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P19532

- TFE3_HUMAN

UniProt

P19532 - TFE3_HUMAN

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Protein

Transcription factor E3

Gene

TFE3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei178 – 1792Breakpoint for translocation to form PRCC-TFE3 oncogene
Sitei260 – 2612Breakpoint for translocation to form ASPSCR1-TFE3 oncogene
Sitei295 – 2962Breakpoint for translocation to form NONO-TFE3, PSF-TFE3 and ASPSCR1-TFE3 oncogenes

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  2. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. humoral immune response Source: UniProtKB
  2. positive regulation of cell adhesion Source: UniProtKB
  3. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. regulation of osteoclast differentiation Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Adaptive immunity, Immunity, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor E3
Alternative name(s):
Class E basic helix-loop-helix protein 33
Short name:
bHLHe33
Gene namesi
Name:TFE3
Synonyms:BHLHE33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:11752. TFE3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TFE3 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with ASPSCR1 forms a ASPSCR1-TFE3 fusion protein.
Chromosomal aberrations involving TFE3 are found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with PRCC; translocation t(X;1)(p11.2;p34) with PSF; inversion inv(X)(p11.2;q12) that fuses NONO to TFE3.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

Orphaneti163699. Alveolar soft-tissue sarcoma.
319308. Translocation renal cell carcinoma.
PharmGKBiPA36467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Transcription factor E3PRO_0000127471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei548 – 5481Phosphoserine1 Publication
Modified residuei556 – 5561Phosphoserine2 Publications
Modified residuei560 – 5601Phosphoserine2 Publications
Modified residuei568 – 5681Phosphoserine1 Publication

Post-translational modificationi

Sumoylated; does not affect dimerization with MITF.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP19532.
PaxDbiP19532.
PRIDEiP19532.

PTM databases

PhosphoSiteiP19532.

Expressioni

Tissue specificityi

Ubiquitous in fetal and adult tissues.

Gene expression databases

BgeeiP19532.
CleanExiHS_TFE3.
ExpressionAtlasiP19532. baseline and differential.
GenevestigatoriP19532.

Organism-specific databases

HPAiHPA023881.

Interactioni

Subunit structurei

Homodimer and heterodimer; with TFEB or MITF.

Protein-protein interaction databases

BioGridi112888. 22 interactions.
IntActiP19532. 1 interaction.
STRINGi9606.ENSP00000314129.

Structurei

3D structure databases

ProteinModelPortaliP19532.
SMRiP19532. Positions 347-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini346 – 39954bHLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni260 – 27112Strong transcription activation domainSequence AnalysisAdd
BLAST
Regioni409 – 43022Leucine-zipperAdd
BLAST

Sequence similaritiesi

Belongs to the MiT/TFE family.Curated
Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG251286.
GeneTreeiENSGT00390000004402.
HOGENOMiHOG000231368.
HOVERGENiHBG006768.
InParanoidiP19532.
KOiK09105.
OMAiPGTATFH.
OrthoDBiEOG72G182.
PhylomeDBiP19532.
TreeFamiTF317174.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR021802. bHLH_ZIP_TF_MiT/TFE.
IPR024100. TFE3.
[Graphical view]
PANTHERiPTHR10014:SF37. PTHR10014:SF37. 1 hit.
PfamiPF11851. DUF3371. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P19532-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHAAEPARD GVEASAEGPR AVFVLLEERR PADSAQLLSL NSLLPESGIV
60 70 80 90 100
ADIELENVLD PDSFYELKSQ PLPLRSSLPI SLQATPATPA TLSASSSAGG
110 120 130 140 150
SRTPAMSSSS SSRVLLRQQL MRAQAQEQER RERREQAAAA PFPSPAPASP
160 170 180 190 200
AISVVGVSAG GHTLSRPPPA QVPREVLKVQ THLENPTRYH LQQARRQQVK
210 220 230 240 250
QYLSTTLGPK LASQALTPPP GPASAQPLPA PEAAHTTGPT GSAPNSPMAL
260 270 280 290 300
LTIGSSSEKE IDDVIDEIIS LESSYNDEML SYLPGGTTGL QLPSTLPVSG
310 320 330 340 350
NLLDVYSSQG VATPAITVSN SCPAELPNIK REISETEAKA LLKERQKKDN
360 370 380 390 400
HNLIERRRRF NINDRIKELG TLIPKSSDPE MRWNKGTILK ASVDYIRKLQ
410 420 430 440 450
KEQQRSKDLE SRQRSLEQAN RSLQLRIQEL ELQAQIHGLP VPPTPGLLSL
460 470 480 490 500
ATTSASDSLK PEQLDIEEEG RPGAATFHVG GGPAQNAPHQ QPPAPPSDAL
510 520 530 540 550
LDLHFPSDHL GDLGDPFHLG LEDILMEEEE GVVGGLSGGA LSPLRAASDP
560 570
LLSSVSPAVS KASSRRSSFS MEEES
Length:575
Mass (Da):61,521
Last modified:November 13, 2007 - v4
Checksum:iEF1F11AB624C6BE1
GO
Isoform 2 (identifier: P19532-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-109: SLPISLQATPATPATLSASSSAGGSRTPAMSSS → RGLQDPCHVVIFFIEGLAAAAANAGPGAGAGEA
     110-575: Missing.

