Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P19404

- NDUV2_HUMAN

UniProt

P19404 - NDUV2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Gene

NDUFV2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 2Fe-2S cluster.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi135 – 1351Iron-sulfur (2Fe-2S)Sequence Analysis
Metal bindingi140 – 1401Iron-sulfur (2Fe-2S)Sequence Analysis
Metal bindingi176 – 1761Iron-sulfur (2Fe-2S)Sequence Analysis
Metal bindingi180 – 1801Iron-sulfur (2Fe-2S)Sequence Analysis

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. electron carrier activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  1. cardiac muscle tissue development Source: UniProtKB
  2. cellular metabolic process Source: Reactome
  3. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  4. nervous system development Source: UniProtKB
  5. respiratory electron transport chain Source: Reactome
  6. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH-ubiquinone oxidoreductase 24 kDa subunit
Gene namesi
Name:NDUFV2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:7717. NDUFV2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial respiratory chain complex I Source: UniProtKB
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti2609. Isolated NADH-CoQ reductase deficiency.
PharmGKBiPA31527.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232MitochondrionAdd
BLAST
Chaini33 – 249217NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialPRO_0000020003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611N6-acetyllysineBy similarity
Modified residuei193 – 1931Phosphotyrosine; by SRC1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP19404.
PaxDbiP19404.
PRIDEiP19404.

2D gel databases

SWISS-2DPAGEP19404.
UCD-2DPAGEP19404.

PTM databases

PhosphoSiteiP19404.

Expressioni

Gene expression databases

BgeeiP19404.
CleanExiHS_NDUFV2.
ExpressionAtlasiP19404. baseline.
GenevestigatoriP19404.

Organism-specific databases

HPAiHPA003404.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.1 Publication

Protein-protein interaction databases

BioGridi110807. 32 interactions.
IntActiP19404. 8 interactions.
MINTiMINT-4991740.
STRINGi9606.ENSP00000327268.

Structurei

3D structure databases

ProteinModelPortaliP19404.
SMRiP19404. Positions 63-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 24 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1905.
GeneTreeiENSGT00390000017580.
HOGENOMiHOG000257748.
HOVERGENiHBG029601.
InParanoidiP19404.
KOiK03943.
PhylomeDBiP19404.
TreeFamiTF300004.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10371. PTHR10371. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
PROSITEiPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19404-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFFSAALRAR AAGLTAHWGR HVRNLHKTVM QNGAGGALFV HRDTPENNPD
60 70 80 90 100
TPFDFTPENY KRIEAIVKNY PEGHKAAAVL PVLDLAQRQN GWLPISAMNK
110 120 130 140 150
VAEVLQVPPM RVYEVATFYT MYNRKPVGKY HIQVCTTTPC MLRNSDSILE
160 170 180 190 200
AIQKKLGIKV GETTPDKLFT LIEVECLGAC VNAPMVQIND NYYEDLTAKD
210 220 230 240
IEEIIDELKA GKIPKPGPRS GRFSCEPAGG LTSLTEPPKG PGFGVQAGL
Length:249
Mass (Da):27,392
Last modified:May 2, 2002 - v2
Checksum:iAAF46ABB0908B177
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291V → A.1 Publication
Corresponds to variant rs906807 [ dbSNP | Ensembl ].
VAR_016167

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22538 mRNA. Translation: AAA75390.1.
BC001632 mRNA. Translation: AAH01632.1.
BC017487 mRNA. Translation: AAH17487.1.
CCDSiCCDS11842.1.
PIRiA30113.
RefSeqiNP_066552.2. NM_021074.4.
UniGeneiHs.464572.

Genome annotation databases

EnsembliENST00000318388; ENSP00000327268; ENSG00000178127.
GeneIDi4729.
KEGGihsa:4729.
UCSCiuc002knu.3. human.

Polymorphism databases

DMDMi20455499.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22538 mRNA. Translation: AAA75390.1 .
BC001632 mRNA. Translation: AAH01632.1 .
BC017487 mRNA. Translation: AAH17487.1 .
CCDSi CCDS11842.1.
PIRi A30113.
RefSeqi NP_066552.2. NM_021074.4.
UniGenei Hs.464572.

3D structure databases

ProteinModelPortali P19404.
SMRi P19404. Positions 63-212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110807. 32 interactions.
IntActi P19404. 8 interactions.
MINTi MINT-4991740.
STRINGi 9606.ENSP00000327268.

Chemistry

ChEMBLi CHEMBL2363065.

PTM databases

PhosphoSitei P19404.

Polymorphism databases

DMDMi 20455499.

2D gel databases

SWISS-2DPAGE P19404.
UCD-2DPAGE P19404.

Proteomic databases

MaxQBi P19404.
PaxDbi P19404.
PRIDEi P19404.

Protocols and materials databases

DNASUi 4729.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318388 ; ENSP00000327268 ; ENSG00000178127 .
GeneIDi 4729.
KEGGi hsa:4729.
UCSCi uc002knu.3. human.

Organism-specific databases

CTDi 4729.
GeneCardsi GC18P009092.
HGNCi HGNC:7717. NDUFV2.
HPAi HPA003404.
MIMi 600532. gene.
neXtProti NX_P19404.
Orphaneti 2609. Isolated NADH-CoQ reductase deficiency.
PharmGKBi PA31527.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1905.
GeneTreei ENSGT00390000017580.
HOGENOMi HOG000257748.
HOVERGENi HBG029601.
InParanoidi P19404.
KOi K03943.
PhylomeDBi P19404.
TreeFami TF300004.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSi NDUFV2. human.
GeneWikii NDUFV2.
GenomeRNAii 4729.
NextBioi 18234.
PROi P19404.
SOURCEi Search...

Gene expression databases

Bgeei P19404.
CleanExi HS_NDUFV2.
ExpressionAtlasi P19404. baseline.
Genevestigatori P19404.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR10371. PTHR10371. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01958. nuoE_fam. 1 hit.
PROSITEi PS01099. COMPLEX1_24K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mitochondrial NADH-ubiquinone reductase: complementary DNA sequences of import precursors of the bovine and human 24-kDa subunit."
    Pilkington S.J., Walker J.E.
    Biochemistry 28:3257-3264(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-29.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
    Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
    J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components."
    Ogura M., Yamaki J., Homma M.K., Homma Y.
    Biochem. J. 447:281-289(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-193.

Entry informationi

Entry nameiNDUV2_HUMAN
AccessioniPrimary (citable) accession number: P19404
Secondary accession number(s): Q9BV41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: May 2, 2002
Last modified: October 29, 2014
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3