Reviewed, UniProtKB/Swiss-Prot P19570 (GUN3_BACS4)

Names and origin

Protein names

Recommended name:
    Endoglucanase C
    EC=3.2.1.4
Alternative name(s):
    Endo-1,4-beta-glucanase C
    Cellulase C

Gene names

Name:

celC

Organism

Bacillus sp. (strain N-4 / JCM 9156)

Taxonomic identifier

1413 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	825 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
Sequence similarities	Belongs to the glycosyl hydrolase 5 (cellulase A) family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Cellulose degradation Polysaccharide degradation
Domain	Signal
Molecular function	Glycosidase Hydrolase
Gene Ontology (GO)
Biological process	cellulose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cation binding Inferred from electronic annotation. Source: InterPro cellulase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 825	797	Endoglucanase C		PRO_0000007836
Sites
	Active site	219	1	Proton donor By similarity
	Active site	335	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	P19570-1 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: A1727DA3D7632617	FASTA	825	92,015
	10 20 30 40 50 60 MRNKLRRLLA IMMAVLLITS LFAPMVSAEE GDNGDDDDLV TPIEIEERPH ESNYEKYPAL 70 80 90 100 110 120 LDGGLDERRP SEAGALQLVE VDGQVTLADQ DGVPIQLRGM STHGLQWFGE IVNENAFAAL 130 140 150 160 170 180 ANDWGSNVIR LALYIGENAY RYNPDLIEKV YAGIELAKEN DMYVIIDWHV HAPGDPNADI 190 200 210 220 230 240 YQGGVNEDGE EYLGAKDFFL HIAEKYPNDP HLIYELANEP SSNSSGGPGI TNDEDGWEAV 250 260 270 280 290 300 REYAQPIVDA LRDSGNAEDN IIIVGSPNWS QRMDLAAADN PIDDHHTMYT LHFYTGTHEG 310 320 330 340 350 360 TNESYPEGIS SEDRSNVMAN AKYALDKGKA IFATEWGVSE ADGNNGPYLN EADVWLNFLN 370 380 390 400 410 420 ENNISWTNWS LTNKNETSGA FTPFILNESD ATDLDPGEDQ VWSMEELSVS GEYVRSRILG 430 440 450 460 470 480 EEYQPIDRTP REEFSEVIWD FNDGTTQGFV QNSDSPLDVT IENVNDALQI TGLDESNAIA 490 500 510 520 530 540 GEEEDYWSNV RISADEWEET FDILGAEELS MDVVVDDPTT VAIAAIPQSS AHEWANASNS 550 560 570 580 590 600 VLITEDDFEE QEDGTYKALL TITGEDAPNL TNIAEDPEGS ELNNIILFVG TENADVISLD 610 620 630 640 650 660 NITVTGDRES VPEPVEHDTK GDSALPSDFE DGTRQGWEWD SESAVRTALT IEEANGSNAL 670 680 690 700 710 720 SWEYAYPEVK PSDDWATAPR LTLYKDDLVR GDYEFVAFDF YIDPIEDRAT EGAIDINLIF 730 740 750 760 770 780 QPPAAGYWAQ ASETFEIDLE ELDSATVTDD GLYHYEVEIN IEDIENDIEL RNLMLIFADD 790 800 810 820 ESDFAGRVFL DNVRMDMSLE TKVEVLERNI NELQEQLVEV EALMR

References

[1]	"The third cellulase of alkalophilic Bacillus sp. strain N-4: evolutionary relationships within the cel gene family." Fukumori F., Kudo T., Sashihara N., Nagata Y., Ito K., Horikoshi K. Gene 76:289-298(1989) [PubMed: 2666258] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M25500 Genomic DNA. Translation: AAA22306.1.
PIR	JS0174.
3D structure databases
HSSP	HSSP built from PDB template 1G0C based on UniProtKB P19424.
SMR	P19570. Positions 615-796.
ModBase	Search...
Protein family/group databases
CAZy	CBM17. Carbohydrate-Binding Module Family 17. CBM28. Carbohydrate-Binding Module Family 28. GH5. Glycoside Hydrolase Family 5.
Family and domain databases
InterPro	IPR005086. CBM_17_28. IPR001547. Glyco_hydro_5. IPR018087. Glyco_hydro_5_CS. IPR013781. Glyco_hydro_sg_catalytic. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
Pfam	PF03424. CBM_17_28. 2 hits. PF00150. Cellulase. 1 hit. [Graphical view]
PROSITE	PS00659. GLYCOSYL_HYDROL_F5. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GUN3_BACS4

Accession

Primary (citable) accession number: P19570

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)