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P19386 (LYS_BPCP9) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
CP-9 lysin
Endolysin
Muramidase
Gene names
Name:CPL9
OrganismStreptococcus phage Cp-9 (Bacteriophage Cp-9)
Taxonomic identifier10749 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaePicovirinaeunassigned Picovirinae
Virus hostStreptococcus pneumoniae [TaxID: 1313]

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for the separation of the host daughter cells at the end of cell division and participates in the liberation of progeny bacteriophage into the medium. Strictly depends on the presence of choline-containing cell walls for activity.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Domain

The C-terminal domain comprising the repeats is involved in choline binding By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 25 family.

Contains 6 cell wall-binding repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Lysozyme
PRO_0000208261

Regions

Repeat200 – 21920Cell wall-binding 1
Repeat220 – 23920Cell wall-binding 2
Repeat241 – 26020Cell wall-binding 3
Repeat261 – 28020Cell wall-binding 4
Repeat281 – 30020Cell wall-binding 5
Repeat303 – 32220Cell wall-binding 6

Sites

Active site101 By similarity
Active site941 By similarity

Sequences

Sequence LengthMass (Da)Tools
P19386 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: A2143F05BDED4EDD

FASTA33939,151
        10         20         30         40         50         60 
MVKKNDLFID VSSHNGYDIT GILEQMGTTN TIVKISESTT YLNPCLSAQV EQSTPIGFYH 

        70         80         90        100        110        120 
FARFGGDVAE AEREAQFFLD NVPTQVKYLV LDYEDDPSGN AQANTNACLR FMQMIADAGY 

       130        140        150        160        170        180 
TPIYYSYKPF TLDNVDYQQI LAQFPNSLWI AGYGLNDGNA DFEYFPSMDG IRWWQYSSNP 

       190        200        210        220        230        240 
FDKNIVLLDD EEDEKPKTAG TWKQDSKGWW FRRNNGSFPY NKWEKIGGVW YYFDSKGYCL 

       250        260        270        280        290        300 
TSEWLKDNEK WYYLKDNGAM VTGWVLVGSE WYYMDDSGAM VTGWVKYKNN WYYMTNERGN 

       310        320        330 
MVSNEFIKSG KGWYFMNTNG ELADNPSFTK EPDGLITVA 

« Hide

References

[1]"Modular organization of the lytic enzymes of Streptococcus pneumoniae and its bacteriophages."
Garcia P., Garcia J.L., Garcia E., Sanchez-Puelles J.M., Lopez R.
Gene 86:81-88(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M34780 Genomic DNA. Translation: AAA72845.1.
PIRMUBPC9. JQ0438.

3D structure databases

ProteinModelPortalP19386.
SMRP19386. Positions 2-339.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH25. Glycoside Hydrolase Family 25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR018337. Cell_wall/Cho-bd_repeat.
IPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF01473. CW_binding_1. 5 hits.
PF01183. Glyco_hydro_25. 1 hit.
[Graphical view]
SMARTSM00641. Glyco_25. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS51170. CW. 5 hits.
PS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYS_BPCP9
AccessionPrimary (citable) accession number: P19386
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 16, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries