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Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

Cox5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90ZincPROSITE-ProRule annotation1
Metal bindingi92ZincPROSITE-ProRule annotation1
Metal bindingi112ZincPROSITE-ProRule annotation1
Metal bindingi115ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene namesi
Name:Cox5b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88475 Cox5b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000000611031 – 128Cytochrome c oxidase subunit 5B, mitochondrialAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67N6-acetyllysineCombined sources1
Modified residuei85N6-acetyllysineCombined sources1
Modified residuei120N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP19536
MaxQBiP19536
PaxDbiP19536
PeptideAtlasiP19536
PRIDEiP19536

2D gel databases

SWISS-2DPAGEiP19536
UCD-2DPAGEiP19536

PTM databases

iPTMnetiP19536
PhosphoSitePlusiP19536
SwissPalmiP19536

Expressioni

Gene expression databases

CleanExiMM_COX5B

Interactioni

Protein-protein interaction databases

CORUMiP19536
IntActiP19536, 1 interactor
STRINGi10090.ENSMUSP00000079944

Structurei

3D structure databases

ProteinModelPortaliP19536
SMRiP19536
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3352 Eukaryota
ENOG4111XEM LUCA
HOVERGENiHBG051089
InParanoidiP19536

Family and domain databases

CDDicd00924 Cyt_c_Oxidase_Vb, 1 hit
Gene3Di2.60.11.10, 1 hit
InterProiView protein in InterPro
IPR002124 Cyt_c_oxidase_su5b
IPR036972 Cyt_c_oxidase_su5b_sf
IPR020893 Cyt_c_oxidase_su5b_Zn_BS
PANTHERiPTHR10122 PTHR10122, 1 hit
PfamiView protein in Pfam
PF01215 COX5B, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007270 Cyt_c_oxidase_su5b, 1 hit
PROSITEiView protein in PROSITE
PS00848 COX5B_1, 1 hit
PS51359 COX5B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLLRGVG ALAAQALRRT ARGAAVTRSM ASGGGVPTDE EQATGLEREI
60 70 80 90 100
MIAAQKGLDP YNMLPPKAAS GTKEDPNLVP SISNKRIVGC ICEEDNCTVI
110 120
WFWLHKGESQ RCPNCGTHYK LVPHQMAH
Length:128
Mass (Da):13,813
Last modified:February 1, 1991 - v1
Checksum:i84AA890F1A074383
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53157 mRNA Translation: CAA37313.1
M77040 Genomic DNA Translation: AAA37515.1
PIRiA39425
UniGeneiMm.180182
Mm.288128

Similar proteinsi

Entry informationi

Entry nameiCOX5B_MOUSE
AccessioniPrimary (citable) accession number: P19536
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health