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P19516 (COX11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase assembly protein COX11, mitochondrial
Gene names
Name:COX11
Ordered Locus Names:YPL132W
ORF Names:LPI13W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I By similarity. HAMAP-Rule MF_00155

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side. Note: Intrinsic component of the inner-membrane. HAMAP-Rule MF_00155

Sequence similarities

Belongs to the COX11/CtaG family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 300Cytochrome c oxidase assembly protein COX11, mitochondrial HAMAP-Rule MF_00155PRO_0000006082

Regions

Topological domain? – 84Mitochondrial matrix Potential
Transmembrane85 – 10521Helical; Potential
Topological domain106 – 300195Mitochondrial intermembrane Potential

Experimental info

Sequence conflict24 – 318WLAPHALA → MVGTSCAS in CAA39263. Ref.3
Sequence conflict1461T → S in CAA39263. Ref.3
Sequence conflict1461T → S in AAA35235. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P19516 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: A8EBE549C6ED5A23

FASTA30034,044
        10         20         30         40         50         60 
MIRICPIVRS KVPLLGTFLR SDSWLAPHAL ALRRAICKNV ALRSYSVNSE QPKHTFDISK 

        70         80         90        100        110        120 
LTRNEIQQLR ELKRARERKF KDRTVAFYFS SVAVLFLGLA YAAVPLYRAI CARTGFGGIP 

       130        140        150        160        170        180 
ITDRRKFTDD KLIPVDTEKR IRISFTSEVS QILPWKFVPQ QREVYVLPGE TALAFYKAKN 

       190        200        210        220        230        240 
YSDKDIIGMA TYSIAPGEAA QYFNKIQCFC FEEQKLAAGE EIDMPVFFFI DPDFASDPAM 

       250        260        270        280        290        300 
RNIDDIILHY TFFRAHYGDG TAVSDSKKEP EMNADEKAAS LANAAILSPE VIDTRKDNSN 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Cytochrome oxidase assembly in yeast requires the product of COX11, a homolog of the P. denitrificans protein encoded by ORF3."
Tzagoloff A., Capitanio N., Nobrega M.P., Gatti D.
EMBO J. 9:2759-2764(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-300.
[4]"Unbalanced regulation of the ribosomal 5 S RNA-binding protein in Saccharomyces cerevisiae expressing mutant 5 S rRNAs."
Tang B., Nazar R.N.
J. Biol. Chem. 267:17738-17742(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 141-300.
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U43703 Genomic DNA. Translation: AAB68227.1.
X55731 Genomic DNA. Translation: CAA39263.1.
M94864 Genomic DNA. Translation: AAA35235.1.
BK006949 Genomic DNA. Translation: DAA11301.1.
PIRS69052.
RefSeqNP_015193.1. NM_001183946.1.

3D structure databases

ProteinModelPortalP19516.
SMRP19516. Positions 138-253.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36049. 28 interactions.
DIPDIP-7497N.
IntActP19516. 2 interactions.
MINTMINT-1354320.
STRING4932.YPL132W.

Protein family/group databases

TCDB3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBP19516.
PaxDbP19516.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPL132W; YPL132W; YPL132W.
GeneID855971.
KEGGsce:YPL132W.

Organism-specific databases

CYGDYPL132w.
SGDS000006053. COX11.

Phylogenomic databases

eggNOGCOG3175.
GeneTreeENSGT00390000007512.
HOGENOMHOG000264965.
KOK02258.
OMAICARTGF.
OrthoDBEOG7MD51P.

Enzyme and pathway databases

BioCycYEAST:G3O-34031-MONOMER.

Gene expression databases

GenevestigatorP19516.

Family and domain databases

Gene3D2.60.370.10. 1 hit.
HAMAPMF_00155. CtaG.
InterProIPR023471. CtaG/Cox11_dom.
IPR007533. Cyt_c_oxidase_assmbl_CtaG.
[Graphical view]
PANTHERPTHR21320. PTHR21320. 1 hit.
PfamPF04442. CtaG_Cox11. 1 hit.
[Graphical view]
SUPFAMSSF110111. SSF110111. 1 hit.
ProtoNetSearch...

Other

NextBio980786.
PROP19516.

Entry information

Entry nameCOX11_YEAST
AccessionPrimary (citable) accession number: P19516
Secondary accession number(s): D6W3N5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families