UniProtKB - P19339 (SXL_DROME)
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Protein sex-lethal
Sxl
Functioni
Caution
GO - Molecular functioni
- mRNA 3'-UTR binding Source: FlyBase
- mRNA 5'-UTR binding Source: FlyBase
- mRNA binding Source: FlyBase
- poly(U) RNA binding Source: FlyBase
- poly-pyrimidine tract binding Source: FlyBase
- pre-mRNA binding Source: FlyBase
- translation repressor activity, mRNA regulatory element binding Source: FlyBase
GO - Biological processi
- alternative mRNA splicing, via spliceosome Source: FlyBase
- dosage compensation Source: FlyBase
- female germ-line sex determination Source: FlyBase
- female sex determination Source: FlyBase
- female somatic sex determination Source: FlyBase
- imaginal disc growth Source: FlyBase
- mRNA splicing, via spliceosome Source: FlyBase
- negative regulation of mRNA splicing, via spliceosome Source: FlyBase
- negative regulation of translation Source: FlyBase
- oocyte differentiation Source: FlyBase
- oogenesis Source: FlyBase
- reciprocal meiotic recombination Source: FlyBase
- regulation of alternative mRNA splicing, via spliceosome Source: FlyBase
- regulation of mRNA splicing, via spliceosome Source: FlyBase
- regulation of transcription, DNA-templated Source: UniProtKB-KW
- sex determination Source: FlyBase
- sex determination, primary response to X:A ratio Source: FlyBase
- sex differentiation Source: FlyBase
- smoothened signaling pathway Source: FlyBase
- somatic sex determination Source: FlyBase
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Biological process | Differentiation, Sexual differentiation, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein sex-lethal |
Gene namesi | Name:Sxl Synonyms:Sx1 ORF Names:CG43770 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0264270 Sxl |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081967 | 1 – 354 | Protein sex-lethalAdd BLAST | 354 |
Proteomic databases
PaxDbi | P19339 |
PRIDEi | P19339 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | FBgn0264270 |
ExpressionAtlasi | P19339 differential |
Genevisiblei | P19339 DM |
Interactioni
Subunit structurei
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Unr | Q9VSK3 | 8 | EBI-16120780,EBI-194879 |
Protein-protein interaction databases
BioGridi | 533777105 interactors. |
DIPi | DIP-44607N |
IntActi | P19339 68 interactors. |
MINTi | P19339 |
STRINGi | 7227.FBpp0303712 |
Structurei
Secondary structure
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 125 – 130 | Combined sources | 6 | |
Helixi | 138 – 146 | Combined sources | 9 | |
Beta strandi | 151 – 155 | Combined sources | 5 | |
Turni | 160 – 163 | Combined sources | 4 | |
Beta strandi | 167 – 175 | Combined sources | 9 | |
Helixi | 176 – 186 | Combined sources | 11 | |
Beta strandi | 190 – 193 | Combined sources | 4 | |
Beta strandi | 197 – 200 | Combined sources | 4 | |
Turni | 207 – 210 | Combined sources | 4 | |
Beta strandi | 212 – 217 | Combined sources | 6 | |
Helixi | 224 – 231 | Combined sources | 8 | |
Beta strandi | 233 – 235 | Combined sources | 3 | |
Beta strandi | 237 – 244 | Combined sources | 8 | |
Turni | 246 – 248 | Combined sources | 3 | |
Beta strandi | 251 – 261 | Combined sources | 11 | |
Helixi | 262 – 272 | Combined sources | 11 | |
Beta strandi | 285 – 288 | Combined sources | 4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B7F | X-ray | 2.60 | A/B | 122-289 | [»] | |
1SXL | NMR | - | A | 199-294 | [»] | |
2SXL | NMR | - | A | 122-209 | [»] | |
3SXL | X-ray | 2.70 | A/B/C | 111-294 | [»] | |
4QQB | X-ray | 2.80 | A/B | 122-294 | [»] | |
ProteinModelPortali | P19339 | |||||
SMRi | P19339 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P19339 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 125 – 203 | RRM 1PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 211 – 291 | RRM 2PROSITE-ProRule annotationAdd BLAST | 81 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 32 | Asn/Gly-richAdd BLAST | 32 | |
Compositional biasi | 57 – 60 | Poly-Ser | 4 | |
Compositional biasi | 312 – 319 | Poly-Pro | 8 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG410IQXB Eukaryota ENOG411112S LUCA |
GeneTreei | ENSGT00760000118913 |
InParanoidi | P19339 |
KOi | K18747 |
OrthoDBi | EOG091G0G9L |
PhylomeDBi | P19339 |
Family and domain databases
Gene3Di | 3.30.70.3302 hits |
InterProi | View protein in InterPro IPR002343 Hud_Sxl_RNA IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR006546 Sxl |
Pfami | View protein in Pfam PF00076 RRM_1, 2 hits |
PRINTSi | PR00961 HUDSXLRNA |
SMARTi | View protein in SMART SM00360 RRM, 2 hits |
SUPFAMi | SSF54928 SSF54928, 1 hit |
TIGRFAMsi | TIGR01659 sex-lethal, 1 hit |
PROSITEi | View protein in PROSITE PS50102 RRM, 2 hits |
s (14)i Sequence
Sequence statusi: Complete.
This entry describes 14 produced by isoformsialternative splicing. AlignAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MYGNNNPGSN NNNGGYPPYG YNNKSSGGRG FGMSHSLPSG MSRYAFSPQD
60 70 80 90 100
TEFSFPSSSS RRGYNDFPGC GGSGGNGGSA NNLGGGNMCH LPPMASNNSL
110 120 130 140 150
NNLCGLSLGS GGSDDLMNDP RASNTNLIVN YLPQDMTDRE LYALFRAIGP
160 170 180 190 200
INTCRIMRDY KTGYSFGYAF VDFTSEMDSQ RAIKVLNGIT VRNKRLKVSY
210 220 230 240 250
ARPGGESIKD TNLYVTNLPR TITDDQLDTI FGKYGSIVQK NILRDKLTGR
260 270 280 290 300
PRGVAFVRYN KREEAQEAIS ALNNVIPEGG SQPLSVRLAE EHGKAKAAHF
310 320 330 340 350
MSQMGVVPAN VPPPPPQPPA HMAAAFNMMH RGRSIKSQQR FQNSHPYFDA
KKFI
The sequence of this isoform differs from the canonical sequence as follows:
26-48: SGGRGFGMSHSLPSGMSRYAFSP → RHIFFHSPERSSHHYHRKAKDTH
49-354: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
42-49: Missing.
332-354: GRSIKSQQRFQNSHPYFDAKKFI → DGAMEKLRSLFDAICDAIFGLDSENFADLLDGLYRRKYHYPYL
The sequence of this isoform differs from the canonical sequence as follows:
333-354: RSIKSQQRFQNSHPYFDAKKFI → ENFADLLDGLYRRKYHYPYL
The sequence of this isoform differs from the canonical sequence as follows:
1-25: MYGNNNPGSNNNNGGYPPYGYNNKS → MDFNFDTVTPCSTMSSYYNFKMA
42-49: Missing.
332-354: GRSIKSQQRFQNSHPYFDAKKFI → DGAMEKLRSLFDAICDAIFGLDSENFADLLDGLYRRKYHYPYL
The sequence of this isoform differs from the canonical sequence as follows:
1-25: MYGNNNPGSNNNNGGYPPYGYNNKS → MDFNFDTVTPCSTMSSYYNFKMA
42-49: Missing.
333-354: RSIKSQQRFQNSHPYFDAKKFI → ENFADLLDGLYRRKYHYPYL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 93 | P → S in AAA28921 (PubMed:1710769).Curated | 1 | ||
Sequence conflicti | 96 | S → G in AAA28921 (PubMed:1710769).Curated | 1 | ||
Sequence conflicti | 96 | S → G in ACY56908 (Ref. 5) Curated | 1 | ||
Sequence conflicti | 96 | S → G in ADD20766 (Ref. 5) Curated | 1 | ||
Sequence conflicti | 273 | N → K in ACY56908 (Ref. 5) Curated | 1 | ||
Isoform 1 (identifier: P19339-2) | |||||
Sequence conflicti | 15 | S → C in AAB21845 (PubMed:1547493).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019287 | 1 – 32 | Missing in isoform A and isoform S. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_005881 | 1 – 25 | MYGNN…YNNKS → MDFNFDTVTPCSTMSSYYNF KMA in isoform 1, isoform C, isoform O and isoform R. CuratedAdd BLAST | 25 | |
Alternative sequenceiVSP_040526 | 1 – 25 | MYGNN…YNNKS → MDFNFDTVTPCSTMSSYYNF KMARNGIDSSY in isoform V. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_005882 | 26 – 48 | SGGRG…YAFSP → RHIFFHSPERSSHHYHRKAK DTH in isoform CM1. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_019289 | 27 – 42 | GGRGF…PSGMS → PERSSHHYHRKAKDTH in isoform K. CuratedAdd BLAST | 16 | |
Alternative sequenceiVSP_005883 | 42 – 49 | Missing in isoform A, isoform C, isoform G, isoform W, isoform MS11, isoform O and isoform R. 2 Publications | 8 | |
Alternative sequenceiVSP_019290 | 43 – 354 | Missing in isoform K. CuratedAdd BLAST | 312 | |
Alternative sequenceiVSP_005884 | 49 – 354 | Missing in isoform CM1. 1 PublicationAdd BLAST | 306 | |
Alternative sequenceiVSP_005885 | 332 – 354 | GRSIK…AKKFI → DGAMEKLRSLFDAICDAIFG LDSENFADLLDGLYRRKYHY PYL in isoform MS11 and isoform O. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_005886 | 333 – 354 | RSIKS…AKKFI → ENFADLLDGLYRRKYHYPYL in isoform W, isoform MS16 and isoform R. 2 PublicationsAdd BLAST | 22 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | SXL_DROME | |
Accessioni | P19339Primary (citable) accession number: P19339 Secondary accession number(s): A4V434 Q9W3S6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | April 25, 2018 | |
This is version 186 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |