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P19485

- CYA1_RHIME

UniProt

P19485 - CYA1_RHIME

Protein

Adenylate cyclase 1

Gene

cya1

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi476 – 4761MagnesiumBy similarity
    Metal bindingi520 – 5201MagnesiumBy similarity

    GO - Molecular functioni

    1. adenylate cyclase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. signal transducer activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-270-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase 1 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 1
    Adenylyl cyclase 1
    Gene namesi
    Name:cya1
    Synonyms:cyaA
    Ordered Locus Names:R00259
    ORF Names:SMc00339
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 665665Adenylate cyclase 1PRO_0000195744Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc00339.

    Structurei

    3D structure databases

    ProteinModelPortaliP19485.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei373 – 39321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini394 – 44451HAMPPROSITE-ProRule annotationAdd
    BLAST
    Domaini471 – 603133Guanylate cyclasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-3 family.Curated
    Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation
    Contains 1 HAMP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0840.
    HOGENOMiHOG000295746.
    KOiK01768.
    OMAiQYTAMGD.
    OrthoDBiEOG6JDW7F.

    Family and domain databases

    Gene3Di3.30.70.1230. 1 hit.
    InterProiIPR001054. A/G_cyclase.
    IPR003660. HAMP_linker_domain.
    IPR029151. Sensor-like.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 1 hit.
    PF00672. HAMP. 1 hit.
    [Graphical view]
    SMARTiSM00044. CYCc. 1 hit.
    SM00304. HAMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF103190. SSF103190. 1 hit.
    SSF55073. SSF55073. 1 hit.
    PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
    PS50885. HAMP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P19485-1 [UniParc]FASTAAdd to Basket

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    MLQRSESGFK DIESMQDSNA DKPSRTWTSS LRSLLGLVMV AMLIVVSATL    50
    VGLDYRRARS AAIAGAEDNM DAFVGRLVDR LGALSGDTSA LVSLVASVAN 100
    SFLVPPPERM NDKVAVLREG IARSPHIDGV YVGYPSGAFF HVVDLDSAAW 150
    RMALDAPRGA AIAVRSMERN DQGKPFDRIL FLDASGLQFA ERHAASNGFD 200
    PRTRPWYRAA VNGKAPVAIG PYEMATTGNL GMTISQAHRG NPQIVIGADV 250
    VLDTITDFLS RERLTDDSVS FVLDAVGRPI IHSDSTMMRR IMASKGRDRP 300
    VATPQEDGLI ESIRRNPPPA GKATLVEVGN RTYLVTVAPL ESALLLSGHR 350
    VVVAAPLDEL LAAANETLVQ GLAVSGAVVV VAVLLALVLA HLITKSLNQL 400
    TDSANRLQDL DFATPIDVSS HVAEISTLNG AMNRARDAIF TFALYVPKEL 450
    VRKGIESGHF GGRAAWRQEV TAMFTDIYDF TTISEGRSPE EVVAMLSEYF 500
    DLFSEVVAAH DGTIIQFHGD SVFAMWNAPV ADTRHAEHAC RCALAVEERL 550
    EAFNSAQRAS GLPEFRTRFG IHTGTAVVGS VGAKERLQYT AMGDTVNVAS 600
    RLEGMNKDYG TSVLASGAVV AQCKDMVKFR PLGTAKAKGR STALDIYEVV 650
    GVVRAVNTTE AGTAA 665
    Length:665
    Mass (Da):71,325
    Last modified:May 30, 2000 - v2
    Checksum:iE6E553FE5FF77A1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC41696.1.
    M35096 Genomic DNA. Translation: AAA26247.1.
    PIRiA35266.
    B35266.
    RefSeqiNP_384365.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC41696; CAC41696; SMc00339.
    GeneIDi1231893.
    KEGGisme:SMc00339.
    PATRICi23629713. VBISinMel96828_1626.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC41696.1 .
    M35096 Genomic DNA. Translation: AAA26247.1 .
    PIRi A35266.
    B35266.
    RefSeqi NP_384365.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali P19485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc00339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC41696 ; CAC41696 ; SMc00339 .
    GeneIDi 1231893.
    KEGGi sme:SMc00339.
    PATRICi 23629713. VBISinMel96828_1626.

    Phylogenomic databases

    eggNOGi COG0840.
    HOGENOMi HOG000295746.
    KOi K01768.
    OMAi QYTAMGD.
    OrthoDBi EOG6JDW7F.

    Enzyme and pathway databases

    BioCyci SMEL266834:GJF6-270-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.1230. 1 hit.
    InterProi IPR001054. A/G_cyclase.
    IPR003660. HAMP_linker_domain.
    IPR029151. Sensor-like.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 1 hit.
    PF00672. HAMP. 1 hit.
    [Graphical view ]
    SMARTi SM00044. CYCc. 1 hit.
    SM00304. HAMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103190. SSF103190. 1 hit.
    SSF55073. SSF55073. 1 hit.
    PROSITEi PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    PS50885. HAMP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    3. "Rhizobium meliloti adenylate cyclase is related to eucaryotic adenylate and guanylate cyclases."
      Beuve A., Boesten B., Crasnier M., Danchin A., O'Gara F.
      J. Bacteriol. 172:2614-2621(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 473-665.

    Entry informationi

    Entry nameiCYA1_RHIME
    AccessioniPrimary (citable) accession number: P19485
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3