Reviewed, UniProtKB/Swiss-Prot P19372 (ACP_RHIME)

Names and origin

Protein names

Recommended name:
    Acyl carrier protein acpP
      Short name=ACP

Gene names

Name:	acpP
Ordered Locus Names:	R01143
ORF Names:	SMc00573

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	78 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Carrier of the growing fatty acid chain in fatty acid biosynthesis. HAMAP MF_01217
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01217
Subcellular location	Cytoplasm By similarity.
Post-translational modification	4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group. HAMAP MF_01217
Sequence similarities	Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	Phosphopantetheine
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: HAMAP cofactor binding Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 78	77	Acyl carrier protein acpP HAMAP MF_01217		PRO_0000180176
Amino acid modifications
	Modified residue	37	1	O-(pantetheine 4'-phosphoryl)serine HAMAP MF_01217

Sequences

	Sequence		Length	Mass (Da)
	P19372-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 5B8EF6618C374760	FASTA	78	8,340
	10 20 30 40 50 60 MSDIAERVKK IVIDHLGVDA EKVSEGASFI DDLGADSLDT VELVMAFEEE FGVEIPDDAA 70 DSILTVGDAV KFIEKAQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression and purification of four different rhizobial acyl carrier proteins." Lopez-Lara I.M., Geiger O. Microbiology 146:839-849(2000) [PubMed: 10784042] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 1021.
[2]	"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.
[3]	"Isolation and characterization of the constitutive acyl carrier protein from Rhizobium meliloti." Platt M.K., Miller K.J., Lane W.S., Kennedy E.P. J. Bacteriol. 172:5440-5444(1990) [PubMed: 2144277] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-78. Strain: 1021.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF159244 Genomic DNA. Translation: AAF24181.1. AL591688 Genomic DNA. Translation: CAC45722.1.
PIR	A36728.
RefSeq	NP_385249.1.
3D structure databases
HSSP	HSSP built from PDB template 1ACP based on UniProtKB P02901.
ModBase	Search...
Genome annotation databases
GeneID	1232787.
GenomeReviews	Gene locus R01143 in contig AL591688_GR.
KEGG	sme:SMc00573.
NMPDR	fig|266834.1.peg.2437.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P19372.
OMA	VELIMEL.
Enzyme and pathway databases
BioCyc	SMEL266834:SMC00573-MON.
Family and domain databases
HAMAP	MF_01217. [Tree]
InterPro	IPR003231. Acyl_carrier. IPR009081. Acyl_carrier_prot-like. IPR006163. Phsphopanteth_bd. IPR006162. PPantetheine_attach_site. [Graphical view]
Pfam	PF00550. PP-binding. 1 hit. [Graphical view]
ProDom	PD000887. Acyl_carrier. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00517. acyl_carrier. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACP_RHIME

Accession

Primary (citable) accession number: P19372

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)