P19332 (TAU_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microtubule-associated protein tau

Alternative name(s):
Neurofibrillary tangle protein
Paired helical filament-tau
Short name=PHF-tau

Gene names

Name:	Mapt
Synonyms:	Mtapt, Tau

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	752 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Subunit structure	Interacts with SQSTM1 when polyubiquitinated. Interacts with PSMC2 through SQSTM1. Binds to CSNK1D By similarity. Interacts with FKBP4. Interacts with SGK1 By similarity. Ref.9
Subcellular location	Cytoplasm › cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton. Cell projection › axon. Note: Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Tissue specificity	Expressed in neurons. The larger forms (isoform tau-A and isoform tau-B) are preferentially expressed in the peripheral nervous system while the other are expressed in the central nervous system. Low amounts of the larger forms are also found in limited areas of the CNS.
Developmental stage	During the immediate postnatal period, the dorsal root ganglia express all isoforms whereas only the larger forms persist in the adults.
Domain	The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats.
Post-translational modification	Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome By similarity. Phosphorylated at various serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1: CDK1, CDK5, GSK3, MAPK) (a few sites per protein in interphase, more in mitosis), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Fetal Tau is much more phosphorylated than adult Tau. Phosphorylation at Ser-573 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylated by PHK. Phosphorylation at Ser-204 by SGK1 mediates microtubule depolymerization and neurite formation in hippocampal neurons By similarity. Ref.7
Sequence similarities	Contains 4 Tau/MAP repeats.

Ontologies

Keywords
Cellular component	Cell membrane Cell projection Cytoplasm Cytoskeleton Membrane Microtubule
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Acetylation Disulfide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from direct assay PubMed 15750210. Source: RGD microtubule cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB neuron differentiation Non-traceable author statement PubMed 15043998. Source: RGD positive regulation of axon extension Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of microtubule polymerization Inferred from sequence or structural similarity. Source: UniProtKB response to nutrient Inferred from direct assay PubMed 16495207. Source: RGD response to organic substance Inferred from direct assay PubMed 16389547. Source: RGD
Cellular_component	axonal growth cone Inferred from direct assay Ref.9. Source: UniProtKB cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB tubulin complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	microtubule binding Inferred from sequence or structural similarity. Source: UniProtKB protein domain specific binding Inferred from mutant phenotype PubMed 10580117. Source: RGD
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 4 of the 14 exons. Two different C-termini are obtained either by the retention or the splicing of intron 13/14.

Isoform Tau-A (identifier: P19332-1)

Also known as: SC1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Tau-B (identifier: P19332-2)

Also known as: Big-tau; HMW-tau;

The sequence of this isoform differs from the canonical sequence as follows:
     387-452: Missing.

Isoform Tau-C (identifier: P19332-3)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     114-367: Missing.
     387-452: Missing.

Isoform Tau-D (identifier: P19332-4)

Also known as: SC2;

The sequence of this isoform differs from the canonical sequence as follows:
     114-367: Missing.

Isoform Tau-E (identifier: P19332-5)

The sequence of this isoform differs from the canonical sequence as follows:
     114-367: Missing.
     387-452: Missing.

Isoform Tau-F (identifier: P19332-6)

The sequence of this isoform differs from the canonical sequence as follows:
     34-91: Missing.
     114-367: Missing.
     387-452: Missing.

Isoform Tau-G (identifier: P19332-7)

Also known as: Fetal-tau;

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     114-367: Missing.
     387-452: Missing.
     586-616: Missing.

Isoform Tau-H (identifier: P19332-8)

