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P19536

- COX5B_MOUSE

UniProt

P19536 - COX5B_MOUSE

Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

Cox5b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi90 – 901ZincPROSITE-ProRule annotation
    Metal bindingi92 – 921ZincPROSITE-ProRule annotation
    Metal bindingi112 – 1121ZincPROSITE-ProRule annotation
    Metal bindingi115 – 1151ZincPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 5B, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide Vb
    Gene namesi
    Name:Cox5b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:88475. Cox5b.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3030MitochondrionBy similarityAdd
    BLAST
    Chaini31 – 12898Cytochrome c oxidase subunit 5B, mitochondrialPRO_0000006110Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei67 – 671N6-acetyllysine1 Publication
    Modified residuei85 – 851N6-acetyllysine1 Publication
    Modified residuei120 – 1201N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP19536.
    PaxDbiP19536.
    PRIDEiP19536.

    2D gel databases

    SWISS-2DPAGEP19536.
    UCD-2DPAGEP19536.

    PTM databases

    PhosphoSiteiP19536.

    Expressioni

    Gene expression databases

    CleanExiMM_COX5B.
    GenevestigatoriP19536.

    Interactioni

    Protein-protein interaction databases

    IntActiP19536. 1 interaction.
    MINTiMINT-1861645.
    STRINGi10090.ENSMUSP00000038961.

    Structurei

    3D structure databases

    ProteinModelPortaliP19536.
    SMRiP19536. Positions 31-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG316751.
    HOVERGENiHBG051089.
    InParanoidiP19536.

    Family and domain databases

    Gene3Di2.60.11.10. 1 hit.
    InterProiIPR002124. Cyt_c_oxidase_su5b.
    IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
    [Graphical view]
    PANTHERiPTHR10122. PTHR10122. 1 hit.
    PfamiPF01215. COX5B. 1 hit.
    [Graphical view]
    ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS00848. COX5B_1. 1 hit.
    PS51359. COX5B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19536-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRLLRGVG ALAAQALRRT ARGAAVTRSM ASGGGVPTDE EQATGLEREI    50
    MIAAQKGLDP YNMLPPKAAS GTKEDPNLVP SISNKRIVGC ICEEDNCTVI 100
    WFWLHKGESQ RCPNCGTHYK LVPHQMAH 128
    Length:128
    Mass (Da):13,813
    Last modified:February 1, 1991 - v1
    Checksum:i84AA890F1A074383
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53157 mRNA. Translation: CAA37313.1.
    M77040 Genomic DNA. Translation: AAA37515.1.
    PIRiA39425.
    UniGeneiMm.180182.
    Mm.288128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53157 mRNA. Translation: CAA37313.1 .
    M77040 Genomic DNA. Translation: AAA37515.1 .
    PIRi A39425.
    UniGenei Mm.180182.
    Mm.288128.

    3D structure databases

    ProteinModelPortali P19536.
    SMRi P19536. Positions 31-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P19536. 1 interaction.
    MINTi MINT-1861645.
    STRINGi 10090.ENSMUSP00000038961.

    PTM databases

    PhosphoSitei P19536.

    2D gel databases

    SWISS-2DPAGE P19536.
    UCD-2DPAGE P19536.

    Proteomic databases

    MaxQBi P19536.
    PaxDbi P19536.
    PRIDEi P19536.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:88475. Cox5b.

    Phylogenomic databases

    eggNOGi NOG316751.
    HOVERGENi HBG051089.
    InParanoidi P19536.

    Miscellaneous databases

    ChiTaRSi COX5B. mouse.
    PROi P19536.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_COX5B.
    Genevestigatori P19536.

    Family and domain databases

    Gene3Di 2.60.11.10. 1 hit.
    InterProi IPR002124. Cyt_c_oxidase_su5b.
    IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
    [Graphical view ]
    PANTHERi PTHR10122. PTHR10122. 1 hit.
    Pfami PF01215. COX5B. 1 hit.
    [Graphical view ]
    ProDomi PD007270. Cyt_c_oxidase_su5b. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS00848. COX5B_1. 1 hit.
    PS51359. COX5B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of cDNA for nuclear encoded subunit Vb of mouse cytochrome-c oxidase."
      Basu A., Avadhani N.G.
      Biochim. Biophys. Acta 1087:98-100(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone marrow tumor.
    2. "Structural organization of nuclear gene for subunit Vb of mouse mitochondrial cytochrome c oxidase."
      Basu A., Avadhani N.G.
      J. Biol. Chem. 266:15450-15456(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 57-67 AND 74-85, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-67; LYS-85 AND LYS-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCOX5B_MOUSE
    AccessioniPrimary (citable) accession number: P19536
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3