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Protein

Protein CYR61

Gene

CYR61

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable secreted regulatory protein.

GO - Molecular functioni

  1. extracellular matrix binding Source: Ensembl

GO - Biological processi

  1. apoptotic process involved in heart morphogenesis Source: Ensembl
  2. atrial septum morphogenesis Source: Ensembl
  3. atrioventricular valve morphogenesis Source: Ensembl
  4. chondroblast differentiation Source: Ensembl
  5. chorio-allantoic fusion Source: Ensembl
  6. extracellular matrix organization Source: Ensembl
  7. intussusceptive angiogenesis Source: Ensembl
  8. labyrinthine layer blood vessel development Source: Ensembl
  9. negative regulation of apoptotic process Source: Ensembl
  10. osteoblast differentiation Source: Ensembl
  11. positive regulation of BMP signaling pathway Source: Ensembl
  12. positive regulation of cartilage development Source: Ensembl
  13. positive regulation of cell migration Source: Ensembl
  14. positive regulation of cell-substrate adhesion Source: Ensembl
  15. positive regulation of ceramide biosynthetic process Source: Ensembl
  16. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  17. positive regulation of osteoblast differentiation Source: Ensembl
  18. positive regulation of osteoblast proliferation Source: Ensembl
  19. positive regulation of phospholipase activity Source: Ensembl
  20. positive regulation of protein kinase activity Source: Ensembl
  21. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  22. reactive oxygen species metabolic process Source: Ensembl
  23. regulation of cell growth Source: InterPro
  24. regulation of ERK1 and ERK2 cascade Source: Ensembl
  25. ventricular septum development Source: Ensembl
  26. wound healing, spreading of cells Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CYR61
Alternative name(s):
CCN family member 1
Protein CEF-10
Gene namesi
Name:CYR61
Synonyms:CCN1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Chaini23 – 375353Protein CYR61PRO_0000014397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi281 ↔ 318By similarity
Disulfide bondi298 ↔ 332By similarity
Disulfide bondi309 ↔ 348By similarity
Disulfide bondi312 ↔ 350By similarity
Disulfide bondi317 ↔ 354By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

By V-Src.

Gene expression databases

ExpressionAtlasiP19336. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014090.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 9472IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini98 – 16467VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini223 – 26846TSP type-1PROSITE-ProRule annotationAdd
BLAST
Domaini281 – 35575CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82014.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiP19336.
KOiK06829.
PhylomeDBiP19336.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAGARPAL AAALLCLARL ALGSPCPAVC QCPAAAPQCA PGVGLVPDGC
60 70 80 90 100
GCCKVCAKQL NEDCSRTQPC DHTKGLECNF GASPAATNGI CRAQSEGRPC
110 120 130 140 150
EYNSKIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPSPRL
160 170 180 190 200
VKVPGQCCEE WVCDESKDAL EELEGFFSKE FGLDASEGEL TRNNELIAIV
210 220 230 240 250
KGGLKMLPVF GSEPQSRAFE NPKCIVQTTS WSQCSKTCGT GISTRVTNDN
260 270 280 290 300
PDCKLIKETR ICEVRPCGQP SYASLKKGKK CTKTKKSPSP VRFTYAGCSS
310 320 330 340 350
VKKYRPKYCG SCVDGRCCTP QQTRTVKIRF RCDDGETFTK SVMMIQSCRC
360 370
NYNCPHANEA YPFYRLVNDI HKFRD
Length:375
Mass (Da):40,652
Last modified:November 1, 1990 - v1
Checksum:i95F28553BE35D5AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04496 mRNA. Translation: AAA48661.1.
PIRiA41428.
RefSeqiNP_001026734.1. NM_001031563.1.
UniGeneiGga.2200.

Genome annotation databases

GeneIDi429089.
KEGGigga:429089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04496 mRNA. Translation: AAA48661.1.
PIRiA41428.
RefSeqiNP_001026734.1. NM_001031563.1.
UniGeneiGga.2200.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi429089.
KEGGigga:429089.

Organism-specific databases

CTDi3491.

Phylogenomic databases

eggNOGiNOG82014.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiP19336.
KOiK06829.
PhylomeDBiP19336.

Miscellaneous databases

NextBioi20829916.
PROiP19336.

Gene expression databases

ExpressionAtlasiP19336. baseline and differential.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a phorbol ester-repressible v-src-inducible gene."
    Simmons D.L., Levy D.B., Yannoni Y., Erikson R.L.
    Proc. Natl. Acad. Sci. U.S.A. 86:1178-1182(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCYR61_CHICK
AccessioniPrimary (citable) accession number: P19336
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 4, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.