The sequence of this isoform differs from the canonical sequence as follows:
     752-752: L → KPVLLSSEVWNYSHDFGHHTDLGL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 752	751	Microtubule-associated protein tau		PRO_0000072746
Regions
	Repeat	555 – 585	31	Tau/MAP 1
	Repeat	586 – 616	31	Tau/MAP 2
	Repeat	617 – 647	31	Tau/MAP 3
	Repeat	648 – 679	32	Tau/MAP 4
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	18	1	Phosphotyrosine; by FYN By similarity
	Modified residue	35	1	Phosphoserine By similarity
	Modified residue	100	1	Phosphothreonine By similarity
	Modified residue	204	1	Phosphoserine; by SGK1 By similarity
	Modified residue	464	1	Phosphothreonine By similarity
	Modified residue	476	1	Phosphothreonine By similarity
	Modified residue	486	1	Phosphothreonine By similarity
	Modified residue	489	1	Phosphoserine By similarity
	Modified residue	492	1	Phosphothreonine Ref.7
	Modified residue	508	1	Phosphotyrosine By similarity
	Modified residue	509	1	Phosphoserine Ref.7
	Modified residue	510	1	Phosphoserine Ref.7
	Modified residue	513	1	Phosphoserine; by CK1, PDPK1 and TTBK1 Ref.7
	Modified residue	516	1	Phosphothreonine; by CK1 and PDPK1
	Modified residue	523	1	Phosphothreonine; by BRSK1, BRSK2, DYRK2 and PDPK1 By similarity
	Modified residue	525	1	Phosphoserine By similarity
	Modified residue	528	1	Phosphothreonine Probable
	Modified residue	542	1	Phosphothreonine; by GSK3-beta and PDPK1 By similarity
	Modified residue	546	1	Phosphoserine Ref.7
	Modified residue	548	1	Phosphoserine; by PHK By similarity
	Modified residue	573	1	Phosphoserine; by MARK1, BRSK1, BRSK2 and PHK By similarity
	Modified residue	596	1	Phosphoserine; by PHK By similarity
	Modified residue	600	1	Phosphoserine; by PHK By similarity
	Modified residue	604	1	Phosphoserine By similarity
	Modified residue	616	1	Phosphoserine By similarity
	Modified residue	635	1	Phosphoserine By similarity
	Modified residue	663	1	Phosphoserine; by PHK By similarity
	Modified residue	667	1	Phosphoserine By similarity
	Modified residue	707	1	Phosphoserine; by CK1 and PDPK1 Ref.7
	Modified residue	711	1	Phosphoserine Ref.7
	Modified residue	714	1	Phosphothreonine By similarity
	Modified residue	715	1	Phosphoserine; by CK1 and PDPK1 Ref.7
	Modified residue	720	1	Phosphoserine By similarity
	Modified residue	723	1	Phosphoserine By similarity
	Modified residue	725	1	Phosphothreonine By similarity
	Modified residue	727	1	Phosphoserine By similarity
	Modified residue	733	1	Phosphoserine By similarity
	Modified residue	738	1	Phosphothreonine By similarity
	Disulfide bond	602 ↔ 633		By similarity
Natural variations
	Alternative sequence	34 – 91	58	Missing in isoform Tau-F.		VSP_003191
