Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Voltage-dependent calcium channel gamma-1 subunit

Gene

CACNG1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-1 subunit
Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Gene namesi
Name:CACNG1
Synonyms:CACNLG
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 2919HelicalSequence analysisAdd
BLAST
Transmembranei105 – 12925HelicalSequence analysisAdd
BLAST
Transmembranei140 – 15516HelicalSequence analysisAdd
BLAST
Transmembranei180 – 20425HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Voltage-dependent calcium channel gamma-1 subunitPRO_0000164671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Skeletal muscle.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Protein-protein interaction databases

IntActiP19518. 1 interaction.
STRINGi9986.ENSOCUP00000007638.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JBRelectron microscopy4.20E1-222[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH0I. Eukaryota.
ENOG4111J5G. LUCA.
GeneTreeiENSGT00390000007786.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiP19518.
KOiK04866.
OMAiLKPASMF.
OrthoDBiEOG7WQ7TF.
TreeFamiTF331651.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005421. VDCC_g1su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01601. VDCCGAMMA1.

Sequencei

Sequence statusi: Complete.

P19518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPTEAPKVR VTLFCILVGI VLAMTAVVSD HWAVLSPHME NHNTTCEAAH
60 70 80 90 100
FGLWRICTKR IALGEDRSCG PITLPGEKNC SYFRHFNPGE SSEIFEFTTQ
110 120 130 140 150
KEYSISAAAI SVFSLGFLIM GTICALMAFR KKRDYLLRPA SMFYVFAGLC
160 170 180 190 200
LFVSLEVMRQ SVKRMIDSED TVWIEYYYSW SFACACAAFV LLFLGGISLL
210 220
LFSLPRMPQN PWESCMDAEP EH
Length:222
Mass (Da):25,058
Last modified:February 1, 1991 - v1
Checksum:i903B6FD8DD78F698
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32231 mRNA. Translation: AAA31181.1.
X56031 mRNA. Translation: CAA39505.1.
PIRiS10728.
RefSeqiNP_001075862.1. NM_001082393.1.
XP_008269323.1. XM_008271101.1.
UniGeneiOcu.1834.

Genome annotation databases

EnsembliENSOCUT00000008846; ENSOCUP00000007638; ENSOCUG00000008850.
GeneIDi100009263.
KEGGiocu:100009263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32231 mRNA. Translation: AAA31181.1.
X56031 mRNA. Translation: CAA39505.1.
PIRiS10728.
RefSeqiNP_001075862.1. NM_001082393.1.
XP_008269323.1. XM_008271101.1.
UniGeneiOcu.1834.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JBRelectron microscopy4.20E1-222[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP19518. 1 interaction.
STRINGi9986.ENSOCUP00000007638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000008846; ENSOCUP00000007638; ENSOCUG00000008850.
GeneIDi100009263.
KEGGiocu:100009263.

Organism-specific databases

CTDi786.

Phylogenomic databases

eggNOGiENOG410IH0I. Eukaryota.
ENOG4111J5G. LUCA.
GeneTreeiENSGT00390000007786.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiP19518.
KOiK04866.
OMAiLKPASMF.
OrthoDBiEOG7WQ7TF.
TreeFamiTF331651.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005421. VDCC_g1su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01601. VDCCGAMMA1.
ProtoNetiSearch...

Publicationsi

  1. "Primary structure of the gamma subunit of the DHP-sensitive calcium channel from skeletal muscle."
    Jay S.D., Ellis S.B., McCue A.F., Williams M.E., Vedvick T.S., Harpold M.M., Campbell K.P.
    Science 248:490-492(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-9.
    Tissue: Skeletal muscle.
  2. "The cDNA and deduced amino acid sequence of the gamma subunit of the L-type calcium channel from rabbit skeletal muscle."
    Bosse E., Regulla S., Biel M., Ruth P., Meyer H.E., Flockerzi V., Hofmann F.
    FEBS Lett. 267:153-156(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiCCG1_RABIT
AccessioniPrimary (citable) accession number: P19518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 17, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.