Note: No experimental confirmation available

Show »
Length:109
Mass (Da):11,363
Checksum:i619001F248C9F76E
GO

Sequence cautioni

The sequence CAA35714.1 differs from that shown. Reason: Frameshift at position 557. Curated
The sequence CAA65800.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1721V → M in CAA65800. (PubMed:8872474)Curated
Sequence conflicti219 – 2191P → S in CAA65800. (PubMed:8872474)Curated
Sequence conflicti222 – 2221P → K in CAA35714. (PubMed:2338243)Curated
Sequence conflicti229 – 2291P → L in CAA65800. (PubMed:8872474)Curated
Sequence conflicti443 – 4431P → G in CAA35714. (PubMed:2338243)Curated
Sequence conflicti455 – 4551A → T in CAA65800. (PubMed:8872474)Curated
Sequence conflicti455 – 4551A → T in CAA35714. (PubMed:2338243)Curated
Sequence conflicti475 – 4751A → R in CAA35714. (PubMed:2338243)Curated
Sequence conflicti575 – 5751S → M in CAA65800. (PubMed:8872474)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961S → C.
Corresponds to variant rs5953258 [ dbSNP | Ensembl ].
VAR_027501
Natural varianti313 – 3131T → A.
Corresponds to variant rs3027470 [ dbSNP | Ensembl ].
VAR_027502

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei77 – 10933SLPIS…AMSSS → RGLQDPCHVVIFFIEGLAAA AANAGPGAGAGEA in isoform 2. 1 PublicationVSP_056882Add
BLAST
Alternative sequencei110 – 575466Missing in isoform 2. 1 PublicationVSP_056883Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96717 mRNA. Translation: CAA65478.1.
AL161985 mRNA. Translation: CAI46207.1.
AC146820 Genomic DNA. No translation available.
AF196779 Genomic DNA. No translation available.
BX572102 Genomic DNA. No translation available.
X99721 Genomic DNA. Translation: CAA68061.1.
X97160, X97161, X97162 Genomic DNA. Translation: CAA65800.1. Sequence problems.
X51330 mRNA. Translation: CAA35714.1. Sequence problems.
CCDSiCCDS14315.3.
PIRiA34596.
RefSeqiNP_001269071.1. NM_001282142.1.
NP_006512.2. NM_006521.5.
UniGeneiHs.730740.

Genome annotation databases

EnsembliENST00000315869; ENSP00000314129; ENSG00000068323. [P19532-1]
ENST00000493583; ENSP00000476976; ENSG00000068323. [P19532-2]
GeneIDi7030.
KEGGihsa:7030.
UCSCiuc004dmb.3. human. [P19532-1]

Polymorphism databases

DMDMi160113240.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96717 mRNA. Translation: CAA65478.1 .
AL161985 mRNA. Translation: CAI46207.1 .
AC146820 Genomic DNA. No translation available.
AF196779 Genomic DNA. No translation available.
BX572102 Genomic DNA. No translation available.
X99721 Genomic DNA. Translation: CAA68061.1 .
X97160 , X97161 , X97162 Genomic DNA. Translation: CAA65800.1 . Sequence problems.
X51330 mRNA. Translation: CAA35714.1 . Sequence problems.
CCDSi CCDS14315.3.
PIRi A34596.
RefSeqi NP_001269071.1. NM_001282142.1.
NP_006512.2. NM_006521.5.
UniGenei Hs.730740.

