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Protein

Fibroblast growth factor 1

Gene

FGF1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33HeparinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-GGA-109704 PI3K Cascade
R-GGA-1257604 PIP3 activates AKT signaling
R-GGA-190322 FGFR4 ligand binding and activation
R-GGA-190370 FGFR1b ligand binding and activation
R-GGA-190371 FGFR3b ligand binding and activation
R-GGA-190372 FGFR3c ligand binding and activation
R-GGA-190373 FGFR1c ligand binding and activation
R-GGA-190375 FGFR2c ligand binding and activation
R-GGA-190377 FGFR2b ligand binding and activation
R-GGA-5654219 Phospholipase C-mediated cascade: FGFR1
R-GGA-5654221 Phospholipase C-mediated cascade, FGFR2
R-GGA-5654227 Phospholipase C-mediated cascade, FGFR3
R-GGA-5654228 Phospholipase C-mediated cascade, FGFR4
R-GGA-5654687 Downstream signaling of activated FGFR1
R-GGA-5654688 SHC-mediated cascade:FGFR1
R-GGA-5654689 PI-3K cascade:FGFR1
R-GGA-5654693 FRS-mediated FGFR1 signaling
R-GGA-5654695 PI-3K cascade:FGFR2
R-GGA-5654699 SHC-mediated cascade:FGFR2
R-GGA-5654700 FRS-mediated FGFR2 signaling
R-GGA-5654704 SHC-mediated cascade:FGFR3
R-GGA-5654706 FRS-mediated FGFR3 signaling
R-GGA-5654710 PI-3K cascade:FGFR3
R-GGA-5654712 FRS-mediated FGFR4 signaling
R-GGA-5654719 SHC-mediated cascade:FGFR4
R-GGA-5654720 PI-3K cascade:FGFR4
R-GGA-5654726 Negative regulation of FGFR1 signaling
R-GGA-5654727 Negative regulation of FGFR2 signaling
R-GGA-5654732 Negative regulation of FGFR3 signaling
R-GGA-5654733 Negative regulation of FGFR4 signaling
R-GGA-5673001 RAF/MAP kinase cascade
R-GGA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 1
Short name:
FGF-1
Alternative name(s):
Acidic fibroblast growth factor
Short name:
aFGF
Endothelial cell growth factor
Short name:
ECGF
Heparin-binding growth factor 1
Short name:
HBGF-1
Cleaved into the following chain:
Gene namesi
Name:FGF1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000089201 – 15Add BLAST15
ChainiPRO_000000892116 – 155Fibroblast growth factor 1Add BLAST140
ChainiPRO_000000892222 – 155Endothelial cell growth factor alphaAdd BLAST134

Proteomic databases

PaxDbiP19596

Expressioni

Gene expression databases

BgeeiENSGALG00000007343

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011866

Structurei

3D structure databases

ProteinModelPortaliP19596
SMRiP19596
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 143Heparin-bindingBy similarityAdd BLAST17

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110923
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP19596
KOiK18496
OMAiLGPRTHY
OrthoDBiEOG091G0NAY
PhylomeDBiP19596
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028210 FGF1
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF86 PTHR11486:SF86, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGEITTFT ALTERFGLPL GNYKKPKLLY CSNGGHFLRI LPDGKVDGTR
60 70 80 90 100
DRSDQHIQLQ LSAEDVGEVY IKSTASGQYL AMDTNGLLYG SQLPGEECLF
110 120 130 140 150
LERLEENHYN TYISKKHADK NWFVGLKKNG NSKLGPRTHY GQKAILFLPL

PVSAD
Length:155
Mass (Da):17,322
Last modified:February 1, 1996 - v2
Checksum:i8EDB70545E2B4365
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63263 mRNA Translation: AAB19629.1
S63261 Genomic DNA Translation: AAD13942.1
U31863 mRNA Translation: AAA80310.1
PIRiA60130
RefSeqiNP_990511.1, NM_205180.1
XP_015149495.1, XM_015294009.1
XP_015149496.1, XM_015294010.1
UniGeneiGga.5059
Gga.51519
Gga.648

Genome annotation databases

EnsembliENSGALT00000077414; ENSGALP00000044660; ENSGALG00000031255
GeneIDi396094
KEGGigga:396094

Similar proteinsi

Entry informationi

Entry nameiFGF1_CHICK
AccessioniPrimary (citable) accession number: P19596
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health