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P19385 (LYS_BPCP7) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
CP-7 lysin
Endolysin
Muramidase
Gene names
Name:CPL7
OrganismStreptococcus phage Cp-7 (Bacteriophage Cp-7)
Taxonomic identifier10748 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaePicovirinaeunassigned Picovirinae
Virus hostStreptococcus pneumoniae [TaxID: 1313]

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for the separation of the host daughter cells at the end of cell division and participates in the liberation of progeny bacteriophage into the medium. Degrades cell walls containing either choline or ethanolamine.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Domain

The C-terminal domain could be responsible for the substrate recognition.

Sequence similarities

Belongs to the glycosyl hydrolase 25 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Lysozyme
PRO_0000208260

Regions

Repeat205 – 242381; truncated
Repeat243 – 290482
Repeat291 – 338483
Region205 – 3381343 X 48 AA tandem repeats

Sites

Active site101 By similarity
Active site941 By similarity

Sequences

Sequence LengthMass (Da)Tools
P19385 [UniParc].

Last modified September 5, 2012. Version 2.
Checksum: 6B1F431DD068CC52

FASTA34238,248
        10         20         30         40         50         60 
MVKKNDLFVD VASHQGYDIS GILEEAGTTN TIIKVSESTS YLNPCLSAQV SQSNPIGFYH 

        70         80         90        100        110        120 
FAWFGGNEEE AEAEARYFLD NVPTQVKYLV LDYEDHASAS VQRNTTACLR FMQIIAEAGY 

       130        140        150        160        170        180 
TPIYYSYKPF TLDNVDYQQI LAQFPNSLWI AGYGLNDGTA NFEYFPSMDG IRWWQYSSNP 

       190        200        210        220        230        240 
FDKNIVLLDD EKEDNINNEN TLKSLTTVAN EVIQGLWGNG QERYDSLANA GYDPQAVQDK 

       250        260        270        280        290        300 
VNEILNAREI ADLTTVANEV IQGLWGNGQE RYDSLANAGY DPQAVQDKVN EILNAREIAD 

       310        320        330        340 
LTTVANEVIQ GLWGNGQERY DSLANAGYDP QAVQDKVNEL LS 

« Hide

References

[1]"Modular organization of the lytic enzymes of Streptococcus pneumoniae and its bacteriophages."
Garcia P., Garcia J.L., Garcia E., Sanchez-Puelles J.M., Lopez R.
Gene 86:81-88(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Garcia P., Garcia J.L., Garcia E., Sanchez-Puelles J.M., Lopez R.
Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 63; 114; 230; 278 AND 326.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M34779 Genomic DNA. Translation: AAA72844.2.
PIRMUBPC7. JQ0437.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH25. Glycoside Hydrolase Family 25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR013168. Cpl_7_lyso_C.
IPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF08230. Cpl-7. 3 hits.
PF01183. Glyco_hydro_25. 1 hit.
[Graphical view]
SMARTSM01095. Cpl-7. 3 hits.
SM00641. Glyco_25. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYS_BPCP7
AccessionPrimary (citable) accession number: P19385
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: September 5, 2012
Last modified: October 16, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries