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P19328

- ADA2B_RAT

UniProt

P19328 - ADA2B_RAT

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Protein
Alpha-2B adrenergic receptor
Gene
Adra2b
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei97 – 971Implicated in ligand binding By similarity
Sitei181 – 1811Implicated in catechol agonist binding By similarity
Sitei185 – 1851Implicated in catechol agonist binding By similarity

GO - Molecular functioni

  1. alpha2-adrenergic receptor activity Source: RGD
  2. epinephrine binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. activation of MAPK activity Source: RGD
  3. activation of MAPK activity by adrenergic receptor signaling pathway Source: Ensembl
  4. activation of protein kinase B activity Source: Ensembl
  5. angiogenesis Source: Ensembl
  6. epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway Source: Ensembl
  7. female pregnancy Source: RGD
  8. platelet activation Source: InterPro
  9. positive regulation of blood pressure Source: RGD
  10. positive regulation of neuron differentiation Source: Ensembl
  11. positive regulation of uterine smooth muscle contraction Source: RGD
  12. regulation of vascular smooth muscle contraction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2B adrenergic receptor
Alternative name(s):
Alpha-2B adrenoreceptor
Short name:
Alpha-2B adrenoceptor
Short name:
Alpha-2BAR
Gene namesi
Name:Adra2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi2057. Adra2b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717Extracellular By similarity
Add
BLAST
Transmembranei18 – 4225Helical; Name=1; By similarity
Add
BLAST
Topological domaini43 – 5412Cytoplasmic By similarity
Add
BLAST
Transmembranei55 – 8026Helical; Name=2; By similarity
Add
BLAST
Topological domaini81 – 9010Extracellular By similarity
Transmembranei91 – 11323Helical; Name=3; By similarity
Add
BLAST
Topological domaini114 – 13522Cytoplasmic By similarity
Add
BLAST
Transmembranei136 – 15823Helical; Name=4; By similarity
Add
BLAST
Topological domaini159 – 17416Extracellular By similarity
Add
BLAST
Transmembranei175 – 19824Helical; Name=5; By similarity
Add
BLAST
Topological domaini199 – 375177Cytoplasmic By similarity
Add
BLAST
Transmembranei376 – 39924Helical; Name=6; By similarity
Add
BLAST
Topological domaini400 – 4089Extracellular By similarity
Transmembranei409 – 43224Helical; Name=7; By similarity
Add
BLAST
Topological domaini433 – 45321Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: RGD
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Alpha-2B adrenergic receptor
PRO_0000069100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi90 ↔ 169 By similarity
Lipidationi445 – 4451S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP19328.
PRIDEiP19328.

Expressioni

Gene expression databases

GenevestigatoriP19328.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP19328.
SMRiP19328. Positions 102-133.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi300 – 31415Asp/Glu-rich (acidic)
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00750000117640.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP19328.
KOiK04139.
OMAiKHCKVPH.
OrthoDBiEOG7J9VPT.
PhylomeDBiP19328.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002233. ADR_fam.
IPR000207. ADRA2B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF26. PTHR24248:SF26. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00559. ADRENRGCA2BR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19328-1 [UniParc]FASTAAdd to Basket

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MSGPTMDHQE PYSVQATAAI ASAITFLILF TIFGNALVIL AVLTSRSLRA    50
PQNLFLVSLA AADILVATLI IPFSLANELL GYWYFWRAWC EVYLALDVLF 100
CTSSIVHLCA ISLDRYWAVS RALEYNSKRT PRRIKCIILT VWLIAAVISL 150
PPLIYKGDQR PEPRGLPQCE LNQEAWYILA SSIGSFFAPC LIMILVYLRI 200
YVIAKRSHCR GLGAKRGSGE GESKKPQPVA GGVPTSAKVP TLVSPLSSVG 250
EANGHPKPPR EKEEGETPED PEARALPPTW SALPRSGQGQ KKGTSGATAE 300
EGDEEDEEEV EECEPQTLPA SPASVCNPPL QQPQTSRVLA TLRGQVLLGK 350
NVGVASGQWW RRRTQLSREK RFTFVLAVVI GVFVVCWFPF FFSYSLGAIC 400
PQHCKVPHGL FQFFFWIGYC NSSLNPVIYT VFNQDFRRAF RRILCRPWTQ 450
TGW 453
Length:453
Mass (Da):50,369
Last modified:October 10, 2003 - v2
Checksum:iCBA69CE23EACB511
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321R → C in AAA40635. 1 Publication
Sequence conflicti162 – 1632EP → DA in AAA40635. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32061 mRNA. Translation: AAA40635.1.
AF366899 Genomic DNA. Translation: AAK53388.1.
X74400 Genomic DNA. Translation: CAA52411.1.
PIRiA35642.
I51883.
RefSeqiNP_612514.2. NM_138505.2.
UniGeneiRn.10296.

Genome annotation databases

EnsembliENSRNOT00000018584; ENSRNOP00000018584; ENSRNOG00000013887.
GeneIDi24174.
KEGGirno:24174.
UCSCiRGD:2057. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32061 mRNA. Translation: AAA40635.1 .
AF366899 Genomic DNA. Translation: AAK53388.1 .
X74400 Genomic DNA. Translation: CAA52411.1 .
PIRi A35642.
I51883.
RefSeqi NP_612514.2. NM_138505.2.
UniGenei Rn.10296.

3D structure databases

ProteinModelPortali P19328.
SMRi P19328. Positions 102-133.
ModBasei Search...

Chemistry

BindingDBi P19328.
ChEMBLi CHEMBL266.
GuidetoPHARMACOLOGYi 26.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi P19328.
PRIDEi P19328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018584 ; ENSRNOP00000018584 ; ENSRNOG00000013887 .
GeneIDi 24174.
KEGGi rno:24174.
UCSCi RGD:2057. rat.

Organism-specific databases

CTDi 151.
RGDi 2057. Adra2b.

Phylogenomic databases

eggNOGi NOG249628.
GeneTreei ENSGT00750000117640.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P19328.
KOi K04139.
OMAi KHCKVPH.
OrthoDBi EOG7J9VPT.
PhylomeDBi P19328.
TreeFami TF316350.

Miscellaneous databases

NextBioi 602505.
PROi P19328.

Gene expression databases

Genevestigatori P19328.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002233. ADR_fam.
IPR000207. ADRA2B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24248:SF26. PTHR24248:SF26. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00559. ADRENRGCA2BR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "Cloning and functional characterization of the rat alpha2B-adrenergic receptor gene promoter region: evidence for binding sites for erythropoiesis-related transcription factors GATA1 and NF-E2."
    Schaak S., Cussac D., Labialle S., Mignotte V., Paris H.
    Biochem. Pharmacol. 70:606-617(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-Dawley.
  3. "Differential sodium regulation between salt-sensitive and salt-resistant Sabra rats is not due to any mutation in the renal alpha 2B-adrenoceptor gene."
    le Jossec M., Cloix J.F., Pecquery R., Giudicelli Y., Dausse J.P.
    Am. J. Hypertens. 8:177-182(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-453.
    Strain: Sabra.
    Tissue: Kidney.

Entry informationi

Entry nameiADA2B_RAT
AccessioniPrimary (citable) accession number: P19328
Secondary accession number(s): Q63021, Q925E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 10, 2003
Last modified: June 11, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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