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Protein

Adenylate cyclase 1

Gene

cya1

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi476MagnesiumBy similarity1
Metal bindingi520MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processcAMP biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase 1 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 1
Adenylyl cyclase 1
Gene namesi
Name:cya1
Synonyms:cyaA
Ordered Locus Names:R00259
ORF Names:SMc00339
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957441 – 665Adenylate cyclase 1Add BLAST665

Proteomic databases

PRIDEiP19485

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc00339

Structurei

3D structure databases

ProteinModelPortaliP19485
SMRiP19485
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 444HAMPPROSITE-ProRule annotationAdd BLAST51
Domaini471 – 603Guanylate cyclasePROSITE-ProRule annotationAdd BLAST133

Sequence similaritiesi

Belongs to the adenylyl cyclase class-3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108T5G Bacteria
COG0840 LUCA
HOGENOMiHOG000295746
KOiK01768
OMAiMERDDQG

Family and domain databases

CDDicd06225 HAMP, 1 hit
Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR033479 dCache_1
IPR003660 HAMP_dom
IPR029787 Nucleotide_cyclase
IPR029151 Sensor-like_sf
PfamiView protein in Pfam
PF02743 dCache_1, 1 hit
PF00211 Guanylate_cyc, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SM00304 HAMP, 1 hit
SUPFAMiSSF103190 SSF103190, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50885 HAMP, 1 hit

Sequencei

Sequence statusi: Complete.

P19485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQRSESGFK DIESMQDSNA DKPSRTWTSS LRSLLGLVMV AMLIVVSATL
60 70 80 90 100
VGLDYRRARS AAIAGAEDNM DAFVGRLVDR LGALSGDTSA LVSLVASVAN
110 120 130 140 150
SFLVPPPERM NDKVAVLREG IARSPHIDGV YVGYPSGAFF HVVDLDSAAW
160 170 180 190 200
RMALDAPRGA AIAVRSMERN DQGKPFDRIL FLDASGLQFA ERHAASNGFD
210 220 230 240 250
PRTRPWYRAA VNGKAPVAIG PYEMATTGNL GMTISQAHRG NPQIVIGADV
260 270 280 290 300
VLDTITDFLS RERLTDDSVS FVLDAVGRPI IHSDSTMMRR IMASKGRDRP
310 320 330 340 350
VATPQEDGLI ESIRRNPPPA GKATLVEVGN RTYLVTVAPL ESALLLSGHR
360 370 380 390 400
VVVAAPLDEL LAAANETLVQ GLAVSGAVVV VAVLLALVLA HLITKSLNQL
410 420 430 440 450
TDSANRLQDL DFATPIDVSS HVAEISTLNG AMNRARDAIF TFALYVPKEL
460 470 480 490 500
VRKGIESGHF GGRAAWRQEV TAMFTDIYDF TTISEGRSPE EVVAMLSEYF
510 520 530 540 550
DLFSEVVAAH DGTIIQFHGD SVFAMWNAPV ADTRHAEHAC RCALAVEERL
560 570 580 590 600
EAFNSAQRAS GLPEFRTRFG IHTGTAVVGS VGAKERLQYT AMGDTVNVAS
610 620 630 640 650
RLEGMNKDYG TSVLASGAVV AQCKDMVKFR PLGTAKAKGR STALDIYEVV
660
GVVRAVNTTE AGTAA
Length:665
Mass (Da):71,325
Last modified:May 30, 2000 - v2
Checksum:iE6E553FE5FF77A1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA Translation: CAC41696.1
M35096 Genomic DNA Translation: AAA26247.1
PIRiA35266
B35266
RefSeqiNP_384365.1, NC_003047.1
WP_010968455.1, NC_003047.1

Genome annotation databases

EnsemblBacteriaiCAC41696; CAC41696; SMc00339
GeneIDi1231893
KEGGisme:SMc00339
PATRICifig|266834.11.peg.1626

Similar proteinsi

Entry informationi

Entry nameiCYA1_RHIME
AccessioniPrimary (citable) accession number: P19485
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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