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Protein

Regulator of drug sensitivity 2

Gene

RDS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which regulates the expression of genes for gluconeogenesis, the TCA cycle, and glucose metabolism. Involved in the cell wall remodeling process and drug resistance.3 Publications

Miscellaneous

Present with 799 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi15 – 45Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

  • carbon utilization Source: GO_Central
  • cellular response to xenobiotic stimulus Source: SGD
  • cell wall organization Source: UniProtKB-KW
  • negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD
  • positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD

Keywordsi

Molecular functionDNA-binding
Biological processCell wall biogenesis/degradation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-34032-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of drug sensitivity 2
Gene namesi
Name:RDS2
Ordered Locus Names:YPL133C
ORF Names:LPI12C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL133C
SGDiS000006054 RDS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Sensitivity to ketoconazole.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001150061 – 446Regulator of drug sensitivity 2Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineCombined sources1
Modified residuei231PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated by SNF1 in absence of glucose. The phosphorylation is required for induction of transcription of gluconeogenic genes.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP19541
PaxDbiP19541
PRIDEiP19541

PTM databases

iPTMnetiP19541

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SHP1P342232EBI-29389,EBI-17093

Protein-protein interaction databases

BioGridi36048, 48 interactors
DIPiDIP-1515N
IntActiP19541, 10 interactors
MINTiP19541
STRINGi4932.YPL133C

Structurei

3D structure databases

ProteinModelPortaliP19541
SMRiP19541
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000068325
HOGENOMiHOG000164620
InParanoidiP19541
OMAiHESSPND
OrthoDBiEOG092C1E3A

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR035965 PAS-like_dom_sf
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
SMARTiView protein in SMART
SM00066 GAL4, 1 hit
SUPFAMiSSF55785 SSF55785, 1 hit
SSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

P19541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANSGVKRA SKAFKTCLFC KRSHVVCDKQ RPCSRCVKRD IAHLCREDDI
60 70 80 90 100
AVPNEMPSQH ESSPNDNNIQ GKYANKAHTG IPSDYQNEPV NKSGSTYGEE
110 120 130 140 150
LSPKLDSSLV NDTTSLLLPQ QPVFVSENVG SEFSSLNEFL SMLENPLLTQ
160 170 180 190 200
TSLSSSSASN VHLENGSQTT QSPLEYQNDN RRDEIGVARQ ENRSPTIMSG
210 220 230 240 250
SSNSISKGDK QDQEKEESRI LANANENSAP TPKEQFFLTA ADPSTEMTPE
260 270 280 290 300
HRLKLVINAK LEAGLLKPYN YAKGYARLQD YMDKYMNQSS KQRILKPLST
310 320 330 340 350
IRPAFRTIAR SLKDVDLVLV EESFERMLLS YDRVFTSMSM PACLCRRTGE
360 370 380 390 400
IYRANKEFAS LVDCTVDDLR DGKLAIYELM TEESAVNFWE KYGSIAFDKG
410 420 430 440
QKAVLTSCSL RTKDGIRKRP CCFSFTIRRD RYNIPICIVG NFIPLS
Length:446
Mass (Da):50,082
Last modified:October 1, 1996 - v2
Checksum:iC78D3632DDCC3EA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA Translation: AAB68226.1
AY693168 Genomic DNA Translation: AAT93187.1
X55731 Genomic DNA Translation: CAA39262.1
BK006949 Genomic DNA Translation: DAA11300.1
PIRiS69051
RefSeqiNP_015192.1, NM_001183947.1

Genome annotation databases

EnsemblFungiiYPL133C; YPL133C; YPL133C
GeneIDi855970
KEGGisce:YPL133C

Similar proteinsi

Entry informationi

Entry nameiRDS2_YEAST
AccessioniPrimary (citable) accession number: P19541
Secondary accession number(s): D6W3N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health