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P19404

- NDUV2_HUMAN

UniProt

P19404 - NDUV2_HUMAN

Protein

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Gene

NDUFV2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 162 (01 Oct 2014)
      Sequence version 2 (02 May 2002)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 2Fe-2S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi135 – 1351Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi140 – 1401Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi176 – 1761Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi180 – 1801Iron-sulfur (2Fe-2S)Sequence Analysis

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. electron carrier activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

    GO - Biological processi

    1. cardiac muscle tissue development Source: UniProtKB
    2. cellular metabolic process Source: Reactome
    3. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
    4. nervous system development Source: UniProtKB
    5. respiratory electron transport chain Source: Reactome
    6. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    NADH-ubiquinone oxidoreductase 24 kDa subunit
    Gene namesi
    Name:NDUFV2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:7717. NDUFV2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Reactome
    2. mitochondrial respiratory chain complex I Source: UniProtKB
    3. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti2609. Isolated NADH-CoQ reductase deficiency.
    PharmGKBiPA31527.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3232MitochondrionAdd
    BLAST
    Chaini33 – 249217NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialPRO_0000020003Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611N6-acetyllysineBy similarity
    Modified residuei193 – 1931Phosphotyrosine; by SRC1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP19404.
    PaxDbiP19404.
    PRIDEiP19404.

    2D gel databases

    SWISS-2DPAGEP19404.
    UCD-2DPAGEP19404.

    PTM databases

    PhosphoSiteiP19404.

    Expressioni

    Gene expression databases

    BgeeiP19404.
    CleanExiHS_NDUFV2.
    GenevestigatoriP19404.

    Organism-specific databases

    HPAiHPA003404.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.1 Publication

    Protein-protein interaction databases

    BioGridi110807. 30 interactions.
    IntActiP19404. 8 interactions.
    MINTiMINT-4991740.
    STRINGi9606.ENSP00000327268.

    Structurei

    3D structure databases

    ProteinModelPortaliP19404.
    SMRiP19404. Positions 63-212.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 24 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1905.
    HOGENOMiHOG000257748.
    HOVERGENiHBG029601.
    KOiK03943.
    PhylomeDBiP19404.
    TreeFamiTF300004.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR002023. NuoE-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR10371. PTHR10371. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
    PROSITEiPS01099. COMPLEX1_24K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19404-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFFSAALRAR AAGLTAHWGR HVRNLHKTVM QNGAGGALFV HRDTPENNPD    50
    TPFDFTPENY KRIEAIVKNY PEGHKAAAVL PVLDLAQRQN GWLPISAMNK 100
    VAEVLQVPPM RVYEVATFYT MYNRKPVGKY HIQVCTTTPC MLRNSDSILE 150
    AIQKKLGIKV GETTPDKLFT LIEVECLGAC VNAPMVQIND NYYEDLTAKD 200
    IEEIIDELKA GKIPKPGPRS GRFSCEPAGG LTSLTEPPKG PGFGVQAGL 249
    Length:249
    Mass (Da):27,392
    Last modified:May 2, 2002 - v2
    Checksum:iAAF46ABB0908B177
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291V → A.1 Publication
    Corresponds to variant rs906807 [ dbSNP | Ensembl ].
    VAR_016167

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22538 mRNA. Translation: AAA75390.1.
    BC001632 mRNA. Translation: AAH01632.1.
    BC017487 mRNA. Translation: AAH17487.1.
    CCDSiCCDS11842.1.
    PIRiA30113.
    RefSeqiNP_066552.2. NM_021074.4.
    UniGeneiHs.464572.

    Genome annotation databases

    EnsembliENST00000318388; ENSP00000327268; ENSG00000178127.
    GeneIDi4729.
    KEGGihsa:4729.
    UCSCiuc002knu.3. human.

    Polymorphism databases

    DMDMi20455499.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22538 mRNA. Translation: AAA75390.1 .
    BC001632 mRNA. Translation: AAH01632.1 .
    BC017487 mRNA. Translation: AAH17487.1 .
    CCDSi CCDS11842.1.
    PIRi A30113.
    RefSeqi NP_066552.2. NM_021074.4.
    UniGenei Hs.464572.

    3D structure databases

    ProteinModelPortali P19404.
    SMRi P19404. Positions 63-212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110807. 30 interactions.
    IntActi P19404. 8 interactions.
    MINTi MINT-4991740.
    STRINGi 9606.ENSP00000327268.

    Chemistry

    ChEMBLi CHEMBL2363065.
    DrugBanki DB00157. NADH.

    PTM databases

    PhosphoSitei P19404.

    Polymorphism databases

    DMDMi 20455499.

    2D gel databases

    SWISS-2DPAGE P19404.
    UCD-2DPAGE P19404.

    Proteomic databases

    MaxQBi P19404.
    PaxDbi P19404.
    PRIDEi P19404.

    Protocols and materials databases

    DNASUi 4729.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318388 ; ENSP00000327268 ; ENSG00000178127 .
    GeneIDi 4729.
    KEGGi hsa:4729.
    UCSCi uc002knu.3. human.

    Organism-specific databases

    CTDi 4729.
    GeneCardsi GC18P009092.
    HGNCi HGNC:7717. NDUFV2.
    HPAi HPA003404.
    MIMi 600532. gene.
    neXtProti NX_P19404.
    Orphaneti 2609. Isolated NADH-CoQ reductase deficiency.
    PharmGKBi PA31527.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1905.
    HOGENOMi HOG000257748.
    HOVERGENi HBG029601.
    KOi K03943.
    PhylomeDBi P19404.
    TreeFami TF300004.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    ChiTaRSi NDUFV2. human.
    GeneWikii NDUFV2.
    GenomeRNAii 4729.
    NextBioi 18234.
    PROi P19404.
    SOURCEi Search...

    Gene expression databases

    Bgeei P19404.
    CleanExi HS_NDUFV2.
    Genevestigatori P19404.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR002023. NuoE-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR10371. PTHR10371. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01958. nuoE_fam. 1 hit.
    PROSITEi PS01099. COMPLEX1_24K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mitochondrial NADH-ubiquinone reductase: complementary DNA sequences of import precursors of the bovine and human 24-kDa subunit."
      Pilkington S.J., Walker J.E.
      Biochemistry 28:3257-3264(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-29.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
      Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
      J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components."
      Ogura M., Yamaki J., Homma M.K., Homma Y.
      Biochem. J. 447:281-289(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-193.

    Entry informationi

    Entry nameiNDUV2_HUMAN
    AccessioniPrimary (citable) accession number: P19404
    Secondary accession number(s): Q9BV41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 162 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3