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Protein

Troponin I, cardiac muscle

Gene

TNNI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei80 – 801Involved in TNI-TNT interactions
Sitei97 – 971Involved in TNI-TNT interactions

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi137 – 14812By similarityAdd
BLAST

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • calcium channel inhibitor activity Source: UniProtKB
  • calcium-dependent protein binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein domain specific binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • troponin C binding Source: UniProtKB
  • troponin T binding Source: UniProtKB

GO - Biological processi

  • cardiac muscle contraction Source: UniProtKB
  • cellular calcium ion homeostasis Source: UniProtKB
  • heart contraction Source: UniProtKB
  • heart development Source: UniProtKB
  • muscle filament sliding Source: Reactome
  • negative regulation of ATPase activity Source: UniProtKB
  • regulation of cardiac conduction Source: Reactome
  • regulation of smooth muscle contraction Source: Ensembl
  • regulation of systemic arterial blood pressure by ischemic conditions Source: UniProtKB
  • skeletal muscle contraction Source: GO_Central
  • vasculogenesis Source: UniProtKB
  • ventricular cardiac muscle tissue morphogenesis Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-390522. Striated Muscle Contraction.
R-HSA-5578775. Ion homeostasis.
SIGNORiP19429.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, cardiac muscle
Alternative name(s):
Cardiac troponin I
Gene namesi
Name:TNNI3
Synonyms:TNNC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:11947. TNNI3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • sarcomere Source: BHF-UCL
  • troponin complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Cardiomyopathy, familial hypertrophic 7 (CMH7)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:613690
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821P → S in CMH7. 1 Publication
Corresponds to variant rs77615401 [ dbSNP | Ensembl ].
VAR_016078
Natural varianti141 – 1411R → Q in CMH7. 1 Publication
Corresponds to variant rs397516347 [ dbSNP | Ensembl ].
VAR_019872
Natural varianti145 – 1451R → G in CMH7. 1 Publication
Corresponds to variant rs104894724 [ dbSNP | Ensembl ].
VAR_007603
Natural varianti157 – 1571A → V in CMH7. 1 Publication
Corresponds to variant rs397516353 [ dbSNP | Ensembl ].
VAR_019873
Natural varianti162 – 1621R → P in CMH7. 2 Publications
Corresponds to variant rs397516354 [ dbSNP | Ensembl ].
VAR_019874
Natural varianti162 – 1621R → Q in CMH7. 1 Publication
Corresponds to variant rs397516354 [ dbSNP | Ensembl ].
VAR_042745
Natural varianti166 – 1661S → F in CMH7. 1 Publication
Corresponds to variant rs727504242 [ dbSNP | Ensembl ].
VAR_029454
Natural varianti177 – 1771Missing in CMH7. 1 Publication
VAR_019875
Natural varianti186 – 1861R → Q in CMH7. 1 Publication
Corresponds to variant rs397516357 [ dbSNP | Ensembl ].
VAR_019876
Natural varianti190 – 1901D → H in CMH7 and RCM1. 1 Publication
VAR_016083
Natural varianti196 – 1961D → N in CMH7. 2 Publications
Corresponds to variant rs104894727 [ dbSNP | Ensembl ].
VAR_016085
Natural varianti204 – 2041R → H in CMH7. 1 Publication
Corresponds to variant rs727504275 [ dbSNP | Ensembl ].
VAR_042746
Natural varianti206 – 2061K → Q in CMH7. 1 Publication
Corresponds to variant rs104894725 [ dbSNP | Ensembl ].
VAR_007604
Cardiomyopathy, familial restrictive 1 (RCM1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
See also OMIM:115210
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti144 – 1441L → Q in RCM1. 1 Publication
Corresponds to variant rs121917760 [ dbSNP | Ensembl ].
VAR_016079
Natural varianti145 – 1451R → W in RCM1. 1 Publication
Corresponds to variant rs28934871 [ dbSNP | Ensembl ].
VAR_016080
Natural varianti171 – 1711A → T in RCM1. 1 Publication
Corresponds to variant rs121917761 [ dbSNP | Ensembl ].
VAR_016081
Natural varianti178 – 1781K → E in RCM1. 1 Publication
Corresponds to variant rs28934870 [ dbSNP | Ensembl ].
VAR_016082
Natural varianti190 – 1901D → H in CMH7 and RCM1. 1 Publication
VAR_016083
Natural varianti192 – 1921R → H in RCM1. 1 Publication
Corresponds to variant rs104894729 [ dbSNP | Ensembl ].
VAR_016084
Cardiomyopathy, dilated 2A (CMD2A)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:611880
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21A → V in CMD2A. 1 Publication
Corresponds to variant rs397516359 [ dbSNP | Ensembl ].
VAR_043989
Cardiomyopathy, dilated 1FF (CMD1FF)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:613286
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361K → Q in CMD1FF. 1 Publication
Corresponds to variant rs267607130 [ dbSNP | Ensembl ].
VAR_063548
Natural varianti116 – 1161A → G in CMD1FF. 1 Publication
Corresponds to variant rs777177571 [ dbSNP | Ensembl ].
VAR_067264
Natural varianti185 – 1851N → K in CMD1FF. 1 Publication
Corresponds to variant rs267607129 [ dbSNP | Ensembl ].
VAR_063549