	Alternative sequence	63 – 91	29	Missing in isoform Tau-C and isoform Tau-G.		VSP_003192
	Alternative sequence	114 – 367	254	Missing in isoform Tau-C, isoform Tau-D, isoform Tau-E, isoform Tau-F and isoform Tau-G.		VSP_003193
	Alternative sequence	387 – 452	66	Missing in isoform Tau-B, isoform Tau-C, isoform Tau-E, isoform Tau-F and isoform Tau-G.		VSP_003194
	Alternative sequence	586 – 616	31	Missing in isoform Tau-G.		VSP_003195
	Alternative sequence	752	1	L → KPVLLSSEVWNYSHDFGHHT DLGL in isoform Tau-H.		VSP_003196
Experimental info
	Sequence conflict	255	1	F → L Ref.2
	Sequence conflict	284	1	G → A Ref.2
	Sequence conflict	292	1	H → D Ref.2
	Sequence conflict	618	1	H → Q Ref.2
	Sequence conflict	618	1	H → Q in CAA55889. Ref.3
	Sequence conflict	618	1	H → Q Ref.4
	Sequence conflict	705	1	Y → H in CAA55889. Ref.3
	Sequence conflict	734	1	P → A Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform Tau-A (SC1) [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 915DCA04EF0B2902	FASTA	752	78,564
	10 20 30 40 50 60 MAEPRQEFDT MEDQAGDYTM LQDQEGDMDH GLKESPPQPP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEDVTAPLVE ERAPDKQATA QSHTEIPEGT TAEEAGIGDT PNMEDQAAGH VTQEPQKVEI 130 140 150 160 170 180 FSQSLLVEPG RREGQAPDSG ISDWTHQQVP SMSGAPLPPQ GLREATHQPL GTRPEDVERS 190 200 210 220 230 240 HPASELLWQE SPQKEAWGKD RLGSEEEVDE DITMDESSQE SPPSQASLAP GTATPQARSV 250 260 270 280 290 300 SASGVSGETT SIPGFPAEGS IPLPADFFSK VSAETQASPP EGPGTGPSEE GHEAAPEFTF 310 320 330 340 350 360 HVEIKASAPK EQDLEGATVV GAPAEEQKAR GPSVGKGTKE ASLLEPTDKQ PAAGLPGRPV 370 380 390 400 410 420 SRVPQLKARV AGVSKDRTGN DEKKAKTSTP SCAKTPSNRP CLSPTRPTPG SSDPLIKPSS 430 440 450 460 470 480 PAVCPEPATS PKYVSSVTPR NGSPGTKQMK LKGADGKTGA KIATPRGAAT PGQKGTSNAT 490 500 510 520 530 540 RIPAKTTPSP KTPPGSGEPP KSGERSGYSS PGSPGTPGSR SRTPSLPTPP TREPKKVAVV 550 560 570 580 590 600 RTPPKSPSAS KSRLQTAPVP MPDLKNVRSK IGSTENLKHQ PGGGKVQIIN KKLDLSNVQS 610 620 630 640 650 660 KCGSKDNIKH VPGGGSVHIV YKPVDLSKVT SKCGSLGNIH HKPGGGQVEV KSEKLDFKDR 670 680 690 700 710 720 VQSKIGSLDN ITHVPGGGNK KIETHKLTFR ENAKAKTDHG AEIVYKSPVV SGDTSPRHLS 730 740 750 NVSSTGSIDM VDSPQLATLA DEVSASLAKQ GL
	Isoform Tau-B (Big-tau) (HMW-tau) [UniParc]. Checksum: F3709D1844C3763D	FASTA	686	71,774
	10 20 30 40 50 60 MAEPRQEFDT MEDQAGDYTM LQDQEGDMDH GLKESPPQPP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEDVTAPLVE ERAPDKQATA QSHTEIPEGT TAEEAGIGDT PNMEDQAAGH VTQEPQKVEI 130 140 150 160 170 180 FSQSLLVEPG RREGQAPDSG ISDWTHQQVP SMSGAPLPPQ GLREATHQPL GTRPEDVERS 190 200 210 220 230 240 HPASELLWQE SPQKEAWGKD RLGSEEEVDE DITMDESSQE SPPSQASLAP GTATPQARSV 250 260 270 280 290 300 SASGVSGETT SIPGFPAEGS IPLPADFFSK VSAETQASPP EGPGTGPSEE GHEAAPEFTF 310 320 330 340 350 360 HVEIKASAPK EQDLEGATVV GAPAEEQKAR GPSVGKGTKE ASLLEPTDKQ PAAGLPGRPV 370 380 390 400 410 420 SRVPQLKARV AGVSKDRTGN DEKKAKGADG KTGAKIATPR GAATPGQKGT SNATRIPAKT 430 440 450 460 470 480 TPSPKTPPGS GEPPKSGERS GYSSPGSPGT PGSRSRTPSL PTPPTREPKK VAVVRTPPKS 490 500 510 520 530 540 PSASKSRLQT APVPMPDLKN VRSKIGSTEN LKHQPGGGKV QIINKKLDLS NVQSKCGSKD 550 560 570 580 590 600 NIKHVPGGGS VHIVYKPVDL SKVTSKCGSL GNIHHKPGGG QVEVKSEKLD FKDRVQSKIG 610 620 630 640 650 660 SLDNITHVPG GGNKKIETHK LTFRENAKAK TDHGAEIVYK SPVVSGDTSP RHLSNVSSTG 670 680 SIDMVDSPQL ATLADEVSAS LAKQGL
	Isoform Tau-C [UniParc]. Checksum: 4ED13493B947A5E7	FASTA	403	42,048
	10 20 30 40 50 60 MAEPRQEFDT MEDQAGDYTM LQDQEGDMDH GLKESPPQPP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEAEEAGIGD TPNMEDQAAG HVTQARVAGV SKDRTGNDEK KAKGADGKTG AKIATPRGAA 130 140 150 160 170 180 TPGQKGTSNA TRIPAKTTPS PKTPPGSGEP PKSGERSGYS SPGSPGTPGS RSRTPSLPTP 190 200 210 220 230 240 PTREPKKVAV VRTPPKSPSA SKSRLQTAPV PMPDLKNVRS KIGSTENLKH QPGGGKVQII 250 260 270 280 290 300 NKKLDLSNVQ SKCGSKDNIK HVPGGGSVHI VYKPVDLSKV TSKCGSLGNI HHKPGGGQVE 310 320 330 340 350 360 VKSEKLDFKD RVQSKIGSLD NITHVPGGGN KKIETHKLTF RENAKAKTDH GAEIVYKSPV 370 380 390 400 VSGDTSPRHL SNVSSTGSID MVDSPQLATL ADEVSASLAK QGL
	Isoform Tau-D (SC2) [UniParc]. Checksum: 6DC5958544984730	FASTA	498	51,912
	10 20 30 40 50 60 MAEPRQEFDT MEDQAGDYTM LQDQEGDMDH GLKESPPQPP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEDVTAPLVE ERAPDKQATA QSHTEIPEGT TAEEAGIGDT PNMEDQAAGH VTQARVAGVS 130 140 150 160 170 180 KDRTGNDEKK AKTSTPSCAK TPSNRPCLSP TRPTPGSSDP LIKPSSPAVC PEPATSPKYV 190 200 210 220 230 240 SSVTPRNGSP GTKQMKLKGA DGKTGAKIAT PRGAATPGQK GTSNATRIPA KTTPSPKTPP 250 260 270 280 290 300 GSGEPPKSGE RSGYSSPGSP GTPGSRSRTP SLPTPPTREP KKVAVVRTPP KSPSASKSRL 310 320 330 340 350 360 QTAPVPMPDL KNVRSKIGST ENLKHQPGGG KVQIINKKLD LSNVQSKCGS KDNIKHVPGG 370 380 390 400 410 420 GSVHIVYKPV DLSKVTSKCG SLGNIHHKPG GGQVEVKSEK LDFKDRVQSK IGSLDNITHV 430 440 450 460 470 480 PGGGNKKIET HKLTFRENAK AKTDHGAEIV YKSPVVSGDT SPRHLSNVSS TGSIDMVDSP 490 QLATLADEVS ASLAKQGL
	Isoform Tau-E [UniParc]. Checksum: BBBC0DF6D0394D72	FASTA	432	45,122
	10 20 30 40 50 60 MAEPRQEFDT MEDQAGDYTM LQDQEGDMDH GLKESPPQPP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEDVTAPLVE ERAPDKQATA QSHTEIPEGT TAEEAGIGDT PNMEDQAAGH VTQARVAGVS 130 140 150 160 170 180 KDRTGNDEKK AKGADGKTGA KIATPRGAAT PGQKGTSNAT RIPAKTTPSP KTPPGSGEPP 190 200 210 220 230 240 KSGERSGYSS PGSPGTPGSR SRTPSLPTPP TREPKKVAVV RTPPKSPSAS KSRLQTAPVP 250 260 270 280 290 300 MPDLKNVRSK IGSTENLKHQ PGGGKVQIIN KKLDLSNVQS KCGSKDNIKH VPGGGSVHIV 310 320 330 340 350 360 YKPVDLSKVT SKCGSLGNIH HKPGGGQVEV KSEKLDFKDR VQSKIGSLDN ITHVPGGGNK 370 380 390 400 410 420 KIETHKLTFR ENAKAKTDHG AEIVYKSPVV SGDTSPRHLS NVSSTGSIDM VDSPQLATLA 430 DEVSASLAKQ GL
