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Protein

Leukocyte surface antigen CD53

Gene

CD53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).By similarity

GO - Biological processi

  • positive regulation of myoblast fusion Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiP19397.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte surface antigen CD53
Alternative name(s):
Cell surface glycoprotein CD53
Tetraspanin-25
Short name:
Tspan-25
CD_antigen: CD53
Gene namesi
Name:CD53
Synonyms:MOX44, TSPAN25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1686. CD53.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Topological domaini33 – 5422ExtracellularSequence AnalysisAdd
BLAST
Transmembranei55 – 6915HelicalSequence AnalysisAdd
BLAST
Topological domaini70 – 8011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei81 – 10626HelicalSequence AnalysisAdd
BLAST
Topological domaini107 – 18175ExtracellularSequence AnalysisAdd
BLAST
Transmembranei182 – 20625HelicalSequence AnalysisAdd
BLAST
Topological domaini207 – 21913CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell-cell junction Source: UniProtKB
  • cell surface Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • immunological synapse Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26225.

Polymorphism and mutation databases

BioMutaiCD53.
DMDMi116019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Leukocyte surface antigen CD53PRO_0000219212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP19397.
PaxDbiP19397.
PRIDEiP19397.

Expressioni

Tissue specificityi

B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.

Gene expression databases

BgeeiP19397.
CleanExiHS_CD53.
GenevestigatoriP19397.

Organism-specific databases

HPAiHPA047216.

Interactioni

Subunit structurei

Interacts with SCIMP.1 Publication

Protein-protein interaction databases

BioGridi107401. 6 interactions.
IntActiP19397. 1 interaction.
MINTiMINT-4656188.
STRINGi9606.ENSP00000271324.

Structurei

3D structure databases

ProteinModelPortaliP19397.
SMRiP19397. Positions 109-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265641.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP19397.
KOiK06489.
OMAiVCVIQVL.
OrthoDBiEOG7PGDRZ.
PhylomeDBiP19397.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL
60 70 80 90 100
TLGNVFVIVG SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA
110 120 130 140 150
ILLFVYEQKL NEYVAKGLTD SIHRYHSDNS TKAAWDSIQS FLQCCGINGT
160 170 180 190 200
SDWTSGPPAS CPSDRKVEGC YAKARLWFHS NFLYIGIITI CVCVIEVLGM
210
SFALTLNCQI DKTSQTIGL
Length:219
Mass (Da):24,341
Last modified:November 1, 1990 - v1
Checksum:i48D4633DBC9110B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37033 mRNA. Translation: AAA35663.1.
M60871 mRNA. Translation: AAA51951.1.
BT019643 mRNA. Translation: AAV38449.1.
AK313582 mRNA. Translation: BAG36352.1.
AL391064 Genomic DNA. Translation: CAH73292.1.
CH471122 Genomic DNA. Translation: EAW56459.1.
BC040693 mRNA. Translation: AAH40693.1.
CCDSiCCDS829.1.
PIRiA37243.
RefSeqiNP_000551.1. NM_000560.3.
NP_001035122.1. NM_001040033.1.
UniGeneiHs.443057.

Genome annotation databases

EnsembliENST00000271324; ENSP00000271324; ENSG00000143119.
GeneIDi963.
KEGGihsa:963.
UCSCiuc001dzw.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37033 mRNA. Translation: AAA35663.1.
M60871 mRNA. Translation: AAA51951.1.
BT019643 mRNA. Translation: AAV38449.1.
AK313582 mRNA. Translation: BAG36352.1.
AL391064 Genomic DNA. Translation: CAH73292.1.
CH471122 Genomic DNA. Translation: EAW56459.1.
BC040693 mRNA. Translation: AAH40693.1.
CCDSiCCDS829.1.
PIRiA37243.
RefSeqiNP_000551.1. NM_000560.3.
NP_001035122.1. NM_001040033.1.
UniGeneiHs.443057.

3D structure databases

ProteinModelPortaliP19397.
SMRiP19397. Positions 109-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107401. 6 interactions.
IntActiP19397. 1 interaction.
MINTiMINT-4656188.
STRINGi9606.ENSP00000271324.

Polymorphism and mutation databases

BioMutaiCD53.
DMDMi116019.

Proteomic databases

MaxQBiP19397.
PaxDbiP19397.
PRIDEiP19397.

Protocols and materials databases

DNASUi963.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271324; ENSP00000271324; ENSG00000143119.
GeneIDi963.
KEGGihsa:963.
UCSCiuc001dzw.3. human.

Organism-specific databases

CTDi963.
GeneCardsiGC01P111413.
HGNCiHGNC:1686. CD53.
HPAiHPA047216.
MIMi151525. gene.
neXtProtiNX_P19397.
PharmGKBiPA26225.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG265641.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP19397.
KOiK06489.
OMAiVCVIQVL.
OrthoDBiEOG7PGDRZ.
PhylomeDBiP19397.
TreeFamiTF352892.

Enzyme and pathway databases

SignaLinkiP19397.

Miscellaneous databases

GeneWikiiCD53.
GenomeRNAii963.
NextBioi4024.
PROiP19397.
SOURCEiSearch...

Gene expression databases

BgeeiP19397.
CleanExiHS_CD53.
GenevestigatoriP19397.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens."
    Angelisova P., Vlcek C., Stefanova I., Lipoldova M., Horejsi V.
    Immunogenetics 32:281-285(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte antigen related to membrane transport proteins."
    Amiot M.
    J. Immunol. 145:4322-4325(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  8. "SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling."
    Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M., Skopcova T., Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A., Brdicka T.
    Mol. Cell. Biol. 31:4550-4562(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCIMP.

Entry informationi

Entry nameiCD53_HUMAN
AccessioniPrimary (citable) accession number: P19397
Secondary accession number(s): B2R905, Q5U0D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 27, 2015
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.