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

MalaCardsiTNNI3.
MIMi115210. phenotype.
611880. phenotype.
613286. phenotype.
613690. phenotype.
Orphaneti154. Familial isolated dilated cardiomyopathy.
155. Familial isolated hypertrophic cardiomyopathy.
75249. Familial isolated restrictive cardiomyopathy.
PharmGKBiPA36636.

Chemistry

ChEMBLiCHEMBL2095202.

Polymorphism and mutation databases

BioMutaiTNNI3.
DMDMi136213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 210209Troponin I, cardiac musclePRO_0000186151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei5 – 51Phosphoserine1 Publication
Modified residuei6 – 61Phosphoserine1 Publication
Modified residuei23 – 231Phosphoserine; by PKA and PKD/PRKD14 Publications
Modified residuei24 – 241Phosphoserine; by PKA and PKD/PRKD14 Publications
Modified residuei26 – 261Phosphotyrosine1 Publication
Modified residuei31 – 311Phosphothreonine; by STK4/MST11 Publication
Modified residuei42 – 421Phosphoserine; by PKC/PRKCEBy similarity
Modified residuei44 – 441Phosphoserine; by PKC/PRKCEBy similarity
Modified residuei51 – 511Phosphothreonine; by STK4/MST12 Publications
Modified residuei77 – 771Phosphoserine1 Publication
Modified residuei78 – 781Phosphothreonine1 Publication
Modified residuei129 – 1291Phosphothreonine; by STK4/MST11 Publication
Modified residuei143 – 1431Phosphothreonine; by STK4/MST12 Publications
Modified residuei150 – 1501Phosphoserine; by PAK31 Publication
Modified residuei166 – 1661Phosphoserine1 Publication
Modified residuei181 – 1811Phosphothreonine1 Publication
Modified residuei199 – 1991Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity). Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).By similarity6 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP19429.
PeptideAtlasiP19429.
PRIDEiP19429.

PTM databases

iPTMnetiP19429.
PhosphoSiteiP19429.

Expressioni

Gene expression databases

BgeeiENSG00000129991.
CleanExiHS_TNNC1.
HS_TNNI3.
ExpressionAtlasiP19429. baseline and differential.
GenevisibleiP19429. HS.

Organism-specific databases

HPAiCAB009349.
HPA046428.
HPA063258.

Interactioni

Subunit structurei

Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PDE4DIPQ5VU43-114EBI-704146,EBI-10769071
RCAN3Q9UKA8-13EBI-704146,EBI-10762111
RCAN3Q9UKA8-42EBI-704146,EBI-10762136
TNNI3KQ59H182EBI-704146,EBI-704142
TNNI3KQ59H18-22EBI-704146,EBI-10762055

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • calcium-dependent protein binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • troponin C binding Source: UniProtKB
  • troponin T binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112991. 15 interactions.
DIPiDIP-34065N.
IntActiP19429. 16 interactions.
MINTiMINT-2801556.
STRINGi9606.ENSP00000341838.

