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Protein

Pro-opiomelanocortin

Gene

POMC

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 10 chains:
Alternative name(s):
Gamma-MSH
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Alpha-MSH
Alternative name(s):
Beta-LPH
Alternative name(s):
Gamma-LPH
Alternative name(s):
Beta-MSH
Gene namesi
Name:POMC
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Peptidei27 – 9771NPPPRO_0000024955Add
BLAST
Peptidei77 – 8711Melanotropin gammaPRO_0000024956Add
BLAST
Propeptidei100 – 12223PRO_0000024957Add
BLAST
Peptidei125 – 16339CorticotropinPRO_0000024958Add
BLAST
Peptidei125 – 13713Melanotropin alphaPRO_0000024959Add
BLAST
Peptidei143 – 16321Corticotropin-like intermediary peptidePRO_0000024960Add
BLAST
Peptidei166 – 25691Lipotropin betaPRO_0000024961Add
BLAST
Peptidei166 – 22358Lipotropin gammaPRO_0000024962Add
BLAST
Peptidei206 – 22318Melanotropin betaPRO_0000024963Add
BLAST
Peptidei226 – 25631Beta-endorphinPRO_0000024964Add
BLAST
Peptidei226 – 2305Met-enkephalinPRO_0000024965

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 50By similarity
Glycosylationi71 – 711O-linked (GalNAc...)By similarity
Modified residuei87 – 871Phenylalanine amideBy similarity
Glycosylationi91 – 911N-linked (GlcNAc...)By similarity
Modified residuei125 – 1251N-acetylserine; in CorticotropinBy similarity
Modified residuei137 – 1371Valine amide
Modified residuei155 – 1551PhosphoserineBy similarity

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

ACTH and MSH are produced by the pituitary gland.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000020054.

Family & Domainsi

Sequence similaritiesi

Belongs to the POMC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKR5. Eukaryota.
ENOG410Z5R4. LUCA.
HOGENOMiHOG000111887.
HOVERGENiHBG004341.
InParanoidiP19402.

Family and domain databases

InterProiIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamiPF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSiPR00383. MELANOCORTIN.
SMARTiSM01363. ACTH_domain. 2 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19402-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSCYSRSG TLLLALLLQI SMEVRGWCLE SSQCQDLTTE RHLLECLRAC
60 70 80 90 100
KPDLSAETPV FPGGADEQTP TESPRKYVTG HFRWGRFGRG NSSGASQKRE
110 120 130 140 150
EEAAAADPGF HGDGVEPGLR EDKRSYSMEH FRWGKPVGKK RRPVKVYANG
160 170 180 190 200
AEEESAEAFP LEFKRELTGE RPAAAPGPDG LGFGLVAEAE AEAAAAEKKD
210 220 230 240 250
AAEKKDDGSY RMEHFRWGTP RKGKRYGGFM TSEKSQTPLV TLFKNAIVKN

AHKKGQ
Length:256
Mass (Da):28,264
Last modified:October 1, 1996 - v2
Checksum:i02619BE7C0A0DA54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78260 mRNA. Translation: AAB20814.2.
PIRiA54322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78260 mRNA. Translation: AAB20814.2.
PIRiA54322.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000020054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IKR5. Eukaryota.
ENOG410Z5R4. LUCA.
HOGENOMiHOG000111887.
HOVERGENiHBG004341.
InParanoidiP19402.

Family and domain databases

InterProiIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamiPF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSiPR00383. MELANOCORTIN.
SMARTiSM01363. ACTH_domain. 2 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequencing of a guinea-pig pro-opiomelanocortin cDNA."
    Keightley M.C., Funder J.W., Fuller P.J.
    Mol. Cell. Endocrinol. 82:89-98(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  2. "Isolation, amino acid sequence and action of guinea-pig ACTH on aldosterone production by glomerulosa cells."
    Smith A.I., Wallace C.A., Moritz R.L., Simpson R.J., Schmauk-White L.B., Woodcock E.A., Funder J.W.
    J. Endocrinol. 115:R5-R8(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 125-163.

Entry informationi

Entry nameiCOLI_CAVPO
AccessioniPrimary (citable) accession number: P19402
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.