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Protein

Cytochrome c oxidase assembly protein COX11, mitochondrial

Gene

COX11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.By similarity

GO - Molecular functioni

  • copper ion binding Source: SGD
  • protein self-association Source: EnsemblPlants

GO - Biological processi

  • aerobic respiration Source: SGD
  • cellular protein-containing complex assembly Source: SGD
  • positive regulation of cytochrome-c oxidase activity Source: EnsemblPlants

Keywordsi

LigandCopper

Enzyme and pathway databases

BioCyciYEAST:G3O-34031-MONOMER

Protein family/group databases

TCDBi3.D.4.8.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX11, mitochondrial
Gene namesi
Name:COX11
Ordered Locus Names:YPL132W
ORF Names:LPI13W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL132W
SGDiS000006053 COX11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini? – 84Mitochondrial matrixSequence analysis
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 300Mitochondrial intermembraneSequence analysisAdd BLAST195

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000006082? – 300Cytochrome c oxidase assembly protein COX11, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP19516
PaxDbiP19516
PRIDEiP19516

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi36049, 50 interactors
DIPiDIP-7497N
IntActiP19516, 2 interactors
MINTiP19516
STRINGi4932.YPL132W

Structurei

3D structure databases

ProteinModelPortaliP19516
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX11/CtaG family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000007512
HOGENOMiHOG000264965
InParanoidiP19516
KOiK02258
OMAiFFRAHYG
OrthoDBiEOG092C1NEZ

Family and domain databases

Gene3Di2.60.370.10, 1 hit
HAMAPiMF_00155 CtaG, 1 hit
InterProiView protein in InterPro
IPR023471 CtaG/Cox11_dom_sf
IPR007533 Cyt_c_oxidase_assmbl_CtaG
PfamiView protein in Pfam
PF04442 CtaG_Cox11, 1 hit
SUPFAMiSSF110111 SSF110111, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19516-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRICPIVRS KVPLLGTFLR SDSWLAPHAL ALRRAICKNV ALRSYSVNSE
60 70 80 90 100
QPKHTFDISK LTRNEIQQLR ELKRARERKF KDRTVAFYFS SVAVLFLGLA
110 120 130 140 150
YAAVPLYRAI CARTGFGGIP ITDRRKFTDD KLIPVDTEKR IRISFTSEVS
160 170 180 190 200
QILPWKFVPQ QREVYVLPGE TALAFYKAKN YSDKDIIGMA TYSIAPGEAA
210 220 230 240 250
QYFNKIQCFC FEEQKLAAGE EIDMPVFFFI DPDFASDPAM RNIDDIILHY
260 270 280 290 300
TFFRAHYGDG TAVSDSKKEP EMNADEKAAS LANAAILSPE VIDTRKDNSN
Length:300
Mass (Da):34,044
Last modified:October 1, 1996 - v2
Checksum:iA8EBE549C6ED5A23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24 – 31WLAPHALA → MVGTSCAS in CAA39263 (PubMed:2167832).Curated8
Sequence conflicti146T → S in CAA39263 (PubMed:2167832).Curated1
Sequence conflicti146T → S in AAA35235 (PubMed:1325447).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA Translation: AAB68227.1
X55731 Genomic DNA Translation: CAA39263.1
M94864 Genomic DNA Translation: AAA35235.1
BK006949 Genomic DNA Translation: DAA11301.1
PIRiS69052
RefSeqiNP_015193.1, NM_001183946.1

Genome annotation databases

EnsemblFungiiYPL132W; YPL132W; YPL132W
GeneIDi855971
KEGGisce:YPL132W

Similar proteinsi

Entry informationi

Entry nameiCOX11_YEAST
AccessioniPrimary (citable) accession number: P19516
Secondary accession number(s): D6W3N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health