Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein CYR61

Gene

CYR61

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable secreted regulatory protein.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-GGA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-GGA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CYR61
Alternative name(s):
CCN family member 1
Protein CEF-10
Gene namesi
Name:CYR61
Synonyms:CCN1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000001439723 – 375Protein CYR61Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi281 ↔ 318By similarity
Disulfide bondi298 ↔ 332By similarity
Disulfide bondi309 ↔ 348By similarity
Disulfide bondi312 ↔ 350By similarity
Disulfide bondi317 ↔ 354By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP19336
PRIDEiP19336

Expressioni

Inductioni

By V-Src.

Gene expression databases

BgeeiENSGALG00000008661
ExpressionAtlasiP19336 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014090

Structurei

3D structure databases

SMRiP19336
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 94IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST72
Domaini98 – 164VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini223 – 268TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini281 – 355CTCKPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIY0 Eukaryota
ENOG41119KZ LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
HOVERGENiHBG000635
InParanoidiP19336
KOiK06829
OrthoDBiEOG091G0SQP
PhylomeDBiP19336

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00090 TSP_1, 1 hit
PF00093 VWC, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAGARPAL AAALLCLARL ALGSPCPAVC QCPAAAPQCA PGVGLVPDGC
60 70 80 90 100
GCCKVCAKQL NEDCSRTQPC DHTKGLECNF GASPAATNGI CRAQSEGRPC
110 120 130 140 150
EYNSKIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPSPRL
160 170 180 190 200
VKVPGQCCEE WVCDESKDAL EELEGFFSKE FGLDASEGEL TRNNELIAIV
210 220 230 240 250
KGGLKMLPVF GSEPQSRAFE NPKCIVQTTS WSQCSKTCGT GISTRVTNDN
260 270 280 290 300
PDCKLIKETR ICEVRPCGQP SYASLKKGKK CTKTKKSPSP VRFTYAGCSS
310 320 330 340 350
VKKYRPKYCG SCVDGRCCTP QQTRTVKIRF RCDDGETFTK SVMMIQSCRC
360 370
NYNCPHANEA YPFYRLVNDI HKFRD
Length:375
Mass (Da):40,652
Last modified:November 1, 1990 - v1
Checksum:i95F28553BE35D5AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04496 mRNA Translation: AAA48661.1
PIRiA41428
RefSeqiNP_001026734.1, NM_001031563.1
UniGeneiGga.2200

Genome annotation databases

EnsembliENSGALT00000014106; ENSGALP00000014090; ENSGALG00000008661
GeneIDi429089
KEGGigga:429089

Similar proteinsi

Entry informationi

Entry nameiCYR61_CHICK
AccessioniPrimary (citable) accession number: P19336
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health