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P19432 (GLNA2_STRVR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase 2

EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase II
Glutamine synthetase II
Short name=GSII
Gene names
Name:glnII
OrganismStreptomyces viridochromogenes
Taxonomic identifier1938 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulation

The activity of this enzyme is not controlled by adenylation.

Subunit structure

Homooctamer.

Subcellular location

Cytoplasm.

Miscellaneous

Overexpression of Streptomyces viridochromogenes glutamine synthetase confers resistance against the antibiotic phosphinathricyl-alenyl-alanine.

Sequence similarities

Belongs to the glutamine synthetase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Glutamine synthetase 2
PRO_0000153270

Sequences

Sequence LengthMass (Da)Tools
P19432 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 537C8F425E2E660F

FASTA34337,259
        10         20         30         40         50         60 
MTFKAEYIWI DGTEPTAKLR SKTKIITGQP AGLDALPIWG FDGSSTNQAE GHSSDCVLKP 

        70         80         90        100        110        120 
VFTCPDPIRG GDDILVLCEV LNIDLTPHAS NTRAALAEVA ERFAAQEPIF GIEQEYTFFQ 

       130        140        150        160        170        180 
DGYPLGFPKG GFPAPQGGYY CGVGADEIFG RDVVEAHLDN CLKAGLAISG INAEVMPGQW 

       190        200        210        220        230        240 
EFQVGPVSPL EVSDHLWVAR WLLYRTAEDF DVAATLDPKP VKGDWNGAGA HTNFSTKAMR 

       250        260        270        280        290        300 
ESYDAIITAA ESLGEGSKPL DHVKNYGAGI DDRLTGLHET APWNEYSYGV SDRGASVRIP 

       310        320        330        340 
WQVEKDGKGY IEDRRPNANV DPYVVTRLLV DTCCSALEKA GQV 

« Hide

References

[1]"Overexpression of a Streptomyces viridochromogenes gene (glnII) encoding a glutamine synthetase similar to those of eucaryotes confers resistance against the antibiotic phosphinothricyl-alanyl-alanine."
Behrmann I., Hillemann D., Puehler A., Strauch E., Wohlleben W.
J. Bacteriol. 172:5326-5334(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ES2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52842 Genomic DNA. Translation: CAA37028.1.
PIRAJSM2V. C36724.

3D structure databases

ProteinModelPortalP19432.
SMRP19432. Positions 3-335.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA2_STRVR
AccessionPrimary (citable) accession number: P19432
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families