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Protein

UDP-glucuronosyltransferase 2B37

Gene

Ugt2b37

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B37 is about 30-fold less active than 2B5 toward testosterone and dihydrotestosterone.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B37 (EC:2.4.1.17)
Short name:
UDPGT 2B37
Alternative name(s):
17-beta-hydroxysteroid-specific UDPGT
UDP-glucuronosyltransferase R-21
Short name:
UDPGTr-21
UDPGTr-5
Gene namesi
Name:Ugt2b37
Synonyms:Ugt2b5, Ugt2b6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3937 Ugt2b37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei494 – 510HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003603024 – 530UDP-glucuronosyltransferase 2B37Add BLAST507

Proteomic databases

PaxDbiP19488
PRIDEiP19488

PTM databases

iPTMnetiP19488
PhosphoSitePlusiP19488

Expressioni

Inductioni

Constitutively expressed.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045002

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HNJmodel-@1-530[»]
2HYCmodel-@1-530[»]
ProteinModelPortaliP19488
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
HOVERGENiHBG004033
InParanoidiP19488
PhylomeDBiP19488

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGKWIFALL LLQISFCLRS AKCGKVLVWP MEFSHWMNIK TILDELVQRG
60 70 80 90 100
HEVTVLKPSA YYVLDPKKSP DLKFETFPTS VSKDELEKYF IKLADAWTYE
110 120 130 140 150
LQRDTCLSFS PLLQNMMDEF SDYYLSVCKD AVSNKQLMAK LQESKFDVLL
160 170 180 190 200
SDPVAACGEL IAEVLHIPFL YSLRASPGHK IEKSSGRFIL PPSYVPVILS
210 220 230 240 250
GLGGQMTFID RVKNMICMLY FDFWFHMFNA KNWDPFYTEI LGRPTTLAET
260 270 280 290 300
MGKAEMWLIR SYWDLEFPHP TLPNVDYIGG LQCKPAKPLP KDIEDFVQSS
310 320 330 340 350
GEHGVVVFSL GSMVSSMTEE KANAIAWALA QIPQKVLWKF DGKIPATLGP
360 370 380 390 400
NTRVYKWLPQ NDLLGHPKTK AFVTHGGANG VYEAIYHGIP MIGIPMFGEQ
410 420 430 440 450
HDNIAHMVAK GAAVTLNIRT MSKSDLFNAL KEVINNPFYK KNAMWLSTIH
460 470 480 490 500
HDQPMKPLDK AIFWIEYVMR HKRAKHLRPL GHNLPWYQYH SLDVIGFLLA
510 520 530
CLAVIAALAV KCFLFIYRFF AKKQKKMKNE
Length:530
Mass (Da):60,593
Last modified:February 1, 1991 - v1
Checksum:iF6B23E436B9BDAEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti397F → L in AAA03218 (PubMed:1692835).Curated1
Sequence conflicti397F → L in AAA03219 (PubMed:1692835).Curated1
Sequence conflicti444M → T in AAA03218 (PubMed:1692835).Curated1
Sequence conflicti444M → T in AAA03219 (PubMed:1692835).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33746 mRNA Translation: AAA03216.1
M33746 mRNA Translation: AAA03217.1
M33747 mRNA Translation: AAA03218.1
M33747 mRNA Translation: AAA03219.1
PIRiA36276
UniGeneiRn.230458
Rn.24945

Genome annotation databases

UCSCiRGD:3937 rat

Similar proteinsi

Entry informationi

Entry nameiUDB37_RAT
AccessioniPrimary (citable) accession number: P19488
Secondary accession number(s): P19489
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome