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Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

Cox5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901ZincPROSITE-ProRule annotation
Metal bindingi92 – 921ZincPROSITE-ProRule annotation
Metal bindingi112 – 1121ZincPROSITE-ProRule annotation
Metal bindingi115 – 1151ZincPROSITE-ProRule annotation

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene namesi
Name:Cox5b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88475. Cox5b.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. myelin sheath Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 12898Cytochrome c oxidase subunit 5B, mitochondrialPRO_0000006110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671N6-acetyllysine1 Publication
Modified residuei85 – 851N6-acetyllysine1 Publication
Modified residuei120 – 1201N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP19536.
PaxDbiP19536.
PRIDEiP19536.

2D gel databases

SWISS-2DPAGEP19536.
UCD-2DPAGEP19536.

PTM databases

PhosphoSiteiP19536.

Expressioni

Gene expression databases

CleanExiMM_COX5B.
GenevestigatoriP19536.

Interactioni

Protein-protein interaction databases

IntActiP19536. 1 interaction.
MINTiMINT-1861645.
STRINGi10090.ENSMUSP00000038961.

Structurei

3D structure databases

ProteinModelPortaliP19536.
SMRiP19536. Positions 31-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG316751.
HOVERGENiHBG051089.
InParanoidiP19536.

Family and domain databases

Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLLRGVG ALAAQALRRT ARGAAVTRSM ASGGGVPTDE EQATGLEREI
60 70 80 90 100
MIAAQKGLDP YNMLPPKAAS GTKEDPNLVP SISNKRIVGC ICEEDNCTVI
110 120
WFWLHKGESQ RCPNCGTHYK LVPHQMAH
Length:128
Mass (Da):13,813
Last modified:February 1, 1991 - v1
Checksum:i84AA890F1A074383
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53157 mRNA. Translation: CAA37313.1.
M77040 Genomic DNA. Translation: AAA37515.1.
PIRiA39425.
UniGeneiMm.180182.
Mm.288128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53157 mRNA. Translation: CAA37313.1.
M77040 Genomic DNA. Translation: AAA37515.1.
PIRiA39425.
UniGeneiMm.180182.
Mm.288128.

3D structure databases

ProteinModelPortaliP19536.
SMRiP19536. Positions 31-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP19536. 1 interaction.
MINTiMINT-1861645.
STRINGi10090.ENSMUSP00000038961.

PTM databases

PhosphoSiteiP19536.

2D gel databases

SWISS-2DPAGEP19536.
UCD-2DPAGEP19536.

Proteomic databases

MaxQBiP19536.
PaxDbiP19536.
PRIDEiP19536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88475. Cox5b.

Phylogenomic databases

eggNOGiNOG316751.
HOVERGENiHBG051089.
InParanoidiP19536.

Miscellaneous databases

ChiTaRSiCox5b. mouse.
PROiP19536.
SOURCEiSearch...

Gene expression databases

CleanExiMM_COX5B.
GenevestigatoriP19536.

Family and domain databases

Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of cDNA for nuclear encoded subunit Vb of mouse cytochrome-c oxidase."
    Basu A., Avadhani N.G.
    Biochim. Biophys. Acta 1087:98-100(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow tumor.
  2. "Structural organization of nuclear gene for subunit Vb of mouse mitochondrial cytochrome c oxidase."
    Basu A., Avadhani N.G.
    J. Biol. Chem. 266:15450-15456(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Lubec G., Kang S.U.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 57-67 AND 74-85, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-67; LYS-85 AND LYS-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCOX5B_MOUSE
AccessioniPrimary (citable) accession number: P19536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 4, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.