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Protein

ATP synthase F(0) complex subunit B1, mitochondrial

Gene

Atp5f1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-163210 Formation of ATP by chemiosmotic coupling
R-RNO-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit B1, mitochondrial
Alternative name(s):
ATP synthase subunit b
Short name:
ATPase subunit b
Gene namesi
Name:Atp5f1
Synonyms:Atp5f
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620041 Atp5f1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionAdd BLAST42
ChainiPRO_000000251643 – 256ATP synthase F(0) complex subunit B1, mitochondrialAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131N6-succinyllysineBy similarity1
Modified residuei139N6-acetyllysineBy similarity1
Modified residuei154N6-acetyllysineBy similarity1
Modified residuei162N6-acetyllysineBy similarity1
Modified residuei221N6-acetyllysineBy similarity1
Modified residuei233N6-acetyllysineBy similarity1
Modified residuei244N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP19511
PRIDEiP19511

PTM databases

CarbonylDBiP19511
iPTMnetiP19511
PhosphoSitePlusiP19511
SwissPalmiP19511

Expressioni

Gene expression databases

BgeeiENSRNOG00000016000
GenevisibleiP19511 RN

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68.1 Publication

Protein-protein interaction databases

CORUMiP19511
IntActiP19511, 4 interactors
MINTiP19511
STRINGi10116.ENSRNOP00000065147

Structurei

3D structure databases

ProteinModelPortaliP19511
SMRiP19511
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ATPase B chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410INNH Eukaryota
ENOG4111WYE LUCA
GeneTreeiENSGT00390000001958
HOGENOMiHOG000007163
HOVERGENiHBG050604
InParanoidiP19511
KOiK02127
OMAiIYVINHE
OrthoDBiEOG091G0DPN
PhylomeDBiP19511
TreeFamiTF313250

Family and domain databases

InterProiView protein in InterPro
IPR008688 ATP_synth_Bsub_B/MI25
IPR013837 ATP_synth_F0_suB
PANTHERiPTHR12733 PTHR12733, 1 hit
PfamiView protein in Pfam
PF05405 Mt_ATP-synt_B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRVVLSAA ATAAPCLKNA AVLGPGVLQA TRVFHTGQPR LAPLPPLPEY
60 70 80 90 100
GGKVRLGLIP EEFFQFLYPK TGVTGPYVLG TGLSLYFLSK EIYVITPETF
110 120 130 140 150
STISVVGLIV YVIKKYGASI GEFIDKLNEE KIAQLEEIKQ SSMKQIQDAI
160 170 180 190 200
NREKAQQALV QKRHYLFDVQ RNNIALALEV TYRERLHKAY KEVKNRLDYH
210 220 230 240 250
ISVQDMMRRK EGEHMINWVE KHVIQSISAQ QEKETIAKCI GDLKMLAKKA

QAQPIM
Length:256
Mass (Da):28,869
Last modified:February 1, 1991 - v1
Checksum:i8E27538E6DF682BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35052 mRNA Translation: AAA42187.1
BC063808 mRNA Translation: AAH63808.1
PIRiA35340
RefSeqiNP_599192.1, NM_134365.2
XP_003749420.1, XM_003749372.2
UniGeneiRn.3689

Genome annotation databases

EnsembliENSRNOT00000021920; ENSRNOP00000021920; ENSRNOG00000016000
ENSRNOT00000075083; ENSRNOP00000065147; ENSRNOG00000046299
GeneIDi100911417
171375
KEGGirno:100911417
rno:171375
UCSCiRGD:620041 rat

Similar proteinsi

Entry informationi

Entry nameiAT5F1_RAT
AccessioniPrimary (citable) accession number: P19511
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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