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Protein

Solute carrier family 2, facilitated glucose transporter member 4

Gene

Slc2a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Insulin-regulated facilitative glucose transporter.

Miscellaneous

Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei333MonosaccharideBy similarity1
Binding sitei404MonosaccharideBy similarity1

GO - Molecular functioni

  • D-glucose transmembrane transporter activity Source: RGD
  • glucose transmembrane transporter activity Source: RGD

GO - Biological processi

  • amylopectin biosynthetic process Source: Ensembl
  • brown fat cell differentiation Source: Ensembl
  • cellular response to hypoxia Source: RGD
  • cellular response to insulin stimulus Source: RGD
  • cellular response to osmotic stress Source: Ensembl
  • cellular response to tumor necrosis factor Source: Ensembl
  • glucose homeostasis Source: Ensembl
  • glucose import Source: BHF-UCL
  • glucose import in response to insulin stimulus Source: Ensembl
  • glucose transport Source: RGD
  • response to ethanol Source: RGD

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-189200. Cellular hexose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 4
Alternative name(s):
Glucose transporter type 4, insulin-responsive
Short name:
GLUT-4
Gene namesi
Name:Slc2a4
Synonyms:Glut-4, Glut4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2711. Slc2a4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 81ExtracellularSequence analysisAdd BLAST36
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini103 – 111CytoplasmicSequence analysis9
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 142ExtracellularSequence analysis10
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 171CytoplasmicSequence analysis8
Transmembranei172 – 192Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini193 – 201ExtracellularSequence analysis9
Transmembranei202 – 222Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini223 – 287CytoplasmicSequence analysisAdd BLAST65
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 323ExtracellularSequence analysisAdd BLAST15
Transmembranei324 – 344Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini345 – 353CytoplasmicSequence analysis9
Transmembranei354 – 374Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini375 – 384ExtracellularSequence analysis10
Transmembranei385 – 405Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini406 – 417CytoplasmicSequence analysisAdd BLAST12
Transmembranei418 – 438Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini439 – 445ExtracellularSequence analysis7
Transmembranei446 – 466Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini467 – 509CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

It is a candidate for certain post-receptor defects in non-insulin-dependent diabetes mellitus.

Chemistry databases

ChEMBLiCHEMBL3286066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503661 – 509Solute carrier family 2, facilitated glucose transporter member 4Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei274Phosphoserine; by SGK1By similarity1
Modified residuei486PhosphothreonineBy similarity1
Modified residuei488PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP19357.
PRIDEiP19357.

PTM databases

iPTMnetiP19357.
PhosphoSitePlusiP19357.

Expressioni

Tissue specificityi

Skeletal and cardiac muscles; brown and white fat.

Gene expression databases

BgeeiENSRNOG00000017226.
GenevisibleiP19357. RN.

Interactioni

Subunit structurei

Binds to DAXX. Interacts via its N-terminus with SRFBP1 (By similarity). Interacts with NDUFA9.By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi247208. 1 interactor.
IntActiP19357. 633 interactors.
MINTiMINT-1775053.
STRINGi10116.ENSRNOP00000023256.

Structurei

3D structure databases

ProteinModelPortaliP19357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 13SRFBP1-bindingBy similarity7
Regioni298 – 304Monosaccharide bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi489 – 490Dileucine internalization motifSequence analysis2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP19357.
KOiK07191.
OMAiGTFVFFG.
OrthoDBiEOG091G0A9K.
PhylomeDBiP19357.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR002441. Glc_transpt_4.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF00083. Sugar_tr. 1 hit.
PRINTSiPR01193. GLUCTRSPORT4.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P19357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSGFQQIGS EDGEPPQQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK
60 70 80 90 100
VIEQSYNATW LGRQGPGGPD SIPQGTLTTL WALSVAIFSV GGMISSFLIG
110 120 130 140 150
IISQWLGRKR AMLANNVLAV LGGALMGLAN AAASYEILIL GRFLIGAYSG
160 170 180 190 200
LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI VIGILVAQVL GLESMLGTAT
210 220 230 240 250
LWPLLLAITV LPALLQLLLL PFCPESPRYL YIIRNLEGPA RKSLKRLTGW
260 270 280 290 300
ADVSDALAEL KDEKRKLERE RPLSLLQLLG SRTHRQPLII AVVLQLSQQL
310 320 330 340 350
SGINAVFYYS TSIFELAGVE QPAYATIGAG VVNTVFTLVS VLLVERAGRR
360 370 380 390 400
TLHLLGLAGM CGCAILMTVA LLLLERVPSM SYVSIVAIFG FVAFFEIGPG
410 420 430 440 450
PIPWFIVAEL FSQGPRPAAM AVAGFSNWTC NFIVGMGFQY VADAMGPYVF
460 470 480 490 500
LLFAVLLLGF FIFTFLRVPE TRGRTFDQIS ATFRRTPSLL EQEVKPSTEL

EYLGPDEND
Length:509
Mass (Da):54,896
Last modified:November 1, 1990 - v1
Checksum:iDA50321E99E4CA90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti349R → Q in AAA41451 (PubMed:2649253).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25482 mRNA. Translation: AAA41451.1.
X14771 mRNA. Translation: CAA32879.1.
J04524 mRNA. Translation: AAA41453.1.
D28561 mRNA. Translation: BAA05911.1.
BC085757 mRNA. Translation: AAH85757.1.
L36125 Genomic DNA. Translation: AAA65751.1.
S77784 mRNA. No translation available.
PIRiA32101.
RefSeqiNP_036883.1. NM_012751.1.
XP_006246658.1. XM_006246596.3.
UniGeneiRn.1314.

Genome annotation databases

EnsembliENSRNOT00000023256; ENSRNOP00000023256; ENSRNOG00000017226.
GeneIDi25139.
KEGGirno:25139.
UCSCiRGD:2711. rat.

Similar proteinsi

Entry informationi

Entry nameiGTR4_RAT
AccessioniPrimary (citable) accession number: P19357
Secondary accession number(s): P97900
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 27, 2017
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families