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P19466 (MTRB_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Transcription attenuation protein MtrB
Alternative name(s):
Trp RNA-binding attenuation protein
Short name=TRAP
Tryptophan RNA-binding attenuator protein
Gene names
Name:mtrB
Ordered Locus Names:BSU22770
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length75 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for transcription attenuation control in the trp operon. This trans-acting factor binds to trinucleotide repeats (GAG or UAG) located in the trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan. Ref.3 Ref.4

Subunit structure

Oligomer of 11 identical subunits arranged in doughnut-like structure.

Sequence similarities

Belongs to the MtrB family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7575Transcription attenuation protein MtrB HAMAP-Rule MF_00798
PRO_0000206028

Secondary structure

............... 75
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P19466 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 34C173A8D15A4B31

FASTA758,328
        10         20         30         40         50         60 
MNQKHSSDFV VIKAVEDGVN VIGLTRGTDT KFHHSEKLDK GEVIIAQFTE HTSAIKVRGE 

        70 
ALIQTAYGEM KSEKK 

« Hide

References

« Hide 'large scale' references
[1]"The mtr locus is a two-gene operon required for transcription attenuation in the trp operon of Bacillus subtilis."
Gollnick P., Ishino S., Kuroda M.I., Henner D.J., Yanofsky C.
Proc. Natl. Acad. Sci. U.S.A. 87:8726-8730(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"The mtrAB operon of Bacillus subtilis encodes GTP cyclohydrolase I (MtrA), an enzyme involved in folic acid biosynthesis, and MtrB, a regulator of tryptophan biosynthesis."
Babitzke P., Gollnick P., Yanofsky C.
J. Bacteriol. 174:2059-2064(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Role of Bacillus subtilis RNase J1 endonuclease and 5'-exonuclease activities in trp leader RNA turnover."
Deikus G., Condon C., Bechhofer D.H.
J. Biol. Chem. 283:17158-17167(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"The structure of trp RNA-binding attenuation protein."
Antson A.A., Otridge J., Brzozowski A.M., Dodson E.J., Dodson G.G., Wilson K.S., Smith T.M., Yan M., Kurecki T., Gollnick P.
Nature 374:693-700(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
[6]"11-fold symmetry of the trp RNA-binding attenuation protein (TRAP) from Bacillus subtilis determined by X-ray analysis."
Antson A.A., Brzozowski A.M., Dodson E.J., Dauter Z., Wilson K.S., Kurecki T., Otridge J., Gollnick P.
J. Mol. Biol. 244:1-5(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M37320 Genomic DNA. Translation: AAA22616.1.
M80245 Genomic DNA. Translation: AAA20853.1.
AL009126 Genomic DNA. Translation: CAB14193.1.
PIRB38256.
RefSeqNP_390158.1. NC_000964.3.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WAPX-ray1.80A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-75[»]
3ZZQX-ray1.75A/B/C/D/E/F7-71[»]
4B27X-ray2.72A/B/C/D/E/F1-75[»]
ProteinModelPortalP19466.
SMRP19466. Positions 8-75.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU22770.

Chemistry

DrugBankDB00150. L-Tryptophan.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB14193; CAB14193; BSU22770.
GeneID938996.
KEGGbsu:BSU22770.
PATRIC18976365. VBIBacSub10457_2373.

Organism-specific databases

GenoListBSU22770. [Micado]

Phylogenomic databases

HOGENOMHOG000245485.
KOK06285.
OMAFHHTEKL.
OrthoDBEOG64V2JJ.

Enzyme and pathway databases

BioCycBSUB:BSU22770-MONOMER.

Family and domain databases

Gene3D2.60.40.50. 1 hit.
HAMAPMF_00798. Trp_attenuator.
InterProIPR000824. MtrB.
IPR016031. Trp_RNA-bd_attenuator-like_dom.
IPR023558. Trp_RNA-bd_attenuator_dom.
[Graphical view]
PfamPF02081. TrpBP. 1 hit.
[Graphical view]
PRINTSPR00687. TRPRNAAP.
SUPFAMSSF51219. SSF51219. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP19466.

Entry information

Entry nameMTRB_BACSU
AccessionPrimary (citable) accession number: P19466
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList