Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP synthase F(0) complex subunit B1, mitochondrial

Gene

Atp5f1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

GO - Biological processi

  • ATP metabolic process Source: RGD
  • ATP synthesis coupled proton transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit B1, mitochondrial
Alternative name(s):
ATP synthase subunit b
Short name:
ATPase subunit b
Gene namesi
Name:Atp5f1
Synonyms:Atp5f
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620041. Atp5f1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242MitochondrionAdd
BLAST
Chaini43 – 256214ATP synthase F(0) complex subunit B1, mitochondrialPRO_0000002516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei131 – 1311N6-succinyllysineBy similarity
Modified residuei139 – 1391N6-acetyllysineBy similarity
Modified residuei154 – 1541N6-acetyllysineBy similarity
Modified residuei162 – 1621N6-acetyllysineBy similarity
Modified residuei221 – 2211N6-acetyllysineBy similarity
Modified residuei233 – 2331N6-acetyllysineBy similarity
Modified residuei244 – 2441N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP19511.
PRIDEiP19511.

PTM databases

iPTMnetiP19511.
PhosphoSiteiP19511.
SwissPalmiP19511.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016000.
GenevisibleiP19511. RN.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.1 Publication

Protein-protein interaction databases

IntActiP19511. 3 interactions.
MINTiMINT-4648340.
STRINGi10116.ENSRNOP00000065147.

Structurei

3D structure databases

ProteinModelPortaliP19511.
SMRiP19511. Positions 121-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ATPase B chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410INNH. Eukaryota.
ENOG4111WYE. LUCA.
GeneTreeiENSGT00390000001958.
HOGENOMiHOG000007163.
HOVERGENiHBG050604.
InParanoidiP19511.
KOiK02127.
OMAiVINHETF.
OrthoDBiEOG091G0DPN.
PhylomeDBiP19511.
TreeFamiTF313250.

Family and domain databases

InterProiIPR008688. ATPase_B_chain/sub_B/MI25.
IPR013837. ATPase_F0_sub_B/B_chain.
[Graphical view]
PANTHERiPTHR12733. PTHR12733. 1 hit.
PfamiPF05405. Mt_ATP-synt_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRVVLSAA ATAAPCLKNA AVLGPGVLQA TRVFHTGQPR LAPLPPLPEY
60 70 80 90 100
GGKVRLGLIP EEFFQFLYPK TGVTGPYVLG TGLSLYFLSK EIYVITPETF
110 120 130 140 150
STISVVGLIV YVIKKYGASI GEFIDKLNEE KIAQLEEIKQ SSMKQIQDAI
160 170 180 190 200
NREKAQQALV QKRHYLFDVQ RNNIALALEV TYRERLHKAY KEVKNRLDYH
210 220 230 240 250
ISVQDMMRRK EGEHMINWVE KHVIQSISAQ QEKETIAKCI GDLKMLAKKA

QAQPIM
Length:256
Mass (Da):28,869
Last modified:February 1, 1991 - v1
Checksum:i8E27538E6DF682BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35052 mRNA. Translation: AAA42187.1.
BC063808 mRNA. Translation: AAH63808.1.
PIRiA35340.
RefSeqiNP_599192.1. NM_134365.2.
XP_003749420.1. XM_003749372.2.
UniGeneiRn.3689.

Genome annotation databases

EnsembliENSRNOT00000021920; ENSRNOP00000021920; ENSRNOG00000016000.
ENSRNOT00000075083; ENSRNOP00000065147; ENSRNOG00000046299.
GeneIDi100911417.
171375.
KEGGirno:100911417.
rno:171375.
UCSCiRGD:620041. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35052 mRNA. Translation: AAA42187.1.
BC063808 mRNA. Translation: AAH63808.1.
PIRiA35340.
RefSeqiNP_599192.1. NM_134365.2.
XP_003749420.1. XM_003749372.2.
UniGeneiRn.3689.

3D structure databases

ProteinModelPortaliP19511.
SMRiP19511. Positions 121-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP19511. 3 interactions.
MINTiMINT-4648340.
STRINGi10116.ENSRNOP00000065147.

PTM databases

iPTMnetiP19511.
PhosphoSiteiP19511.
SwissPalmiP19511.

Proteomic databases

PaxDbiP19511.
PRIDEiP19511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021920; ENSRNOP00000021920; ENSRNOG00000016000.
ENSRNOT00000075083; ENSRNOP00000065147; ENSRNOG00000046299.
GeneIDi100911417.
171375.
KEGGirno:100911417.
rno:171375.
UCSCiRGD:620041. rat.

Organism-specific databases

CTDi515.
RGDi620041. Atp5f1.

Phylogenomic databases

eggNOGiENOG410INNH. Eukaryota.
ENOG4111WYE. LUCA.
GeneTreeiENSGT00390000001958.
HOGENOMiHOG000007163.
HOVERGENiHBG050604.
InParanoidiP19511.
KOiK02127.
OMAiVINHETF.
OrthoDBiEOG091G0DPN.
PhylomeDBiP19511.
TreeFamiTF313250.

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

PROiP19511.

Gene expression databases

BgeeiENSRNOG00000016000.
GenevisibleiP19511. RN.

Family and domain databases

InterProiIPR008688. ATPase_B_chain/sub_B/MI25.
IPR013837. ATPase_F0_sub_B/B_chain.
[Graphical view]
PANTHERiPTHR12733. PTHR12733. 1 hit.
PfamiPF05405. Mt_ATP-synt_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT5F1_RAT
AccessioniPrimary (citable) accession number: P19511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.