P19581 (CAPC_BACAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Capsule biosynthesis protein CapC

Gene names

Name:	capC
Ordered Locus Names:	pXO2-57, BXB0065, GBAA_pXO2_0065

Encoded on

Plasmid pXO2 Ref.2 Ref.3 Ref.4 Ref.5
Plasmid pTE702 Ref.1

Organism

Bacillus anthracis [Reference proteome] [HAMAP]

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapA and CapB. CapC may be the endogenous acceptor of glutamyl residues.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Induction	Capsule synthesis is transcriptionally regulated by AtxA, AcpA and AcpB. Ref.5

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Virulence
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Plasmid Reference proteome
Gene Ontology (GO)
Biological_process	capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 149	149	Capsule biosynthesis protein CapC		PRO_0000089310
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	24 – 44	21	Helical; Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	129 – 149	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P19581 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: A93D4F792FA5E940	FASTA	149	16,523
	10 20 30 40 50 60 MFGSDLYIAL VLGVTLSLIF TERTGILPAG LVVPGYLALV FNQPVFMLVV LFISILTYVI 70 80 90 100 110 120 VTYGVSRFMI LYGRRKFAAT LITGICLKLL FDYCYPVMPF EIFEFRGIGV IVPGLIANTI 130 140 QRQGLPLTIG TTILLSGATF AIMNIYYLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis." Makino S., Uchida I., Terakado N., Sasakawa C., Yoshikawa M. J. Bacteriol. 171:722-730(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence, assembly and analysis of pXO1 and pXO2." Okinaka R.T., Cloud K., Hampton O., Hoffmaster A., Hill K.K., Keim P., Koehler T., Lamke G., Kumano S., Manter D., Martinez Y., Ricke D., Svensson R., Jackson P.J. J. Appl. Microbiol. 87:261-262(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Pasteur.
[3]	"Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis." Read T.D., Salzberg S.L., Pop M., Shumway M.F., Umayam L., Jiang L., Holtzapple E., Busch J.D., Smith K.L., Schupp J.M., Solomon D., Keim P., Fraser C.M. Science 296:2028-2033(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Ames / isolate Florida / A2012.
[4]	"The complete genome sequence of Bacillus anthracis Ames 'Ancestor'." Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D., Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A. J. Bacteriol. 191:445-446(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[5]	"atxA controls Bacillus anthracis capsule synthesis via acpA and a newly discovered regulator, acpB." Drysdale M., Bourgogne A., Hilsenbeck S.G., Koehler T.M. J. Bacteriol. 186:307-315(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M24150 Genomic DNA. Translation: AAA22287.1. AF188935 Genomic DNA. Translation: AAF13662.1. AE011191 Genomic DNA. Translation: AAM26221.1. AE017335 Genomic DNA. Translation: AAT28995.2.
PIR	B30091.
RefSeq	NP_053212.1. NC_002146.1. NP_653032.1. NC_003981.1. YP_016575.2. NC_007323.3.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	261594.GBAA_pXO2_0065.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM26221; AAM26221; BX_B0065. AAT28995; AAT28995; GBAA_pXO2_0065.
GeneID	1158841. 2820409. 3361856.
KEGG	bar:GBAA_pXO2_0065.
PATRIC	24662358. VBIBacAnt106580_0268.
Phylogenomic databases
eggNOG	NOG15769.
HOGENOM	HOG000065358.
OMA	TIQKQGL.
ProtClustDB	CLSK862266.
Enzyme and pathway databases
BioCyc	BANT261594:GJ7F-5857-MONOMER. MetaCyc:MONOMER-16981.
UniPathway	UPA00934.
Family and domain databases
InterPro	IPR008338. Capsule_biosynth_CapC. [Graphical view]
Pfam	PF14102. Caps_synth_CapC. 1 hit. [Graphical view]
PRINTS	PR01759. CAPSULEPROTC.
TIGRFAMs	TIGR04011. poly_gGlu_PgsC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CAPC_BACAN

Accession

Primary (citable) accession number: P19581

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program