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Protein

Hexokinase-1

Gene

HK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Enzyme regulationi

Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30ATP 11
Binding sitei155Substrate 11
Binding sitei209Glucose-6-phosphate 12 Publications1
Binding sitei232Glucose-6-phosphate 12 Publications1
Binding sitei235Substrate 11
Binding sitei260Substrate 11
Binding sitei345ATP 11
Binding sitei449Glucose-6-phosphate 12 Publications1
Binding sitei657Glucose-6-phosphate 22 Publications1
Binding sitei680ATP 21
Binding sitei680Glucose-6-phosphate 22 Publications1
Binding sitei708Substrate 21
Binding sitei742Substrate 21
Binding sitei897Glucose-6-phosphate 22 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi84 – 89ATP 1Sequence analysis6
Nucleotide bindingi425 – 426ATP 12
Nucleotide bindingi532 – 537ATP 26
Nucleotide bindingi747 – 748ATP 22
Nucleotide bindingi784 – 788ATP 25
Nucleotide bindingi863 – 867ATP 25

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • fructokinase activity Source: GO_Central
  • glucokinase activity Source: GO_Central
  • glucose binding Source: InterPro
  • hexokinase activity Source: ProtInc
  • mannokinase activity Source: GO_Central

GO - Biological processi

  • canonical glycolysis Source: Reactome
  • cellular glucose homeostasis Source: GO_Central
  • establishment of protein localization to mitochondrion Source: ParkinsonsUK-UCL
  • glucose transport Source: Reactome
  • glycolytic process Source: ProtInc
  • maintenance of protein location in mitochondrion Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS08136-MONOMER.
ZFISH:HS08136-MONOMER.
BRENDAi2.7.1.1. 2681.
ReactomeiR-HSA-70153. Glucose transport.
R-HSA-70171. Glycolysis.
SABIO-RKP19367.
SIGNORiP19367.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-1 (EC:2.7.1.1)
Alternative name(s):
Brain form hexokinase
Hexokinase type I
Short name:
HK I
Gene namesi
Name:HK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:4922. HK1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • membrane raft Source: Ensembl
  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB
  • sperm principal piece Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Involvement in diseasei

Hexokinase deficiency (HK deficiency)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature.
See also OMIM:235700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009878529L → S in HK deficiency. 1 PublicationCorresponds to variant rs137853249dbSNPEnsembl.1
Natural variantiVAR_023780680T → S in HK deficiency; HK Utrecht. 1 PublicationCorresponds to variant rs398122379dbSNPEnsembl.1
Neuropathy, hereditary motor and sensory, Russe type (HMSNR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive progressive complex peripheral neuropathy characterized by onset in the first decade of distal lower limb weakness and muscle atrophy resulting in walking difficulties. Distal impairment of the upper limbs usually occurs later, as does proximal lower limb weakness. There is distal sensory impairment, with pes cavus and areflexia. Laboratory studies suggest that it is a myelinopathy resulting in reduced nerve conduction velocities in the demyelinating range as well as a length-dependent axonopathy.
See also OMIM:605285

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNETi3098.
MalaCardsiHK1.
MIMi235700. phenotype.
605285. phenotype.
OpenTargetsiENSG00000156515.
Orphaneti99953. Charcot-Marie-Tooth disease type 4G.
90031. Non-spherocytic hemolytic anemia due to hexokinase deficiency.
PharmGKBiPA29300.

Chemistry databases

ChEMBLiCHEMBL2688.

Polymorphism and mutation databases

BioMutaiHK1.
DMDMi116242516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975851 – 917Hexokinase-1Add BLAST917

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei337PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP19367.
MaxQBiP19367.
PaxDbiP19367.
PeptideAtlasiP19367.
PRIDEiP19367.

PTM databases

iPTMnetiP19367.
PhosphoSitePlusiP19367.
SwissPalmiP19367.

Expressioni

Tissue specificityi

Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific.

Gene expression databases

BgeeiENSG00000156515.
CleanExiHS_HK1.
ExpressionAtlasiP19367. baseline and differential.
GenevisibleiP19367. HS.

Organism-specific databases

HPAiCAB010052.
HPA007043.
HPA007044.

