Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P19581

- CAPC_BACAN

UniProt

P19581 - CAPC_BACAN

Protein

Capsule biosynthesis protein CapC

Gene

capC

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapA and CapB. CapC may be the endogenous acceptor of glutamyl residues.

    Pathwayi

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Capsule biogenesis/degradation, Virulence

    Enzyme and pathway databases

    BioCyciANTHRA:GBAA_PXO2_0065-MONOMER.
    BANT261594:GJ7F-5857-MONOMER.
    MetaCyc:MONOMER-16981.
    UniPathwayiUPA00934.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Capsule biosynthesis protein CapC
    Gene namesi
    Name:capC
    Ordered Locus Names:pXO2-57, BXB0065, GBAA_pXO2_0065
    Encoded oniPlasmid pXO24 Publications
    Plasmid pTE7021 Publication
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000594: Plasmid pXO2

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 149149Capsule biosynthesis protein CapCPRO_0000089310Add
    BLAST

    Expressioni

    Inductioni

    Capsule synthesis is transcriptionally regulated by AtxA, AcpA and AcpB.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi261594.GBAA_pXO2_0065.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG15769.
    HOGENOMiHOG000065358.
    OMAiATFAIMF.
    OrthoDBiEOG66XBFQ.

    Family and domain databases

    InterProiIPR008338. Capsule_biosynth_CapC.
    [Graphical view]
    PfamiPF14102. Caps_synth_CapC. 1 hit.
    [Graphical view]
    PRINTSiPR01759. CAPSULEPROTC.
    TIGRFAMsiTIGR04011. poly_gGlu_PgsC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P19581-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFGSDLYIAL VLGVTLSLIF TERTGILPAG LVVPGYLALV FNQPVFMLVV    50
    LFISILTYVI VTYGVSRFMI LYGRRKFAAT LITGICLKLL FDYCYPVMPF 100
    EIFEFRGIGV IVPGLIANTI QRQGLPLTIG TTILLSGATF AIMNIYYLF 149
    Length:149
    Mass (Da):16,523
    Last modified:February 1, 1991 - v1
    Checksum:iA93D4F792FA5E940
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24150 Genomic DNA. Translation: AAA22287.1.
    AF188935 Genomic DNA. Translation: AAF13662.1.
    AE011191 Genomic DNA. Translation: AAM26221.1.
    AE017335 Genomic DNA. Translation: AAT28995.2.
    PIRiB30091.
    RefSeqiNP_053212.1. NC_002146.1.
    NP_653032.1. NC_003981.1.
    WP_000468007.1. NC_002146.1.
    YP_016575.2. NC_007323.3.

    Genome annotation databases

    EnsemblBacteriaiAAT28995; AAT28995; GBAA_pXO2_0065.
    GeneIDi1158841.
    2820409.
    3361856.
    KEGGibar:GBAA_pXO2_0065.
    PATRICi24662358. VBIBacAnt106580_0268.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24150 Genomic DNA. Translation: AAA22287.1 .
    AF188935 Genomic DNA. Translation: AAF13662.1 .
    AE011191 Genomic DNA. Translation: AAM26221.1 .
    AE017335 Genomic DNA. Translation: AAT28995.2 .
    PIRi B30091.
    RefSeqi NP_053212.1. NC_002146.1.
    NP_653032.1. NC_003981.1.
    WP_000468007.1. NC_002146.1.
    YP_016575.2. NC_007323.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 261594.GBAA_pXO2_0065.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT28995 ; AAT28995 ; GBAA_pXO2_0065 .
    GeneIDi 1158841.
    2820409.
    3361856.
    KEGGi bar:GBAA_pXO2_0065.
    PATRICi 24662358. VBIBacAnt106580_0268.

    Phylogenomic databases

    eggNOGi NOG15769.
    HOGENOMi HOG000065358.
    OMAi ATFAIMF.
    OrthoDBi EOG66XBFQ.

    Enzyme and pathway databases

    UniPathwayi UPA00934 .
    BioCyci ANTHRA:GBAA_PXO2_0065-MONOMER.
    BANT261594:GJ7F-5857-MONOMER.
    MetaCyc:MONOMER-16981.

    Family and domain databases

    InterProi IPR008338. Capsule_biosynth_CapC.
    [Graphical view ]
    Pfami PF14102. Caps_synth_CapC. 1 hit.
    [Graphical view ]
    PRINTSi PR01759. CAPSULEPROTC.
    TIGRFAMsi TIGR04011. poly_gGlu_PgsC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis."
      Makino S., Uchida I., Terakado N., Sasakawa C., Yoshikawa M.
      J. Bacteriol. 171:722-730(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Plasmid: pTE702
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Pasteur.
      Plasmid: pXO2
    3. "Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis."
      Read T.D., Salzberg S.L., Pop M., Shumway M.F., Umayam L., Jiang L., Holtzapple E., Busch J.D., Smith K.L., Schupp J.M., Solomon D., Keim P., Fraser C.M.
      Science 296:2028-2033(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Ames / isolate Florida / A2012.
      Plasmid: pXO2
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
      Plasmid: pXO2
    5. "atxA controls Bacillus anthracis capsule synthesis via acpA and a newly discovered regulator, acpB."
      Drysdale M., Bourgogne A., Hilsenbeck S.G., Koehler T.M.
      J. Bacteriol. 186:307-315(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
      Plasmid: pXO2

    Entry informationi

    Entry nameiCAPC_BACAN
    AccessioniPrimary (citable) accession number: P19581
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3