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Protein

Transcription attenuation protein MtrB

Gene

mtrB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for transcription attenuation control in the trp operon. This trans-acting factor binds to trinucleotide repeats (GAG or UAG) located in the trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU22770-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription attenuation protein MtrB
Alternative name(s):
Trp RNA-binding attenuation protein
Short name:
TRAP
Tryptophan RNA-binding attenuator protein
Gene namesi
Name:mtrB
Ordered Locus Names:BSU22770
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7575Transcription attenuation protein MtrBPRO_0000206028Add
BLAST

Proteomic databases

PaxDbiP19466.

Interactioni

Subunit structurei

Oligomer of 11 identical subunits arranged in doughnut-like structure.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100012511.

Structurei

Secondary structure

1
75
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 168Combined sources
Beta strandi19 – 257Combined sources
Beta strandi27 – 293Combined sources
Beta strandi32 – 387Combined sources
Beta strandi43 – 475Combined sources
Beta strandi50 – 6516Combined sources
Beta strandi68 – 703Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WAPX-ray1.80A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-75[»]
3ZZQX-ray1.75A/B/C/D/E/F7-71[»]
4B27X-ray2.72A/B/C/D/E/F1-75[»]
ProteinModelPortaliP19466.
SMRiP19466. Positions 8-75.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19466.

Family & Domainsi

Sequence similaritiesi

Belongs to the MtrB family.Curated

Phylogenomic databases

HOGENOMiHOG000245485.
KOiK06285.
OMAiDTKFHHT.

Family and domain databases

Gene3Di2.60.40.50. 1 hit.
HAMAPiMF_00798. Trp_attenuator. 1 hit.
InterProiIPR000824. MtrB.
IPR016031. Trp_RNA-bd_attenuator-like_dom.
IPR023558. Trp_RNA-bd_attenuator_dom.
[Graphical view]
PfamiPF02081. TrpBP. 1 hit.
[Graphical view]
PRINTSiPR00687. TRPRNAAP.
SUPFAMiSSF51219. SSF51219. 1 hit.

Sequencei

Sequence statusi: Complete.

P19466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQKHSSDFV VIKAVEDGVN VIGLTRGTDT KFHHSEKLDK GEVIIAQFTE
60 70
HTSAIKVRGE ALIQTAYGEM KSEKK
Length:75
Mass (Da):8,328
Last modified:February 1, 1991 - v1
Checksum:i34C173A8D15A4B31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37320 Genomic DNA. Translation: AAA22616.1.
M80245 Genomic DNA. Translation: AAA20853.1.
AL009126 Genomic DNA. Translation: CAB14193.1.
PIRiB38256.
RefSeqiNP_390158.1. NC_000964.3.
WP_003230576.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14193; CAB14193; BSU22770.
GeneIDi23410310.
938996.
KEGGibsu:BSU22770.
PATRICi18976365. VBIBacSub10457_2373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37320 Genomic DNA. Translation: AAA22616.1.
M80245 Genomic DNA. Translation: AAA20853.1.
AL009126 Genomic DNA. Translation: CAB14193.1.
PIRiB38256.
RefSeqiNP_390158.1. NC_000964.3.
WP_003230576.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WAPX-ray1.80A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-75[»]
3ZZQX-ray1.75A/B/C/D/E/F7-71[»]
4B27X-ray2.72A/B/C/D/E/F1-75[»]
ProteinModelPortaliP19466.
SMRiP19466. Positions 8-75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100012511.

Proteomic databases

PaxDbiP19466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14193; CAB14193; BSU22770.
GeneIDi23410310.
938996.
KEGGibsu:BSU22770.
PATRICi18976365. VBIBacSub10457_2373.

Phylogenomic databases

HOGENOMiHOG000245485.
KOiK06285.
OMAiDTKFHHT.

Enzyme and pathway databases

BioCyciBSUB:BSU22770-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP19466.

Family and domain databases

Gene3Di2.60.40.50. 1 hit.
HAMAPiMF_00798. Trp_attenuator. 1 hit.
InterProiIPR000824. MtrB.
IPR016031. Trp_RNA-bd_attenuator-like_dom.
IPR023558. Trp_RNA-bd_attenuator_dom.
[Graphical view]
PfamiPF02081. TrpBP. 1 hit.
[Graphical view]
PRINTSiPR00687. TRPRNAAP.
SUPFAMiSSF51219. SSF51219. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTRB_BACSU
AccessioniPrimary (citable) accession number: P19466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.