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P19336

- CYR61_CHICK

UniProt

P19336 - CYR61_CHICK

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Protein
Protein CYR61
Gene
CYR61, CCN1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable secreted regulatory protein.

GO - Molecular functioni

  1. extracellular matrix binding Source: Ensembl

GO - Biological processi

  1. apoptotic process involved in heart morphogenesis Source: Ensembl
  2. atrial septum morphogenesis Source: Ensembl
  3. atrioventricular valve morphogenesis Source: Ensembl
  4. chondroblast differentiation Source: Ensembl
  5. chorio-allantoic fusion Source: Ensembl
  6. extracellular matrix organization Source: Ensembl
  7. intussusceptive angiogenesis Source: Ensembl
  8. labyrinthine layer blood vessel development Source: Ensembl
  9. negative regulation of apoptotic process Source: Ensembl
  10. osteoblast differentiation Source: Ensembl
  11. positive regulation of BMP signaling pathway Source: Ensembl
  12. positive regulation of apoptotic process Source: Ensembl
  13. positive regulation of cartilage development Source: Ensembl
  14. positive regulation of cell migration Source: Ensembl
  15. positive regulation of cell-substrate adhesion Source: Ensembl
  16. positive regulation of ceramide biosynthetic process Source: Ensembl
  17. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  18. positive regulation of osteoblast differentiation Source: Ensembl
  19. positive regulation of osteoblast proliferation Source: Ensembl
  20. positive regulation of phospholipase activity Source: Ensembl
  21. positive regulation of protein kinase activity Source: Ensembl
  22. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  23. reactive oxygen species metabolic process Source: Ensembl
  24. regulation of ERK1 and ERK2 cascade Source: Ensembl
  25. regulation of cell growth Source: InterPro
  26. ventricular septum development Source: Ensembl
  27. wound healing, spreading of cells Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CYR61
Alternative name(s):
CCN family member 1
Protein CEF-10
Gene namesi
Name:CYR61
Synonyms:CCN1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222
Add
BLAST
Chaini23 – 375353Protein CYR61
PRO_0000014397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi281 ↔ 318 By similarity
Disulfide bondi298 ↔ 332 By similarity
Disulfide bondi309 ↔ 348 By similarity
Disulfide bondi312 ↔ 350 By similarity
Disulfide bondi317 ↔ 354 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

By V-Src.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014090.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 9472IGFBP N-terminal
Add
BLAST
Domaini98 – 16467VWFC
Add
BLAST
Domaini223 – 26846TSP type-1
Add
BLAST
Domaini281 – 35575CTCK
Add
BLAST

Sequence similaritiesi

Belongs to the CCN family.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82014.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiP19336.
KOiK06829.
PhylomeDBiP19336.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19336-1 [UniParc]FASTAAdd to Basket

« Hide

MGSAGARPAL AAALLCLARL ALGSPCPAVC QCPAAAPQCA PGVGLVPDGC    50
GCCKVCAKQL NEDCSRTQPC DHTKGLECNF GASPAATNGI CRAQSEGRPC 100
EYNSKIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPSPRL 150
VKVPGQCCEE WVCDESKDAL EELEGFFSKE FGLDASEGEL TRNNELIAIV 200
KGGLKMLPVF GSEPQSRAFE NPKCIVQTTS WSQCSKTCGT GISTRVTNDN 250
PDCKLIKETR ICEVRPCGQP SYASLKKGKK CTKTKKSPSP VRFTYAGCSS 300
VKKYRPKYCG SCVDGRCCTP QQTRTVKIRF RCDDGETFTK SVMMIQSCRC 350
NYNCPHANEA YPFYRLVNDI HKFRD 375
Length:375
Mass (Da):40,652
Last modified:November 1, 1990 - v1
Checksum:i95F28553BE35D5AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04496 mRNA. Translation: AAA48661.1.
PIRiA41428.
RefSeqiNP_001026734.1. NM_001031563.1.
UniGeneiGga.2200.

Genome annotation databases

GeneIDi429089.
KEGGigga:429089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04496 mRNA. Translation: AAA48661.1 .
PIRi A41428.
RefSeqi NP_001026734.1. NM_001031563.1.
UniGenei Gga.2200.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000014090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 429089.
KEGGi gga:429089.

Organism-specific databases

CTDi 3491.

Phylogenomic databases

eggNOGi NOG82014.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi P19336.
KOi K06829.
PhylomeDBi P19336.

Miscellaneous databases

NextBioi 20829916.
PROi P19336.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a phorbol ester-repressible v-src-inducible gene."
    Simmons D.L., Levy D.B., Yannoni Y., Erikson R.L.
    Proc. Natl. Acad. Sci. U.S.A. 86:1178-1182(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCYR61_CHICK
AccessioniPrimary (citable) accession number: P19336
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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