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Protein

T-cell surface glycoprotein CD3 delta chain

Gene

Cd3d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The CD3 complex mediates signal transduction.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-202424. Downstream TCR signaling.
R-RNO-202427. Phosphorylation of CD3 and TCR zeta chains.
R-RNO-202430. Translocation of ZAP-70 to Immunological synapse.
R-RNO-202433. Generation of second messenger molecules.
R-RNO-389948. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD3 delta chain
Alternative name(s):
T-cell receptor T3 delta chain
CD_antigen: CD3d
Gene namesi
Name:Cd3d
Synonyms:T3d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2304. Cd3d.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 10685ExtracellularSequence analysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence analysisAdd
BLAST
Topological domaini128 – 17346CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 173152T-cell surface glycoprotein CD3 delta chainPRO_0000016491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 73By similarity
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Modified residuei149 – 1491PhosphotyrosinePROSITE-ProRule annotationBy similarity
Modified residuei160 – 1601PhosphotyrosinePROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP19377.

Expressioni

Gene expression databases

GenevisibleiP19377. RN.

Interactioni

Subunit structurei

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021489.

Structurei

3D structure databases

ProteinModelPortaliP19377.
SMRiP19377. Positions 22-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 16629ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWAX. Eukaryota.
ENOG410Y2TD. LUCA.
GeneTreeiENSGT00510000046930.
HOGENOMiHOG000015287.
HOVERGENiHBG005278.
InParanoidiP19377.
KOiK06450.
OMAiMCQSCVE.
OrthoDBiEOG7S4X7Q.
PhylomeDBiP19377.
TreeFamiTF335892.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR015485. CD3D.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR032052. Ig_4.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PTHR10570:SF5. PTHR10570:SF5. 1 hit.
PfamiPF16680. Ig_4. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHYGILVSL LLATVLPQGS PFKIEVVEYE DKVFVNCNTS IRHLDGSVER
60 70 80 90 100
WLTKNKSLIL GKGILDPRGM YMCNGTEELA KEVSTVQVYY RMCQNCVELD
110 120 130 140 150
SATLAGVIIT DLIATLLLAL GVYCFAGHET GRLSGAVDTQ VLLKNEQLYQ
160 170
PLRDRDDAQY SRLGGNWPRN KRS
Length:173
Mass (Da):19,356
Last modified:November 1, 1990 - v1
Checksum:iC462DFF34E7FDB60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53430 mRNA. Translation: CAA37521.1.
PIRiS10975.
RefSeqiNP_037301.1. NM_013169.1.
UniGeneiRn.10329.

Genome annotation databases

EnsembliENSRNOT00000021488; ENSRNOP00000021489; ENSRNOG00000015994.
GeneIDi25710.
KEGGirno:25710.
UCSCiRGD:2304. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53430 mRNA. Translation: CAA37521.1.
PIRiS10975.
RefSeqiNP_037301.1. NM_013169.1.
UniGeneiRn.10329.

3D structure databases

ProteinModelPortaliP19377.
SMRiP19377. Positions 22-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021489.

Proteomic databases

PaxDbiP19377.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021488; ENSRNOP00000021489; ENSRNOG00000015994.
GeneIDi25710.
KEGGirno:25710.
UCSCiRGD:2304. rat.

Organism-specific databases

CTDi915.
RGDi2304. Cd3d.

Phylogenomic databases

eggNOGiENOG410IWAX. Eukaryota.
ENOG410Y2TD. LUCA.
GeneTreeiENSGT00510000046930.
HOGENOMiHOG000015287.
HOVERGENiHBG005278.
InParanoidiP19377.
KOiK06450.
OMAiMCQSCVE.
OrthoDBiEOG7S4X7Q.
PhylomeDBiP19377.
TreeFamiTF335892.

Enzyme and pathway databases

ReactomeiR-RNO-202424. Downstream TCR signaling.
R-RNO-202427. Phosphorylation of CD3 and TCR zeta chains.
R-RNO-202430. Translocation of ZAP-70 to Immunological synapse.
R-RNO-202433. Generation of second messenger molecules.
R-RNO-389948. PD-1 signaling.

Miscellaneous databases

NextBioi607771.
PROiP19377.

Gene expression databases

GenevisibleiP19377. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR015485. CD3D.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR032052. Ig_4.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PTHR10570:SF5. PTHR10570:SF5. 1 hit.
PfamiPF16680. Ig_4. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of a cDNA encoding the rat T3 delta chain."
    Davies J.D., Mueller D., Wilson D.B., Gold D.P.
    Nucleic Acids Res. 18:4617-4617(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiCD3D_RAT
AccessioniPrimary (citable) accession number: P19377
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: February 17, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.