Structurei

Secondary structure

1
210
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi43 – 7937Combined sources
Helixi85 – 873Combined sources
Helixi90 – 13647Combined sources
Helixi151 – 1599Combined sources
Helixi160 – 1623Combined sources
Helixi163 – 18826Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J1DX-ray2.61C/F31-163[»]
1J1EX-ray3.30C/F31-210[»]
1LXFNMR-I148-164[»]
1MXLNMR-I148-164[»]
1OZSNMR-B129-148[»]
2KGBNMR-I145-164[»]
2KRDNMR-I148-164[»]
2L1RNMR-B145-164[»]
2MZPNMR-I145-171[»]
4Y99X-ray2.00C1-210[»]
DisProtiDP00166.
ProteinModelPortaliP19429.
SMRiP19429. Positions 35-191.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19429.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 7948Involved in binding TNCAdd
BLAST
Regioni129 – 14921Involved in binding TNC and actinAdd
BLAST

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiKOG3977. Eukaryota.
ENOG410Y9IX. LUCA.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP19429.
KOiK12044.
OMAiCRQLHTR.
OrthoDBiEOG091G0NOD.
PhylomeDBiP19429.
TreeFamiTF313374.

Family and domain databases

InterProiIPR001978. Troponin.
IPR021666. Troponin-I_N.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
PF11636. Troponin-I_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGSSDAAR EPRPAPAPIR RRSSNYRAYA TEPHAKKKSK ISASRKLQLK
60 70 80 90 100
TLLLQIAKQE LEREAEERRG EKGRALSTRC QPLELAGLGF AELQDLCRQL
110 120 130 140 150
HARVDKVDEE RYDIEAKVTK NITEIADLTQ KIFDLRGKFK RPTLRRVRIS
160 170 180 190 200
ADAMMQALLG ARAKESLDLR AHLKQVKKED TEKENREVGD WRKNIDALSG
210
MEGRKKKFES
Length:210
Mass (Da):24,008
Last modified:January 23, 2007 - v3
Checksum:i20A804F8C24AE1B0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21A → V in CMD2A. 1 Publication
Corresponds to variant rs397516359 [ dbSNP | Ensembl ].
VAR_043989
Natural varianti36 – 361K → Q in CMD1FF. 1 Publication
Corresponds to variant rs267607130 [ dbSNP | Ensembl ].
VAR_063548
Natural varianti79 – 791R → C.
Corresponds to variant rs3729712 [ dbSNP | Ensembl ].
VAR_029453
Natural varianti82 – 821P → S in CMH7. 1 Publication
Corresponds to variant rs77615401 [ dbSNP | Ensembl ].
VAR_016078
Natural varianti116 – 1161A → G in CMD1FF. 1 Publication
Corresponds to variant rs777177571 [ dbSNP | Ensembl ].
VAR_067264
Natural varianti141 – 1411R → Q in CMH7. 1 Publication
Corresponds to variant rs397516347 [ dbSNP | Ensembl ].
VAR_019872
Natural varianti144 – 1441L → Q in RCM1. 1 Publication
Corresponds to variant rs121917760 [ dbSNP | Ensembl ].
VAR_016079
Natural varianti145 – 1451R → G in CMH7. 1 Publication
Corresponds to variant rs104894724 [ dbSNP | Ensembl ].
VAR_007603
Natural varianti145 – 1451R → W in RCM1. 1 Publication
Corresponds to variant rs28934871 [ dbSNP | Ensembl ].
VAR_016080
Natural varianti157 – 1571A → V in CMH7. 1 Publication
Corresponds to variant rs397516353 [ dbSNP | Ensembl ].
VAR_019873
Natural varianti162 – 1621R → P in CMH7. 2 Publications
Corresponds to variant rs397516354 [ dbSNP | Ensembl ].
VAR_019874
Natural varianti162 – 1621R → Q in CMH7. 1 Publication
Corresponds to variant rs397516354 [ dbSNP | Ensembl ].
VAR_042745
Natural varianti166 – 1661S → F in CMH7. 1 Publication
Corresponds to variant rs727504242 [ dbSNP | Ensembl ].
VAR_029454
Natural varianti171 – 1711A → T in RCM1. 1 Publication
Corresponds to variant rs121917761 [ dbSNP | Ensembl ].
VAR_016081
Natural varianti177 – 1771Missing in CMH7. 1 Publication
VAR_019875
Natural varianti178 – 1781K → E in RCM1. 1 Publication
Corresponds to variant rs28934870 [ dbSNP | Ensembl ].
VAR_016082
Natural varianti185 – 1851N → K in CMD1FF. 1 Publication
Corresponds to variant rs267607129 [ dbSNP | Ensembl ].
VAR_063549
Natural varianti186 – 1861R → Q in CMH7. 1 Publication
Corresponds to variant rs397516357 [ dbSNP | Ensembl ].
VAR_019876
Natural varianti190 – 1901D → H in CMH7 and RCM1. 1 Publication
VAR_016083
Natural varianti192 – 1921R → H in RCM1. 1 Publication
Corresponds to variant rs104894729 [ dbSNP | Ensembl ].
VAR_016084
Natural varianti196 – 1961D → N in CMH7. 2 Publications
Corresponds to variant rs104894727 [ dbSNP | Ensembl ].
VAR_016085
Natural varianti204 – 2041R → H in CMH7. 1 Publication
Corresponds to variant rs727504275 [ dbSNP | Ensembl ].
VAR_042746
Natural varianti206 – 2061K → Q in CMH7. 1 Publication
Corresponds to variant rs104894725 [ dbSNP | Ensembl ].
VAR_007604

