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Protein

Cytochrome c oxidase assembly protein COX11, mitochondrial

Gene

COX11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.By similarity

GO - Molecular functioni

  1. copper ion binding Source: SGD

GO - Biological processi

  1. aerobic respiration Source: SGD
  2. protein complex assembly Source: SGD
Complete GO annotation...

Keywords - Ligandi

Copper

Enzyme and pathway databases

BioCyciYEAST:G3O-34031-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX11, mitochondrial
Gene namesi
Name:COX11
Ordered Locus Names:YPL132W
ORF Names:LPI13W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XVI

Organism-specific databases

CYGDiYPL132w.
EuPathDBiFungiDB:YPL132W.
SGDiS000006053. COX11.

Subcellular locationi

  1. Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side

  2. Note: Intrinsic component of the inner-membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 84Mitochondrial matrixSequence Analysis
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Topological domaini106 – 300195Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial envelope Source: SGD
  3. mitochondrial inner membrane Source: SGD
  4. mitochondrial intermembrane space Source: SGD
  5. mitochondrial ribosome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 300Cytochrome c oxidase assembly protein COX11, mitochondrialPRO_0000006082
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiP19516.
PaxDbiP19516.

Expressioni

Gene expression databases

GenevestigatoriP19516.

Interactioni

Protein-protein interaction databases

BioGridi36049. 29 interactions.
DIPiDIP-7497N.
IntActiP19516. 2 interactions.
MINTiMINT-1354320.
STRINGi4932.YPL132W.

Structurei

3D structure databases

ProteinModelPortaliP19516.
SMRiP19516. Positions 138-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX11/CtaG family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3175.
GeneTreeiENSGT00390000007512.
HOGENOMiHOG000264965.
InParanoidiP19516.
KOiK02258.
OMAiCARTGFG.
OrthoDBiEOG7MD51P.

Family and domain databases

Gene3Di2.60.370.10. 1 hit.
HAMAPiMF_00155. CtaG.
InterProiIPR023471. CtaG/Cox11_dom.
IPR007533. Cyt_c_oxidase_assmbl_CtaG.
[Graphical view]
PANTHERiPTHR21320. PTHR21320. 1 hit.
PfamiPF04442. CtaG_Cox11. 1 hit.
[Graphical view]
SUPFAMiSSF110111. SSF110111. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19516-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRICPIVRS KVPLLGTFLR SDSWLAPHAL ALRRAICKNV ALRSYSVNSE
60 70 80 90 100
QPKHTFDISK LTRNEIQQLR ELKRARERKF KDRTVAFYFS SVAVLFLGLA
110 120 130 140 150
YAAVPLYRAI CARTGFGGIP ITDRRKFTDD KLIPVDTEKR IRISFTSEVS
160 170 180 190 200
QILPWKFVPQ QREVYVLPGE TALAFYKAKN YSDKDIIGMA TYSIAPGEAA
210 220 230 240 250
QYFNKIQCFC FEEQKLAAGE EIDMPVFFFI DPDFASDPAM RNIDDIILHY
260 270 280 290 300
TFFRAHYGDG TAVSDSKKEP EMNADEKAAS LANAAILSPE VIDTRKDNSN
Length:300
Mass (Da):34,044
Last modified:October 1, 1996 - v2
Checksum:iA8EBE549C6ED5A23
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 318WLAPHALA → MVGTSCAS in CAA39263 (PubMed:2167832).Curated
Sequence conflicti146 – 1461T → S in CAA39263 (PubMed:2167832).Curated
Sequence conflicti146 – 1461T → S in AAA35235 (PubMed:1325447).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA. Translation: AAB68227.1.
X55731 Genomic DNA. Translation: CAA39263.1.
M94864 Genomic DNA. Translation: AAA35235.1.
BK006949 Genomic DNA. Translation: DAA11301.1.
PIRiS69052.
RefSeqiNP_015193.1. NM_001183946.1.

Genome annotation databases

EnsemblFungiiYPL132W; YPL132W; YPL132W.
GeneIDi855971.
KEGGisce:YPL132W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA. Translation: AAB68227.1.
X55731 Genomic DNA. Translation: CAA39263.1.
M94864 Genomic DNA. Translation: AAA35235.1.
BK006949 Genomic DNA. Translation: DAA11301.1.
PIRiS69052.
RefSeqiNP_015193.1. NM_001183946.1.

3D structure databases

ProteinModelPortaliP19516.
SMRiP19516. Positions 138-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36049. 29 interactions.
DIPiDIP-7497N.
IntActiP19516. 2 interactions.
MINTiMINT-1354320.
STRINGi4932.YPL132W.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBiP19516.
PaxDbiP19516.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL132W; YPL132W; YPL132W.
GeneIDi855971.
KEGGisce:YPL132W.

Organism-specific databases

CYGDiYPL132w.
EuPathDBiFungiDB:YPL132W.
SGDiS000006053. COX11.

Phylogenomic databases

eggNOGiCOG3175.
GeneTreeiENSGT00390000007512.
HOGENOMiHOG000264965.
InParanoidiP19516.
KOiK02258.
OMAiCARTGFG.
OrthoDBiEOG7MD51P.

Enzyme and pathway databases

BioCyciYEAST:G3O-34031-MONOMER.

Miscellaneous databases

NextBioi980786.
PROiP19516.

Gene expression databases

GenevestigatoriP19516.

Family and domain databases

Gene3Di2.60.370.10. 1 hit.
HAMAPiMF_00155. CtaG.
InterProiIPR023471. CtaG/Cox11_dom.
IPR007533. Cyt_c_oxidase_assmbl_CtaG.
[Graphical view]
PANTHERiPTHR21320. PTHR21320. 1 hit.
PfamiPF04442. CtaG_Cox11. 1 hit.
[Graphical view]
SUPFAMiSSF110111. SSF110111. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Cytochrome oxidase assembly in yeast requires the product of COX11, a homolog of the P. denitrificans protein encoded by ORF3."
    Tzagoloff A., Capitanio N., Nobrega M.P., Gatti D.
    EMBO J. 9:2759-2764(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-300.
  4. "Unbalanced regulation of the ribosomal 5 S RNA-binding protein in Saccharomyces cerevisiae expressing mutant 5 S rRNAs."
    Tang B., Nazar R.N.
    J. Biol. Chem. 267:17738-17742(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 141-300.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiCOX11_YEAST
AccessioniPrimary (citable) accession number: P19516
Secondary accession number(s): D6W3N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1996
Last modified: April 29, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.