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P19488 (UDB37_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B37

Short name=UDPGT 2B37
EC=2.4.1.17
Alternative name(s):
17-beta-hydroxysteroid-specific UDPGT
UDP-glucuronosyltransferase R-21
Short name=UDPGTr-21
UDPGTr-5
Gene names
Name:Ugt2b37
Synonyms:Ugt2b5, Ugt2b6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B37 is about 30-fold less active than 2B5 toward testosterone and dihydrotestosterone.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Induction

Constitutively expressed.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 530507UDP-glucuronosyltransferase 2B37
PRO_0000036030

Regions

Transmembrane494 – 51017Helical; Potential

Experimental info

Sequence conflict3971F → L in AAA03218. Ref.1
Sequence conflict3971F → L in AAA03219. Ref.1
Sequence conflict4441M → T in AAA03218. Ref.1
Sequence conflict4441M → T in AAA03219. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P19488 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: F6B23E436B9BDAEA

FASTA53060,593
        10         20         30         40         50         60 
MPGKWIFALL LLQISFCLRS AKCGKVLVWP MEFSHWMNIK TILDELVQRG HEVTVLKPSA 

        70         80         90        100        110        120 
YYVLDPKKSP DLKFETFPTS VSKDELEKYF IKLADAWTYE LQRDTCLSFS PLLQNMMDEF 

       130        140        150        160        170        180 
SDYYLSVCKD AVSNKQLMAK LQESKFDVLL SDPVAACGEL IAEVLHIPFL YSLRASPGHK 

       190        200        210        220        230        240 
IEKSSGRFIL PPSYVPVILS GLGGQMTFID RVKNMICMLY FDFWFHMFNA KNWDPFYTEI 

       250        260        270        280        290        300 
LGRPTTLAET MGKAEMWLIR SYWDLEFPHP TLPNVDYIGG LQCKPAKPLP KDIEDFVQSS 

       310        320        330        340        350        360 
GEHGVVVFSL GSMVSSMTEE KANAIAWALA QIPQKVLWKF DGKIPATLGP NTRVYKWLPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFVTHGGANG VYEAIYHGIP MIGIPMFGEQ HDNIAHMVAK GAAVTLNIRT 

       430        440        450        460        470        480 
MSKSDLFNAL KEVINNPFYK KNAMWLSTIH HDQPMKPLDK AIFWIEYVMR HKRAKHLRPL 

       490        500        510        520        530 
GHNLPWYQYH SLDVIGFLLA CLAVIAALAV KCFLFIYRFF AKKQKKMKNE 

« Hide

References

[1]"The cDNA sequence and expression of a variant 17 beta-hydroxysteroid UDP-glucuronosyltransferase."
McKenzie P.I.
J. Biol. Chem. 265:8699-8703(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33746 mRNA. Translation: AAA03216.1.
M33746 mRNA. Translation: AAA03217.1.
M33747 mRNA. Translation: AAA03218.1.
M33747 mRNA. Translation: AAA03219.1.
PIRA36276.
UniGeneRn.230458.
Rn.24945.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2HNJmodel-@1-530[»]
2HYCmodel-@1-530[»]
ProteinModelPortalP19488.
SMRP19488. Positions 286-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4577277.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEP19488.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:3937. rat.

Organism-specific databases

RGD3937. Ugt2b37.

Phylogenomic databases

HOVERGENHBG004033.
PhylomeDBP19488.

Gene expression databases

GenevestigatorP19488.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13949083.

Entry information

Entry nameUDB37_RAT
AccessionPrimary (citable) accession number: P19488
Secondary accession number(s): P19489
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references