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54163 mRNA. Translation: CAA38102.1.
M64247 mRNA. Translation: AAA16157.1.
X90780 Genomic DNA. Translation: CAA62301.1.
CCDSiCCDS42628.1.
PIRiA61229. TPHUIC.
RefSeqiNP_000354.4. NM_000363.4.
UniGeneiHs.709179.

Genome annotation databases

EnsembliENST00000344887; ENSP00000341838; ENSG00000129991.
GeneIDi7137.
KEGGihsa:7137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54163 mRNA. Translation: CAA38102.1.
M64247 mRNA. Translation: AAA16157.1.
X90780 Genomic DNA. Translation: CAA62301.1.
CCDSiCCDS42628.1.
PIRiA61229. TPHUIC.
RefSeqiNP_000354.4. NM_000363.4.
UniGeneiHs.709179.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J1DX-ray2.61C/F31-163[»]
1J1EX-ray3.30C/F31-210[»]
1LXFNMR-I148-164[»]
1MXLNMR-I148-164[»]
1OZSNMR-B129-148[»]
2KGBNMR-I145-164[»]
2KRDNMR-I148-164[»]
2L1RNMR-B145-164[»]
2MZPNMR-I145-171[»]
4Y99X-ray2.00C1-210[»]
DisProtiDP00166.
ProteinModelPortaliP19429.
SMRiP19429. Positions 35-191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112991. 15 interactions.
DIPiDIP-34065N.
IntActiP19429. 16 interactions.
MINTiMINT-2801556.
STRINGi9606.ENSP00000341838.

Chemistry

ChEMBLiCHEMBL2095202.

PTM databases

iPTMnetiP19429.
PhosphoSiteiP19429.

Polymorphism and mutation databases

BioMutaiTNNI3.
DMDMi136213.

Proteomic databases

PaxDbiP19429.
PeptideAtlasiP19429.
PRIDEiP19429.

Protocols and materials databases

DNASUi7137.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344887; ENSP00000341838; ENSG00000129991.
GeneIDi7137.
KEGGihsa:7137.

Organism-specific databases

CTDi7137.
GeneCardsiTNNI3.
GeneReviewsiTNNI3.
HGNCiHGNC:11947. TNNI3.
HPAiCAB009349.
HPA046428.
HPA063258.
MalaCardsiTNNI3.
MIMi115210. phenotype.
191044. gene.
611880. phenotype.
613286. phenotype.
613690. phenotype.
neXtProtiNX_P19429.
Orphaneti154. Familial isolated dilated cardiomyopathy.
155. Familial isolated hypertrophic cardiomyopathy.
75249. Familial isolated restrictive cardiomyopathy.
PharmGKBiPA36636.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3977. Eukaryota.
ENOG410Y9IX. LUCA.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP19429.
KOiK12044.
OMAiCRQLHTR.
OrthoDBiEOG091G0NOD.
PhylomeDBiP19429.
TreeFamiTF313374.

Enzyme and pathway databases

ReactomeiR-HSA-390522. Striated Muscle Contraction.
R-HSA-5578775. Ion homeostasis.
SIGNORiP19429.

Miscellaneous databases

ChiTaRSiTNNI3. human.
EvolutionaryTraceiP19429.
GeneWikiiTNNI3.
GenomeRNAii7137.
PROiP19429.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129991.
CleanExiHS_TNNC1.
HS_TNNI3.
ExpressionAtlasiP19429. baseline and differential.
GenevisibleiP19429. HS.

Family and domain databases

InterProiIPR001978. Troponin.
IPR021666. Troponin-I_N.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
PF11636. Troponin-I_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNI3_HUMAN
AccessioniPrimary (citable) accession number: P19429
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 169 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.