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Protein

B-lymphocyte antigen CD20

Gene

Ms4a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein may be involved in the regulation of B-cell activation and proliferation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

B-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
B-lymphocyte antigen CD20
Alternative name(s):
B-cell differentiation antigen Ly-44
Lymphocyte antigen 44
Membrane-spanning 4-domains subfamily A member 1
CD_antigen: CD20
Gene namesi
Name:Ms4a1
Synonyms:Cd20, Ly-44, Ms4a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:88321. Ms4a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Topological domaini66 – 683ExtracellularSequence Analysis
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Topological domaini90 – 11122CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence AnalysisAdd
BLAST
Topological domaini133 – 18250ExtracellularSequence AnalysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST
Topological domaini204 – 29188CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice have severely impaired T-cell independent antipolysaccharide antibody responses.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291B-lymphocyte antigen CD20PRO_0000158628Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi214 – 2141S-palmitoyl cysteineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP19437.
PRIDEiP19437.

PTM databases

PhosphoSiteiP19437.

Expressioni

Gene expression databases

BgeeiP19437.
ExpressionAtlasiP19437. baseline and differential.
GenevestigatoriP19437.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
P018823EBI-10683749,EBI-10683684
IghmP018723EBI-10683749,EBI-645833

Protein-protein interaction databases

IntActiP19437. 2 interactions.
STRINGi10090.ENSMUSP00000025576.

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43290.
HOGENOMiHOG000111479.
HOVERGENiHBG048815.
InParanoidiP19437.
KOiK06466.
OMAiGIVENEW.
OrthoDBiEOG7VHSZF.
PhylomeDBiP19437.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030418. MS4A1.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF6. PTHR23320:SF6. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGPFPAEPT KGPLAMQPAP KVNLKRTSSL VGPTQSFFMR ESKALGAVQI
60 70 80 90 100
MNGLFHITLG GLLMIPTGVF APICLSVWYP LWGGIMYIIS GSLLAAAAEK
110 120 130 140 150
TSRKSLVKAK VIMSSLSLFA AISGIILSIM DILNMTLSHF LKMRRLELIQ
160 170 180 190 200
TSKPYVDIYD CEPSNSSEKN SPSTQYCNSI QSVFLGILSA MLISAFFQKL
210 220 230 240 250
VTAGIVENEW KRMCTRSKSN VVLLSAGEKN EQTIKMKEEI IELSGVSSQP
260 270 280 290
KNEEEIEIIP VQEEEEEEAE INFPAPPQEQ ESLPVENEIA P
Length:291
Mass (Da):31,958
Last modified:February 1, 1991 - v1
Checksum:iDF478ECD2C5C16FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62541 mRNA. Translation: AAA37394.1.
AK017903 mRNA. Translation: BAB30996.1.
BC028322 mRNA. Translation: AAH28322.1.
CCDSiCCDS37923.1.
PIRiA30558.
RefSeqiNP_031667.1. NM_007641.5.
UniGeneiMm.4046.

Genome annotation databases

EnsembliENSMUST00000169159; ENSMUSP00000126422; ENSMUSG00000024673.
GeneIDi12482.
KEGGimmu:12482.
UCSCiuc008grw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62541 mRNA. Translation: AAA37394.1.
AK017903 mRNA. Translation: BAB30996.1.
BC028322 mRNA. Translation: AAH28322.1.
CCDSiCCDS37923.1.
PIRiA30558.
RefSeqiNP_031667.1. NM_007641.5.
UniGeneiMm.4046.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP19437. 2 interactions.
STRINGi10090.ENSMUSP00000025576.

PTM databases

PhosphoSiteiP19437.

Proteomic databases

MaxQBiP19437.
PRIDEiP19437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169159; ENSMUSP00000126422; ENSMUSG00000024673.
GeneIDi12482.
KEGGimmu:12482.
UCSCiuc008grw.1. mouse.

Organism-specific databases

CTDi931.
MGIiMGI:88321. Ms4a1.

Phylogenomic databases

eggNOGiNOG43290.
HOGENOMiHOG000111479.
HOVERGENiHBG048815.
InParanoidiP19437.
KOiK06466.
OMAiGIVENEW.
OrthoDBiEOG7VHSZF.
PhylomeDBiP19437.
TreeFamiTF335157.

Miscellaneous databases

NextBioi281382.
PROiP19437.
SOURCEiSearch...

Gene expression databases

BgeeiP19437.
ExpressionAtlasiP19437. baseline and differential.
GenevestigatoriP19437.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030418. MS4A1.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF6. PTHR23320:SF6. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19."
    Tedder T.F., Klejman G., Disteche C.M., Adler D.A., Schlossman S.F., Saito H.
    J. Immunol. 141:4388-4394(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  4. "The oligomeric nature of the murine Fc epsilon RII/CD23. Implications for function."
    Dierks S.E., Bartlett W.C., Edmeades R.L., Gould H.J., Rao M., Conrad D.H.
    J. Immunol. 150:2372-2382(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  5. Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCD20_MOUSE
AccessioniPrimary (citable) accession number: P19437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 27, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.