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Protein

B-lymphocyte antigen CD20

Gene

Ms4a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein may be involved in the regulation of B-cell activation and proliferation.

GO - Biological processi

Keywordsi

Biological processB-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
B-lymphocyte antigen CD20
Alternative name(s):
B-cell differentiation antigen Ly-44
Lymphocyte antigen 44
Membrane-spanning 4-domains subfamily A member 1
CD_antigen: CD20
Gene namesi
Name:Ms4a1
Synonyms:Cd20, Ly-44, Ms4a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:88321 Ms4a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 68ExtracellularSequence analysis3
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 111CytoplasmicSequence analysisAdd BLAST22
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 182ExtracellularSequence analysisAdd BLAST50
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 291CytoplasmicSequence analysisAdd BLAST88

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice have severely impaired T-cell independent antipolysaccharide antibody responses.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586281 – 291B-lymphocyte antigen CD20Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1
Lipidationi214S-palmitoyl cysteineBy similarity1
Modified residuei219PhosphoserineCombined sources1
Modified residuei233PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP19437
PRIDEiP19437

PTM databases

iPTMnetiP19437
PhosphoSitePlusiP19437

Expressioni

Gene expression databases

BgeeiENSMUSG00000024673
ExpressionAtlasiP19437 baseline and differential
GenevisibleiP19437 MM

Interactioni

Subunit structurei

Homotrimer.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi198580, 1 interactor
IntActiP19437, 2 interactors
STRINGi10090.ENSMUSP00000126422

Structurei

3D structure databases

SMRiP19437
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFXM Eukaryota
ENOG41119VB LUCA
GeneTreeiENSGT00510000048781
HOGENOMiHOG000111479
HOVERGENiHBG048815
InParanoidiP19437
KOiK06466
OMAiGIVENEW
OrthoDBiEOG091G0IBB
PhylomeDBiP19437
TreeFamiTF335157

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030418 MS4A1
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF79 PTHR23320:SF79, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

Sequencei

Sequence statusi: Complete.

P19437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGPFPAEPT KGPLAMQPAP KVNLKRTSSL VGPTQSFFMR ESKALGAVQI
60 70 80 90 100
MNGLFHITLG GLLMIPTGVF APICLSVWYP LWGGIMYIIS GSLLAAAAEK
110 120 130 140 150
TSRKSLVKAK VIMSSLSLFA AISGIILSIM DILNMTLSHF LKMRRLELIQ
160 170 180 190 200
TSKPYVDIYD CEPSNSSEKN SPSTQYCNSI QSVFLGILSA MLISAFFQKL
210 220 230 240 250
VTAGIVENEW KRMCTRSKSN VVLLSAGEKN EQTIKMKEEI IELSGVSSQP
260 270 280 290
KNEEEIEIIP VQEEEEEEAE INFPAPPQEQ ESLPVENEIA P
Length:291
Mass (Da):31,958
Last modified:February 1, 1991 - v1
Checksum:iDF478ECD2C5C16FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62541 mRNA Translation: AAA37394.1
AK017903 mRNA Translation: BAB30996.1
BC028322 mRNA Translation: AAH28322.1
CCDSiCCDS37923.1
PIRiA30558
RefSeqiNP_031667.1, NM_007641.5
UniGeneiMm.4046

Genome annotation databases

EnsembliENSMUST00000169159; ENSMUSP00000126422; ENSMUSG00000024673
GeneIDi12482
KEGGimmu:12482
UCSCiuc008grw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCD20_MOUSE
AccessioniPrimary (citable) accession number: P19437
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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