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P19336

- CYR61_CHICK

UniProt

P19336 - CYR61_CHICK

Protein

Protein CYR61

Gene

CYR61

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Probable secreted regulatory protein.

    GO - Molecular functioni

    1. extracellular matrix binding Source: Ensembl

    GO - Biological processi

    1. apoptotic process involved in heart morphogenesis Source: Ensembl
    2. atrial septum morphogenesis Source: Ensembl
    3. atrioventricular valve morphogenesis Source: Ensembl
    4. chondroblast differentiation Source: Ensembl
    5. chorio-allantoic fusion Source: Ensembl
    6. extracellular matrix organization Source: Ensembl
    7. intussusceptive angiogenesis Source: Ensembl
    8. labyrinthine layer blood vessel development Source: Ensembl
    9. negative regulation of apoptotic process Source: Ensembl
    10. osteoblast differentiation Source: Ensembl
    11. positive regulation of apoptotic process Source: Ensembl
    12. positive regulation of BMP signaling pathway Source: Ensembl
    13. positive regulation of cartilage development Source: Ensembl
    14. positive regulation of cell migration Source: Ensembl
    15. positive regulation of cell-substrate adhesion Source: Ensembl
    16. positive regulation of ceramide biosynthetic process Source: Ensembl
    17. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    18. positive regulation of osteoblast differentiation Source: Ensembl
    19. positive regulation of osteoblast proliferation Source: Ensembl
    20. positive regulation of phospholipase activity Source: Ensembl
    21. positive regulation of protein kinase activity Source: Ensembl
    22. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    23. reactive oxygen species metabolic process Source: Ensembl
    24. regulation of cell growth Source: InterPro
    25. regulation of ERK1 and ERK2 cascade Source: Ensembl
    26. ventricular septum development Source: Ensembl
    27. wound healing, spreading of cells Source: Ensembl

    Keywords - Ligandi

    Growth factor binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CYR61
    Alternative name(s):
    CCN family member 1
    Protein CEF-10
    Gene namesi
    Name:CYR61
    Synonyms:CCN1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Add
    BLAST
    Chaini23 – 375353Protein CYR61PRO_0000014397Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi281 ↔ 318By similarity
    Disulfide bondi298 ↔ 332By similarity
    Disulfide bondi309 ↔ 348By similarity
    Disulfide bondi312 ↔ 350By similarity
    Disulfide bondi317 ↔ 354By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Inductioni

    By V-Src.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000014090.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 9472IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 16467VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini223 – 26846TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini281 – 35575CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG82014.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiP19336.
    KOiK06829.
    PhylomeDBiP19336.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19336-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSAGARPAL AAALLCLARL ALGSPCPAVC QCPAAAPQCA PGVGLVPDGC    50
    GCCKVCAKQL NEDCSRTQPC DHTKGLECNF GASPAATNGI CRAQSEGRPC 100
    EYNSKIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPSPRL 150
    VKVPGQCCEE WVCDESKDAL EELEGFFSKE FGLDASEGEL TRNNELIAIV 200
    KGGLKMLPVF GSEPQSRAFE NPKCIVQTTS WSQCSKTCGT GISTRVTNDN 250
    PDCKLIKETR ICEVRPCGQP SYASLKKGKK CTKTKKSPSP VRFTYAGCSS 300
    VKKYRPKYCG SCVDGRCCTP QQTRTVKIRF RCDDGETFTK SVMMIQSCRC 350
    NYNCPHANEA YPFYRLVNDI HKFRD 375
    Length:375
    Mass (Da):40,652
    Last modified:November 1, 1990 - v1
    Checksum:i95F28553BE35D5AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04496 mRNA. Translation: AAA48661.1.
    PIRiA41428.
    RefSeqiNP_001026734.1. NM_001031563.1.
    UniGeneiGga.2200.

    Genome annotation databases

    GeneIDi429089.
    KEGGigga:429089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04496 mRNA. Translation: AAA48661.1 .
    PIRi A41428.
    RefSeqi NP_001026734.1. NM_001031563.1.
    UniGenei Gga.2200.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000014090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 429089.
    KEGGi gga:429089.

    Organism-specific databases

    CTDi 3491.

    Phylogenomic databases

    eggNOGi NOG82014.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi P19336.
    KOi K06829.
    PhylomeDBi P19336.

    Miscellaneous databases

    NextBioi 20829916.
    PROi P19336.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a phorbol ester-repressible v-src-inducible gene."
      Simmons D.L., Levy D.B., Yannoni Y., Erikson R.L.
      Proc. Natl. Acad. Sci. U.S.A. 86:1178-1182(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCYR61_CHICK
    AccessioniPrimary (citable) accession number: P19336
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3