Reviewed, UniProtKB/Swiss-Prot P19377 (CD3D_RAT)

Names and origin

Protein names

Recommended name:
    T-cell surface glycoprotein CD3 delta chain
Alternative name(s):
    T-cell receptor T3 delta chain
    CD_antigen=CD3d

Gene names

Name:	Cd3d
Synonyms:	T3d

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The CD3 complex mediates signal transduction.
Subunit structure	The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 1 ITAM domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	cell surface receptor linked signal transduction Inferred from electronic annotation. Source: InterPro positive thymic T cell selection Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transmembrane receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21
	Chain	22 – 173	152	T-cell surface glycoprotein CD3 delta chain		PRO_0000016491
Regions
	Topological domain	22 – 106	85	Extracellular Potential
	Transmembrane	107 – 127	21	Potential
	Topological domain	128 – 173	46	Cytoplasmic Potential
	Domain	138 – 166	29	ITAM
Amino acid modifications
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	55	1	N-linked (GlcNAc...) Potential
	Glycosylation	74	1	N-linked (GlcNAc...) Potential
	Disulfide bond	37 ↔ 73		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P19377-1 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: C462DFF34E7FDB60	FASTA	173	19,356
	10 20 30 40 50 60 MEHYGILVSL LLATVLPQGS PFKIEVVEYE DKVFVNCNTS IRHLDGSVER WLTKNKSLIL 70 80 90 100 110 120 GKGILDPRGM YMCNGTEELA KEVSTVQVYY RMCQNCVELD SATLAGVIIT DLIATLLLAL 130 140 150 160 170 GVYCFAGHET GRLSGAVDTQ VLLKNEQLYQ PLRDRDDAQY SRLGGNWPRN KRS

References

[1]	"Nucleotide sequence of a cDNA encoding the rat T3 delta chain." Davies J.D., Mueller D., Wilson D.B., Gold D.P. Nucleic Acids Res. 18:4617-4617(1990) [PubMed: 2143819] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X53430 mRNA. Translation: CAA37521.1.
IPI	IPI00194403.
PIR	S10975.
RefSeq	NP_037301.1.
UniGene	Rn.10329
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P19377.
Genome annotation databases
Ensembl	ENSRNOT00000021488; ENSRNOP00000021489; ENSRNOG00000015994; Rattus norvegicus. [Genome view]
GeneID	25710.
KEGG	rno:25710.
UCSC	NM_013169. rat.
Organism-specific databases
CTD	25710.
RGD	2304. Cd3d.
Phylogenomic databases
HOVERGEN	P19377.
Gene expression databases
ArrayExpress	P19377.
Genevestigator	P19377.
GermOnline	ENSRNOG00000015994. Rattus norvegicus.
Family and domain databases
InterPro	IPR015485. CD3_delta. IPR015484. CD3_gsu/dsu. IPR013783. Ig-like_fold. IPR003110. Phos_immunorcpt_sig_ITAM. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PANTHER	PTHR10570:SF1. CD3_delta. 1 hit. PTHR10570. CD3_gamma_delta. 1 hit.
Pfam	PF02189. ITAM. 1 hit. [Graphical view]
SMART	SM00077. ITAM. 1 hit. [Graphical view]
PROSITE	PS51055. ITAM_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	607771.

Entry information

Entry name

CD3D_RAT

Accession

Primary (citable) accession number: P19377

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	October 13, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)