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P19536 (COX5B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene names
Name:Cox5b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length128 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 5B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3030Mitochondrion By similarity
Chain31 – 12898Cytochrome c oxidase subunit 5B, mitochondrial
PRO_0000006110

Sites

Metal binding901Zinc By similarity
Metal binding921Zinc By similarity
Metal binding1121Zinc By similarity
Metal binding1151Zinc By similarity

Amino acid modifications

Modified residue671N6-acetyllysine Ref.4
Modified residue851N6-acetyllysine Ref.4
Modified residue1201N6-acetyllysine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P19536 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 84AA890F1A074383

FASTA12813,813
        10         20         30         40         50         60 
MASRLLRGVG ALAAQALRRT ARGAAVTRSM ASGGGVPTDE EQATGLEREI MIAAQKGLDP 

        70         80         90        100        110        120 
YNMLPPKAAS GTKEDPNLVP SISNKRIVGC ICEEDNCTVI WFWLHKGESQ RCPNCGTHYK 


LVPHQMAH 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of cDNA for nuclear encoded subunit Vb of mouse cytochrome-c oxidase."
Basu A., Avadhani N.G.
Biochim. Biophys. Acta 1087:98-100(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Bone marrow tumor.
[2]"Structural organization of nuclear gene for subunit Vb of mouse mitochondrial cytochrome c oxidase."
Basu A., Avadhani N.G.
J. Biol. Chem. 266:15450-15456(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 57-67 AND 74-85, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[4]"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-67; LYS-85 AND LYS-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53157 mRNA. Translation: CAA37313.1.
M77040 Genomic DNA. Translation: AAA37515.1.
PIRA39425.
UniGeneMm.180182.
Mm.288128.

3D structure databases

ProteinModelPortalP19536.
SMRP19536. Positions 31-128.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP19536. 1 interaction.
MINTMINT-1861645.
STRING10090.ENSMUSP00000038961.

PTM databases

PhosphoSiteP19536.

2D gel databases

SWISS-2DPAGEP19536.
UCD-2DPAGEP19536.

Proteomic databases

MaxQBP19536.
PaxDbP19536.
PRIDEP19536.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:88475. Cox5b.

Phylogenomic databases

eggNOGNOG316751.
HOVERGENHBG051089.
InParanoidP19536.

Gene expression databases

CleanExMM_COX5B.
GenevestigatorP19536.

Family and domain databases

Gene3D2.60.11.10. 1 hit.
InterProIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERPTHR10122. PTHR10122. 1 hit.
PfamPF01215. COX5B. 1 hit.
[Graphical view]
ProDomPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCOX5B. mouse.
PROP19536.
SOURCESearch...

Entry information

Entry nameCOX5B_MOUSE
AccessionPrimary (citable) accession number: P19536
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 14, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot