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P19488

- UDB37_RAT

UniProt

P19488 - UDB37_RAT

Protein

UDP-glucuronosyltransferase 2B37

Gene

Ugt2b37

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B37 is about 30-fold less active than 2B5 toward testosterone and dihydrotestosterone.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: RGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B37 (EC:2.4.1.17)
    Short name:
    UDPGT 2B37
    Alternative name(s):
    17-beta-hydroxysteroid-specific UDPGT
    UDP-glucuronosyltransferase R-21
    Short name:
    UDPGTr-21
    UDPGTr-5
    Gene namesi
    Name:Ugt2b37
    Synonyms:Ugt2b5, Ugt2b6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3937. Ugt2b37.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 530507UDP-glucuronosyltransferase 2B37PRO_0000036030Add
    BLAST

    Proteomic databases

    PRIDEiP19488.

    Expressioni

    Inductioni

    Constitutively expressed.

    Gene expression databases

    GenevestigatoriP19488.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4577277.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HNJmodel-@1-530[»]
    2HYCmodel-@1-530[»]
    ProteinModelPortaliP19488.
    SMRiP19488. Positions 286-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004033.
    PhylomeDBiP19488.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19488-1 [UniParc]FASTAAdd to Basket

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    MPGKWIFALL LLQISFCLRS AKCGKVLVWP MEFSHWMNIK TILDELVQRG    50
    HEVTVLKPSA YYVLDPKKSP DLKFETFPTS VSKDELEKYF IKLADAWTYE 100
    LQRDTCLSFS PLLQNMMDEF SDYYLSVCKD AVSNKQLMAK LQESKFDVLL 150
    SDPVAACGEL IAEVLHIPFL YSLRASPGHK IEKSSGRFIL PPSYVPVILS 200
    GLGGQMTFID RVKNMICMLY FDFWFHMFNA KNWDPFYTEI LGRPTTLAET 250
    MGKAEMWLIR SYWDLEFPHP TLPNVDYIGG LQCKPAKPLP KDIEDFVQSS 300
    GEHGVVVFSL GSMVSSMTEE KANAIAWALA QIPQKVLWKF DGKIPATLGP 350
    NTRVYKWLPQ NDLLGHPKTK AFVTHGGANG VYEAIYHGIP MIGIPMFGEQ 400
    HDNIAHMVAK GAAVTLNIRT MSKSDLFNAL KEVINNPFYK KNAMWLSTIH 450
    HDQPMKPLDK AIFWIEYVMR HKRAKHLRPL GHNLPWYQYH SLDVIGFLLA 500
    CLAVIAALAV KCFLFIYRFF AKKQKKMKNE 530
    Length:530
    Mass (Da):60,593
    Last modified:February 1, 1991 - v1
    Checksum:iF6B23E436B9BDAEA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti397 – 3971F → L in AAA03218. (PubMed:1692835)Curated
    Sequence conflicti397 – 3971F → L in AAA03219. (PubMed:1692835)Curated
    Sequence conflicti444 – 4441M → T in AAA03218. (PubMed:1692835)Curated
    Sequence conflicti444 – 4441M → T in AAA03219. (PubMed:1692835)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33746 mRNA. Translation: AAA03216.1.
    M33746 mRNA. Translation: AAA03217.1.
    M33747 mRNA. Translation: AAA03218.1.
    M33747 mRNA. Translation: AAA03219.1.
    PIRiA36276.
    UniGeneiRn.230458.
    Rn.24945.

    Genome annotation databases

    UCSCiRGD:3937. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33746 mRNA. Translation: AAA03216.1 .
    M33746 mRNA. Translation: AAA03217.1 .
    M33747 mRNA. Translation: AAA03218.1 .
    M33747 mRNA. Translation: AAA03219.1 .
    PIRi A36276.
    UniGenei Rn.230458.
    Rn.24945.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HNJ model - @ 1-530 [» ]
    2HYC model - @ 1-530 [» ]
    ProteinModelPortali P19488.
    SMRi P19488. Positions 286-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4577277.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PRIDEi P19488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:3937. rat.

    Organism-specific databases

    RGDi 3937. Ugt2b37.

    Phylogenomic databases

    HOVERGENi HBG004033.
    PhylomeDBi P19488.

    Miscellaneous databases

    NextBioi 13949083.

    Gene expression databases

    Genevestigatori P19488.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cDNA sequence and expression of a variant 17 beta-hydroxysteroid UDP-glucuronosyltransferase."
      McKenzie P.I.
      J. Biol. Chem. 265:8699-8703(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiUDB37_RAT
    AccessioniPrimary (citable) accession number: P19488
    Secondary accession number(s): P19489
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3