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Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

Cox5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901ZincPROSITE-ProRule annotation
Metal bindingi92 – 921ZincPROSITE-ProRule annotation
Metal bindingi112 – 1121ZincPROSITE-ProRule annotation
Metal bindingi115 – 1151ZincPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene namesi
Name:Cox5b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88475. Cox5b.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • myelin sheath Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 12898Cytochrome c oxidase subunit 5B, mitochondrialPRO_0000006110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671N6-acetyllysineCombined sources
Modified residuei85 – 851N6-acetyllysineCombined sources
Modified residuei120 – 1201N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP19536.
MaxQBiP19536.
PaxDbiP19536.
PeptideAtlasiP19536.
PRIDEiP19536.

2D gel databases

SWISS-2DPAGEP19536.
UCD-2DPAGEP19536.

PTM databases

iPTMnetiP19536.
PhosphoSiteiP19536.

Expressioni

Gene expression databases

CleanExiMM_COX5B.

Interactioni

Protein-protein interaction databases

IntActiP19536. 1 interaction.
MINTiMINT-1861645.
STRINGi10090.ENSMUSP00000079944.

Structurei

3D structure databases

ProteinModelPortaliP19536.
SMRiP19536. Positions 31-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3352. Eukaryota.
ENOG4111XEM. LUCA.
HOVERGENiHBG051089.
InParanoidiP19536.

Family and domain databases

CDDicd00924. Cyt_c_Oxidase_Vb. 1 hit.
Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLLRGVG ALAAQALRRT ARGAAVTRSM ASGGGVPTDE EQATGLEREI
60 70 80 90 100
MIAAQKGLDP YNMLPPKAAS GTKEDPNLVP SISNKRIVGC ICEEDNCTVI
110 120
WFWLHKGESQ RCPNCGTHYK LVPHQMAH
Length:128
Mass (Da):13,813
Last modified:February 1, 1991 - v1
Checksum:i84AA890F1A074383
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53157 mRNA. Translation: CAA37313.1.
M77040 Genomic DNA. Translation: AAA37515.1.
PIRiA39425.
UniGeneiMm.180182.
Mm.288128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53157 mRNA. Translation: CAA37313.1.
M77040 Genomic DNA. Translation: AAA37515.1.
PIRiA39425.
UniGeneiMm.180182.
Mm.288128.

3D structure databases

ProteinModelPortaliP19536.
SMRiP19536. Positions 31-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP19536. 1 interaction.
MINTiMINT-1861645.
STRINGi10090.ENSMUSP00000079944.

PTM databases

iPTMnetiP19536.
PhosphoSiteiP19536.

2D gel databases

SWISS-2DPAGEP19536.
UCD-2DPAGEP19536.

Proteomic databases

EPDiP19536.
MaxQBiP19536.
PaxDbiP19536.
PeptideAtlasiP19536.
PRIDEiP19536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88475. Cox5b.

Phylogenomic databases

eggNOGiKOG3352. Eukaryota.
ENOG4111XEM. LUCA.
HOVERGENiHBG051089.
InParanoidiP19536.

Miscellaneous databases

ChiTaRSiCox5b. mouse.
PROiP19536.
SOURCEiSearch...

Gene expression databases

CleanExiMM_COX5B.

Family and domain databases

CDDicd00924. Cyt_c_Oxidase_Vb. 1 hit.
Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX5B_MOUSE
AccessioniPrimary (citable) accession number: P19536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.