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P19327

- 5HT1A_RAT

UniProt

P19327 - 5HT1A_RAT

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Protein
5-hydroxytryptamine receptor 1A
Gene
Htr1a, 5ht1a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.2 Publications

GO - Molecular functioni

  1. G-protein alpha-subunit binding Source: RGD
  2. drug binding Source: RGD
  3. protein binding Source: IntAct
  4. serotonin binding Source: RGD
  5. serotonin receptor activity Source: RGD

GO - Biological processi

  1. N-methyl-D-aspartate receptor clustering Source: RGD
  2. adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: RGD
  3. behavioral fear response Source: UniProtKB
  4. cell proliferation Source: InterPro
  5. exploration behavior Source: UniProtKB
  6. positive regulation of microtubule depolymerization Source: RGD
  7. regulation of dopamine metabolic process Source: UniProtKB
  8. regulation of feeding behavior Source: RGD
  9. regulation of hormone secretion Source: InterPro
  10. regulation of serotonin secretion Source: UniProtKB
  11. serotonin metabolic process Source: UniProtKB
  12. serotonin receptor signaling pathway Source: RGD
  13. vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1A
Short name:
5-HT-1A
Short name:
5-HT1A
Alternative name(s):
Serotonin receptor 1A
Gene namesi
Name:Htr1a
Synonyms:5ht1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2845. Htr1a.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Extracellular By similarity
Add
BLAST
Transmembranei37 – 6226Helical; Name=1; By similarity
Add
BLAST
Topological domaini63 – 7311Cytoplasmic By similarity
Add
BLAST
Transmembranei74 – 9825Helical; Name=2; By similarity
Add
BLAST
Topological domaini99 – 11012Extracellular By similarity
Add
BLAST
Transmembranei111 – 13222Helical; Name=3; By similarity
Add
BLAST
Topological domaini133 – 15220Cytoplasmic By similarity
Add
BLAST
Transmembranei153 – 17826Helical; Name=4; By similarity
Add
BLAST
Topological domaini179 – 19113Extracellular By similarity
Add
BLAST
Transmembranei192 – 21726Helical; Name=5; By similarity
Add
BLAST
Topological domaini218 – 345128Cytoplasmic By similarity
Add
BLAST
Transmembranei346 – 36722Helical; Name=6; By similarity
Add
BLAST
Topological domaini368 – 37811Extracellular By similarity
Add
BLAST
Transmembranei379 – 40325Helical; Name=7; By similarity
Add
BLAST
Topological domaini404 – 42219Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. axon hillock Source: RGD
  2. integral component of plasma membrane Source: UniProtKB
  3. membrane Source: RGD
  4. neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4224225-hydroxytryptamine receptor 1A
PRO_0000068907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi11 – 111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi24 – 241N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi109 ↔ 187 By similarity
Cross-linki334 – 334Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP19327.
PRIDEiP19327.

PTM databases

PhosphoSiteiP19327.

Expressioni

Tissue specificityi

Detected in hypothalamus, mesencephalon, amygdala, medulla, thalamus, septum and hippocampus.1 Publication

Gene expression databases

GenevestigatoriP19327.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with GPER1 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Fgfr1Q045896EBI-6570156,EBI-2480918

Protein-protein interaction databases

IntActiP19327. 2 interactions.
STRINGi10116.ENSRNOP00000013618.

Structurei

3D structure databases

ProteinModelPortaliP19327.
SMRiP19327. Positions 121-152.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni112 – 12110Agonist binding By similarity
Regioni358 – 3625Agonist binding By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi133 – 1353DRY motif; important for ligand-induced conformation changes By similarity
Motifi396 – 4005NPxxY motif; important for ligand-induced conformation changes and signaling By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP19327.
KOiK04153.
PhylomeDBiP19327.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000610. 5HT1A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF20. PTHR24247:SF20. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00512. 5HT1ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19327-1 [UniParc]FASTAAdd to Basket

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MDVFSFGQGN NTTASQEPFG TGGNVTSISD VTFSYQVITS LLLGTLIFCA    50
VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN 100
KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP 150
RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST 200
FGAFYIPLLL MLVLYGRIFR AARFRIRKTV RKVEKKGAGT SLGTSSAPPP 250
KKSLNGQPGS GDWRRCAENR AVGTPCTNGA VRQGDDEATL EVIEVHRVGN 300
SKEHLPLPSE SGSNSYAPAC LERKNERNAE AKRKMALARE RKTVKTLGII 350
MGTFILCWLP FFIVALVLPF CESSCHMPAL LGAIINWLGY SNSLLNPVIY 400
AYFNKDFQNA FKKIIKCKFC RR 422
Length:422
Mass (Da):46,429
Last modified:November 1, 1990 - v1
Checksum:i19C2731834C4BBC9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti373 – 3731S → N1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05276 Genomic DNA. Translation: AAA40612.1.
PIRiJH0315.
RefSeqiNP_036717.1. NM_012585.1.
UniGeneiRn.44486.

Genome annotation databases

GeneIDi24473.
KEGGirno:24473.
UCSCiRGD:2845. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05276 Genomic DNA. Translation: AAA40612.1 .
PIRi JH0315.
RefSeqi NP_036717.1. NM_012585.1.
UniGenei Rn.44486.

3D structure databases

ProteinModelPortali P19327.
SMRi P19327. Positions 121-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P19327. 2 interactions.
STRINGi 10116.ENSRNOP00000013618.

Chemistry

BindingDBi P19327.
ChEMBLi CHEMBL2095159.
GuidetoPHARMACOLOGYi 1.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P19327.

Proteomic databases

PaxDbi P19327.
PRIDEi P19327.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 24473.
KEGGi rno:24473.
UCSCi RGD:2845. rat.

Organism-specific databases

CTDi 3350.
RGDi 2845. Htr1a.

Phylogenomic databases

eggNOGi NOG249628.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P19327.
KOi K04153.
PhylomeDBi P19327.

Miscellaneous databases

NextBioi 603421.
PROi P19327.

Gene expression databases

Genevestigatori P19327.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000610. 5HT1A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF20. PTHR24247:SF20. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00512. 5HT1ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene."
    Albert P.R., Zhou Q.-Y., van Tol H.H.M., Bunzow J.R., Civelli O.
    J. Biol. Chem. 265:5825-5832(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Role of cytochrome P450 in the control of the production of erythropoietin."
    Fujiwara Y., Nelson D.L., Kashihara K., Varga E., Roeske W.R., Yamamura H.I.
    Life Sci. 47:127-134(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Serotonin receptor activation reduces calcium current in an acutely dissociated adult central neuron."
    Penington N.J., Kelly J.S.
    Neuron 4:751-758(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry namei5HT1A_RAT
AccessioniPrimary (citable) accession number: P19327
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 11, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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