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P19568 (TLCA_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ADP,ATP carrier protein 1
Alternative name(s):
ADP/ATP translocase 1
Gene names
Name:tlcA
Synonyms:tlc, tlc1
Ordered Locus Names:RP053
OrganismRickettsia prowazekii (strain Madrid E)
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP:ADP antiporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498ADP,ATP carrier protein 1
PRO_0000102580

Regions

Topological domain1 – 3333Cytoplasmic Probable
Transmembrane34 – 5421Helical; Probable
Topological domain55 – 6713Extracellular Probable
Transmembrane68 – 8821Helical; Probable
Topological domain89 – 924Cytoplasmic Probable
Transmembrane93 – 11321Helical; Probable
Topological domain114 – 14734Extracellular Probable
Transmembrane148 – 16821Helical; Probable
Topological domain169 – 18416Cytoplasmic Probable
Transmembrane185 – 20521Helical; Probable
Topological domain206 – 21813Extracellular Probable
Transmembrane219 – 23921Helical; Probable
Topological domain240 – 27940Cytoplasmic Probable
Transmembrane280 – 30021Helical; Probable
Topological domain301 – 32020Extracellular Probable
Transmembrane321 – 34121Helical; Probable
Topological domain342 – 3487Cytoplasmic Probable
Transmembrane349 – 36921Helical; Probable
Topological domain370 – 37910Extracellular Probable
Transmembrane380 – 40021Helical; Probable
Topological domain401 – 43838Cytoplasmic Probable
Transmembrane439 – 45921Helical; Probable
Topological domain460 – 4656Extracellular Probable
Transmembrane466 – 48621Helical; Probable
Topological domain487 – 49812Cytoplasmic Probable
Nucleotide binding436 – 4427ATP Potential

Amino acid modifications

Disulfide bond37 ↔ 85 Probable

Sequences

Sequence LengthMass (Da)Tools
P19568 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: D3C450D2BC0BE53E

FASTA49856,822
        10         20         30         40         50         60 
MSTSKSENYL SELRKIIWPI EQYENKKFLP LAFMMFCILL NYSTLRSIKD GFVVTDIGTE 

        70         80         90        100        110        120 
SISFLKTYIV LPSAVIAMII YVKLCDILKQ ENVFYVITSF FLGYFALFAF VLYPYPDLVH 

       130        140        150        160        170        180 
PDHKTIESLS LAYPNFKWFI KIVGKWSFAS FYTIAELWGT MMLSLLFWQF ANQITKIAEA 

       190        200        210        220        230        240 
KRFYSMFGLL ANLALPVTSV VIGYFLHEKT QIVAEHLKFV PLFVIMITSS FLIILTYRWM 

       250        260        270        280        290        300 
NKNVLTDPRL YDPALVKEKK TKAKLSFIES LKMIFTSKYV GYIALLIIAY GVSVNLVEGV 

       310        320        330        340        350        360 
WKSKVKELYP TKEAYTIYMG QFQFYQGWVA IAFMLIGSNI LRKVSWLTAA MITPLMMFIT 

       370        380        390        400        410        420 
GAAFFSFIFF DSVIAMNLTG ILASSPLTLA VMIGMIQNVL SKGVKYSLFD ATKNMAYIPL 

       430        440        450        460        470        480 
DKDLRVKGQA AVEVIGGRLG KSGGAIIQST FFILFPVFGF IEATPYFASI FFIIVILWIF 

       490 
AVKGLNKEYQ VLVNKNEK

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the Rickettsia prowazekii ATP/ADP translocase-encoding gene."
Williamson L.R., Plano G.V., Winkler H.H., Krause D.C., Wood D.O.
Gene 80:269-278(1989) [PubMed: 2555259] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Madrid E.
[2]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed: 9823893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.
[3]"Identification and initial topological analysis of the Rickettsia prowazekii ATP/ADP translocase."
Plano G.V., Winkler H.H.
J. Bacteriol. 173:3389-3396(1991) [PubMed: 1904433] [Abstract]
Cited for: TOPOLOGY.
[4]"Rickettsia prowazekii and ATP/ADP translocase. Analysis of gene fusions encoding beta-galactosidase-ATP/ADP translocase fusion proteins."
Plano G.V., Wood D.O., Winkler H.H.
Ann. N. Y. Acad. Sci. 590:397-407(1990) [PubMed: 2165754] [Abstract]
Cited for: TOPOLOGY.
[5]"Membrane topology of the Rickettsia prowazekii ATP/ADP translocase revealed by novel dual pho-lac reporters."
Alexeyev M.F., Winkler H.H.
J. Mol. Biol. 285:1503-1513(1999) [PubMed: 9917392] [Abstract]
Cited for: TOPOLOGY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M28816 Genomic DNA. Translation: AAA26382.1.
AJ235270 Genomic DNA. Translation: CAA14524.1.
PIRJQ0026.
RefSeqNP_220447.1. NC_000963.1.

3D structure databases

ProteinModelPortalP19568.
ModBaseSearch...

Protein family/group databases

TCDB2.A.12.1.1. ATP:ADP antiporter (AAA) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID883599.
GenomeReviewsGene locus RP053 in contig AJ235269_GR.
KEGGrpr:RP053.
PATRIC17900840. VBIRicPro72556_0054.

Phylogenomic databases

HOGENOMHBG586333.
OMAAYPNFKW.
ProtClustDBCLSK870724.

Enzyme and pathway databases

BioCycRPRO272947:RP053-MONOMER.

Family and domain databases

InterProIPR004667. ADP_ATP_car.
[Graphical view]
KOK03301.
PfamPF03219. TLC. 1 hit.
[Graphical view]
TIGRFAMsTIGR00769. AAA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTLCA_RICPR
AccessionPrimary (citable) accession number: P19568
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

SIMILARITY comments

Index of protein domains and families

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