Interactioni

Subunit structurei

Monomer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with VDAC1. The HK1-VDAC1 complex interacts with ATF2. Interacts (via N-terminal spermatogenic cell-specific region) with PFKM (via C-terminus) (By similarity).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VDAC1P217962EBI-713162,EBI-354158

Protein-protein interaction databases

BioGridi109345. 48 interactors.
DIPiDIP-56245N.
IntActiP19367. 16 interactors.
MINTiMINT-1422832.
STRINGi9606.ENSP00000384774.

Chemistry databases

BindingDBiP19367.

Structurei

Secondary structure

1917
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 25Combined sources9
Helixi27 – 29Combined sources3
Helixi33 – 51Combined sources19
Turni53 – 55Combined sources3
Helixi56 – 58Combined sources3
Beta strandi78 – 100Combined sources23
Beta strandi103 – 112Combined sources10
Helixi116 – 119Combined sources4
Beta strandi120 – 122Combined sources3
Helixi123 – 141Combined sources19
Beta strandi144 – 146Combined sources3
Beta strandi150 – 154Combined sources5
Beta strandi161 – 164Combined sources4
Turni179 – 182Combined sources4
Helixi185 – 196Combined sources12
Beta strandi203 – 207Combined sources5
Helixi209 – 220Combined sources12
Beta strandi224 – 241Combined sources18
Helixi242 – 244Combined sources3
Beta strandi252 – 258Combined sources7
Helixi261 – 263Combined sources3
Turni264 – 273Combined sources10
Helixi276 – 283Combined sources8
Beta strandi285 – 287Combined sources3
Helixi294 – 297Combined sources4
Helixi299 – 315Combined sources17
Helixi320 – 322Combined sources3
Turni326 – 329Combined sources4
Helixi336 – 342Combined sources7
Turni345 – 347Combined sources3
Helixi348 – 358Combined sources11
Helixi365 – 401Combined sources37
Beta strandi404 – 413Combined sources10
Helixi415 – 419Combined sources5
Helixi423 – 434Combined sources12
Beta strandi438 – 444Combined sources7
Helixi449 – 475Combined sources27
Helixi481 – 499Combined sources19
Helixi501 – 504Combined sources4
Beta strandi526 – 546Combined sources21
Beta strandi548 – 550Combined sources3
Beta strandi552 – 560Combined sources9
Helixi564 – 567Combined sources4
Beta strandi568 – 570Combined sources3
Helixi571 – 589Combined sources19
Beta strandi597 – 602Combined sources6
Beta strandi606 – 610Combined sources5
Beta strandi613 – 616Combined sources4
Helixi633 – 644Combined sources12
Beta strandi650 – 655Combined sources6
Helixi657 – 666Combined sources10
Beta strandi672 – 689Combined sources18
Turni690 – 692Combined sources3
Beta strandi700 – 706Combined sources7
Helixi709 – 711Combined sources3
Turni712 – 715Combined sources4
Turni717 – 721Combined sources5
Helixi724 – 731Combined sources8
Turni734 – 737Combined sources4
Helixi742 – 744Combined sources3
Turni747 – 749Combined sources3
Helixi750 – 763Combined sources14
Helixi768 – 770Combined sources3
Turni774 – 777Combined sources4
Helixi784 – 790Combined sources7
Helixi797 – 807Combined sources11
Helixi813 – 848Combined sources36
Beta strandi852 – 861Combined sources10
Helixi863 – 867Combined sources5
Helixi871 – 882Combined sources12
Beta strandi886 – 892Combined sources7
Helixi898 – 912Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CZAX-ray1.90N1-917[»]
1DGKX-ray2.80N1-917[»]
1HKBX-ray2.80A/B1-917[»]
1HKCX-ray2.80A1-917[»]
1QHAX-ray2.25A/B1-917[»]
4F9OX-ray2.65A/B1-914[»]
4FOEX-ray2.70A/B1-917[»]
4FOIX-ray2.40A/B1-917[»]
4FPAX-ray2.48A/B1-917[»]
4FPBX-ray3.00A/B1-917[»]
ProteinModelPortaliP19367.
SMRiP19367.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19367.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 458Hexokinase 1PROSITE-ProRule annotationAdd BLAST443
Domaini464 – 906Hexokinase 2PROSITE-ProRule annotationAdd BLAST443

