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Protein

Myogenic factor 6

Gene

Myf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. May play a role in controlling terminal differentiation events.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-375170. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factor 6
Short name:
Myf-6
Alternative name(s):
Muscle-specific regulatory factor 4
Gene namesi
Name:Myf6
Synonyms:Mrf4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi3134. Myf6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273541 – 242Myogenic factor 6Add BLAST242

Proteomic databases

PaxDbiP19335.
PRIDEiP19335.

PTM databases

iPTMnetiP19335.
PhosphoSitePlusiP19335.

Expressioni

Tissue specificityi

Skeletal muscle in late fetal and adult rats.

Gene expression databases

BgeeiENSRNOG00000004878.
GenevisibleiP19335. RN.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with CSRP3.1 Publication

Protein-protein interaction databases

DIPiDIP-485N.
IntActiP19335. 1 interactor.
STRINGi10116.ENSRNOP00000006523.

Structurei

3D structure databases

ProteinModelPortaliP19335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 144bHLHPROSITE-ProRule annotationAdd BLAST52

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3960. Eukaryota.
ENOG4111SED. LUCA.
GeneTreeiENSGT00530000063004.
HOGENOMiHOG000234799.
HOVERGENiHBG006429.
InParanoidiP19335.
KOiK18485.
OMAiQQDKMQE.
OrthoDBiEOG091G0GKD.
PhylomeDBiP19335.
TreeFamiTF316344.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR002546. Basic.
IPR011598. bHLH_dom.
[Graphical view]
PfamiPF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPQ
60 70 80 90 100
EAGSDSSGEE HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL
110 120 130 140 150
RERRRLKKIN EAFEALKRRT VANPNQRLPK VEILRSAINY IERLQDLLHR
160 170 180 190 200
LDQQEKMQEL GVDPYSYKPK QEILEGADFL RTCSPQWPSV SDHSRGLVIT
210 220 230 240
AKEGGASVDA SASSSLQRLS SIVDSISSEE RKLPSVEEVV EK
Length:242
Mass (Da):26,987
Last modified:November 1, 1990 - v1
Checksum:i4EFD739BB6C4F6C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27151 mRNA. Translation: AAA41636.1.
M84685 Genomic DNA. Translation: AAA41635.1.
PIRiJC1233.
RefSeqiNP_037304.1. NM_013172.2.
UniGeneiRn.2236.

Genome annotation databases

EnsembliENSRNOT00000006523; ENSRNOP00000006523; ENSRNOG00000004878.
GeneIDi25714.
KEGGirno:25714.
UCSCiRGD:3134. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27151 mRNA. Translation: AAA41636.1.
M84685 Genomic DNA. Translation: AAA41635.1.
PIRiJC1233.
RefSeqiNP_037304.1. NM_013172.2.
UniGeneiRn.2236.

3D structure databases

ProteinModelPortaliP19335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-485N.
IntActiP19335. 1 interactor.
STRINGi10116.ENSRNOP00000006523.

PTM databases

iPTMnetiP19335.
PhosphoSitePlusiP19335.

Proteomic databases

PaxDbiP19335.
PRIDEiP19335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006523; ENSRNOP00000006523; ENSRNOG00000004878.
GeneIDi25714.
KEGGirno:25714.
UCSCiRGD:3134. rat.

Organism-specific databases

CTDi4618.
RGDi3134. Myf6.

Phylogenomic databases

eggNOGiKOG3960. Eukaryota.
ENOG4111SED. LUCA.
GeneTreeiENSGT00530000063004.
HOGENOMiHOG000234799.
HOVERGENiHBG006429.
InParanoidiP19335.
KOiK18485.
OMAiQQDKMQE.
OrthoDBiEOG091G0GKD.
PhylomeDBiP19335.
TreeFamiTF316344.

Enzyme and pathway databases

ReactomeiR-RNO-375170. CDO in myogenesis.

Miscellaneous databases

PROiP19335.

Gene expression databases

BgeeiENSRNOG00000004878.
GenevisibleiP19335. RN.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR002546. Basic.
IPR011598. bHLH_dom.
[Graphical view]
PfamiPF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYF6_RAT
AccessioniPrimary (citable) accession number: P19335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.