3D structure databases

ProteinModelPortali P19532.
SMRi P19532. Positions 347-437.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112888. 22 interactions.
IntActi P19532. 1 interaction.
STRINGi 9606.ENSP00000314129.

PTM databases

PhosphoSitei P19532.

Polymorphism databases

DMDMi 160113240.

Proteomic databases

MaxQBi P19532.
PaxDbi P19532.
PRIDEi P19532.

Protocols and materials databases

DNASUi 7030.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315869 ; ENSP00000314129 ; ENSG00000068323 . [P19532-1 ]
ENST00000493583 ; ENSP00000476976 ; ENSG00000068323 . [P19532-2 ]
GeneIDi 7030.
KEGGi hsa:7030.
UCSCi uc004dmb.3. human. [P19532-1 ]

Organism-specific databases

CTDi 7030.
GeneCardsi GC0XM048886.
HGNCi HGNC:11752. TFE3.
HPAi HPA023881.
MIMi 314310. gene.
neXtProti NX_P19532.
Orphaneti 163699. Alveolar soft-tissue sarcoma.
319308. Translocation renal cell carcinoma.
PharmGKBi PA36467.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251286.
GeneTreei ENSGT00390000004402.
HOGENOMi HOG000231368.
HOVERGENi HBG006768.
InParanoidi P19532.
KOi K09105.
OMAi PGTATFH.
OrthoDBi EOG72G182.
PhylomeDBi P19532.
TreeFami TF317174.

Miscellaneous databases

ChiTaRSi TFE3. human.
GeneWikii TFE3.
GenomeRNAii 7030.
NextBioi 27465.
PROi P19532.
SOURCEi Search...

Gene expression databases

Bgeei P19532.
CleanExi HS_TFE3.
ExpressionAtlasi P19532. baseline and differential.
Genevestigatori P19532.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR021802. bHLH_ZIP_TF_MiT/TFE.
IPR024100. TFE3.
[Graphical view ]
PANTHERi PTHR10014:SF37. PTHR10014:SF37. 1 hit.
Pfami PF11851. DUF3371. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma."
    Clark J., Lu Y.-J., Sidhar S.K., Parker C., Gill S., Smedley D., Hamoudi R., Linehan W.M., Shipley J., Cooper C.S.
    Oncogene 15:2233-2239(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL TRANSLOCATION WITH PSF AND NONO.
  2. Clark J.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas."
    Weterman M.A.J., Wilbrink M., Geurts van Kessel A.
    Proc. Natl. Acad. Sci. U.S.A. 93:15294-15298(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-219, CHROMOSOMAL TRANSLOCATION WITH PRCC.
  6. "The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene."
    Sidhar S.K., Clark J., Gill S., Hamoudi R., Crew A.J., Gwilliam R., Ross M., Linehan W.M., Birdsall S., Shipley J., Cooper C.S.
    Hum. Mol. Genet. 5:1333-1338(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 149-575, CHROMOSOMAL TRANSLOCATION WITH PRCC.
    Tissue: Monocyte.
  7. "TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif."
    Beckmann H., Su L.-K., Kadesch T.
    Genes Dev. 4:167-179(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 212-575 (ISOFORM 1).
    Tissue: Leukemia.
  8. "Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17)(p11.2;q25.3)-bearing papillary renal cell carcinomas."
    Heimann P., El Housni H., Ogur G., Weterman M.A.J., Petty E.M., Vassart G.
    Cancer Res. 61:4130-4135(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH ASPSCR1.
  9. "The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25."
    Ladanyi M., Lui M.Y., Antonescu C.R., Krause-Boehm A., Meindl A., Argani P., Healey J.H., Ueda T., Yoshikawa H., Meloni-Ehrig A., Sorensen P.H.B., Mertens F., Mandahl N., van den Berghe H., Sciot R., Dal Cin P., Bridge J.
    Oncogene 20:48-57(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH ASPSCR1, INVOLVEMENT IN ASPS.
  10. "Sumoylation of MITF and its related family members TFE3 and TFEB."
    Miller A.J., Levy C., Davis I.J., Razin E., Fisher D.E.
    J. Biol. Chem. 280:146-155(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION, INTERACTION WITH MITF.
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548; SER-556 AND SER-560, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-556 AND SER-568, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTFE3_HUMAN
AccessioniPrimary (citable) accession number: P19532
Secondary accession number(s): A8MZL6
, Q5JU74, Q92757, Q92758, Q99964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 160 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

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    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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