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P19327 (5HT1A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 1A
Short name=5-HT-1A
Short name=5-HT1A
Alternative name(s):
Serotonin receptor 1A
Gene names
Name:Htr1a
Synonyms:5ht1a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4224225-hydroxytryptamine receptor 1A
PRO_0000068907

Regions

Topological domain1 – 3636Extracellular By similarity
Transmembrane37 – 6226Helical; Name=1; By similarity
Topological domain63 – 7311Cytoplasmic By similarity
Transmembrane74 – 9825Helical; Name=2; By similarity
Topological domain99 – 10911Extracellular By similarity
Transmembrane110 – 13223Helical; Name=3; By similarity
Topological domain133 – 15220Cytoplasmic By similarity
Transmembrane153 – 17826Helical; Name=4; By similarity
Topological domain179 – 19113Extracellular By similarity
Transmembrane192 – 21726Helical; Name=5; By similarity
Topological domain218 – 345128Cytoplasmic By similarity
Transmembrane346 – 36722Helical; Name=6; By similarity
Topological domain368 – 37811Extracellular By similarity
Transmembrane379 – 40325Helical; Name=7; By similarity
Topological domain404 – 42219Cytoplasmic By similarity

Amino acid modifications

Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation241N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 187 By similarity
Cross-link334Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Experimental info

Sequence conflict3731S → N Ref.2

Sequences

Sequence LengthMass (Da)Tools
P19327 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 19C2731834C4BBC9

FASTA42246,429
        10         20         30         40         50         60 
MDVFSFGQGN NTTASQEPFG TGGNVTSISD VTFSYQVITS LLLGTLIFCA VLGNACVVAA 

        70         80         90        100        110        120 
IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC 

       130        140        150        160        170        180 
TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED 

       190        200        210        220        230        240 
RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV RKVEKKGAGT 

       250        260        270        280        290        300 
SLGTSSAPPP KKSLNGQPGS GDWRRCAENR AVGTPCTNGA VRQGDDEATL EVIEVHRVGN 

       310        320        330        340        350        360 
SKEHLPLPSE SGSNSYAPAC LERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP 

       370        380        390        400        410        420 
FFIVALVLPF CESSCHMPAL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC 


RR

« Hide

References

[1]"Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene."
Albert P.R., Zhou Q.-Y., van Tol H.H.M., Bunzow J.R., Civelli O.
J. Biol. Chem. 265:5825-5832(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Role of cytochrome P450 in the control of the production of erythropoietin."
Fujiwara Y., Nelson D.L., Kashihara K., Varga E., Roeske W.R., Yamamura H.I.
Life Sci. 47:127-134(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J05276 Genomic DNA. Translation: AAA40612.1.
IPIIPI00194250.
PIRJH0315.
RefSeqNP_036717.1. NM_012585.1.
UniGeneRn.44486.

3D structure databases

ProteinModelPortalP19327.
SMRP19327. Positions 121-152.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000013618.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP19327.

Proteomic databases

PaxDbP19327.
PRIDEP19327.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID24473.
KEGGrno:24473.
UCSCRGD:2845. rat.

Organism-specific databases

CTD3350.
RGD2845. Htr1a.

Phylogenomic databases

eggNOGNOG249628.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP19327.
KOK04153.
OrthoDBEOG4CC41F.

Gene expression databases

GenevestigatorP19327.
GermOnlineENSRNOG00000010254. Rattus norvegicus.

Family and domain databases

InterProIPR000610. 5HT1A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00512. 5HT1ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP19327.
ChEMBLCHEMBL273.
NextBio603421.

Entry information

Entry name5HT1A_RAT
AccessionPrimary (citable) accession number: P19327
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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