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Protein

T-cell surface glycoprotein CD3 delta chain

Gene

Cd3d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The CD3 complex mediates signal transduction.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-RNO-202424. Downstream TCR signaling.
R-RNO-202427. Phosphorylation of CD3 and TCR zeta chains.
R-RNO-202430. Translocation of ZAP-70 to Immunological synapse.
R-RNO-202433. Generation of second messenger molecules.
R-RNO-389948. PD-1 signaling.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD3 delta chain
Alternative name(s):
T-cell receptor T3 delta chain
CD_antigen: CD3d
Gene namesi
Name:Cd3d
Synonyms:T3d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2304. Cd3d.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 106ExtracellularSequence analysisAdd BLAST85
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 173CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001649122 – 173T-cell surface glycoprotein CD3 delta chainAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 73By similarity
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Modified residuei149PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei160PhosphotyrosinePROSITE-ProRule annotationBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP19377.
PRIDEiP19377.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015994.
GenevisibleiP19377. RN.

Interactioni

Subunit structurei

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021489.

Structurei

3D structure databases

ProteinModelPortaliP19377.
SMRiP19377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 166ITAMPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWAX. Eukaryota.
ENOG410Y2TD. LUCA.
GeneTreeiENSGT00510000046930.
HOGENOMiHOG000015287.
HOVERGENiHBG005278.
InParanoidiP19377.
KOiK06450.
OMAiMCQSCVE.
OrthoDBiEOG091G0U7X.
PhylomeDBiP19377.
TreeFamiTF335892.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR015485. CD3D.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR032052. Ig_4.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PTHR10570:SF5. PTHR10570:SF5. 1 hit.
PfamiPF16680. Ig_4. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHYGILVSL LLATVLPQGS PFKIEVVEYE DKVFVNCNTS IRHLDGSVER
60 70 80 90 100
WLTKNKSLIL GKGILDPRGM YMCNGTEELA KEVSTVQVYY RMCQNCVELD
110 120 130 140 150
SATLAGVIIT DLIATLLLAL GVYCFAGHET GRLSGAVDTQ VLLKNEQLYQ
160 170
PLRDRDDAQY SRLGGNWPRN KRS
Length:173
Mass (Da):19,356
Last modified:November 1, 1990 - v1
Checksum:iC462DFF34E7FDB60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53430 mRNA. Translation: CAA37521.1.
PIRiS10975.
RefSeqiNP_037301.1. NM_013169.1.
UniGeneiRn.10329.

Genome annotation databases

EnsembliENSRNOT00000021488; ENSRNOP00000021489; ENSRNOG00000015994.
GeneIDi25710.
KEGGirno:25710.
UCSCiRGD:2304. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53430 mRNA. Translation: CAA37521.1.
PIRiS10975.
RefSeqiNP_037301.1. NM_013169.1.
UniGeneiRn.10329.

3D structure databases

ProteinModelPortaliP19377.
SMRiP19377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021489.

Proteomic databases

PaxDbiP19377.
PRIDEiP19377.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021488; ENSRNOP00000021489; ENSRNOG00000015994.
GeneIDi25710.
KEGGirno:25710.
UCSCiRGD:2304. rat.

Organism-specific databases

CTDi915.
RGDi2304. Cd3d.

Phylogenomic databases

eggNOGiENOG410IWAX. Eukaryota.
ENOG410Y2TD. LUCA.
GeneTreeiENSGT00510000046930.
HOGENOMiHOG000015287.
HOVERGENiHBG005278.
InParanoidiP19377.
KOiK06450.
OMAiMCQSCVE.
OrthoDBiEOG091G0U7X.
PhylomeDBiP19377.
TreeFamiTF335892.

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-RNO-202424. Downstream TCR signaling.
R-RNO-202427. Phosphorylation of CD3 and TCR zeta chains.
R-RNO-202430. Translocation of ZAP-70 to Immunological synapse.
R-RNO-202433. Generation of second messenger molecules.
R-RNO-389948. PD-1 signaling.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiP19377.

Gene expression databases

BgeeiENSRNOG00000015994.
GenevisibleiP19377. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR015485. CD3D.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR032052. Ig_4.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PTHR10570:SF5. PTHR10570:SF5. 1 hit.
PfamiPF16680. Ig_4. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD3D_RAT
AccessioniPrimary (citable) accession number: P19377
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.