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 12HydrophobicAdd BLAST12
Regioni13 – 475RegulatoryAdd BLAST463
Regioni73 – 207Hexokinase small subdomain 1PROSITE-ProRule annotationAdd BLAST135
Regioni84 – 88Glucose-6-phosphate 1 binding5
Regioni172 – 173Substrate 1 binding2
Regioni208 – 447Hexokinase large subdomain 1PROSITE-ProRule annotationAdd BLAST240
Regioni208 – 209Substrate 1 binding2
Regioni291 – 294Substrate 1 binding4
Regioni413 – 415Glucose-6-phosphate 1 binding3
Regioni476 – 917CatalyticAdd BLAST442
Regioni521 – 655Hexokinase small subdomain 2PROSITE-ProRule annotationAdd BLAST135
Regioni532 – 536Glucose-6-phosphate 2 binding5
Regioni603 – 604Substrate 2 binding2
Regioni620 – 621Substrate 2 binding2
Regioni656 – 895Hexokinase large subdomain 2PROSITE-ProRule annotationAdd BLAST240
Regioni656 – 657Substrate 2 binding2
Regioni682 – 683Substrate 2 binding2
Regioni861 – 863Glucose-6-phosphate 2 binding3

Domaini

The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule.

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 2 hexokinase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
GeneTreeiENSGT00390000017159.
HOVERGENiHBG005020.
InParanoidiP19367.
KOiK00844.
OMAiHMESEIY.
PhylomeDBiP19367.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P19367-1) [UniParc]FASTAAdd to basket
Also known as: Common

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIAAQLLAYY FTELKDDQVK KIDKYLYAMR LSDETLIDIM TRFRKEMKNG
60 70 80 90 100
LSRDFNPTAT VKMLPTFVRS IPDGSEKGDF IALDLGGSSF RILRVQVNHE
110 120 130 140 150
KNQNVHMESE VYDTPENIVH GSGSQLFDHV AECLGDFMEK RKIKDKKLPV
160 170 180 190 200
GFTFSFPCQQ SKIDEAILIT WTKRFKASGV EGADVVKLLN KAIKKRGDYD
210 220 230 240 250
ANIVAVVNDT VGTMMTCGYD DQHCEVGLII GTGTNACYME ELRHIDLVEG
260 270 280 290 300
DEGRMCINTE WGAFGDDGSL EDIRTEFDRE IDRGSLNPGK QLFEKMVSGM
310 320 330 340 350
YLGELVRLIL VKMAKEGLLF EGRITPELLT RGKFNTSDVS AIEKNKEGLH
360 370 380 390 400
NAKEILTRLG VEPSDDDCVS VQHVCTIVSF RSANLVAATL GAILNRLRDN
410 420 430 440 450
KGTPRLRTTV GVDGSLYKTH PQYSRRFHKT LRRLVPDSDV RFLLSESGSG
460 470 480 490 500
KGAAMVTAVA YRLAEQHRQI EETLAHFHLT KDMLLEVKKR MRAEMELGLR
510 520 530 540 550
KQTHNNAVVK MLPSFVRRTP DGTENGDFLA LDLGGTNFRV LLVKIRSGKK
560 570 580 590 600
RTVEMHNKIY AIPIEIMQGT GEELFDHIVS CISDFLDYMG IKGPRMPLGF
610 620 630 640 650
TFSFPCQQTS LDAGILITWT KGFKATDCVG HDVVTLLRDA IKRREEFDLD
660 670 680 690 700
VVAVVNDTVG TMMTCAYEEP TCEVGLIVGT GSNACYMEEM KNVEMVEGDQ
710 720 730 740 750
GQMCINMEWG AFGDNGCLDD IRTHYDRLVD EYSLNAGKQR YEKMISGMYL
760 770 780 790 800
GEIVRNILID FTKKGFLFRG QISETLKTRG IFETKFLSQI ESDRLALLQV
810 820 830 840 850
RAILQQLGLN STCDDSILVK TVCGVVSRRA AQLCGAGMAA VVDKIRENRG
860 870 880 890 900
LDRLNVTVGV DGTLYKLHPH FSRIMHQTVK ELSPKCNVSF LLSEDGSGKG
910
AALITAVGVR LRTEASS
Length:917
Mass (Da):102,486
Last modified:October 17, 2006 - v3
Checksum:iF29A6837531C0594
GO
Isoform 2 (identifier: P19367-2) [UniParc]FASTAAdd to basket
Also known as: Erythrocyte, R

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MIAAQLLAYYFTELKDDQVKK → MDCEHSLSLPCRGAEAWEIG

Show »
Length:916
Mass (Da):102,201
Checksum:i6E528FC4BEC5100B
GO
Isoform 3 (identifier: P19367-3) [UniParc]FASTAAdd to basket
Also known as: TA, TB

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MIAAQLLAYYFTELKDDQVKK → MGQICQRESATAAEKPKLHLLAESE

Show »
Length:921
Mass (Da):102,738
Checksum:i329F41F87DF6E1D1
GO
Isoform 4 (identifier: P19367-4) [UniParc]FASTAAdd to basket
Also known as: TD

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MIAAQLLAYYFTELKDDQVKK → MAKRALHDF

Show »
Length:905
Mass (Da):101,085
Checksum:iAE1BC4A3D2604AB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti730D → N in AAA52646 (PubMed:3207429).Curated1
Sequence conflicti730D → N in CAA47379 (PubMed:1637300).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009878529L → S in HK deficiency. 1 PublicationCorresponds to variant rs137853249dbSNPEnsembl.1
Natural variantiVAR_023780680T → S in HK deficiency; HK Utrecht. 1 PublicationCorresponds to variant rs398122379dbSNPEnsembl.1
Natural variantiVAR_023781776L → M.2 PublicationsCorresponds to variant rs1054203dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0020711 – 21MIAAQ…DQVKK → MDCEHSLSLPCRGAEAWEIG in isoform 2. CuratedAdd BLAST21
Alternative sequenceiVSP_0020721 – 21MIAAQ…DQVKK → MGQICQRESATAAEKPKLHL LAESE in isoform 3. CuratedAdd BLAST21
Alternative sequenceiVSP_0020731 – 21MIAAQ…DQVKK → MAKRALHDF in isoform 4. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75126 mRNA. Translation: AAA52646.1.
AF016365
, AF016349, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA. Translation: AAC15862.1.
AF016365
, AF016349, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA. Translation: AAC15863.1.
AF016365
, AF163910, AF163911, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA. Translation: AAF82319.1.
AF016365
, AF163912, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA. Translation: AAF82320.1.
AL596223, AC016821 Genomic DNA. Translation: CAH71506.1.
AL672126 Genomic DNA. No translation available.
BC008730 mRNA. Translation: AAH08730.1.
AF073786 mRNA. Translation: AAC25424.1.
AF029306 Genomic DNA. Translation: AAC00172.1.
X66957 mRNA. Translation: CAA47379.1.
CCDSiCCDS7289.1. [P19367-3]
CCDS7290.1. [P19367-4]
CCDS7291.1. [P19367-2]
CCDS7292.1. [P19367-1]
PIRiA31869.
RefSeqiNP_000179.2. NM_000188.2. [P19367-1]
NP_001309293.1. NM_001322364.1. [P19367-3]
NP_277031.1. NM_033496.2. [P19367-2]
NP_277032.1. NM_033497.2. [P19367-3]
NP_277033.1. NM_033498.2. [P19367-3]
NP_277035.2. NM_033500.2. [P19367-4]
XP_011538034.1. XM_011539732.1. [P19367-4]
UniGeneiHs.370365.

Genome annotation databases

EnsembliENST00000298649; ENSP00000298649; ENSG00000156515. [P19367-2]
ENST00000359426; ENSP00000352398; ENSG00000156515. [P19367-1]
ENST00000360289; ENSP00000353433; ENSG00000156515. [P19367-4]
ENST00000448642; ENSP00000402103; ENSG00000156515. [P19367-3]
GeneIDi3098.
KEGGihsa:3098.
UCSCiuc001jpg.5. human. [P19367-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Hexokinase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75126 mRNA. Translation: AAA52646.1.
AF016365
, AF016349, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA. Translation: AAC15862.1.
AF016365
, AF016349, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA. Translation: AAC15863.1.
AF016365
, AF163910, AF163911, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA. Translation: AAF82319.1.
AF016365
, AF163912, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA. Translation: AAF82320.1.
AL596223, AC016821 Genomic DNA. Translation: CAH71506.1.
AL672126 Genomic DNA. No translation available.
BC008730 mRNA. Translation: AAH08730.1.
AF073786 mRNA. Translation: AAC25424.1.
AF029306 Genomic DNA. Translation: AAC00172.1.
X66957 mRNA. Translation: CAA47379.1.
CCDSiCCDS7289.1. [P19367-3]
CCDS7290.1. [P19367-4]
CCDS7291.1. [P19367-2]
CCDS7292.1. [P19367-1]
PIRiA31869.
RefSeqiNP_000179.2. NM_000188.2. [P19367-1]
NP_001309293.1. NM_001322364.1. [P19367-3]
NP_277031.1. NM_033496.2. [P19367-2]
NP_277032.1. NM_033497.2. [P19367-3]
NP_277033.1. NM_033498.2. [P19367-3]
NP_277035.2. NM_033500.2. [P19367-4]
XP_011538034.1. XM_011539732.1. [P19367-4]
UniGeneiHs.370365.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CZAX-ray1.90N1-917[»]
1DGKX-ray2.80N1-917[»]
1HKBX-ray2.80A/B1-917[»]
1HKCX-ray2.80A1-917[»]
1QHAX-ray2.25A/B1-917[»]
4F9OX-ray2.65A/B1-914[»]
4FOEX-ray2.70A/B1-917[»]
4FOIX-ray2.40A/B1-917[»]
4FPAX-ray2.48A/B1-917[»]
4FPBX-ray3.00A/B1-917[»]
ProteinModelPortaliP19367.
SMRiP19367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109345. 48 interactors.
DIPiDIP-56245N.
IntActiP19367. 16 interactors.
MINTiMINT-1422832.
STRINGi9606.ENSP00000384774.

Chemistry databases

BindingDBiP19367.
ChEMBLiCHEMBL2688.

PTM databases

iPTMnetiP19367.
PhosphoSitePlusiP19367.
SwissPalmiP19367.

Polymorphism and mutation databases

BioMutaiHK1.
DMDMi116242516.

Proteomic databases

EPDiP19367.
MaxQBiP19367.
PaxDbiP19367.
PeptideAtlasiP19367.
PRIDEiP19367.

Protocols and materials databases

DNASUi3098.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298649; ENSP00000298649; ENSG00000156515. [P19367-2]
ENST00000359426; ENSP00000352398; ENSG00000156515. [P19367-1]
ENST00000360289; ENSP00000353433; ENSG00000156515. [P19367-4]
ENST00000448642; ENSP00000402103; ENSG00000156515. [P19367-3]
GeneIDi3098.
KEGGihsa:3098.
UCSCiuc001jpg.5. human. [P19367-1]

Organism-specific databases

CTDi3098.
DisGeNETi3098.
GeneCardsiHK1.
HGNCiHGNC:4922. HK1.
HPAiCAB010052.
HPA007043.
HPA007044.
MalaCardsiHK1.
MIMi142600. gene.
235700. phenotype.
605285. phenotype.
neXtProtiNX_P19367.
OpenTargetsiENSG00000156515.
Orphaneti99953. Charcot-Marie-Tooth disease type 4G.
90031. Non-spherocytic hemolytic anemia due to hexokinase deficiency.
PharmGKBiPA29300.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
GeneTreeiENSGT00390000017159.
HOVERGENiHBG005020.
InParanoidiP19367.
KOiK00844.
OMAiHMESEIY.
PhylomeDBiP19367.
TreeFamiTF314238.

Enzyme and pathway databases

UniPathwayiUPA00242.
BioCyciMetaCyc:HS08136-MONOMER.
ZFISH:HS08136-MONOMER.
BRENDAi2.7.1.1. 2681.
ReactomeiR-HSA-70153. Glucose transport.
R-HSA-70171. Glycolysis.
SABIO-RKP19367.
SIGNORiP19367.

Miscellaneous databases

ChiTaRSiHK1. human.
EvolutionaryTraceiP19367.
GenomeRNAii3098.
PROiP19367.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156515.
CleanExiHS_HK1.
ExpressionAtlasiP19367. baseline and differential.
GenevisibleiP19367. HS.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXK1_HUMAN
AccessioniPrimary (citable) accession number: P19367
Secondary accession number(s): E9PCK0
, O43443, O43444, O75574, Q5VTC3, Q96HC8, Q9NNZ4, Q9NNZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 203 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

Keywords - Technical termi

3D-structure, Allosteric enzyme, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.