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Protein

Alpha-2B adrenergic receptor

Gene

Adra2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei97Implicated in ligand bindingBy similarity1
Sitei181Implicated in catechol agonist bindingBy similarity1
Sitei185Implicated in catechol agonist bindingBy similarity1

GO - Molecular functioni

  • alpha2-adrenergic receptor activity Source: RGD

GO - Biological processi

  • activation of MAPK activity Source: RGD
  • adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
  • cell-cell signaling Source: GO_Central
  • female pregnancy Source: RGD
  • platelet activation Source: InterPro
  • positive regulation of blood pressure Source: RGD
  • positive regulation of uterine smooth muscle contraction Source: RGD
  • regulation of vascular smooth muscle contraction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2B adrenergic receptor
Alternative name(s):
Alpha-2B adrenoreceptor
Short name:
Alpha-2B adrenoceptor
Short name:
Alpha-2BAR
Gene namesi
Name:Adra2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2057. Adra2b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17ExtracellularBy similarityAdd BLAST17
Transmembranei18 – 42Helical; Name=1By similarityAdd BLAST25
Topological domaini43 – 54CytoplasmicBy similarityAdd BLAST12
Transmembranei55 – 80Helical; Name=2By similarityAdd BLAST26
Topological domaini81 – 90ExtracellularBy similarity10
Transmembranei91 – 113Helical; Name=3By similarityAdd BLAST23
Topological domaini114 – 135CytoplasmicBy similarityAdd BLAST22
Transmembranei136 – 158Helical; Name=4By similarityAdd BLAST23
Topological domaini159 – 174ExtracellularBy similarityAdd BLAST16
Transmembranei175 – 198Helical; Name=5By similarityAdd BLAST24
Topological domaini199 – 375CytoplasmicBy similarityAdd BLAST177
Transmembranei376 – 399Helical; Name=6By similarityAdd BLAST24
Topological domaini400 – 408ExtracellularBy similarity9
Transmembranei409 – 432Helical; Name=7By similarityAdd BLAST24
Topological domaini433 – 453CytoplasmicBy similarityAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL266.
GuidetoPHARMACOLOGYi26.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691001 – 453Alpha-2B adrenergic receptorAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi90 ↔ 169PROSITE-ProRule annotation
Lipidationi445S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP19328.
PRIDEiP19328.

PTM databases

PhosphoSitePlusiP19328.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013887.
GenevisibleiP19328. RN.

Interactioni

Subunit structurei

Interacts with RAB26. Interacts with PPP1R9B.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018584.

Chemistry databases

BindingDBiP19328.

Structurei

3D structure databases

ProteinModelPortaliP19328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi300 – 314Asp/Glu-rich (acidic)Add BLAST15

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP19328.
KOiK04139.
OMAiKHCKVPH.
OrthoDBiEOG091G06VI.
PhylomeDBiP19328.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000207. ADRA2B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00559. ADRENRGCA2BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGPTMDHQE PYSVQATAAI ASAITFLILF TIFGNALVIL AVLTSRSLRA
60 70 80 90 100
PQNLFLVSLA AADILVATLI IPFSLANELL GYWYFWRAWC EVYLALDVLF
110 120 130 140 150
CTSSIVHLCA ISLDRYWAVS RALEYNSKRT PRRIKCIILT VWLIAAVISL
160 170 180 190 200
PPLIYKGDQR PEPRGLPQCE LNQEAWYILA SSIGSFFAPC LIMILVYLRI
210 220 230 240 250
YVIAKRSHCR GLGAKRGSGE GESKKPQPVA GGVPTSAKVP TLVSPLSSVG
260 270 280 290 300
EANGHPKPPR EKEEGETPED PEARALPPTW SALPRSGQGQ KKGTSGATAE
310 320 330 340 350
EGDEEDEEEV EECEPQTLPA SPASVCNPPL QQPQTSRVLA TLRGQVLLGK
360 370 380 390 400
NVGVASGQWW RRRTQLSREK RFTFVLAVVI GVFVVCWFPF FFSYSLGAIC
410 420 430 440 450
PQHCKVPHGL FQFFFWIGYC NSSLNPVIYT VFNQDFRRAF RRILCRPWTQ

TGW
Length:453
Mass (Da):50,369
Last modified:October 10, 2003 - v2
Checksum:iCBA69CE23EACB511
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132R → C in AAA40635 (PubMed:2158103).Curated1
Sequence conflicti162 – 163EP → DA in AAA40635 (PubMed:2158103).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32061 mRNA. Translation: AAA40635.1.
AF366899 Genomic DNA. Translation: AAK53388.1.
X74400 Genomic DNA. Translation: CAA52411.1.
PIRiA35642.
I51883.
RefSeqiNP_612514.2. NM_138505.2.
UniGeneiRn.10296.

Genome annotation databases

EnsembliENSRNOT00000018584; ENSRNOP00000018584; ENSRNOG00000013887.
GeneIDi24174.
KEGGirno:24174.
UCSCiRGD:2057. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32061 mRNA. Translation: AAA40635.1.
AF366899 Genomic DNA. Translation: AAK53388.1.
X74400 Genomic DNA. Translation: CAA52411.1.
PIRiA35642.
I51883.
RefSeqiNP_612514.2. NM_138505.2.
UniGeneiRn.10296.

3D structure databases

ProteinModelPortaliP19328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018584.

Chemistry databases

BindingDBiP19328.
ChEMBLiCHEMBL266.
GuidetoPHARMACOLOGYi26.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP19328.

Proteomic databases

PaxDbiP19328.
PRIDEiP19328.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018584; ENSRNOP00000018584; ENSRNOG00000013887.
GeneIDi24174.
KEGGirno:24174.
UCSCiRGD:2057. rat.

Organism-specific databases

CTDi151.
RGDi2057. Adra2b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP19328.
KOiK04139.
OMAiKHCKVPH.
OrthoDBiEOG091G06VI.
PhylomeDBiP19328.
TreeFamiTF316350.

Miscellaneous databases

PROiP19328.

Gene expression databases

BgeeiENSRNOG00000013887.
GenevisibleiP19328. RN.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000207. ADRA2B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00559. ADRENRGCA2BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA2B_RAT
AccessioniPrimary (citable) accession number: P19328
Secondary accession number(s): Q63021, Q925E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 10, 2003
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.