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P19432

- GLNA2_STRVR

UniProt

P19432 - GLNA2_STRVR

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Protein

Glutamine synthetase 2

Gene

glnII

Organism
Streptomyces viridochromogenes
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is not controlled by adenylation.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase 2 (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase II
Glutamine synthetase II
Short name:
GSII
Gene namesi
Name:glnII
OrganismiStreptomyces viridochromogenes
Taxonomic identifieri1938 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Glutamine synthetase 2PRO_0000153270Add
BLAST

Interactioni

Subunit structurei

Homooctamer.

Structurei

3D structure databases

ProteinModelPortaliP19432.
SMRiP19432. Positions 3-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19432-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTFKAEYIWI DGTEPTAKLR SKTKIITGQP AGLDALPIWG FDGSSTNQAE
60 70 80 90 100
GHSSDCVLKP VFTCPDPIRG GDDILVLCEV LNIDLTPHAS NTRAALAEVA
110 120 130 140 150
ERFAAQEPIF GIEQEYTFFQ DGYPLGFPKG GFPAPQGGYY CGVGADEIFG
160 170 180 190 200
RDVVEAHLDN CLKAGLAISG INAEVMPGQW EFQVGPVSPL EVSDHLWVAR
210 220 230 240 250
WLLYRTAEDF DVAATLDPKP VKGDWNGAGA HTNFSTKAMR ESYDAIITAA
260 270 280 290 300
ESLGEGSKPL DHVKNYGAGI DDRLTGLHET APWNEYSYGV SDRGASVRIP
310 320 330 340
WQVEKDGKGY IEDRRPNANV DPYVVTRLLV DTCCSALEKA GQV
Length:343
Mass (Da):37,259
Last modified:February 1, 1991 - v1
Checksum:i537C8F425E2E660F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52842 Genomic DNA. Translation: CAA37028.1.
PIRiC36724. AJSM2V.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52842 Genomic DNA. Translation: CAA37028.1 .
PIRi C36724. AJSM2V.

3D structure databases

ProteinModelPortali P19432.
SMRi P19432. Positions 3-335.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Overexpression of a Streptomyces viridochromogenes gene (glnII) encoding a glutamine synthetase similar to those of eucaryotes confers resistance against the antibiotic phosphinothricyl-alanyl-alanine."
    Behrmann I., Hillemann D., Puehler A., Strauch E., Wohlleben W.
    J. Bacteriol. 172:5326-5334(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ES2.

Entry informationi

Entry nameiGLNA2_STRVR
AccessioniPrimary (citable) accession number: P19432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression of Streptomyces viridochromogenes glutamine synthetase confers resistance against the antibiotic phosphinathricyl-alenyl-alanine.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3