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Protein

Regulator of drug sensitivity 2

Gene

RDS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor which regulates the expression of genes for gluconeogenesis, the TCA cycle, and glucose metabolism. Involved in the cell wall remodeling process and drug resistance.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi15 – 45Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

  • carbon utilization Source: GO_Central
  • cellular response to xenobiotic stimulus Source: SGD
  • cell wall organization Source: UniProtKB-KW
  • negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD
  • positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell wall biogenesis/degradation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-34032-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of drug sensitivity 2
Gene namesi
Name:RDS2
Ordered Locus Names:YPL133C
ORF Names:LPI12C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL133C.
SGDiS000006054. RDS2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Sensitivity to ketoconazole.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001150061 – 446Regulator of drug sensitivity 2Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineCombined sources1
Modified residuei231PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated by SNF1 in absence of glucose. The phosphorylation is required for induction of transcription of gluconeogenic genes.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP19541.
PRIDEiP19541.

PTM databases

iPTMnetiP19541.

Interactioni

Protein-protein interaction databases

BioGridi36048. 32 interactors.
DIPiDIP-1515N.
IntActiP19541. 5 interactors.
MINTiMINT-400287.

Structurei

3D structure databases

ProteinModelPortaliP19541.
SMRiP19541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000068325.
HOGENOMiHOG000164620.
InParanoidiP19541.
OMAiGNSNANQ.
OrthoDBiEOG092C1E3A.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR000014. PAS.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
SSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANSGVKRA SKAFKTCLFC KRSHVVCDKQ RPCSRCVKRD IAHLCREDDI
60 70 80 90 100
AVPNEMPSQH ESSPNDNNIQ GKYANKAHTG IPSDYQNEPV NKSGSTYGEE
110 120 130 140 150
LSPKLDSSLV NDTTSLLLPQ QPVFVSENVG SEFSSLNEFL SMLENPLLTQ
160 170 180 190 200
TSLSSSSASN VHLENGSQTT QSPLEYQNDN RRDEIGVARQ ENRSPTIMSG
210 220 230 240 250
SSNSISKGDK QDQEKEESRI LANANENSAP TPKEQFFLTA ADPSTEMTPE
260 270 280 290 300
HRLKLVINAK LEAGLLKPYN YAKGYARLQD YMDKYMNQSS KQRILKPLST
310 320 330 340 350
IRPAFRTIAR SLKDVDLVLV EESFERMLLS YDRVFTSMSM PACLCRRTGE
360 370 380 390 400
IYRANKEFAS LVDCTVDDLR DGKLAIYELM TEESAVNFWE KYGSIAFDKG
410 420 430 440
QKAVLTSCSL RTKDGIRKRP CCFSFTIRRD RYNIPICIVG NFIPLS
Length:446
Mass (Da):50,082
Last modified:October 1, 1996 - v2
Checksum:iC78D3632DDCC3EA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA. Translation: AAB68226.1.
AY693168 Genomic DNA. Translation: AAT93187.1.
X55731 Genomic DNA. Translation: CAA39262.1.
BK006949 Genomic DNA. Translation: DAA11300.1.
PIRiS69051.
RefSeqiNP_015192.1. NM_001183947.1.

Genome annotation databases

EnsemblFungiiYPL133C; YPL133C; YPL133C.
GeneIDi855970.
KEGGisce:YPL133C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA. Translation: AAB68226.1.
AY693168 Genomic DNA. Translation: AAT93187.1.
X55731 Genomic DNA. Translation: CAA39262.1.
BK006949 Genomic DNA. Translation: DAA11300.1.
PIRiS69051.
RefSeqiNP_015192.1. NM_001183947.1.

3D structure databases

ProteinModelPortaliP19541.
SMRiP19541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36048. 32 interactors.
DIPiDIP-1515N.
IntActiP19541. 5 interactors.
MINTiMINT-400287.

PTM databases

iPTMnetiP19541.

Proteomic databases

MaxQBiP19541.
PRIDEiP19541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL133C; YPL133C; YPL133C.
GeneIDi855970.
KEGGisce:YPL133C.

Organism-specific databases

EuPathDBiFungiDB:YPL133C.
SGDiS000006054. RDS2.

Phylogenomic databases

GeneTreeiENSGT00530000068325.
HOGENOMiHOG000164620.
InParanoidiP19541.
OMAiGNSNANQ.
OrthoDBiEOG092C1E3A.

Enzyme and pathway databases

BioCyciYEAST:G3O-34032-MONOMER.

Miscellaneous databases

PROiP19541.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR000014. PAS.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
SSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRDS2_YEAST
AccessioniPrimary (citable) accession number: P19541
Secondary accession number(s): D6W3N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 799 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.