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Protein

Leukocyte surface antigen CD53

Gene

CD53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
SignaLinkiP19397

Protein family/group databases

TCDBi8.A.40.1.18 the tetraspanin (tetraspanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte surface antigen CD53
Alternative name(s):
Cell surface glycoprotein CD53
Tetraspanin-25
Short name:
Tspan-25
CD_antigen: CD53
Gene namesi
Name:CD53
Synonyms:MOX44, TSPAN25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143119.12
HGNCiHGNC:1686 CD53
MIMi151525 gene
neXtProtiNX_P19397

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 54ExtracellularSequence analysisAdd BLAST22
Transmembranei55 – 69HelicalSequence analysisAdd BLAST15
Topological domaini70 – 80CytoplasmicSequence analysisAdd BLAST11
Transmembranei81 – 106HelicalSequence analysisAdd BLAST26
Topological domaini107 – 181ExtracellularSequence analysisAdd BLAST75
Transmembranei182 – 206HelicalSequence analysisAdd BLAST25
Topological domaini207 – 219CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi963
OpenTargetsiENSG00000143119
PharmGKBiPA26225

Polymorphism and mutation databases

BioMutaiCD53
DMDMi116019

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192121 – 219Leukocyte surface antigen CD53Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP19397
PaxDbiP19397
PeptideAtlasiP19397
PRIDEiP19397

PTM databases

SwissPalmiP19397

Expressioni

Tissue specificityi

B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.

Gene expression databases

BgeeiENSG00000143119
CleanExiHS_CD53
GenevisibleiP19397 HS

Organism-specific databases

HPAiHPA047216

Interactioni

Subunit structurei

Interacts with SCIMP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L13Q9BXK54EBI-6657396,EBI-747430

Protein-protein interaction databases

BioGridi10740126 interactors.
CORUMiP19397
IntActiP19397 8 interactors.
STRINGi9606.ENSP00000271324

Structurei

3D structure databases

ProteinModelPortaliP19397
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP19397
KOiK06489
OMAiVCVIQVL
OrthoDBiEOG091G0CQO
PhylomeDBiP19397
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.101 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

P19397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL
60 70 80 90 100
TLGNVFVIVG SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA
110 120 130 140 150
ILLFVYEQKL NEYVAKGLTD SIHRYHSDNS TKAAWDSIQS FLQCCGINGT
160 170 180 190 200
SDWTSGPPAS CPSDRKVEGC YAKARLWFHS NFLYIGIITI CVCVIEVLGM
210
SFALTLNCQI DKTSQTIGL
Length:219
Mass (Da):24,341
Last modified:November 1, 1990 - v1
Checksum:i48D4633DBC9110B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37033 mRNA Translation: AAA35663.1
M60871 mRNA Translation: AAA51951.1
BT019643 mRNA Translation: AAV38449.1
AK313582 mRNA Translation: BAG36352.1
AL391064 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56459.1
BC040693 mRNA Translation: AAH40693.1
CCDSiCCDS829.1
PIRiA37243
RefSeqiNP_000551.1, NM_000560.3
NP_001035122.1, NM_001040033.1
UniGeneiHs.443057

Genome annotation databases

EnsembliENST00000271324; ENSP00000271324; ENSG00000143119
GeneIDi963
KEGGihsa:963
UCSCiuc001dzx.4 human

Similar proteinsi

Entry informationi

Entry nameiCD53_HUMAN
AccessioniPrimary (citable) accession number: P19397
Secondary accession number(s): B2R905, Q5U0D6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: February 28, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome