P19516 (COX11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase assembly protein COX11, mitochondrial

Gene names

Name:	COX11
Ordered Locus Names:	YPL132W
ORF Names:	LPI13W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I By similarity.
Subcellular location	Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side. Note: Intrinsic component of the inner-membrane.
Sequence similarities	Belongs to the COX11/CtaG family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Ligand	Copper
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from mutant phenotype PubMed 10617659. Source: SGD protein complex assembly Inferred from mutant phenotype Ref.3. Source: SGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from direct assay PubMed 10501934PubMed 15776235. Source: SGD mitochondrial intermembrane space Inferred from direct assay PubMed 22984289. Source: SGD mitochondrial ribosome Inferred from direct assay PubMed 15776235. Source: SGD
Molecular_function	copper ion binding Inferred from direct assay PubMed 12063264. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 300		Cytochrome c oxidase assembly protein COX11, mitochondrial		PRO_0000006082
Regions
	Topological domain	? – 84		Mitochondrial matrix Potential
	Transmembrane	85 – 105	21	Helical; Potential
	Topological domain	106 – 300	195	Mitochondrial intermembrane Potential
Experimental info
	Sequence conflict	24 – 31	8	WLAPHALA → MVGTSCAS in CAA39263. Ref.3
	Sequence conflict	146	1	T → S in CAA39263. Ref.3
	Sequence conflict	146	1	T → S in AAA35235. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P19516 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: A8EBE549C6ED5A23	FASTA	300	34,044
	10 20 30 40 50 60 MIRICPIVRS KVPLLGTFLR SDSWLAPHAL ALRRAICKNV ALRSYSVNSE QPKHTFDISK 70 80 90 100 110 120 LTRNEIQQLR ELKRARERKF KDRTVAFYFS SVAVLFLGLA YAAVPLYRAI CARTGFGGIP 130 140 150 160 170 180 ITDRRKFTDD KLIPVDTEKR IRISFTSEVS QILPWKFVPQ QREVYVLPGE TALAFYKAKN 190 200 210 220 230 240 YSDKDIIGMA TYSIAPGEAA QYFNKIQCFC FEEQKLAAGE EIDMPVFFFI DPDFASDPAM 250 260 270 280 290 300 RNIDDIILHY TFFRAHYGDG TAVSDSKKEP EMNADEKAAS LANAAILSPE VIDTRKDNSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J. Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Cytochrome oxidase assembly in yeast requires the product of COX11, a homolog of the P. denitrificans protein encoded by ORF3." Tzagoloff A., Capitanio N., Nobrega M.P., Gatti D. EMBO J. 9:2759-2764(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-300.
[4]	"Unbalanced regulation of the ribosomal 5 S RNA-binding protein in Saccharomyces cerevisiae expressing mutant 5 S rRNAs." Tang B., Nazar R.N. J. Biol. Chem. 267:17738-17742(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 141-300. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43703 Genomic DNA. Translation: AAB68227.1. X55731 Genomic DNA. Translation: CAA39263.1. M94864 Genomic DNA. Translation: AAA35235.1. BK006949 Genomic DNA. Translation: DAA11301.1.
PIR	S69052.
RefSeq	NP_015193.1. NM_001183946.1.
3D structure databases
ProteinModelPortal	P19516.
SMR	P19516. Positions 138-253.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-7497N.
IntAct	P19516. 1 interaction.
MINT	MINT-1354320.
STRING	4932.YPL132W.
Protein family/group databases
TCDB	3.D.4.8.1. proton-translocating cytochrome oxidase (COX) superfamily.
Proteomic databases
PaxDb	P19516.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YPL132W; YPL132W; YPL132W.
GeneID	855971.
KEGG	sce:YPL132W.
Organism-specific databases
CYGD	YPL132w.
SGD	S000006053. COX11.
Phylogenomic databases
eggNOG	COG3175.
GeneTree	ENSGT00390000007512.
HOGENOM	HOG000264965.
KO	K02258.
OMA	CARTGFG.
OrthoDB	EOG46QB30.
Gene expression databases
Genevestigator	P19516.
GermOnline	YPL132W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	2.60.370.10. 1 hit.
InterPro	IPR023471. CtaG/Cox11_dom. IPR007533. Cyt_c_oxidase_assmbl_CtaG. [Graphical view]
PANTHER	PTHR21320. PTHR21320. 1 hit.
Pfam	PF04442. CtaG_Cox11. 1 hit. [Graphical view]
SUPFAM	SSF110111. CtaG_Cox11. 1 hit.
ProtoNet	Search...
Other
NextBio	980786.

Entry information

Entry name

COX11_YEAST

Accession

Primary (citable) accession number: P19516
Secondary accession number(s): D6W3N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program