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P19516

- COX11_YEAST

UniProt

P19516 - COX11_YEAST

Protein

Cytochrome c oxidase assembly protein COX11, mitochondrial

Gene

COX11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.By similarity

    GO - Molecular functioni

    1. copper ion binding Source: SGD

    GO - Biological processi

    1. aerobic respiration Source: SGD
    2. protein complex assembly Source: SGD

    Keywords - Ligandi

    Copper

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34031-MONOMER.

    Protein family/group databases

    TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase assembly protein COX11, mitochondrial
    Gene namesi
    Name:COX11
    Ordered Locus Names:YPL132W
    ORF Names:LPI13W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPL132w.
    SGDiS000006053. COX11.

    Subcellular locationi

    Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side
    Note: Intrinsic component of the inner-membrane.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial envelope Source: SGD
    3. mitochondrial inner membrane Source: SGD
    4. mitochondrial intermembrane space Source: SGD
    5. mitochondrial ribosome Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 300Cytochrome c oxidase assembly protein COX11, mitochondrialPRO_0000006082
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiP19516.
    PaxDbiP19516.

    Expressioni

    Gene expression databases

    GenevestigatoriP19516.

    Interactioni

    Protein-protein interaction databases

    BioGridi36049. 28 interactions.
    DIPiDIP-7497N.
    IntActiP19516. 2 interactions.
    MINTiMINT-1354320.
    STRINGi4932.YPL132W.

    Structurei

    3D structure databases

    ProteinModelPortaliP19516.
    SMRiP19516. Positions 138-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini? – 84Mitochondrial matrixSequence Analysis
    Topological domaini106 – 300195Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COX11/CtaG family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3175.
    GeneTreeiENSGT00390000007512.
    HOGENOMiHOG000264965.
    KOiK02258.
    OMAiICARTGF.
    OrthoDBiEOG7MD51P.

    Family and domain databases

    Gene3Di2.60.370.10. 1 hit.
    HAMAPiMF_00155. CtaG.
    InterProiIPR023471. CtaG/Cox11_dom.
    IPR007533. Cyt_c_oxidase_assmbl_CtaG.
    [Graphical view]
    PANTHERiPTHR21320. PTHR21320. 1 hit.
    PfamiPF04442. CtaG_Cox11. 1 hit.
    [Graphical view]
    SUPFAMiSSF110111. SSF110111. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19516-1 [UniParc]FASTAAdd to Basket

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    MIRICPIVRS KVPLLGTFLR SDSWLAPHAL ALRRAICKNV ALRSYSVNSE    50
    QPKHTFDISK LTRNEIQQLR ELKRARERKF KDRTVAFYFS SVAVLFLGLA 100
    YAAVPLYRAI CARTGFGGIP ITDRRKFTDD KLIPVDTEKR IRISFTSEVS 150
    QILPWKFVPQ QREVYVLPGE TALAFYKAKN YSDKDIIGMA TYSIAPGEAA 200
    QYFNKIQCFC FEEQKLAAGE EIDMPVFFFI DPDFASDPAM RNIDDIILHY 250
    TFFRAHYGDG TAVSDSKKEP EMNADEKAAS LANAAILSPE VIDTRKDNSN 300
    Length:300
    Mass (Da):34,044
    Last modified:October 1, 1996 - v2
    Checksum:iA8EBE549C6ED5A23
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 318WLAPHALA → MVGTSCAS in CAA39263. (PubMed:2167832)Curated
    Sequence conflicti146 – 1461T → S in CAA39263. (PubMed:2167832)Curated
    Sequence conflicti146 – 1461T → S in AAA35235. (PubMed:1325447)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43703 Genomic DNA. Translation: AAB68227.1.
    X55731 Genomic DNA. Translation: CAA39263.1.
    M94864 Genomic DNA. Translation: AAA35235.1.
    BK006949 Genomic DNA. Translation: DAA11301.1.
    PIRiS69052.
    RefSeqiNP_015193.1. NM_001183946.1.

    Genome annotation databases

    EnsemblFungiiYPL132W; YPL132W; YPL132W.
    GeneIDi855971.
    KEGGisce:YPL132W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43703 Genomic DNA. Translation: AAB68227.1 .
    X55731 Genomic DNA. Translation: CAA39263.1 .
    M94864 Genomic DNA. Translation: AAA35235.1 .
    BK006949 Genomic DNA. Translation: DAA11301.1 .
    PIRi S69052.
    RefSeqi NP_015193.1. NM_001183946.1.

    3D structure databases

    ProteinModelPortali P19516.
    SMRi P19516. Positions 138-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36049. 28 interactions.
    DIPi DIP-7497N.
    IntActi P19516. 2 interactions.
    MINTi MINT-1354320.
    STRINGi 4932.YPL132W.

    Protein family/group databases

    TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Proteomic databases

    MaxQBi P19516.
    PaxDbi P19516.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPL132W ; YPL132W ; YPL132W .
    GeneIDi 855971.
    KEGGi sce:YPL132W.

    Organism-specific databases

    CYGDi YPL132w.
    SGDi S000006053. COX11.

    Phylogenomic databases

    eggNOGi COG3175.
    GeneTreei ENSGT00390000007512.
    HOGENOMi HOG000264965.
    KOi K02258.
    OMAi ICARTGF.
    OrthoDBi EOG7MD51P.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34031-MONOMER.

    Miscellaneous databases

    NextBioi 980786.
    PROi P19516.

    Gene expression databases

    Genevestigatori P19516.

    Family and domain databases

    Gene3Di 2.60.370.10. 1 hit.
    HAMAPi MF_00155. CtaG.
    InterProi IPR023471. CtaG/Cox11_dom.
    IPR007533. Cyt_c_oxidase_assmbl_CtaG.
    [Graphical view ]
    PANTHERi PTHR21320. PTHR21320. 1 hit.
    Pfami PF04442. CtaG_Cox11. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110111. SSF110111. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Cytochrome oxidase assembly in yeast requires the product of COX11, a homolog of the P. denitrificans protein encoded by ORF3."
      Tzagoloff A., Capitanio N., Nobrega M.P., Gatti D.
      EMBO J. 9:2759-2764(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-300.
    4. "Unbalanced regulation of the ribosomal 5 S RNA-binding protein in Saccharomyces cerevisiae expressing mutant 5 S rRNAs."
      Tang B., Nazar R.N.
      J. Biol. Chem. 267:17738-17742(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 141-300.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiCOX11_YEAST
    AccessioniPrimary (citable) accession number: P19516
    Secondary accession number(s): D6W3N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3