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P19397

- CD53_HUMAN

UniProt

P19397 - CD53_HUMAN

Protein

Leukocyte surface antigen CD53

Gene

CD53

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. positive regulation of myoblast fusion Source: UniProtKB
    2. signal transduction Source: ProtInc

    Enzyme and pathway databases

    SignaLinkiP19397.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukocyte surface antigen CD53
    Alternative name(s):
    Cell surface glycoprotein CD53
    Tetraspanin-25
    Short name:
    Tspan-25
    CD_antigen: CD53
    Gene namesi
    Name:CD53
    Synonyms:MOX44, TSPAN25
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:1686. CD53.

    Subcellular locationi

    Cell membrane By similarity. Cell junction By similarity. Membrane; Multi-pass membrane protein
    Note: Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.By similarity

    GO - Cellular componenti

    1. cell-cell junction Source: UniProtKB
    2. cell surface Source: Ensembl
    3. extracellular vesicular exosome Source: UniProt
    4. immunological synapse Source: UniProtKB
    5. integral component of membrane Source: UniProtKB-KW
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26225.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 219218Leukocyte surface antigen CD53PRO_0000219212Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP19397.
    PaxDbiP19397.
    PRIDEiP19397.

    Expressioni

    Tissue specificityi

    B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.

    Gene expression databases

    ArrayExpressiP19397.
    BgeeiP19397.
    CleanExiHS_CD53.
    GenevestigatoriP19397.

    Organism-specific databases

    HPAiHPA047216.

    Interactioni

    Subunit structurei

    Interacts with SCIMP.1 Publication

    Protein-protein interaction databases

    BioGridi107401. 6 interactions.
    IntActiP19397. 1 interaction.
    MINTiMINT-4656188.
    STRINGi9606.ENSP00000271324.

    Structurei

    3D structure databases

    ProteinModelPortaliP19397.
    SMRiP19397. Positions 109-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1110CytoplasmicSequence Analysis
    Topological domaini33 – 5422ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini70 – 8011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 18175ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini207 – 21913CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei55 – 6915HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10626HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20625HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG265641.
    HOGENOMiHOG000230651.
    HOVERGENiHBG002324.
    InParanoidiP19397.
    KOiK06489.
    OMAiVCVIQVL.
    OrthoDBiEOG7PGDRZ.
    PhylomeDBiP19397.
    TreeFamiTF352892.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19397-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL    50
    TLGNVFVIVG SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA 100
    ILLFVYEQKL NEYVAKGLTD SIHRYHSDNS TKAAWDSIQS FLQCCGINGT 150
    SDWTSGPPAS CPSDRKVEGC YAKARLWFHS NFLYIGIITI CVCVIEVLGM 200
    SFALTLNCQI DKTSQTIGL 219
    Length:219
    Mass (Da):24,341
    Last modified:November 1, 1990 - v1
    Checksum:i48D4633DBC9110B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37033 mRNA. Translation: AAA35663.1.
    M60871 mRNA. Translation: AAA51951.1.
    BT019643 mRNA. Translation: AAV38449.1.
    AK313582 mRNA. Translation: BAG36352.1.
    AL391064 Genomic DNA. Translation: CAH73292.1.
    CH471122 Genomic DNA. Translation: EAW56459.1.
    BC040693 mRNA. Translation: AAH40693.1.
    CCDSiCCDS829.1.
    PIRiA37243.
    RefSeqiNP_000551.1. NM_000560.3.
    NP_001035122.1. NM_001040033.1.
    UniGeneiHs.443057.

    Genome annotation databases

    EnsembliENST00000271324; ENSP00000271324; ENSG00000143119.
    GeneIDi963.
    KEGGihsa:963.
    UCSCiuc001dzw.3. human.

    Polymorphism databases

    DMDMi116019.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37033 mRNA. Translation: AAA35663.1 .
    M60871 mRNA. Translation: AAA51951.1 .
    BT019643 mRNA. Translation: AAV38449.1 .
    AK313582 mRNA. Translation: BAG36352.1 .
    AL391064 Genomic DNA. Translation: CAH73292.1 .
    CH471122 Genomic DNA. Translation: EAW56459.1 .
    BC040693 mRNA. Translation: AAH40693.1 .
    CCDSi CCDS829.1.
    PIRi A37243.
    RefSeqi NP_000551.1. NM_000560.3.
    NP_001035122.1. NM_001040033.1.
    UniGenei Hs.443057.

    3D structure databases

    ProteinModelPortali P19397.
    SMRi P19397. Positions 109-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107401. 6 interactions.
    IntActi P19397. 1 interaction.
    MINTi MINT-4656188.
    STRINGi 9606.ENSP00000271324.

    Polymorphism databases

    DMDMi 116019.

    Proteomic databases

    MaxQBi P19397.
    PaxDbi P19397.
    PRIDEi P19397.

    Protocols and materials databases

    DNASUi 963.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271324 ; ENSP00000271324 ; ENSG00000143119 .
    GeneIDi 963.
    KEGGi hsa:963.
    UCSCi uc001dzw.3. human.

    Organism-specific databases

    CTDi 963.
    GeneCardsi GC01P111413.
    HGNCi HGNC:1686. CD53.
    HPAi HPA047216.
    MIMi 151525. gene.
    neXtProti NX_P19397.
    PharmGKBi PA26225.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265641.
    HOGENOMi HOG000230651.
    HOVERGENi HBG002324.
    InParanoidi P19397.
    KOi K06489.
    OMAi VCVIQVL.
    OrthoDBi EOG7PGDRZ.
    PhylomeDBi P19397.
    TreeFami TF352892.

    Enzyme and pathway databases

    SignaLinki P19397.

    Miscellaneous databases

    GeneWikii CD53.
    GenomeRNAii 963.
    NextBioi 4024.
    PROi P19397.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P19397.
    Bgeei P19397.
    CleanExi HS_CD53.
    Genevestigatori P19397.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens."
      Angelisova P., Vlcek C., Stefanova I., Lipoldova M., Horejsi V.
      Immunogenetics 32:281-285(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte antigen related to membrane transport proteins."
      Amiot M.
      J. Immunol. 145:4322-4325(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.
    8. "SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling."
      Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M., Skopcova T., Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A., Brdicka T.
      Mol. Cell. Biol. 31:4550-4562(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SCIMP.

    Entry informationi

    Entry nameiCD53_HUMAN
    AccessioniPrimary (citable) accession number: P19397
    Secondary accession number(s): B2R905, Q5U0D6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3