ID CCN1_CHICK Reviewed; 375 AA. AC P19336; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1990, sequence version 1. DT 24-JAN-2024, entry version 144. DE RecName: Full=CCN family member 1; DE AltName: Full=Cellular communication network factor 1; DE AltName: Full=Protein CEF-10; DE AltName: Full=Protein CYR61; DE Flags: Precursor; GN Name=CCN1; Synonyms=CYR61; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; OC Phasianinae; Gallus. OX NCBI_TaxID=9031; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2537491; DOI=10.1073/pnas.86.4.1178; RA Simmons D.L., Levy D.B., Yannoni Y., Erikson R.L.; RT "Identification of a phorbol ester-repressible v-src-inducible gene."; RL Proc. Natl. Acad. Sci. U.S.A. 86:1178-1182(1989). CC -!- FUNCTION: Probable secreted regulatory protein. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- INDUCTION: By V-Src. CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J04496; AAA48661.1; -; mRNA. DR PIR; A41428; A41428. DR RefSeq; NP_001026734.1; NM_001031563.1. DR AlphaFoldDB; P19336; -. DR SMR; P19336; -. DR STRING; 9031.ENSGALP00000014090; -. DR PaxDb; 9031-ENSGALP00000014090; -. DR Ensembl; ENSGALT00000014106; ENSGALP00000014090; ENSGALG00000008661. DR Ensembl; ENSGALT00010049947.1; ENSGALP00010029502.1; ENSGALG00010020677.1. DR Ensembl; ENSGALT00015052934; ENSGALP00015031243; ENSGALG00015021691. DR GeneID; 429089; -. DR KEGG; gga:429089; -. DR CTD; 429089; -. DR VEuPathDB; HostDB:geneid_429089; -. DR eggNOG; ENOG502QQQQ; Eukaryota. DR GeneTree; ENSGT00940000155151; -. DR HOGENOM; CLU_063247_1_0_1; -. DR InParanoid; P19336; -. DR OMA; IQSCRCS; -. DR OrthoDB; 2970572at2759; -. DR PhylomeDB; P19336; -. DR Reactome; R-GGA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). DR Reactome; R-GGA-8957275; Post-translational protein phosphorylation. DR PRO; PR:P19336; -. DR Proteomes; UP000000539; Chromosome 8. DR Bgee; ENSGALG00000008661; Expressed in spermatocyte and 13 other cell types or tissues. DR ExpressionAtlas; P19336; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl. DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW. DR GO; GO:0005178; F:integrin binding; IEA:Ensembl. DR GO; GO:0003278; P:apoptotic process involved in heart morphogenesis; IEA:Ensembl. DR GO; GO:0060413; P:atrial septum morphogenesis; IEA:Ensembl. DR GO; GO:0003181; P:atrioventricular valve morphogenesis; IEA:Ensembl. DR GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl. DR GO; GO:0060591; P:chondroblast differentiation; IEA:Ensembl. DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl. DR GO; GO:0002041; P:intussusceptive angiogenesis; IEA:Ensembl. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl. DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl. DR GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl. DR GO; GO:0061036; P:positive regulation of cartilage development; IEA:Ensembl. DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl. DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl. DR GO; GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl. DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl. DR GO; GO:0033690; P:positive regulation of osteoblast proliferation; IEA:Ensembl. DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl. DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl. DR GO; GO:0044319; P:wound healing, spreading of cells; IEA:Ensembl. DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1. DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1. DR InterPro; IPR006207; Cys_knot_C. DR InterPro; IPR006208; Glyco_hormone_CN. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR000867; IGFBP-like. DR InterPro; IPR012395; IGFBP_CNN. DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS. DR InterPro; IPR043973; TSP1_CCN. DR InterPro; IPR000884; TSP1_rpt. DR InterPro; IPR036383; TSP1_rpt_sf. DR InterPro; IPR001007; VWF_dom. DR PANTHER; PTHR11348:SF18; CCN FAMILY MEMBER 1; 1. DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1. DR Pfam; PF00007; Cys_knot; 1. DR Pfam; PF00219; IGFBP; 1. DR Pfam; PF19035; TSP1_CCN; 1. DR Pfam; PF00093; VWC; 1. DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1. DR SMART; SM00041; CT; 1. DR SMART; SM00121; IB; 1. DR SMART; SM00209; TSP1; 1. DR SMART; SM00214; VWC; 1. DR SUPFAM; SSF57603; FnI-like domain; 1. DR SUPFAM; SSF57184; Growth factor receptor domain; 1. DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1. DR PROSITE; PS01185; CTCK_1; 1. DR PROSITE; PS01225; CTCK_2; 1. DR PROSITE; PS00222; IGFBP_N_1; 1. DR PROSITE; PS51323; IGFBP_N_2; 1. DR PROSITE; PS50092; TSP1; 1. DR PROSITE; PS01208; VWFC_1; 1. DR PROSITE; PS50184; VWFC_2; 1. PE 2: Evidence at transcript level; KW Disulfide bond; Growth factor binding; Phosphoprotein; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..22 FT CHAIN 23..375 FT /note="CCN family member 1" FT /id="PRO_0000014397" FT DOMAIN 23..94 FT /note="IGFBP N-terminal" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DOMAIN 98..164 FT /note="VWFC" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220" FT DOMAIN 223..268 FT /note="TSP type-1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 281..355 FT /note="CTCK" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039" FT REGION 274..310 FT /note="Heparin-binding" FT /evidence="ECO:0000250|UniProtKB:P18406" FT DISULFID 26..50 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 30..52 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 32..53 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 39..56 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 64..78 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 70..91 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653" FT DISULFID 281..318 FT /evidence="ECO:0000250" FT DISULFID 298..332 FT /evidence="ECO:0000250" FT DISULFID 309..348 FT /evidence="ECO:0000250" FT DISULFID 312..350 FT /evidence="ECO:0000250" FT DISULFID 317..354 FT /evidence="ECO:0000250" SQ SEQUENCE 375 AA; 40652 MW; 95F28553BE35D5AE CRC64; MGSAGARPAL AAALLCLARL ALGSPCPAVC QCPAAAPQCA PGVGLVPDGC GCCKVCAKQL NEDCSRTQPC DHTKGLECNF GASPAATNGI CRAQSEGRPC EYNSKIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPSPRL VKVPGQCCEE WVCDESKDAL EELEGFFSKE FGLDASEGEL TRNNELIAIV KGGLKMLPVF GSEPQSRAFE NPKCIVQTTS WSQCSKTCGT GISTRVTNDN PDCKLIKETR ICEVRPCGQP SYASLKKGKK CTKTKKSPSP VRFTYAGCSS VKKYRPKYCG SCVDGRCCTP QQTRTVKIRF RCDDGETFTK SVMMIQSCRC NYNCPHANEA YPFYRLVNDI HKFRD //