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P19485

- CYA1_RHIME

UniProt

P19485 - CYA1_RHIME

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Protein

Adenylate cyclase 1

Gene

cya1

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi476 – 4761MagnesiumBy similarity
Metal bindingi520 – 5201MagnesiumBy similarity

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. signal transducer activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-270-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase 1 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 1
Adenylyl cyclase 1
Gene namesi
Name:cya1
Synonyms:cyaA
Ordered Locus Names:R00259
ORF Names:SMc00339
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665Adenylate cyclase 1PRO_0000195744Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc00339.

Structurei

3D structure databases

ProteinModelPortaliP19485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini394 – 44451HAMPPROSITE-ProRule annotationAdd
BLAST
Domaini471 – 603133Guanylate cyclasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-3 family.Curated
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation
Contains 1 HAMP domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0840.
HOGENOMiHOG000295746.
KOiK01768.
OMAiQYTAMGD.
OrthoDBiEOG6JDW7F.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR003660. HAMP_linker_domain.
IPR029787. Nucleotide_cyclase.
IPR029151. Sensor-like.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF00672. HAMP. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
SM00304. HAMP. 1 hit.
[Graphical view]
SUPFAMiSSF103190. SSF103190. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19485-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQRSESGFK DIESMQDSNA DKPSRTWTSS LRSLLGLVMV AMLIVVSATL
60 70 80 90 100
VGLDYRRARS AAIAGAEDNM DAFVGRLVDR LGALSGDTSA LVSLVASVAN
110 120 130 140 150
SFLVPPPERM NDKVAVLREG IARSPHIDGV YVGYPSGAFF HVVDLDSAAW
160 170 180 190 200
RMALDAPRGA AIAVRSMERN DQGKPFDRIL FLDASGLQFA ERHAASNGFD
210 220 230 240 250
PRTRPWYRAA VNGKAPVAIG PYEMATTGNL GMTISQAHRG NPQIVIGADV
260 270 280 290 300
VLDTITDFLS RERLTDDSVS FVLDAVGRPI IHSDSTMMRR IMASKGRDRP
310 320 330 340 350
VATPQEDGLI ESIRRNPPPA GKATLVEVGN RTYLVTVAPL ESALLLSGHR
360 370 380 390 400
VVVAAPLDEL LAAANETLVQ GLAVSGAVVV VAVLLALVLA HLITKSLNQL
410 420 430 440 450
TDSANRLQDL DFATPIDVSS HVAEISTLNG AMNRARDAIF TFALYVPKEL
460 470 480 490 500
VRKGIESGHF GGRAAWRQEV TAMFTDIYDF TTISEGRSPE EVVAMLSEYF
510 520 530 540 550
DLFSEVVAAH DGTIIQFHGD SVFAMWNAPV ADTRHAEHAC RCALAVEERL
560 570 580 590 600
EAFNSAQRAS GLPEFRTRFG IHTGTAVVGS VGAKERLQYT AMGDTVNVAS
610 620 630 640 650
RLEGMNKDYG TSVLASGAVV AQCKDMVKFR PLGTAKAKGR STALDIYEVV
660
GVVRAVNTTE AGTAA
Length:665
Mass (Da):71,325
Last modified:May 30, 2000 - v2
Checksum:iE6E553FE5FF77A1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC41696.1.
M35096 Genomic DNA. Translation: AAA26247.1.
PIRiA35266.
B35266.
RefSeqiNP_384365.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC41696; CAC41696; SMc00339.
GeneIDi1231893.
KEGGisme:SMc00339.
PATRICi23629713. VBISinMel96828_1626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC41696.1 .
M35096 Genomic DNA. Translation: AAA26247.1 .
PIRi A35266.
B35266.
RefSeqi NP_384365.1. NC_003047.1.

3D structure databases

ProteinModelPortali P19485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc00339.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC41696 ; CAC41696 ; SMc00339 .
GeneIDi 1231893.
KEGGi sme:SMc00339.
PATRICi 23629713. VBISinMel96828_1626.

Phylogenomic databases

eggNOGi COG0840.
HOGENOMi HOG000295746.
KOi K01768.
OMAi QYTAMGD.
OrthoDBi EOG6JDW7F.

Enzyme and pathway databases

BioCyci SMEL266834:GJF6-270-MONOMER.

Family and domain databases

Gene3Di 3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR003660. HAMP_linker_domain.
IPR029787. Nucleotide_cyclase.
IPR029151. Sensor-like.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 1 hit.
PF00672. HAMP. 1 hit.
[Graphical view ]
SMARTi SM00044. CYCc. 1 hit.
SM00304. HAMP. 1 hit.
[Graphical view ]
SUPFAMi SSF103190. SSF103190. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEi PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. "Rhizobium meliloti adenylate cyclase is related to eucaryotic adenylate and guanylate cyclases."
    Beuve A., Boesten B., Crasnier M., Danchin A., O'Gara F.
    J. Bacteriol. 172:2614-2621(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 473-665.

Entry informationi

Entry nameiCYA1_RHIME
AccessioniPrimary (citable) accession number: P19485
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 30, 2000
Last modified: November 26, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3