	Isoform Tau-F [UniParc]. Checksum: 2323D277377BDBB7	FASTA	374	39,152
	10 20 30 40 50 60 MAEPRQEFDT MEDQAGDYTM LQDQEGDMDH GLKAEEAGIG DTPNMEDQAA GHVTQARVAG 70 80 90 100 110 120 VSKDRTGNDE KKAKGADGKT GAKIATPRGA ATPGQKGTSN ATRIPAKTTP SPKTPPGSGE 130 140 150 160 170 180 PPKSGERSGY SSPGSPGTPG SRSRTPSLPT PPTREPKKVA VVRTPPKSPS ASKSRLQTAP 190 200 210 220 230 240 VPMPDLKNVR SKIGSTENLK HQPGGGKVQI INKKLDLSNV QSKCGSKDNI KHVPGGGSVH 250 260 270 280 290 300 IVYKPVDLSK VTSKCGSLGN IHHKPGGGQV EVKSEKLDFK DRVQSKIGSL DNITHVPGGG 310 320 330 340 350 360 NKKIETHKLT FRENAKAKTD HGAEIVYKSP VVSGDTSPRH LSNVSSTGSI DMVDSPQLAT 370 LADEVSASLA KQGL
	Isoform Tau-G (Fetal-tau) [UniParc]. Checksum: D4A2BD9C6DEAD376	FASTA	372	38,801
	10 20 30 40 50 60 MAEPRQEFDT MEDQAGDYTM LQDQEGDMDH GLKESPPQPP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEAEEAGIGD TPNMEDQAAG HVTQARVAGV SKDRTGNDEK KAKGADGKTG AKIATPRGAA 130 140 150 160 170 180 TPGQKGTSNA TRIPAKTTPS PKTPPGSGEP PKSGERSGYS SPGSPGTPGS RSRTPSLPTP 190 200 210 220 230 240 PTREPKKVAV VRTPPKSPSA SKSRLQTAPV PMPDLKNVRS KIGSTENLKH QPGGGKVHIV 250 260 270 280 290 300 YKPVDLSKVT SKCGSLGNIH HKPGGGQVEV KSEKLDFKDR VQSKIGSLDN ITHVPGGGNK 310 320 330 340 350 360 KIETHKLTFR ENAKAKTDHG AEIVYKSPVV SGDTSPRHLS NVSSTGSIDM VDSPQLATLA 370 DEVSASLAKQ GL
	Isoform Tau-H [UniParc]. Checksum: AF16994BB897B2DE	FASTA	775	81,185
	10 20 30 40 50 60 MAEPRQEFDT MEDQAGDYTM LQDQEGDMDH GLKESPPQPP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEDVTAPLVE ERAPDKQATA QSHTEIPEGT TAEEAGIGDT PNMEDQAAGH VTQEPQKVEI 130 140 150 160 170 180 FSQSLLVEPG RREGQAPDSG ISDWTHQQVP SMSGAPLPPQ GLREATHQPL GTRPEDVERS 190 200 210 220 230 240 HPASELLWQE SPQKEAWGKD RLGSEEEVDE DITMDESSQE SPPSQASLAP GTATPQARSV 250 260 270 280 290 300 SASGVSGETT SIPGFPAEGS IPLPADFFSK VSAETQASPP EGPGTGPSEE GHEAAPEFTF 310 320 330 340 350 360 HVEIKASAPK EQDLEGATVV GAPAEEQKAR GPSVGKGTKE ASLLEPTDKQ PAAGLPGRPV 370 380 390 400 410 420 SRVPQLKARV AGVSKDRTGN DEKKAKTSTP SCAKTPSNRP CLSPTRPTPG SSDPLIKPSS 430 440 450 460 470 480 PAVCPEPATS PKYVSSVTPR NGSPGTKQMK LKGADGKTGA KIATPRGAAT PGQKGTSNAT 490 500 510 520 530 540 RIPAKTTPSP KTPPGSGEPP KSGERSGYSS PGSPGTPGSR SRTPSLPTPP TREPKKVAVV 550 560 570 580 590 600 RTPPKSPSAS KSRLQTAPVP MPDLKNVRSK IGSTENLKHQ PGGGKVQIIN KKLDLSNVQS 610 620 630 640 650 660 KCGSKDNIKH VPGGGSVHIV YKPVDLSKVT SKCGSLGNIH HKPGGGQVEV KSEKLDFKDR 670 680 690 700 710 720 VQSKIGSLDN ITHVPGGGNK KIETHKLTFR ENAKAKTDHG AEIVYKSPVV SGDTSPRHLS 730 740 750 760 770 NVSSTGSIDM VDSPQLATLA DEVSASLAKQ GKPVLLSSEV WNYSHDFGHH TDLGL

