Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leukocyte surface antigen CD53

Gene

CD53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143119-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
SignaLinkiP19397.

Protein family/group databases

TCDBi8.A.40.1.18. the tetraspanin (tetraspanin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte surface antigen CD53
Alternative name(s):
Cell surface glycoprotein CD53
Tetraspanin-25
Short name:
Tspan-25
CD_antigen: CD53
Gene namesi
Name:CD53
Synonyms:MOX44, TSPAN25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1686. CD53.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 11CytoplasmicSequence analysis10
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 54ExtracellularSequence analysisAdd BLAST22
Transmembranei55 – 69HelicalSequence analysisAdd BLAST15
Topological domaini70 – 80CytoplasmicSequence analysisAdd BLAST11
Transmembranei81 – 106HelicalSequence analysisAdd BLAST26
Topological domaini107 – 181ExtracellularSequence analysisAdd BLAST75
Transmembranei182 – 206HelicalSequence analysisAdd BLAST25
Topological domaini207 – 219CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • cell-cell junction Source: UniProtKB
  • cell surface Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • immunological synapse Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi963.
OpenTargetsiENSG00000143119.
PharmGKBiPA26225.

Polymorphism and mutation databases

BioMutaiCD53.
DMDMi116019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002192122 – 219Leukocyte surface antigen CD53Add BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP19397.
PaxDbiP19397.
PeptideAtlasiP19397.
PRIDEiP19397.

PTM databases

SwissPalmiP19397.

Expressioni

Tissue specificityi

B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.

Gene expression databases

BgeeiENSG00000143119.
CleanExiHS_CD53.
GenevisibleiP19397. HS.

Organism-specific databases

HPAiHPA047216.

Interactioni

Subunit structurei

Interacts with SCIMP.1 Publication

Protein-protein interaction databases

BioGridi107401. 6 interactors.
IntActiP19397. 2 interactors.
MINTiMINT-4656188.
STRINGi9606.ENSP00000271324.

Structurei

3D structure databases

ProteinModelPortaliP19397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP19397.
KOiK06489.
OMAiAKLWFHS.
OrthoDBiEOG091G0CQO.
PhylomeDBiP19397.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL
60 70 80 90 100
TLGNVFVIVG SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA
110 120 130 140 150
ILLFVYEQKL NEYVAKGLTD SIHRYHSDNS TKAAWDSIQS FLQCCGINGT
160 170 180 190 200
SDWTSGPPAS CPSDRKVEGC YAKARLWFHS NFLYIGIITI CVCVIEVLGM
210
SFALTLNCQI DKTSQTIGL
Length:219
Mass (Da):24,341
Last modified:November 1, 1990 - v1
Checksum:i48D4633DBC9110B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37033 mRNA. Translation: AAA35663.1.
M60871 mRNA. Translation: AAA51951.1.
BT019643 mRNA. Translation: AAV38449.1.
AK313582 mRNA. Translation: BAG36352.1.
AL391064 Genomic DNA. Translation: CAH73292.1.
CH471122 Genomic DNA. Translation: EAW56459.1.
BC040693 mRNA. Translation: AAH40693.1.
CCDSiCCDS829.1.
PIRiA37243.
RefSeqiNP_000551.1. NM_000560.3.
NP_001035122.1. NM_001040033.1.
UniGeneiHs.443057.

Genome annotation databases

EnsembliENST00000271324; ENSP00000271324; ENSG00000143119.
GeneIDi963.
KEGGihsa:963.
UCSCiuc001dzx.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37033 mRNA. Translation: AAA35663.1.
M60871 mRNA. Translation: AAA51951.1.
BT019643 mRNA. Translation: AAV38449.1.
AK313582 mRNA. Translation: BAG36352.1.
AL391064 Genomic DNA. Translation: CAH73292.1.
CH471122 Genomic DNA. Translation: EAW56459.1.
BC040693 mRNA. Translation: AAH40693.1.
CCDSiCCDS829.1.
PIRiA37243.
RefSeqiNP_000551.1. NM_000560.3.
NP_001035122.1. NM_001040033.1.
UniGeneiHs.443057.

3D structure databases

ProteinModelPortaliP19397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107401. 6 interactors.
IntActiP19397. 2 interactors.
MINTiMINT-4656188.
STRINGi9606.ENSP00000271324.

Protein family/group databases

TCDBi8.A.40.1.18. the tetraspanin (tetraspanin) family.

PTM databases

SwissPalmiP19397.

Polymorphism and mutation databases

BioMutaiCD53.
DMDMi116019.

Proteomic databases

MaxQBiP19397.
PaxDbiP19397.
PeptideAtlasiP19397.
PRIDEiP19397.

Protocols and materials databases

DNASUi963.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271324; ENSP00000271324; ENSG00000143119.
GeneIDi963.
KEGGihsa:963.
UCSCiuc001dzx.4. human.

Organism-specific databases

CTDi963.
DisGeNETi963.
GeneCardsiCD53.
HGNCiHGNC:1686. CD53.
HPAiHPA047216.
MIMi151525. gene.
neXtProtiNX_P19397.
OpenTargetsiENSG00000143119.
PharmGKBiPA26225.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP19397.
KOiK06489.
OMAiAKLWFHS.
OrthoDBiEOG091G0CQO.
PhylomeDBiP19397.
TreeFamiTF352892.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143119-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
SignaLinkiP19397.

Miscellaneous databases

GeneWikiiCD53.
GenomeRNAii963.
PROiP19397.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143119.
CleanExiHS_CD53.
GenevisibleiP19397. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD53_HUMAN
AccessioniPrimary (citable) accession number: P19397
Secondary accession number(s): B2R905, Q5U0D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.