Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P19437 (CD20_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
B-lymphocyte antigen CD20
Alternative name(s):
B-cell differentiation antigen Ly-44
Lymphocyte antigen 44
Membrane-spanning 4-domains subfamily A member 1
CD_antigen=CD20
Gene names
Name:Ms4a1
Synonyms:Cd20, Ly-44, Ms4a2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein may be involved in the regulation of B-cell activation and proliferation.

Subunit structure

Homotrimer. Ref.4

Subcellular location

Cell membrane By similarity; Multi-pass membrane protein. Cell membrane; Lipid-anchor By similarity.

Post-translational modification

Phosphorylated By similarity.

Disruption phenotype

Mice have severely impaired T-cell independent antipolysaccharide antibody responses. Ref.5

Sequence similarities

Belongs to the MS4A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291B-lymphocyte antigen CD20
PRO_0000158628

Regions

Topological domain1 – 4444Cytoplasmic Potential
Transmembrane45 – 6521Helical; Potential
Topological domain66 – 683Extracellular Potential
Transmembrane69 – 8921Helical; Potential
Topological domain90 – 11122Cytoplasmic Potential
Transmembrane112 – 13221Helical; Potential
Topological domain133 – 18250Extracellular Potential
Transmembrane183 – 20321Helical; Potential
Topological domain204 – 29188Cytoplasmic Potential

Amino acid modifications

Lipidation2141S-palmitoyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P19437 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: DF478ECD2C5C16FC

FASTA29131,958
        10         20         30         40         50         60 
MSGPFPAEPT KGPLAMQPAP KVNLKRTSSL VGPTQSFFMR ESKALGAVQI MNGLFHITLG 

        70         80         90        100        110        120 
GLLMIPTGVF APICLSVWYP LWGGIMYIIS GSLLAAAAEK TSRKSLVKAK VIMSSLSLFA 

       130        140        150        160        170        180 
AISGIILSIM DILNMTLSHF LKMRRLELIQ TSKPYVDIYD CEPSNSSEKN SPSTQYCNSI 

       190        200        210        220        230        240 
QSVFLGILSA MLISAFFQKL VTAGIVENEW KRMCTRSKSN VVLLSAGEKN EQTIKMKEEI 

       250        260        270        280        290 
IELSGVSSQP KNEEEIEIIP VQEEEEEEAE INFPAPPQEQ ESLPVENEIA P 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19."
Tedder T.F., Klejman G., Disteche C.M., Adler D.A., Schlossman S.F., Saito H.
J. Immunol. 141:4388-4394(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Retina.
[4]"The oligomeric nature of the murine Fc epsilon RII/CD23. Implications for function."
Dierks S.E., Bartlett W.C., Edmeades R.L., Gould H.J., Rao M., Conrad D.H.
J. Immunol. 150:2372-2382(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[5]"CD20 deficiency in humans results in impaired T cell-independent antibody responses."
Kuijpers T.W., Bende R.J., Baars P.A., Grummels A., Derks I.A.M., Dolman K.M., Beaumont T., Tedder T.F., van Noesel C.J.M., Eldering E., van Lier R.A.W.
J. Clin. Invest. 120:214-222(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M62541 mRNA. Translation: AAA37394.1.
AK017903 mRNA. Translation: BAB30996.1.
BC028322 mRNA. Translation: AAH28322.1.
PIRA30558.
RefSeqNP_031667.1. NM_007641.5.
UniGeneMm.4046.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000025576.

PTM databases

PhosphoSiteP19437.

Proteomic databases

PRIDEP19437.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000169159; ENSMUSP00000126422; ENSMUSG00000024673.
GeneID12482.
KEGGmmu:12482.
UCSCuc008grw.1. mouse.

Organism-specific databases

CTD931.
MGIMGI:88321. Ms4a1.

Phylogenomic databases

eggNOGNOG43290.
HOGENOMHOG000111479.
HOVERGENHBG048815.
InParanoidP19437.
KOK06466.
OMAGIVENEW.
OrthoDBEOG7VHSZF.
PhylomeDBP19437.
TreeFamTF335157.

Gene expression databases

ArrayExpressP19437.
BgeeP19437.
GenevestigatorP19437.

Family and domain databases

InterProIPR007237. CD20-like.
[Graphical view]
PfamPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281382.
PROP19437.
SOURCESearch...

Entry information

Entry nameCD20_MOUSE
AccessionPrimary (citable) accession number: P19437
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot