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Protein

Mucin-13

Gene

Muc13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-913709. O-linked glycosylation of mucins.
R-MMU-977068. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-13
Short name:
MUC-13
Alternative name(s):
Cell surface antigen 114/A10
Lymphocyte antigen 64
Gene namesi
Name:Muc13
Synonyms:Ly64
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:103190. Muc13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 480463ExtracellularSequence analysisAdd
BLAST
Transmembranei481 – 50828HelicalSequence analysisAdd
BLAST
Topological domaini509 – 57365CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 573556Mucin-13PRO_0000019285Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi237 ↔ 248PROSITE-ProRule annotation
Disulfide bondi242 ↔ 257PROSITE-ProRule annotation
Disulfide bondi259 ↔ 272PROSITE-ProRule annotation
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence analysis
Disulfide bondi389 ↔ 402PROSITE-ProRule annotation
Disulfide bondi394 ↔ 408PROSITE-ProRule annotation
Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence analysis
Disulfide bondi410 ↔ 424PROSITE-ProRule annotation
Disulfide bondi429 ↔ 441PROSITE-ProRule annotation
Disulfide bondi433 ↔ 451PROSITE-ProRule annotation
Disulfide bondi453 ↔ 466PROSITE-ProRule annotation

Post-translational modificationi

Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homooligomerization into dimers is dependent on intrachain disulfide bonds (By similarity).By similarity
Highly N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP19467.
PeptideAtlasiP19467.
PRIDEiP19467.

PTM databases

iPTMnetiP19467.
PhosphoSiteiP19467.

Expressioni

Gene expression databases

BgeeiP19467.
CleanExiMM_MUC13.
ExpressionAtlasiP19467. baseline and differential.
GenevisibleiP19467. MM.

Interactioni

Subunit structurei

Homodimer of beta subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023520.

Structurei

3D structure databases

ProteinModelPortaliP19467.
SMRiP19467. Positions 385-480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini233 – 27341EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini274 – 391118SEAPROSITE-ProRule annotationAdd
BLAST
Domaini385 – 42541EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini425 – 46743EGF-like 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXVD. Eukaryota.
ENOG410XXX6. LUCA.
HOVERGENiHBG052532.
InParanoidiP19467.
KOiK17298.
OMAiPCQDDPC.
OrthoDBiEOG7D85X1.
PhylomeDBiP19467.
TreeFamiTF335941.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR009030. Growth_fac_rcpt_.
IPR000082. SEA_dom.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS01186. EGF_2. 2 hits.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGFLLLSLS LLLVTVGSSS QASSTTSSSG GTSPPTTVQS QSPGSSSQAS
60 70 80 90 100
TTTSSSGGAS PPTTVQSQSP GSSSQASTTT SSSGGASPPT TVQSQSPGSS
110 120 130 140 150
SQASTTTSSS GGASPPTTVQ SQSPGSSSQA STTTSSSGGA SPPTTVQSQS
160 170 180 190 200
PGSSSQASTT TSSSGGASPP TTVQSQSPGS SSQVSTTTSS SGGASPPTTV
210 220 230 240 250
QSQSPGSSSQ PGPTQPSGGA SSSTVPSGGS TGPSDLCNPN PCKGTASCVK
260 270 280 290 300
LHSKHFCLCL EGYYYNSSLS SCVKGTTFPG DISMSVSETA NLEDENSVGY
310 320 330 340 350
QELYNSVTDF FETTFNKTDY GQTVIIKVST APSRSARSAM RDATKDVSVS
360 370 380 390 400
VVNIFGADTK ETEKSVSSAI ETAIKTSGNV KDYVSINLCD HYGCVGNDSS
410 420 430 440 450
KCQDILQCTC KPGLDRLNPQ VPFCVAVTCS QPCNAEEKEQ CLKMDNGVMD
460 470 480 490 500
CVCMPGYQRA NGNRKCEECP FGYSGMNCKD QFQLILTIVG TIAGALILIL
510 520 530 540 550
LIAFIVSARS KNKKKDGEEQ RLIEDDFHNL RLRQTGFSNL GADNSIFPKV
560 570
RTGVPSQTPN PYANQRSMPR PDY
Length:573
Mass (Da):58,701
Last modified:February 1, 1991 - v1
Checksum:i1154C4F04E2D58A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04634 mRNA. Translation: AAA37239.1.
BC024321 mRNA. Translation: AAH24321.1.
CCDSiCCDS28134.1.
PIRiA33533.
RefSeqiNP_034869.1. NM_010739.2.
XP_011244137.1. XM_011245835.1.
UniGeneiMm.3177.

Genome annotation databases

EnsembliENSMUST00000023520; ENSMUSP00000023520; ENSMUSG00000022824.
ENSMUST00000115044; ENSMUSP00000110696; ENSMUSG00000022824.
GeneIDi17063.
KEGGimmu:17063.
UCSCiuc007zal.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04634 mRNA. Translation: AAA37239.1.
BC024321 mRNA. Translation: AAH24321.1.
CCDSiCCDS28134.1.
PIRiA33533.
RefSeqiNP_034869.1. NM_010739.2.
XP_011244137.1. XM_011245835.1.
UniGeneiMm.3177.

3D structure databases

ProteinModelPortaliP19467.
SMRiP19467. Positions 385-480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023520.

PTM databases

iPTMnetiP19467.
PhosphoSiteiP19467.

Proteomic databases

PaxDbiP19467.
PeptideAtlasiP19467.
PRIDEiP19467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023520; ENSMUSP00000023520; ENSMUSG00000022824.
ENSMUST00000115044; ENSMUSP00000110696; ENSMUSG00000022824.
GeneIDi17063.
KEGGimmu:17063.
UCSCiuc007zal.1. mouse.

Organism-specific databases

CTDi56667.
MGIiMGI:103190. Muc13.

Phylogenomic databases

eggNOGiENOG410IXVD. Eukaryota.
ENOG410XXX6. LUCA.
HOVERGENiHBG052532.
InParanoidiP19467.
KOiK17298.
OMAiPCQDDPC.
OrthoDBiEOG7D85X1.
PhylomeDBiP19467.
TreeFamiTF335941.

Enzyme and pathway databases

ReactomeiR-MMU-913709. O-linked glycosylation of mucins.
R-MMU-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

PROiP19467.
SOURCEiSearch...

Gene expression databases

BgeeiP19467.
CleanExiMM_MUC13.
ExpressionAtlasiP19467. baseline and differential.
GenevisibleiP19467. MM.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR009030. Growth_fac_rcpt_.
IPR000082. SEA_dom.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS01186. EGF_2. 2 hits.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of 114/A10, a cell surface antigen containing highly conserved repeated elements, which is expressed by murine hemopoietic progenitor cells and interleukin-3-dependent cell lines."
    Dougherty G.J., Kay R.J., Humphries R.K.
    J. Biol. Chem. 264:6509-6514(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiMUC13_MOUSE
AccessioniPrimary (citable) accession number: P19467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 6, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.