Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P19581 (CAPC_BACAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Capsule biosynthesis protein CapC
Gene names
Name:capC
Ordered Locus Names:pXO2-57, BXB0065, GBAA_pXO2_0065
Encoded onPlasmid pXO2 Ref.2 Ref.3 Ref.4 Ref.5
Plasmid pTE702 Ref.1
OrganismBacillus anthracis [Reference proteome] [HAMAP]
Taxonomic identifier1392 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length149 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapA and CapB. CapC may be the endogenous acceptor of glutamyl residues.

Pathway

Capsule biogenesis; capsule polysaccharide biosynthesis.

Subcellular location

Cell membrane; Multi-pass membrane protein Probable.

Induction

Capsule synthesis is transcriptionally regulated by AtxA, AcpA and AcpB. Ref.5

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 149149Capsule biosynthesis protein CapC
PRO_0000089310

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane24 – 4421Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane129 – 14921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P19581 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: A93D4F792FA5E940

FASTA14916,523
        10         20         30         40         50         60 
MFGSDLYIAL VLGVTLSLIF TERTGILPAG LVVPGYLALV FNQPVFMLVV LFISILTYVI 

        70         80         90        100        110        120 
VTYGVSRFMI LYGRRKFAAT LITGICLKLL FDYCYPVMPF EIFEFRGIGV IVPGLIANTI 

       130        140 
QRQGLPLTIG TTILLSGATF AIMNIYYLF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis."
Makino S., Uchida I., Terakado N., Sasakawa C., Yoshikawa M.
J. Bacteriol. 171:722-730(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence, assembly and analysis of pXO1 and pXO2."
Okinaka R.T., Cloud K., Hampton O., Hoffmaster A., Hill K.K., Keim P., Koehler T., Lamke G., Kumano S., Manter D., Martinez Y., Ricke D., Svensson R., Jackson P.J.
J. Appl. Microbiol. 87:261-262(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Pasteur.
[3]"Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis."
Read T.D., Salzberg S.L., Pop M., Shumway M.F., Umayam L., Jiang L., Holtzapple E., Busch J.D., Smith K.L., Schupp J.M., Solomon D., Keim P., Fraser C.M.
Science 296:2028-2033(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Ames / isolate Florida / A2012.
[4]"The complete genome sequence of Bacillus anthracis Ames 'Ancestor'."
Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D., Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.
J. Bacteriol. 191:445-446(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames ancestor.
[5]"atxA controls Bacillus anthracis capsule synthesis via acpA and a newly discovered regulator, acpB."
Drysdale M., Bourgogne A., Hilsenbeck S.G., Koehler T.M.
J. Bacteriol. 186:307-315(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M24150 Genomic DNA. Translation: AAA22287.1.
AF188935 Genomic DNA. Translation: AAF13662.1.
AE011191 Genomic DNA. Translation: AAM26221.1.
AE017335 Genomic DNA. Translation: AAT28995.2.
PIRB30091.
RefSeqNP_053212.1. NC_002146.1.
NP_653032.1. NC_003981.1.
YP_016575.2. NC_007323.3.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING261594.GBAA_pXO2_0065.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT28995; AAT28995; GBAA_pXO2_0065.
GeneID1158841.
2820409.
3361856.
KEGGbar:GBAA_pXO2_0065.
PATRIC24662358. VBIBacAnt106580_0268.

Phylogenomic databases

eggNOGNOG15769.
HOGENOMHOG000065358.
OMAATFAIMF.
OrthoDBEOG66XBFQ.
ProtClustDBCLSK862266.

Enzyme and pathway databases

BioCycANTHRA:GBAA_PXO2_0065-MONOMER.
BANT261594:GJ7F-5857-MONOMER.
MetaCyc:MONOMER-16981.
UniPathwayUPA00934.

Family and domain databases

InterProIPR008338. Capsule_biosynth_CapC.
[Graphical view]
PfamPF14102. Caps_synth_CapC. 1 hit.
[Graphical view]
PRINTSPR01759. CAPSULEPROTC.
TIGRFAMsTIGR04011. poly_gGlu_PgsC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCAPC_BACAN
AccessionPrimary (citable) accession number: P19581
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 19, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways