P19596 (FGF1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 1
Short name=FGF-1

Alternative name(s):
Acidic fibroblast growth factor
Short name=aFGF
Endothelial cell growth factor
Short name=ECGF
Heparin-binding growth factor 1
Short name=HBGF-1

Cleaved into the following chain:

1. Endothelial cell growth factor alpha

Gene names

Name:

FGF1

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro By similarity.
Subcellular location	Secreted By similarity. Cytoplasm By similarity. Cytoplasm › cell cortex By similarity. Cytoplasm › cytosol By similarity. Nucleus By similarity. Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13 By similarity. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery By similarity.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Cytoplasm Nucleus Secreted
Ligand	Heparin-binding
Molecular function	Developmental protein Growth factor Mitogen
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW branch elongation involved in ureteric bud branching Inferred from sequence or structural similarity. Source: UniProtKB cellular response to heat Inferred from electronic annotation. Source: Compara epicardial cell to mesenchymal cell transition Traceable author statement PubMed 20299672. Source: DFLAT fibroblast growth factor receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB lung development Inferred from electronic annotation. Source: Compara mesonephric epithelium development Inferred from sequence or structural similarity. Source: UniProtKB organ induction Inferred from electronic annotation. Source: Compara positive regulation of angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell division Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cholesterol biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of intracellular protein kinase cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from sequence or structural similarity. Source: UniProtKB extracellular space Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrix Inferred from electronic annotation. Source: Compara
Molecular_function	S100 protein binding Inferred from sequence or structural similarity. Source: UniProtKB fibroblast growth factor receptor binding Inferred from sequence or structural similarity. Source: UniProtKB growth factor activity Inferred from sequence or structural similarity. Source: UniProtKB heparin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 15	15			PRO_0000008920
	Chain	16 – 155	140	Fibroblast growth factor 1		PRO_0000008921
	Chain	22 – 155	134	Endothelial cell growth factor alpha		PRO_0000008922
Regions
	Region	127 – 143	17	Heparin-binding By similarity
Sites
	Binding site	33	1	Heparin By similarity

Sequences

	Sequence		Length	Mass (Da)
	P19596 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 8EDB70545E2B4365	FASTA	155	17,322
	10 20 30 40 50 60 MAEGEITTFT ALTERFGLPL GNYKKPKLLY CSNGGHFLRI LPDGKVDGTR DRSDQHIQLQ 70 80 90 100 110 120 LSAEDVGEVY IKSTASGQYL AMDTNGLLYG SQLPGEECLF LERLEENHYN TYISKKHADK 130 140 150 NWFVGLKKNG NSKLGPRTHY GQKAILFLPL PVSAD

References

[1]	"Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development." Schnurch H., Risau W. Development 111:1143-1154(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	Martin G.R., Han J.K. Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor." Risau W., Gautschi-Sova P., Boehlen P. EMBO J. 7:959-962(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-48.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S63263 mRNA. Translation: AAB19629.1. S63261 Genomic DNA. Translation: AAD13942.1. U31863 mRNA. Translation: AAA80310.1.
IPI	IPI00592513.
PIR	A60130.
RefSeq	NP_990511.1. NM_205180.1.
UniGene	Gga.648.
3D structure databases
ProteinModelPortal	P19596.
SMR	P19596. Positions 5-155.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000011866.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000011880; ENSGALP00000011866; ENSGALG00000007343.
GeneID	396094.
KEGG	gga:396094.
Organism-specific databases
CTD	2246.
Phylogenomic databases
eggNOG	NOG246422.
GeneTree	ENSGT00690000101834.
HOGENOM	HOG000236341.
HOVERGEN	HBG007580.
InParanoid	P19596.
KO	K04358.
OMA	PSEECLF.
OrthoDB	EOG48KRCM.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816152.

Entry information

Entry name

FGF1_CHICK

Accession

Primary (citable) accession number: P19596

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program