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Protein

Lectin DB58

Gene
N/A
Organism
Vigna unguiculata subsp. cylindrica (Horse gram) (Dolichos biflorus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Metalloglycoprotein, containing Ca, Mg, Mn, and Zn and the carbohydrates galactose, glucosamine, mannose, and fucose. It agglutinates erythrocytes of blood group A1.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Mannose-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lectin DB58
Cleaved into the following 2 chains:
OrganismiVigna unguiculata subsp. cylindrica (Horse gram) (Dolichos biflorus)
Taxonomic identifieri3840 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000001761323 – 275Lectin DB58 subunit alphaAdd BLAST253
ChainiPRO_000001761423 – 264Lectin DB58 subunit betaAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)1
Glycosylationi101N-linked (GlcNAc...)1

Post-translational modificationi

Leu-264 is missing in a major portion of the beta subunit, suggesting an origin by sequential removal of amino acids rather than a processing by endoproteolytic cleavage.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP19588.

Interactioni

Subunit structurei

Heterodimer, composed of an alpha and a beta subunit derived from a single precursor.

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 31Combined sources8
Beta strandi38 – 42Combined sources5
Beta strandi48 – 52Combined sources5
Beta strandi67 – 74Combined sources8
Turni81 – 83Combined sources3
Beta strandi88 – 96Combined sources9
Helixi102 – 104Combined sources3
Beta strandi108 – 115Combined sources8
Turni127 – 129Combined sources3
Helixi137 – 139Combined sources3
Beta strandi142 – 147Combined sources6
Beta strandi160 – 169Combined sources10
Beta strandi171 – 175Combined sources5
Beta strandi182 – 191Combined sources10
Turni192 – 195Combined sources4
Beta strandi196 – 203Combined sources8
Helixi204 – 206Combined sources3
Beta strandi208 – 215Combined sources8
Helixi218 – 221Combined sources4
Beta strandi224 – 233Combined sources10
Beta strandi245 – 255Combined sources11
Helixi266 – 273Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G7YX-ray2.50A/B/C/D/E/F23-275[»]
1LULX-ray3.30A/B/C/D/E/F23-275[»]
ProteinModelPortaliP19588.
SMRiP19588.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19588.

Family & Domainsi

Sequence similaritiesi

Belongs to the leguminous lectin family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR016363. L-lectin.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 1 hit.
[Graphical view]
PIRSFiPIRSF002690. L-type_lectin_plant. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTVSVVL SLFLLLLTQA YSADIQSFSF KNFNSSSFIL QGDATVSSSK
60 70 80 90 100
LRLTKVKGNG LPTLSSLGRA FYSSPIQIYD KSTGAVASWA TSFTANIFAP
110 120 130 140 150
NKSSSADGIA FALVPVGSEP KSNSGFLGVF DSDVYDNSAQ TVAVEFDTFS
160 170 180 190 200
NTDWDPTSRH IGIDVNSIKS IRTASWGLAN GQNAEILITY NAATSLLVAS
210 220 230 240 250
LVHPSRRTSY IVSERVDITN ELPEYVSIGF SATTGLSEGY TETHDVLSWS
260 270
FASKLPDDST TEPLDIASYL VRNVL
Length:275
Mass (Da):29,453
Last modified:July 15, 1999 - v2
Checksum:i53D72ACB02EAE03F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236 – 237LS → FF in AAA33142 (PubMed:2844781).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23216 mRNA. Translation: AAA33142.1.
M34271 Genomic DNA. Translation: AAA33140.1.
PIRiA31972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23216 mRNA. Translation: AAA33142.1.
M34271 Genomic DNA. Translation: AAA33140.1.
PIRiA31972.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G7YX-ray2.50A/B/C/D/E/F23-275[»]
1LULX-ray3.30A/B/C/D/E/F23-275[»]
ProteinModelPortaliP19588.
SMRiP19588.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP19588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP19588.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR016363. L-lectin.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 1 hit.
[Graphical view]
PIRSFiPIRSF002690. L-type_lectin_plant. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEC5_VIGUC
AccessioniPrimary (citable) accession number: P19588
Secondary accession number(s): Q39665
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 15, 1999
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.