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P19336 (CYR61_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein CYR61
Alternative name(s):
CCN family member 1
Protein CEF-10
Gene names
Name:CYR61
Synonyms:CCN1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable secreted regulatory protein.

Subcellular location

Secreted Probable.

Induction

By V-Src.

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandGrowth factor binding
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process involved in heart morphogenesis

Inferred from electronic annotation. Source: Ensembl

atrial septum morphogenesis

Inferred from electronic annotation. Source: Ensembl

atrioventricular valve morphogenesis

Inferred from electronic annotation. Source: Ensembl

chondroblast differentiation

Inferred from electronic annotation. Source: Ensembl

chorio-allantoic fusion

Inferred from electronic annotation. Source: Ensembl

extracellular matrix organization

Inferred from electronic annotation. Source: Ensembl

intussusceptive angiogenesis

Inferred from electronic annotation. Source: Ensembl

labyrinthine layer blood vessel development

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of BMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cartilage development

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell-substrate adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of ceramide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of phospholipase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

regulation of cell growth

Inferred from electronic annotation. Source: InterPro

ventricular septum development

Inferred from electronic annotation. Source: Ensembl

wound healing, spreading of cells

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionextracellular matrix binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222
Chain23 – 375353Protein CYR61
PRO_0000014397

Regions

Domain23 – 9472IGFBP N-terminal
Domain98 – 16467VWFC
Domain223 – 26846TSP type-1
Domain281 – 35575CTCK

Amino acid modifications

Disulfide bond281 ↔ 318 By similarity
Disulfide bond298 ↔ 332 By similarity
Disulfide bond309 ↔ 348 By similarity
Disulfide bond312 ↔ 350 By similarity
Disulfide bond317 ↔ 354 By similarity

Sequences

Sequence LengthMass (Da)Tools
P19336 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 95F28553BE35D5AE

FASTA37540,652
        10         20         30         40         50         60 
MGSAGARPAL AAALLCLARL ALGSPCPAVC QCPAAAPQCA PGVGLVPDGC GCCKVCAKQL 

        70         80         90        100        110        120 
NEDCSRTQPC DHTKGLECNF GASPAATNGI CRAQSEGRPC EYNSKIYQNG ESFQPNCKHQ 

       130        140        150        160        170        180 
CTCIDGAVGC IPLCPQELSL PNLGCPSPRL VKVPGQCCEE WVCDESKDAL EELEGFFSKE 

       190        200        210        220        230        240 
FGLDASEGEL TRNNELIAIV KGGLKMLPVF GSEPQSRAFE NPKCIVQTTS WSQCSKTCGT 

       250        260        270        280        290        300 
GISTRVTNDN PDCKLIKETR ICEVRPCGQP SYASLKKGKK CTKTKKSPSP VRFTYAGCSS 

       310        320        330        340        350        360 
VKKYRPKYCG SCVDGRCCTP QQTRTVKIRF RCDDGETFTK SVMMIQSCRC NYNCPHANEA 

       370 
YPFYRLVNDI HKFRD 

« Hide

References

[1]"Identification of a phorbol ester-repressible v-src-inducible gene."
Simmons D.L., Levy D.B., Yannoni Y., Erikson R.L.
Proc. Natl. Acad. Sci. U.S.A. 86:1178-1182(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04496 mRNA. Translation: AAA48661.1.
PIRA41428.
RefSeqNP_001026734.1. NM_001031563.1.
UniGeneGga.2200.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000014090.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID429089.
KEGGgga:429089.

Organism-specific databases

CTD3491.

Phylogenomic databases

eggNOGNOG82014.
HOGENOMHOG000231462.
HOVERGENHBG000635.
InParanoidP19336.
KOK06829.
PhylomeDBP19336.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20829916.
PROP19336.

Entry information

Entry nameCYR61_CHICK
AccessionPrimary (citable) accession number: P19336
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families