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Reviewed, UniProtKB/Swiss-Prot P19397 (CD53_HUMAN)

Last modified June 16, 2009. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Leukocyte surface antigen CD53
Alternative name(s):
    Cell surface glycoprotein CD53
    Tetraspanin-25
      Short name=Tspan-25
    CD_antigen=CD53
Gene names
Name: CD53
Synonyms: MOX44, TSPAN25
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May be involved in growth regulation in hematopoietic cells.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

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Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processsignal transduction

Non-traceable author statement. Source: ProtInc

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Leukocyte surface antigen CD53
PRO_0000219212

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 3221 Potential
Topological domain33 – 5422Extracellular Potential
Transmembrane55 – 6915 Potential
Topological domain70 – 8011Cytoplasmic Potential
Transmembrane81 – 10626 Potential
Topological domain107 – 18175Extracellular Potential
Transmembrane182 – 20625 Potential
Topological domain207 – 21913Cytoplasmic Potential

Amino acid modifications

Glycosylation1291N-linked (GlcNAc...) Potential
Glycosylation1481N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
P19397-1 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 48D4633DBC9110B6

FASTA21924,341
        10         20         30         40         50         60 
MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL TLGNVFVIVG 

        70         80         90        100        110        120 
SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA ILLFVYEQKL NEYVAKGLTD 

       130        140        150        160        170        180 
SIHRYHSDNS TKAAWDSIQS FLQCCGINGT SDWTSGPPAS CPSDRKVEGC YAKARLWFHS 

       190        200        210 
NFLYIGIITI CVCVIEVLGM SFALTLNCQI DKTSQTIGL

« Hide

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References

« Hide 'large scale' references
[1]"The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens."
Angelisova P., Vlcek C., Stefanova I., Lipoldova M., Horejsi V.
Immunogenetics 32:281-285(1990) [PubMed: 1700763] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte antigen related to membrane transport proteins."
Amiot M.
J. Immunol. 145:4322-4325(1990) [PubMed: 2258620] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
+Additional computationally mapped references.

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Cross-references

Sequence databases

M37033 mRNA. Translation: AAA35663.1.
M60871 mRNA. Translation: AAA51951.1.
BT019643 mRNA. Translation: AAV38449.1.
AL391064 Genomic DNA. Translation: CAH73292.1.
BC040693 mRNA. Translation: AAH40693.1.
IPIIPI00018307.
PIRA37243.
RefSeqNP_000551.1.
NP_001035122.1.
UniGeneHs.443057

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEP19397.

Genome annotation databases

EnsemblENSG00000143119. Homo sapiens. [Contig view]
GeneID963.
KEGGhsa:963.

Organism-specific databases

GeneCardsGC01P111127.
H-InvDBHIX0023631.
HGNCHGNC:1686. CD53.
MIM151525. gene.
PharmGKBPA26225.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP19397.
HOVERGENP19397.
OMAP19397. VIQVLGM.

Gene expression databases

ArrayExpressP19397.
BgeeP19397.
CleanExHS_CD53.
GermOnlineENSG00000143119. Homo sapiens.

Family and domain databases

InterProIPR018499. Tetraspanin.
IPR018503. Tetraspanin_CS.
IPR000301. Tetraspanin_sub.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSPR00259. TMFOUR.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio4024.
SOURCESearch...

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Entry information

Entry nameCD53_HUMAN
AccessionPrimary (citable) accession number: P19397
Secondary accession number(s): Q5U0D6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 16, 2009
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents