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P19488

- UDB37_RAT

UniProt

P19488 - UDB37_RAT

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Protein

UDP-glucuronosyltransferase 2B37

Gene

Ugt2b37

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B37 is about 30-fold less active than 2B5 toward testosterone and dihydrotestosterone.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B37 (EC:2.4.1.17)
Short name:
UDPGT 2B37
Alternative name(s):
17-beta-hydroxysteroid-specific UDPGT
UDP-glucuronosyltransferase R-21
Short name:
UDPGTr-21
UDPGTr-5
Gene namesi
Name:Ugt2b37
Synonyms:Ugt2b5, Ugt2b6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3937. Ugt2b37.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei494 – 51017HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 530507UDP-glucuronosyltransferase 2B37PRO_0000036030Add
BLAST

Proteomic databases

PRIDEiP19488.

Expressioni

Inductioni

Constitutively expressed.

Gene expression databases

GenevestigatoriP19488.

Interactioni

Protein-protein interaction databases

MINTiMINT-4577277.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HNJmodel-@1-530[»]
2HYCmodel-@1-530[»]
ProteinModelPortaliP19488.
SMRiP19488. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.
InParanoidiP19488.
PhylomeDBiP19488.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19488-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGKWIFALL LLQISFCLRS AKCGKVLVWP MEFSHWMNIK TILDELVQRG
60 70 80 90 100
HEVTVLKPSA YYVLDPKKSP DLKFETFPTS VSKDELEKYF IKLADAWTYE
110 120 130 140 150
LQRDTCLSFS PLLQNMMDEF SDYYLSVCKD AVSNKQLMAK LQESKFDVLL
160 170 180 190 200
SDPVAACGEL IAEVLHIPFL YSLRASPGHK IEKSSGRFIL PPSYVPVILS
210 220 230 240 250
GLGGQMTFID RVKNMICMLY FDFWFHMFNA KNWDPFYTEI LGRPTTLAET
260 270 280 290 300
MGKAEMWLIR SYWDLEFPHP TLPNVDYIGG LQCKPAKPLP KDIEDFVQSS
310 320 330 340 350
GEHGVVVFSL GSMVSSMTEE KANAIAWALA QIPQKVLWKF DGKIPATLGP
360 370 380 390 400
NTRVYKWLPQ NDLLGHPKTK AFVTHGGANG VYEAIYHGIP MIGIPMFGEQ
410 420 430 440 450
HDNIAHMVAK GAAVTLNIRT MSKSDLFNAL KEVINNPFYK KNAMWLSTIH
460 470 480 490 500
HDQPMKPLDK AIFWIEYVMR HKRAKHLRPL GHNLPWYQYH SLDVIGFLLA
510 520 530
CLAVIAALAV KCFLFIYRFF AKKQKKMKNE
Length:530
Mass (Da):60,593
Last modified:February 1, 1991 - v1
Checksum:iF6B23E436B9BDAEA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti397 – 3971F → L in AAA03218. (PubMed:1692835)Curated
Sequence conflicti397 – 3971F → L in AAA03219. (PubMed:1692835)Curated
Sequence conflicti444 – 4441M → T in AAA03218. (PubMed:1692835)Curated
Sequence conflicti444 – 4441M → T in AAA03219. (PubMed:1692835)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33746 mRNA. Translation: AAA03216.1.
M33746 mRNA. Translation: AAA03217.1.
M33747 mRNA. Translation: AAA03218.1.
M33747 mRNA. Translation: AAA03219.1.
PIRiA36276.
UniGeneiRn.230458.
Rn.24945.

Genome annotation databases

UCSCiRGD:3937. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33746 mRNA. Translation: AAA03216.1 .
M33746 mRNA. Translation: AAA03217.1 .
M33747 mRNA. Translation: AAA03218.1 .
M33747 mRNA. Translation: AAA03219.1 .
PIRi A36276.
UniGenei Rn.230458.
Rn.24945.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HNJ model - @ 1-530 [» ]
2HYC model - @ 1-530 [» ]
ProteinModelPortali P19488.
SMRi P19488. Positions 286-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4577277.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEi P19488.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3937. rat.

Organism-specific databases

RGDi 3937. Ugt2b37.

Phylogenomic databases

HOVERGENi HBG004033.
InParanoidi P19488.
PhylomeDBi P19488.

Miscellaneous databases

NextBioi 13949083.

Gene expression databases

Genevestigatori P19488.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cDNA sequence and expression of a variant 17 beta-hydroxysteroid UDP-glucuronosyltransferase."
    McKenzie P.I.
    J. Biol. Chem. 265:8699-8703(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiUDB37_RAT
AccessioniPrimary (citable) accession number: P19488
Secondary accession number(s): P19489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3