SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P19397

- CD53_HUMAN

UniProt

P19397 - CD53_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Leukocyte surface antigen CD53
Gene
CD53, MOX44, TSPAN25
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells By similarity.

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. positive regulation of myoblast fusion Source: UniProtKB
  2. signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiP19397.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte surface antigen CD53
Alternative name(s):
Cell surface glycoprotein CD53
Tetraspanin-25
Short name:
Tspan-25
CD_antigen: CD53
Gene namesi
Name:CD53
Synonyms:MOX44, TSPAN25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1686. CD53.

Subcellular locationi

Cell membrane By similarity. Cell junction By similarity. Membrane; Multi-pass membrane protein
Note: Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1110Cytoplasmic Reviewed prediction
Transmembranei12 – 3221Helical; Reviewed prediction
Add
BLAST
Topological domaini33 – 5422Extracellular Reviewed prediction
Add
BLAST
Transmembranei55 – 6915Helical; Reviewed prediction
Add
BLAST
Topological domaini70 – 8011Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei81 – 10626Helical; Reviewed prediction
Add
BLAST
Topological domaini107 – 18175Extracellular Reviewed prediction
Add
BLAST
Transmembranei182 – 20625Helical; Reviewed prediction
Add
BLAST
Topological domaini207 – 21913Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. cell-cell junction Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. immunological synapse Source: UniProtKB
  5. integral component of membrane Source: UniProtKB-KW
  6. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 219218Leukocyte surface antigen CD53
PRO_0000219212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi129 – 1291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi148 – 1481N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP19397.
PaxDbiP19397.
PRIDEiP19397.

Expressioni

Tissue specificityi

B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.

Gene expression databases

ArrayExpressiP19397.
BgeeiP19397.
CleanExiHS_CD53.
GenevestigatoriP19397.

Organism-specific databases

HPAiHPA047216.

Interactioni

Subunit structurei

Interacts with SCIMP.1 Publication

Protein-protein interaction databases

BioGridi107401. 6 interactions.
IntActiP19397. 1 interaction.
MINTiMINT-4656188.
STRINGi9606.ENSP00000271324.

Structurei

3D structure databases

ProteinModelPortaliP19397.
SMRiP19397. Positions 109-173.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265641.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP19397.
KOiK06489.
OMAiVCVIQVL.
OrthoDBiEOG7PGDRZ.
PhylomeDBiP19397.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19397-1 [UniParc]FASTAAdd to Basket

« Hide

MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL    50
TLGNVFVIVG SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA 100
ILLFVYEQKL NEYVAKGLTD SIHRYHSDNS TKAAWDSIQS FLQCCGINGT 150
SDWTSGPPAS CPSDRKVEGC YAKARLWFHS NFLYIGIITI CVCVIEVLGM 200
SFALTLNCQI DKTSQTIGL 219
Length:219
Mass (Da):24,341
Last modified:November 1, 1990 - v1
Checksum:i48D4633DBC9110B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37033 mRNA. Translation: AAA35663.1.
M60871 mRNA. Translation: AAA51951.1.
BT019643 mRNA. Translation: AAV38449.1.
AK313582 mRNA. Translation: BAG36352.1.
AL391064 Genomic DNA. Translation: CAH73292.1.
CH471122 Genomic DNA. Translation: EAW56459.1.
BC040693 mRNA. Translation: AAH40693.1.
CCDSiCCDS829.1.
PIRiA37243.
RefSeqiNP_000551.1. NM_000560.3.
NP_001035122.1. NM_001040033.1.
UniGeneiHs.443057.

Genome annotation databases

EnsembliENST00000271324; ENSP00000271324; ENSG00000143119.
GeneIDi963.
KEGGihsa:963.
UCSCiuc001dzw.3. human.

Polymorphism databases

DMDMi116019.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37033 mRNA. Translation: AAA35663.1 .
M60871 mRNA. Translation: AAA51951.1 .
BT019643 mRNA. Translation: AAV38449.1 .
AK313582 mRNA. Translation: BAG36352.1 .
AL391064 Genomic DNA. Translation: CAH73292.1 .
CH471122 Genomic DNA. Translation: EAW56459.1 .
BC040693 mRNA. Translation: AAH40693.1 .
CCDSi CCDS829.1.
PIRi A37243.
RefSeqi NP_000551.1. NM_000560.3.
NP_001035122.1. NM_001040033.1.
UniGenei Hs.443057.

3D structure databases

ProteinModelPortali P19397.
SMRi P19397. Positions 109-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107401. 6 interactions.
IntActi P19397. 1 interaction.
MINTi MINT-4656188.
STRINGi 9606.ENSP00000271324.

Polymorphism databases

DMDMi 116019.

Proteomic databases

MaxQBi P19397.
PaxDbi P19397.
PRIDEi P19397.

Protocols and materials databases

DNASUi 963.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000271324 ; ENSP00000271324 ; ENSG00000143119 .
GeneIDi 963.
KEGGi hsa:963.
UCSCi uc001dzw.3. human.

Organism-specific databases

CTDi 963.
GeneCardsi GC01P111413.
HGNCi HGNC:1686. CD53.
HPAi HPA047216.
MIMi 151525. gene.
neXtProti NX_P19397.
PharmGKBi PA26225.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265641.
HOGENOMi HOG000230651.
HOVERGENi HBG002324.
InParanoidi P19397.
KOi K06489.
OMAi VCVIQVL.
OrthoDBi EOG7PGDRZ.
PhylomeDBi P19397.
TreeFami TF352892.

Enzyme and pathway databases

SignaLinki P19397.

Miscellaneous databases

GeneWikii CD53.
GenomeRNAii 963.
NextBioi 4024.
PROi P19397.
SOURCEi Search...

Gene expression databases

ArrayExpressi P19397.
Bgeei P19397.
CleanExi HS_CD53.
Genevestigatori P19397.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens."
    Angelisova P., Vlcek C., Stefanova I., Lipoldova M., Horejsi V.
    Immunogenetics 32:281-285(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte antigen related to membrane transport proteins."
    Amiot M.
    J. Immunol. 145:4322-4325(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  8. "SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling."
    Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M., Skopcova T., Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A., Brdicka T.
    Mol. Cell. Biol. 31:4550-4562(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCIMP.

Entry informationi

Entry nameiCD53_HUMAN
AccessioniPrimary (citable) accession number: P19397
Secondary accession number(s): B2R905, Q5U0D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi