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Protein

Tropomyosin beta chain

Gene

TPM2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin beta chain
Alternative name(s):
Beta-tropomyosin
Tropomyosin-2
Gene namesi
Name:TPM2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056311 – 284Tropomyosin beta chainAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP19352.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

IntActiP19352. 1 interactor.
MINTiMINT-7966140.

Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 95Combined sources95

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U59X-ray2.50A/B/C/D1-98[»]
ProteinModelPortaliP19352.
SMRiP19352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 284By similarityAdd BLAST284

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00550000074494.
HOVERGENiHBG107404.
InParanoidiP19352.
PhylomeDBiP19352.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P19352-1) [UniParc]FASTAAdd to basket
Also known as: Skeletal muscle

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQGLQKKL
60 70 80 90 100
KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEAEVASLNR RIQLVEEELD
110 120 130 140 150
RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE
160 170 180 190 200
AKHIAEEADR KYEEVARKLV VLEGELERSE ERAEVAESKC GDLEEELKIV
210 220 230 240 250
TNNLKSLEAQ ADKYSTKEDK YEEEIKLLGE KLKEAETRAE FAERSVAKLE
260 270 280
KTIDDLEDEV YAQKMKYKAI SEELDNALND ITSL
Length:284
Mass (Da):32,777
Last modified:November 1, 1990 - v1
Checksum:iD1898F7C698F6F71
GO
Isoform 2 (identifier: P19352-2) [UniParc]FASTAAdd to basket
Also known as: Smooth muscle, Gizzard

The sequence of this isoform differs from the canonical sequence as follows:
     189-213: KCGDLEEELKIVTNNLKSLEAQADK → RVRQLEEELRTMDQSLKSLIASEEE
     258-284: DEVYAQKMKYKAISEELDNALNDITSL → ESLASAKEENVGIHQVLDQTLLELNNL

Show »
Length:284
Mass (Da):32,854
Checksum:i43939E18CC538585
GO
Isoform 3 (identifier: P19352-3) [UniParc]FASTAAdd to basket
Also known as: Fibroblast, 3b

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MEAIKKKMQM...LEQAEKKATD → MAGISSIDAV...ADAERQARER
     189-213: KCGDLEEELKIVTNNLKSLEAQADK → RVRQLEEELRTMDQSLKSLIASEEE
     258-284: DEVYAQKMKYKAISEELDNALNDITSL → ESLASAKEENVGIHQVLDQTLLELNNL

Show »
Length:248
Mass (Da):28,548
Checksum:i1EA853C29B040A08
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0066011 – 80MEAIK…KKATD → MAGISSIDAVKKKIQSLQQV ADEAEERAEHLQREADAERQ ARER in isoform 3. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_006602189 – 213KCGDL…AQADK → RVRQLEEELRTMDQSLKSLI ASEEE in isoform 2 and isoform 3. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_006603258 – 284DEVYA…DITSL → ESLASAKEENVGIHQVLDQT LLELNNL in isoform 2 and isoform 3. 3 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02446 mRNA. Translation: AAA49109.1.
M21226
, M21223, M21224, M21225 Genomic DNA. Translation: AAA49116.1.
M23081 mRNA. Translation: AAA49117.1.
M23082 mRNA. Translation: AAA49112.1.
PIRiA30125.
A92462. TMCHS1.
B30125.
RefSeqiXP_015132746.1. XM_015277260.1. [P19352-2]
XP_015132749.1. XM_015277263.1. [P19352-1]
XP_015132753.1. XM_015277267.1. [P19352-3]
UniGeneiGga.4975.

Genome annotation databases

EnsembliENSGALT00000080904; ENSGALP00000050776; ENSGALG00000025842. [P19352-3]
GeneIDi396430.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02446 mRNA. Translation: AAA49109.1.
M21226
, M21223, M21224, M21225 Genomic DNA. Translation: AAA49116.1.
M23081 mRNA. Translation: AAA49117.1.
M23082 mRNA. Translation: AAA49112.1.
PIRiA30125.
A92462. TMCHS1.
B30125.
RefSeqiXP_015132746.1. XM_015277260.1. [P19352-2]
XP_015132749.1. XM_015277263.1. [P19352-1]
XP_015132753.1. XM_015277267.1. [P19352-3]
UniGeneiGga.4975.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U59X-ray2.50A/B/C/D1-98[»]
ProteinModelPortaliP19352.
SMRiP19352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP19352. 1 interactor.
MINTiMINT-7966140.

Proteomic databases

PRIDEiP19352.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000080904; ENSGALP00000050776; ENSGALG00000025842. [P19352-3]
GeneIDi396430.

Organism-specific databases

CTDi7169.

Phylogenomic databases

GeneTreeiENSGT00550000074494.
HOVERGENiHBG107404.
InParanoidiP19352.
PhylomeDBiP19352.

Miscellaneous databases

PROiP19352.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPM2_CHICK
AccessioniPrimary (citable) accession number: P19352
Secondary accession number(s): P04267, P19353
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.