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P19516

- COX11_YEAST

UniProt

P19516 - COX11_YEAST

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Protein

Cytochrome c oxidase assembly protein COX11, mitochondrial

Gene
COX11, YPL132W, LPI13W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I By similarity.UniRule annotation

GO - Molecular functioni

  1. copper ion binding Source: SGD

GO - Biological processi

  1. aerobic respiration Source: SGD
  2. protein complex assembly Source: SGD
Complete GO annotation...

Keywords - Ligandi

Copper

Enzyme and pathway databases

BioCyciYEAST:G3O-34031-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX11, mitochondrial
Gene namesi
Name:COX11
Ordered Locus Names:YPL132W
ORF Names:LPI13W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPL132w.
SGDiS000006053. COX11.

Subcellular locationi

Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side
Note: Intrinsic component of the inner-membrane.UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 84Mitochondrial matrix Reviewed prediction
Transmembranei85 – 10521Helical; Reviewed predictionAdd
BLAST
Topological domaini106 – 300195Mitochondrial intermembrane Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial envelope Source: SGD
  3. mitochondrial inner membrane Source: SGD
  4. mitochondrial intermembrane space Source: SGD
  5. mitochondrial ribosome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 300Cytochrome c oxidase assembly protein COX11, mitochondrialUniRule annotationPRO_0000006082
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

MaxQBiP19516.
PaxDbiP19516.

Expressioni

Gene expression databases

GenevestigatoriP19516.

Interactioni

Protein-protein interaction databases

BioGridi36049. 28 interactions.
DIPiDIP-7497N.
IntActiP19516. 2 interactions.
MINTiMINT-1354320.
STRINGi4932.YPL132W.

Structurei

3D structure databases

ProteinModelPortaliP19516.
SMRiP19516. Positions 138-253.

Family & Domainsi

Sequence similaritiesi

Belongs to the COX11/CtaG family.

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3175.
GeneTreeiENSGT00390000007512.
HOGENOMiHOG000264965.
KOiK02258.
OMAiICARTGF.
OrthoDBiEOG7MD51P.

Family and domain databases

Gene3Di2.60.370.10. 1 hit.
HAMAPiMF_00155. CtaG.
InterProiIPR023471. CtaG/Cox11_dom.
IPR007533. Cyt_c_oxidase_assmbl_CtaG.
[Graphical view]
PANTHERiPTHR21320. PTHR21320. 1 hit.
PfamiPF04442. CtaG_Cox11. 1 hit.
[Graphical view]
SUPFAMiSSF110111. SSF110111. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19516-1 [UniParc]FASTAAdd to Basket

« Hide

MIRICPIVRS KVPLLGTFLR SDSWLAPHAL ALRRAICKNV ALRSYSVNSE    50
QPKHTFDISK LTRNEIQQLR ELKRARERKF KDRTVAFYFS SVAVLFLGLA 100
YAAVPLYRAI CARTGFGGIP ITDRRKFTDD KLIPVDTEKR IRISFTSEVS 150
QILPWKFVPQ QREVYVLPGE TALAFYKAKN YSDKDIIGMA TYSIAPGEAA 200
QYFNKIQCFC FEEQKLAAGE EIDMPVFFFI DPDFASDPAM RNIDDIILHY 250
TFFRAHYGDG TAVSDSKKEP EMNADEKAAS LANAAILSPE VIDTRKDNSN 300
Length:300
Mass (Da):34,044
Last modified:October 1, 1996 - v2
Checksum:iA8EBE549C6ED5A23
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 318WLAPHALA → MVGTSCAS in CAA39263. 1 Publication
Sequence conflicti146 – 1461T → S in CAA39263. 1 Publication
Sequence conflicti146 – 1461T → S in AAA35235. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43703 Genomic DNA. Translation: AAB68227.1.
X55731 Genomic DNA. Translation: CAA39263.1.
M94864 Genomic DNA. Translation: AAA35235.1.
BK006949 Genomic DNA. Translation: DAA11301.1.
PIRiS69052.
RefSeqiNP_015193.1. NM_001183946.1.

Genome annotation databases

EnsemblFungiiYPL132W; YPL132W; YPL132W.
GeneIDi855971.
KEGGisce:YPL132W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43703 Genomic DNA. Translation: AAB68227.1 .
X55731 Genomic DNA. Translation: CAA39263.1 .
M94864 Genomic DNA. Translation: AAA35235.1 .
BK006949 Genomic DNA. Translation: DAA11301.1 .
PIRi S69052.
RefSeqi NP_015193.1. NM_001183946.1.

3D structure databases

ProteinModelPortali P19516.
SMRi P19516. Positions 138-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36049. 28 interactions.
DIPi DIP-7497N.
IntActi P19516. 2 interactions.
MINTi MINT-1354320.
STRINGi 4932.YPL132W.

Protein family/group databases

TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBi P19516.
PaxDbi P19516.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPL132W ; YPL132W ; YPL132W .
GeneIDi 855971.
KEGGi sce:YPL132W.

Organism-specific databases

CYGDi YPL132w.
SGDi S000006053. COX11.

Phylogenomic databases

eggNOGi COG3175.
GeneTreei ENSGT00390000007512.
HOGENOMi HOG000264965.
KOi K02258.
OMAi ICARTGF.
OrthoDBi EOG7MD51P.

Enzyme and pathway databases

BioCyci YEAST:G3O-34031-MONOMER.

Miscellaneous databases

NextBioi 980786.
PROi P19516.

Gene expression databases

Genevestigatori P19516.

Family and domain databases

Gene3Di 2.60.370.10. 1 hit.
HAMAPi MF_00155. CtaG.
InterProi IPR023471. CtaG/Cox11_dom.
IPR007533. Cyt_c_oxidase_assmbl_CtaG.
[Graphical view ]
PANTHERi PTHR21320. PTHR21320. 1 hit.
Pfami PF04442. CtaG_Cox11. 1 hit.
[Graphical view ]
SUPFAMi SSF110111. SSF110111. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Cytochrome oxidase assembly in yeast requires the product of COX11, a homolog of the P. denitrificans protein encoded by ORF3."
    Tzagoloff A., Capitanio N., Nobrega M.P., Gatti D.
    EMBO J. 9:2759-2764(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-300.
  4. "Unbalanced regulation of the ribosomal 5 S RNA-binding protein in Saccharomyces cerevisiae expressing mutant 5 S rRNAs."
    Tang B., Nazar R.N.
    J. Biol. Chem. 267:17738-17742(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 141-300.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiCOX11_YEAST
AccessioniPrimary (citable) accession number: P19516
Secondary accession number(s): D6W3N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

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