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Reviewed, UniProtKB/Swiss-Prot P19488 (UD2B5_RAT)

Last modified June 16, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    UDP-glucuronosyltransferase 2B5
      Short name=UDPGT 2B5
    EC=2.4.1.17
Alternative name(s):
    17-beta-hydroxysteroid specific
    UDPGTr-5
    UDP-glucuronosyltransferase R-21
      Short name=UDPGTr-21
Gene names
Name: Ugt2b5
Synonyms: Ugt2b6
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B6 is about 30-fold less active than 2B3 toward testosterone and dihydrotestosterone.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Induction

Constitutively expressed.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

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Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   DomainSignal
Transmembrane
   Molecular functionGlycosyltransferase
Transferase
   Technical term3D-structure
Gene Ontology (GO)
   Biological processmetabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

microsome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucuronosyltransferase activity Ref.1

Inferred from direct assay. Source: RGD

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 530507UDP-glucuronosyltransferase 2B5
PRO_0000036030

Regions

Transmembrane494 – 51017 Potential

Experimental info

Sequence conflict3971F → L in AAA03218. Ref.1
Sequence conflict3971F → L in AAA03219. Ref.1
Sequence conflict4441M → T in AAA03218. Ref.1
Sequence conflict4441M → T in AAA03219. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P19488-1 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: F6B23E436B9BDAEA

FASTA53060,593
        10         20         30         40         50         60 
MPGKWIFALL LLQISFCLRS AKCGKVLVWP MEFSHWMNIK TILDELVQRG HEVTVLKPSA 

        70         80         90        100        110        120 
YYVLDPKKSP DLKFETFPTS VSKDELEKYF IKLADAWTYE LQRDTCLSFS PLLQNMMDEF 

       130        140        150        160        170        180 
SDYYLSVCKD AVSNKQLMAK LQESKFDVLL SDPVAACGEL IAEVLHIPFL YSLRASPGHK 

       190        200        210        220        230        240 
IEKSSGRFIL PPSYVPVILS GLGGQMTFID RVKNMICMLY FDFWFHMFNA KNWDPFYTEI 

       250        260        270        280        290        300 
LGRPTTLAET MGKAEMWLIR SYWDLEFPHP TLPNVDYIGG LQCKPAKPLP KDIEDFVQSS 

       310        320        330        340        350        360 
GEHGVVVFSL GSMVSSMTEE KANAIAWALA QIPQKVLWKF DGKIPATLGP NTRVYKWLPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFVTHGGANG VYEAIYHGIP MIGIPMFGEQ HDNIAHMVAK GAAVTLNIRT 

       430        440        450        460        470        480 
MSKSDLFNAL KEVINNPFYK KNAMWLSTIH HDQPMKPLDK AIFWIEYVMR HKRAKHLRPL 

       490        500        510        520        530 
GHNLPWYQYH SLDVIGFLLA CLAVIAALAV KCFLFIYRFF AKKQKKMKNE

« Hide

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References

[1]"The cDNA sequence and expression of a variant 17 beta-hydroxysteroid UDP-glucuronosyltransferase."
McKenzie P.I.
J. Biol. Chem. 265:8699-8703(1990) [PubMed: 1692835] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

M33746 mRNA. Translation: AAA03216.1.
M33746 mRNA. Translation: AAA03217.1.
M33747 mRNA. Translation: AAA03218.1.
M33747 mRNA. Translation: AAA03219.1.
IPIIPI00195423.
PIRA36276.
RefSeqNP_001007265.1.
UniGeneRn.217178

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2HNJmodel-@1-530[»]
2HYCmodel-@1-530[»]
SMRP19488. Positions 286-447.
ModBaseSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEP19488.

Genome annotation databases

EnsemblENSRNOG00000033139. Rattus norvegicus. [Contig view]
GeneID29623.
KEGGrno:29623.

Organism-specific databases

RGD3937. Ugt2b5.

Phylogenomic databases

HOVERGENP19488.

Enzyme and pathway databases

BRENDA2.4.1.17. 248.

Gene expression databases

ArrayExpressP19488.
GermOnlineENSRNOG00000033139. Rattus norvegicus.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. UDP_glucos_trans. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio609828.

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Entry information

Entry nameUD2B5_RAT
AccessionPrimary (citable) accession number: P19488
Secondary accession number(s): P19489
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 16, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents