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Protein

Achaete-scute homolog 2

Gene

Ascl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute homolog 2
Alternative name(s):
Mash2
Gene namesi
Name:Ascl2
Synonyms:Ash2, Mash-2, Mash2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2159 Ascl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271321 – 260Achaete-scute homolog 2Add BLAST260

Proteomic databases

PaxDbiP19360
PRIDEiP19360

Expressioni

Tissue specificityi

Neuronal precursor cells.

Gene expression databases

BgeeiENSRNOG00000020434
GenevisibleiP19360 RN

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027688

Structurei

3D structure databases

ProteinModelPortaliP19360
SMRiP19360
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 170bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 107Poly-Arg4
Compositional biasi114 – 117Poly-Ser4

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00530000063321
HOGENOMiHOG000013056
HOVERGENiHBG050590
InParanoidiP19360
KOiK09067
OMAiACPRESC
OrthoDBiEOG091G0OB6
PhylomeDBiP19360
TreeFamiTF322889

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR015660 MASH1/Ascl1a-like
PANTHERiPTHR13935 PTHR13935, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P19360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESHFNWYGV PRLQKASDAC PRESCSSALP EAREGANVHF PPHPVPREHF
60 70 80 90 100
SCGAPKPVAG APALNASLMD GGALPRLVPT SSGVAGACTA RRRPPSPELL
110 120 130 140 150
RCSRRRRSGA TEASSSSAAV ARRNERERNR VKLVNLGFQA LRQHVPHGGA
160 170 180 190 200
NKKLSKVETL RSAVEYIRAL QRLLAEHDAV RAALSGGLLT PATRPSDVCT
210 220 230 240 250
QPSASPASAS LSCTSTSPDR LGCSEPASPR SAYSSEDSSC EGETYPMGQM
260
FDFSNWLGGY
Length:260
Mass (Da):27,695
Last modified:November 1, 1990 - v1
Checksum:iE10402DD1F7434C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53724 mRNA Translation: CAA37759.1
PIRiS11562
RefSeqiNP_113691.1, NM_031503.2
UniGeneiRn.10486

Genome annotation databases

EnsembliENSRNOT00000027688; ENSRNOP00000027688; ENSRNOG00000020434
GeneIDi24209
KEGGirno:24209
UCSCiRGD:2159 rat

Similar proteinsi

Entry informationi

Entry nameiASCL2_RAT
AccessioniPrimary (citable) accession number: P19360
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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