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P19432

- GLNA2_STRVR

UniProt

P19432 - GLNA2_STRVR

Protein

Glutamine synthetase 2

Gene

glnII

Organism
Streptomyces viridochromogenes
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is not controlled by adenylation.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase 2 (EC:6.3.1.2)
    Alternative name(s):
    Glutamate--ammonia ligase II
    Glutamine synthetase II
    Short name:
    GSII
    Gene namesi
    Name:glnII
    OrganismiStreptomyces viridochromogenes
    Taxonomic identifieri1938 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Glutamine synthetase 2PRO_0000153270Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer.

    Structurei

    3D structure databases

    ProteinModelPortaliP19432.
    SMRiP19432. Positions 3-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Family and domain databases

    Gene3Di3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P19432-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTFKAEYIWI DGTEPTAKLR SKTKIITGQP AGLDALPIWG FDGSSTNQAE    50
    GHSSDCVLKP VFTCPDPIRG GDDILVLCEV LNIDLTPHAS NTRAALAEVA 100
    ERFAAQEPIF GIEQEYTFFQ DGYPLGFPKG GFPAPQGGYY CGVGADEIFG 150
    RDVVEAHLDN CLKAGLAISG INAEVMPGQW EFQVGPVSPL EVSDHLWVAR 200
    WLLYRTAEDF DVAATLDPKP VKGDWNGAGA HTNFSTKAMR ESYDAIITAA 250
    ESLGEGSKPL DHVKNYGAGI DDRLTGLHET APWNEYSYGV SDRGASVRIP 300
    WQVEKDGKGY IEDRRPNANV DPYVVTRLLV DTCCSALEKA GQV 343
    Length:343
    Mass (Da):37,259
    Last modified:February 1, 1991 - v1
    Checksum:i537C8F425E2E660F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52842 Genomic DNA. Translation: CAA37028.1.
    PIRiC36724. AJSM2V.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52842 Genomic DNA. Translation: CAA37028.1 .
    PIRi C36724. AJSM2V.

    3D structure databases

    ProteinModelPortali P19432.
    SMRi P19432. Positions 3-335.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Overexpression of a Streptomyces viridochromogenes gene (glnII) encoding a glutamine synthetase similar to those of eucaryotes confers resistance against the antibiotic phosphinothricyl-alanyl-alanine."
      Behrmann I., Hillemann D., Puehler A., Strauch E., Wohlleben W.
      J. Bacteriol. 172:5326-5334(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ES2.

    Entry informationi

    Entry nameiGLNA2_STRVR
    AccessioniPrimary (citable) accession number: P19432
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Overexpression of Streptomyces viridochromogenes glutamine synthetase confers resistance against the antibiotic phosphinathricyl-alenyl-alanine.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3