180.1.
UniGeneiGga.648.

3D structure databases

ProteinModelPortaliP19596.
SMRiP19596. Positions 5-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000011880; ENSGALP00000011866; ENSGALG00000007343.
GeneIDi396094.
KEGGigga:396094.

Organism-specific databases

CTDi2246.

Phylogenomic databases

eggNOGiNOG246422.
GeneTreeiENSGT00730000110923.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP19596.
KOiK18496.
OMAiLGPRTHY.
OrthoDBiEOG7992S1.
PhylomeDBiP19596.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_284939. PIP3 activates AKT signaling.
REACT_290454. FGFR3c ligand binding and activation.
REACT_297795. FRS2-mediated cascade.
REACT_301570. FGFR2c ligand binding and activation.
REACT_303797. Signaling by activated point mutants of FGFR1.
REACT_309205. SHC-mediated cascade.
REACT_310443. FGFR1c ligand binding and activation.
REACT_317212. Negative regulation of FGFR signaling.
REACT_321666. Activated point mutants of FGFR2.
REACT_322908. FGFR3b ligand binding and activation.
REACT_329873. Signaling by activated point mutants of FGFR3.
REACT_330475. Signaling by FGFR3 mutants.
REACT_332547. Phospholipase C-mediated cascade.
REACT_333432. FGFR1b ligand binding and activation.
REACT_338659. FGFR2b ligand binding and activation.
REACT_343900. Constitutive PI3K/AKT Signaling in Cancer.
REACT_344129. PI3K Cascade.
REACT_344411. PI-3K cascade.
REACT_347570. FGFR4 ligand binding and activation.
REACT_351988. Signaling by FGFR mutants.

Miscellaneous databases

NextBioi20816152.
PROiP19596.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF65. PTHR11486:SF65. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development."
    Schnurch H., Risau W.
    Development 111:1143-1154(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. Martin G.R., Han J.K.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor."
    Risau W., Gautschi-Sova P., Boehlen P.
    EMBO J. 7:959-962(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-48.

Entry informationi

Entry nameiFGF1_CHICK
AccessioniPrimary (citable) accession number: P19596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: April 1, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.