References

[1]	"Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system." Goedert M., Spillantini M.G., Crowther R.A. Proc. Natl. Acad. Sci. U.S.A. 89:1983-1987(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TAU-B). Tissue: Pheochromocytoma.
[2]	"Expression of high molecular weight tau in the central and peripheral nervous systems." Georgieff I.S., Liem R.K.H., Couchie D., Mavilia C., Nunez J., Shelanski M.L. J. Cell Sci. 105:729-737(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TAU-B). Tissue: Spinal ganglion.
[3]	"Complete sequence of 3'-untranslated region of tau from rat central nervous system. Implications for mRNA heterogeneity." Sadot E., Marx R., Barg J., Behar L., Ginzburg I. J. Mol. Biol. 241:325-331(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TAU-F). Strain: Wistar. Tissue: Brain.
[4]	"Developmentally regulated expression of specific tau sequences." Kosik K.S., Orecchio L.D., Bakalis S., Neve R.L. Neuron 2:1389-1397(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TAU-E AND TAU-G). Tissue: Brain.
[5]	"Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA." Kanai Y., Takemura R., Oshima T., Mori H., Ihara Y., Yanagisawa M., Masaki T., Hirokawa N. J. Cell Biol. 109:1173-1184(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TAU-E AND TAU-C).
[6]	"Diversity of high-molecular-weight tau proteins in different regions of the nervous system." Mavilia C., Couchie D., Nunez J. J. Neurochem. 63:2300-2306(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 360-461 (ISOFORM TAU-A), NUCLEOTIDE SEQUENCE OF 106-113 AND 368-461 (ISOFORM TAU-D). Tissue: Spinal cord.
[7]	"In vivo phosphorylation sites in fetal and adult rat tau." Watanabe A., Hasegawa M., Suzuki M., Takio K., Morishima-Kawashima M., Titani K., Arai T., Kosik K.S., Ihara Y. J. Biol. Chem. 268:25712-25717(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 492-501; 506-515; 523-532; 537-551 AND 698-726, PHOSPHORYLATION AT THR-492; SER-509; SER-510; SER-513; THR-528; THR-542; SER-546; SER-707; SER-711 AND SER-715.
[8]	"Molecular diversity at the carboxyl terminus of human and rat tau." Sawa A., Oyama F., Matsushita M., Ihara Y. Brain Res. Mol. Brain Res. 27:111-117(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 697-752 (ISOFORMS TAU-A; TAU-B; TAU-C; TAU-D; TAU-E; TAU-F AND TAU-G), NUCLEOTIDE SEQUENCE [MRNA] OF 752-775 (ISOFORM TAU-H). Strain: Sprague-Dawley. Tissue: Brain.
[9]	"A role for FKBP52 in Tau protein function." Chambraud B., Sardin E., Giustiniani J., Dounane O., Schumacher M., Goedert M., Baulieu E.E. Proc. Natl. Acad. Sci. U.S.A. 107:2658-2663(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FKBP4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M84156 mRNA. Translation: AAA42204.1. X79321 mRNA. Translation: CAA55889.1. D30628 Genomic DNA. No translation available. D30629 mRNA. No translation available.
IPI	IPI00230972. IPI00679178. IPI00679181. IPI00679236. IPI00679248. IPI00758434. IPI00817094. IPI00957830.
PIR	A38235. JS0306. S46264.
UniGene	Rn.2455.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-41779N.
MINT	MINT-1037362.
PTM databases
PhosphoSite	P19332.
Proteomic databases
PaxDb	P19332.
PRIDE	P19332.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:69329. rat.
Organism-specific databases
RGD	69329. Mapt.
Phylogenomic databases
eggNOG	NOG148882.
HOGENOM	HOG000231029.
HOVERGEN	HBG000991.
OrthoDB	EOG4B8JDC.
Gene expression databases
ArrayExpress	P19332.
Genevestigator	P19332.
GermOnline	ENSRNOG00000005133. Rattus norvegicus.
Family and domain databases
InterPro	IPR027324. MAP2/MAP4/Tau. IPR001084. Tau/MAP_tubulin-bd_rpt. IPR002955. Tau_protein. [Graphical view]
PANTHER	PTHR11501. PTHR11501. 1 hit.
Pfam	PF00418. Tubulin-binding. 4 hits. [Graphical view]
PRINTS	PR01261. TAUPROTEIN.
PROSITE	PS00229. TAU_MAP_1. 4 hits. PS51491. TAU_MAP_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P19332.
ChEMBL	CHEMBL1075117.

Entry information

Entry name

TAU_RAT

Accession

Primary (citable) accession number: P19332
Secondary accession number(s): Q63567, Q63677, Q9QW06

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 123 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program