Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P19485 (CYA1_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenylate cyclase 1

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase 1
Adenylyl cyclase 1
Gene names
Name:cya1
Synonyms:cyaA
Ordered Locus Names:R00259
ORF Names:SMc00339
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length665 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the adenylyl cyclase class-3 family.

Contains 1 guanylate cyclase domain.

Contains 1 HAMP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 665665Adenylate cyclase 1
PRO_0000195744

Regions

Transmembrane33 – 5321Helical; Potential
Transmembrane373 – 39321Helical; Potential
Domain394 – 44451HAMP
Domain471 – 603133Guanylate cyclase

Sites

Metal binding4761Magnesium By similarity
Metal binding5201Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P19485 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: E6E553FE5FF77A1B

FASTA66571,325
        10         20         30         40         50         60 
MLQRSESGFK DIESMQDSNA DKPSRTWTSS LRSLLGLVMV AMLIVVSATL VGLDYRRARS 

        70         80         90        100        110        120 
AAIAGAEDNM DAFVGRLVDR LGALSGDTSA LVSLVASVAN SFLVPPPERM NDKVAVLREG 

       130        140        150        160        170        180 
IARSPHIDGV YVGYPSGAFF HVVDLDSAAW RMALDAPRGA AIAVRSMERN DQGKPFDRIL 

       190        200        210        220        230        240 
FLDASGLQFA ERHAASNGFD PRTRPWYRAA VNGKAPVAIG PYEMATTGNL GMTISQAHRG 

       250        260        270        280        290        300 
NPQIVIGADV VLDTITDFLS RERLTDDSVS FVLDAVGRPI IHSDSTMMRR IMASKGRDRP 

       310        320        330        340        350        360 
VATPQEDGLI ESIRRNPPPA GKATLVEVGN RTYLVTVAPL ESALLLSGHR VVVAAPLDEL 

       370        380        390        400        410        420 
LAAANETLVQ GLAVSGAVVV VAVLLALVLA HLITKSLNQL TDSANRLQDL DFATPIDVSS 

       430        440        450        460        470        480 
HVAEISTLNG AMNRARDAIF TFALYVPKEL VRKGIESGHF GGRAAWRQEV TAMFTDIYDF 

       490        500        510        520        530        540 
TTISEGRSPE EVVAMLSEYF DLFSEVVAAH DGTIIQFHGD SVFAMWNAPV ADTRHAEHAC 

       550        560        570        580        590        600 
RCALAVEERL EAFNSAQRAS GLPEFRTRFG IHTGTAVVGS VGAKERLQYT AMGDTVNVAS 

       610        620        630        640        650        660 
RLEGMNKDYG TSVLASGAVV AQCKDMVKFR PLGTAKAKGR STALDIYEVV GVVRAVNTTE 


AGTAA 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021."
Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. expand/collapse author list , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.
Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.
[2]"The composite genome of the legume symbiont Sinorhizobium meliloti."
Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., Cowie A. expand/collapse author list , Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., Wong K., Yeh K.-C., Batut J.
Science 293:668-672(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.
[3]"Rhizobium meliloti adenylate cyclase is related to eucaryotic adenylate and guanylate cyclases."
Beuve A., Boesten B., Crasnier M., Danchin A., O'Gara F.
J. Bacteriol. 172:2614-2621(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 473-665.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591688 Genomic DNA. Translation: CAC41696.1.
M35096 Genomic DNA. Translation: AAA26247.1.
PIRA35266.
B35266.
RefSeqNP_384365.1. NC_003047.1.

3D structure databases

ProteinModelPortalP19485.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc00339.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC41696; CAC41696; SMc00339.
GeneID1231893.
KEGGsme:SMc00339.
PATRIC23629713. VBISinMel96828_1626.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0840.
HOGENOMHOG000295746.
KOK01768.
OMAQYTAMGD.
OrthoDBEOG6JDW7F.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-270-MONOMER.

Family and domain databases

Gene3D3.30.70.1230. 1 hit.
InterProIPR001054. A/G_cyclase.
IPR003660. HAMP_linker_domain.
IPR029151. Sensor-like.
[Graphical view]
PfamPF00211. Guanylate_cyc. 1 hit.
PF00672. HAMP. 1 hit.
[Graphical view]
SMARTSM00044. CYCc. 1 hit.
SM00304. HAMP. 1 hit.
[Graphical view]
SUPFAMSSF103190. SSF103190. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYA1_RHIME
AccessionPrimary (citable) accession number: P19485
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families