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Protein

Achaete-scute homolog 2

Gene

Ascl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute homolog 2
Alternative name(s):
Mash2
Gene namesi
Name:Ascl2
Synonyms:Ash2, Mash-2, Mash2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2159. Ascl2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Achaete-scute homolog 2PRO_0000127132Add
BLAST

Proteomic databases

PaxDbiP19360.
PRIDEiP19360.

Expressioni

Tissue specificityi

Neuronal precursor cells.

Gene expression databases

GenevisibleiP19360. RN.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027688.

Structurei

3D structure databases

ProteinModelPortaliP19360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 17053bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi104 – 1074Poly-Arg
Compositional biasi114 – 1174Poly-Ser

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00530000063321.
HOGENOMiHOG000013056.
HOVERGENiHBG050590.
InParanoidiP19360.
KOiK09067.
OMAiGCEGELS.
OrthoDBiEOG7HHWTC.
PhylomeDBiP19360.
TreeFamiTF322889.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR015660. Achaete-scute-rel.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR13935. PTHR13935. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESHFNWYGV PRLQKASDAC PRESCSSALP EAREGANVHF PPHPVPREHF
60 70 80 90 100
SCGAPKPVAG APALNASLMD GGALPRLVPT SSGVAGACTA RRRPPSPELL
110 120 130 140 150
RCSRRRRSGA TEASSSSAAV ARRNERERNR VKLVNLGFQA LRQHVPHGGA
160 170 180 190 200
NKKLSKVETL RSAVEYIRAL QRLLAEHDAV RAALSGGLLT PATRPSDVCT
210 220 230 240 250
QPSASPASAS LSCTSTSPDR LGCSEPASPR SAYSSEDSSC EGETYPMGQM
260
FDFSNWLGGY
Length:260
Mass (Da):27,695
Last modified:November 1, 1990 - v1
Checksum:iE10402DD1F7434C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53724 mRNA. Translation: CAA37759.1.
PIRiS11562.
RefSeqiNP_113691.1. NM_031503.2.
UniGeneiRn.10486.

Genome annotation databases

EnsembliENSRNOT00000027688; ENSRNOP00000027688; ENSRNOG00000020434.
GeneIDi24209.
KEGGirno:24209.
UCSCiRGD:2159. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53724 mRNA. Translation: CAA37759.1.
PIRiS11562.
RefSeqiNP_113691.1. NM_031503.2.
UniGeneiRn.10486.

3D structure databases

ProteinModelPortaliP19360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027688.

Proteomic databases

PaxDbiP19360.
PRIDEiP19360.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027688; ENSRNOP00000027688; ENSRNOG00000020434.
GeneIDi24209.
KEGGirno:24209.
UCSCiRGD:2159. rat.

Organism-specific databases

CTDi430.
RGDi2159. Ascl2.

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00530000063321.
HOGENOMiHOG000013056.
HOVERGENiHBG050590.
InParanoidiP19360.
KOiK09067.
OMAiGCEGELS.
OrthoDBiEOG7HHWTC.
PhylomeDBiP19360.
TreeFamiTF322889.

Miscellaneous databases

PROiP19360.

Gene expression databases

GenevisibleiP19360. RN.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR015660. Achaete-scute-rel.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR13935. PTHR13935. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors."
    Johnson J.E., Birren S.J., Anderson D.J.
    Nature 346:858-861(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiASCL2_RAT
AccessioniPrimary (citable) accession number: P19360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.