Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P19596

- FGF1_CHICK

UniProt

P19596 - FGF1_CHICK

Protein

Fibroblast growth factor 1

Gene

FGF1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331HeparinBy similarity

    GO - Molecular functioni

    1. fibroblast growth factor receptor binding Source: UniProtKB
    2. growth factor activity Source: UniProtKB
    3. heparin binding Source: UniProtKB
    4. S100 protein binding Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. branch elongation involved in ureteric bud branching Source: UniProtKB
    3. cellular response to heat Source: Ensembl
    4. epicardial cell to mesenchymal cell transition Source: DFLAT
    5. fibroblast growth factor receptor signaling pathway Source: UniProtKB
    6. lung development Source: Ensembl
    7. mesonephric epithelium development Source: UniProtKB
    8. organ induction Source: Ensembl
    9. positive regulation of angiogenesis Source: UniProtKB
    10. positive regulation of cell division Source: UniProtKB
    11. positive regulation of cell migration Source: UniProtKB
    12. positive regulation of cell proliferation Source: UniProtKB
    13. positive regulation of cholesterol biosynthetic process Source: UniProtKB
    14. positive regulation of epithelial cell proliferation Source: Ensembl
    15. positive regulation of intracellular signal transduction Source: UniProtKB
    16. positive regulation of protein phosphorylation Source: Ensembl
    17. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_197153. Negative regulation of FGFR signaling.
    REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198103. Signaling by activated point mutants of FGFR1.
    REACT_198105. Activated point mutants of FGFR2.
    REACT_198138. Signaling by FGFR mutants.
    REACT_198173. Signaling by activated point mutants of FGFR3.
    REACT_198174. Signaling by FGFR3 mutants.
    REACT_202388. FGFR1b ligand binding and activation.
    REACT_202481. FGFR2b ligand binding and activation.
    REACT_205965. FGFR4 ligand binding and activation.
    REACT_207556. PI-3K cascade.
    REACT_212391. FGFR3b ligand binding and activation.
    REACT_216625. FGFR3c ligand binding and activation.
    REACT_224574. FGFR1c ligand binding and activation.
    REACT_224844. FGFR2c ligand binding and activation.
    REACT_94545. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 1
    Short name:
    FGF-1
    Alternative name(s):
    Acidic fibroblast growth factor
    Short name:
    aFGF
    Endothelial cell growth factor
    Short name:
    ECGF
    Heparin-binding growth factor 1
    Short name:
    HBGF-1
    Cleaved into the following chain:
    Gene namesi
    Name:FGF1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 13

    Subcellular locationi

    Secreted By similarity. Cytoplasm By similarity. Cytoplasmcell cortex By similarity. Cytoplasmcytosol By similarity. Nucleus By similarity
    Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13 By similarity. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery By similarity.By similarity

    GO - Cellular componenti

    1. cell cortex Source: UniProtKB-SubCell
    2. cytosol Source: UniProtKB
    3. extracellular region Source: UniProtKB
    4. extracellular space Source: UniProtKB
    5. nucleus Source: UniProtKB-SubCell
    6. proteinaceous extracellular matrix Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 1515PRO_0000008920Add
    BLAST
    Chaini16 – 155140Fibroblast growth factor 1PRO_0000008921Add
    BLAST
    Chaini22 – 155134Endothelial cell growth factor alphaPRO_0000008922Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000011866.

    Structurei

    3D structure databases

    ProteinModelPortaliP19596.
    SMRiP19596. Positions 5-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 14317Heparin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG246422.
    GeneTreeiENSGT00730000110923.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiP19596.
    KOiK04358.
    OMAiNGLLYGS.
    OrthoDBiEOG7992S1.
    PhylomeDBiP19596.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028210. FGF1.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF65. PTHR11486:SF65. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19596-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEGEITTFT ALTERFGLPL GNYKKPKLLY CSNGGHFLRI LPDGKVDGTR    50
    DRSDQHIQLQ LSAEDVGEVY IKSTASGQYL AMDTNGLLYG SQLPGEECLF 100
    LERLEENHYN TYISKKHADK NWFVGLKKNG NSKLGPRTHY GQKAILFLPL 150
    PVSAD 155
    Length:155
    Mass (Da):17,322
    Last modified:February 1, 1996 - v2
    Checksum:i8EDB70545E2B4365
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S63263 mRNA. Translation: AAB19629.1.
    S63261 Genomic DNA. Translation: AAD13942.1.
    U31863 mRNA. Translation: AAA80310.1.
    PIRiA60130.
    RefSeqiNP_990511.1. NM_205180.1.
    UniGeneiGga.648.

    Genome annotation databases

    EnsembliENSGALT00000011880; ENSGALP00000011866; ENSGALG00000007343.
    GeneIDi396094.
    KEGGigga:396094.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S63263 mRNA. Translation: AAB19629.1 .
    S63261 Genomic DNA. Translation: AAD13942.1 .
    U31863 mRNA. Translation: AAA80310.1 .
    PIRi A60130.
    RefSeqi NP_990511.1. NM_205180.1.
    UniGenei Gga.648.

    3D structure databases

    ProteinModelPortali P19596.
    SMRi P19596. Positions 5-155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000011866.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000011880 ; ENSGALP00000011866 ; ENSGALG00000007343 .
    GeneIDi 396094.
    KEGGi gga:396094.

    Organism-specific databases

    CTDi 2246.

    Phylogenomic databases

    eggNOGi NOG246422.
    GeneTreei ENSGT00730000110923.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi P19596.
    KOi K04358.
    OMAi NGLLYGS.
    OrthoDBi EOG7992S1.
    PhylomeDBi P19596.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_197153. Negative regulation of FGFR signaling.
    REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198103. Signaling by activated point mutants of FGFR1.
    REACT_198105. Activated point mutants of FGFR2.
    REACT_198138. Signaling by FGFR mutants.
    REACT_198173. Signaling by activated point mutants of FGFR3.
    REACT_198174. Signaling by FGFR3 mutants.
    REACT_202388. FGFR1b ligand binding and activation.
    REACT_202481. FGFR2b ligand binding and activation.
    REACT_205965. FGFR4 ligand binding and activation.
    REACT_207556. PI-3K cascade.
    REACT_212391. FGFR3b ligand binding and activation.
    REACT_216625. FGFR3c ligand binding and activation.
    REACT_224574. FGFR1c ligand binding and activation.
    REACT_224844. FGFR2c ligand binding and activation.
    REACT_94545. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 20816152.
    PROi P19596.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028210. FGF1.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF65. PTHR11486:SF65. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development."
      Schnurch H., Risau W.
      Development 111:1143-1154(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. Martin G.R., Han J.K.
      Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor."
      Risau W., Gautschi-Sova P., Boehlen P.
      EMBO J. 7:959-962(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-48.

    Entry informationi

    Entry nameiFGF1_CHICK
    AccessioniPrimary (citable) accession number: P19596
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3