P19336 (CYR61_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein CYR61

Alternative name(s):
CCN family member 1
Protein CEF-10

Gene names

Name:	CYR61
Synonyms:	CCN1

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable secreted regulatory protein.
Subcellular location	Secreted Probable.
Induction	By V-Src.
Sequence similarities	Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Growth factor binding
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process involved in heart morphogenesis Inferred from electronic annotation. Source: Compara atrial septum morphogenesis Inferred from electronic annotation. Source: Compara atrioventricular valve morphogenesis Inferred from electronic annotation. Source: Compara chondroblast differentiation Inferred from electronic annotation. Source: Compara chorio-allantoic fusion Inferred from electronic annotation. Source: Compara extracellular matrix organization Inferred from electronic annotation. Source: Compara intussusceptive angiogenesis Inferred from electronic annotation. Source: Compara labyrinthine layer blood vessel development Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of BMP signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of cartilage development Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from electronic annotation. Source: Compara positive regulation of cell-substrate adhesion Inferred from electronic annotation. Source: Compara positive regulation of ceramide biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of osteoblast proliferation Inferred from electronic annotation. Source: Compara positive regulation of phospholipase activity Inferred from electronic annotation. Source: Compara positive regulation of protein kinase activity Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara reactive oxygen species metabolic process Inferred from electronic annotation. Source: Compara regulation of ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara regulation of cell growth Inferred from electronic annotation. Source: InterPro ventricular septum development Inferred from electronic annotation. Source: Compara wound healing, spreading of cells Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	extracellular matrix binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22
	Chain	23 – 375	353	Protein CYR61		PRO_0000014397
Regions
	Domain	23 – 94	72	IGFBP N-terminal
	Domain	98 – 164	67	VWFC
	Domain	223 – 268	46	TSP type-1
	Domain	281 – 355	75	CTCK
Amino acid modifications
	Disulfide bond	281 ↔ 318		By similarity
	Disulfide bond	298 ↔ 332		By similarity
	Disulfide bond	309 ↔ 348		By similarity
	Disulfide bond	312 ↔ 350		By similarity
	Disulfide bond	317 ↔ 354		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P19336 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 95F28553BE35D5AE	FASTA	375	40,652
	10 20 30 40 50 60 MGSAGARPAL AAALLCLARL ALGSPCPAVC QCPAAAPQCA PGVGLVPDGC GCCKVCAKQL 70 80 90 100 110 120 NEDCSRTQPC DHTKGLECNF GASPAATNGI CRAQSEGRPC EYNSKIYQNG ESFQPNCKHQ 130 140 150 160 170 180 CTCIDGAVGC IPLCPQELSL PNLGCPSPRL VKVPGQCCEE WVCDESKDAL EELEGFFSKE 190 200 210 220 230 240 FGLDASEGEL TRNNELIAIV KGGLKMLPVF GSEPQSRAFE NPKCIVQTTS WSQCSKTCGT 250 260 270 280 290 300 GISTRVTNDN PDCKLIKETR ICEVRPCGQP SYASLKKGKK CTKTKKSPSP VRFTYAGCSS 310 320 330 340 350 360 VKKYRPKYCG SCVDGRCCTP QQTRTVKIRF RCDDGETFTK SVMMIQSCRC NYNCPHANEA 370 YPFYRLVNDI HKFRD

References

[1]	"Identification of a phorbol ester-repressible v-src-inducible gene." Simmons D.L., Levy D.B., Yannoni Y., Erikson R.L. Proc. Natl. Acad. Sci. U.S.A. 86:1178-1182(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04496 mRNA. Translation: AAA48661.1.
IPI	IPI00578074.
PIR	A41428.
RefSeq	NP_001026734.1. NM_001031563.1.
UniGene	Gga.2200.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000014090.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	429089.
KEGG	gga:429089.
Organism-specific databases
CTD	3491.
Phylogenomic databases
eggNOG	NOG82014.
HOGENOM	HOG000231462.
HOVERGEN	HBG000635.
InParanoid	P19336.
KO	K06829.
OrthoDB	EOG4J3WH3.
Gene expression databases
ArrayExpress	P19336.
Family and domain databases
InterPro	IPR006208. Cys_knot. IPR006207. Cys_knot_C. IPR000867. IGFBP-like. IPR012395. IGFBP_CNN. IPR017891. Insulin_GF-bd_Cys-rich_CS. IPR000884. Thrombospondin_1_rpt. IPR001007. VWF_C. [Graphical view]
Pfam	PF00007. Cys_knot. 1 hit. PF00219. IGFBP. 1 hit. PF00090. TSP_1. 1 hit. PF00093. VWC. 1 hit. [Graphical view]
PIRSF	PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMART	SM00041. CT. 1 hit. SM00121. IB. 1 hit. SM00209. TSP1. 1 hit. SM00214. VWC. 1 hit. [Graphical view]
SUPFAM	SSF82895. TSP1. 1 hit.
PROSITE	PS01185. CTCK_1. 1 hit. PS01225. CTCK_2. 1 hit. PS00222. IGFBP_N_1. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS50092. TSP1. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20829916.

Entry information

Entry name

CYR61_CHICK

Accession

Primary (citable) accession number: P19336

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program