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P19437

- CD20_MOUSE

UniProt

P19437 - CD20_MOUSE

Protein

B-lymphocyte antigen CD20

Gene

Ms4a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    This protein may be involved in the regulation of B-cell activation and proliferation.

    GO - Biological processi

    1. B cell activation Source: UniProtKB-KW

    Keywords - Biological processi

    B-cell activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-lymphocyte antigen CD20
    Alternative name(s):
    B-cell differentiation antigen Ly-44
    Lymphocyte antigen 44
    Membrane-spanning 4-domains subfamily A member 1
    CD_antigen: CD20
    Gene namesi
    Name:Ms4a1
    Synonyms:Cd20, Ly-44, Ms4a2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:88321. Ms4a1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein. Cell membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice have severely impaired T-cell independent antipolysaccharide antibody responses.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291B-lymphocyte antigen CD20PRO_0000158628Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi214 – 2141S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    MaxQBiP19437.
    PRIDEiP19437.

    PTM databases

    PhosphoSiteiP19437.

    Expressioni

    Gene expression databases

    ArrayExpressiP19437.
    BgeeiP19437.
    GenevestigatoriP19437.

    Interactioni

    Subunit structurei

    Homotrimer.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000025576.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini66 – 683ExtracellularSequence Analysis
    Topological domaini90 – 11122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini133 – 18250ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini204 – 29188CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MS4A family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43290.
    HOGENOMiHOG000111479.
    HOVERGENiHBG048815.
    InParanoidiP19437.
    KOiK06466.
    OMAiIVENEWK.
    OrthoDBiEOG7VHSZF.
    PhylomeDBiP19437.
    TreeFamiTF335157.

    Family and domain databases

    InterProiIPR007237. CD20-like.
    [Graphical view]
    PfamiPF04103. CD20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P19437-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGPFPAEPT KGPLAMQPAP KVNLKRTSSL VGPTQSFFMR ESKALGAVQI    50
    MNGLFHITLG GLLMIPTGVF APICLSVWYP LWGGIMYIIS GSLLAAAAEK 100
    TSRKSLVKAK VIMSSLSLFA AISGIILSIM DILNMTLSHF LKMRRLELIQ 150
    TSKPYVDIYD CEPSNSSEKN SPSTQYCNSI QSVFLGILSA MLISAFFQKL 200
    VTAGIVENEW KRMCTRSKSN VVLLSAGEKN EQTIKMKEEI IELSGVSSQP 250
    KNEEEIEIIP VQEEEEEEAE INFPAPPQEQ ESLPVENEIA P 291
    Length:291
    Mass (Da):31,958
    Last modified:February 1, 1991 - v1
    Checksum:iDF478ECD2C5C16FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62541 mRNA. Translation: AAA37394.1.
    AK017903 mRNA. Translation: BAB30996.1.
    BC028322 mRNA. Translation: AAH28322.1.
    CCDSiCCDS37923.1.
    PIRiA30558.
    RefSeqiNP_031667.1. NM_007641.5.
    UniGeneiMm.4046.

    Genome annotation databases

    EnsembliENSMUST00000169159; ENSMUSP00000126422; ENSMUSG00000024673.
    GeneIDi12482.
    KEGGimmu:12482.
    UCSCiuc008grw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62541 mRNA. Translation: AAA37394.1 .
    AK017903 mRNA. Translation: BAB30996.1 .
    BC028322 mRNA. Translation: AAH28322.1 .
    CCDSi CCDS37923.1.
    PIRi A30558.
    RefSeqi NP_031667.1. NM_007641.5.
    UniGenei Mm.4046.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000025576.

    PTM databases

    PhosphoSitei P19437.

    Proteomic databases

    MaxQBi P19437.
    PRIDEi P19437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000169159 ; ENSMUSP00000126422 ; ENSMUSG00000024673 .
    GeneIDi 12482.
    KEGGi mmu:12482.
    UCSCi uc008grw.1. mouse.

    Organism-specific databases

    CTDi 931.
    MGIi MGI:88321. Ms4a1.

    Phylogenomic databases

    eggNOGi NOG43290.
    HOGENOMi HOG000111479.
    HOVERGENi HBG048815.
    InParanoidi P19437.
    KOi K06466.
    OMAi IVENEWK.
    OrthoDBi EOG7VHSZF.
    PhylomeDBi P19437.
    TreeFami TF335157.

    Miscellaneous databases

    NextBioi 281382.
    PROi P19437.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P19437.
    Bgeei P19437.
    Genevestigatori P19437.

    Family and domain databases

    InterProi IPR007237. CD20-like.
    [Graphical view ]
    Pfami PF04103. CD20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19."
      Tedder T.F., Klejman G., Disteche C.M., Adler D.A., Schlossman S.F., Saito H.
      J. Immunol. 141:4388-4394(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.
    4. "The oligomeric nature of the murine Fc epsilon RII/CD23. Implications for function."
      Dierks S.E., Bartlett W.C., Edmeades R.L., Gould H.J., Rao M., Conrad D.H.
      J. Immunol. 150:2372-2382(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    5. Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiCD20_MOUSE
    AccessioniPrimary (citable) accession number: P19437
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3