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Protein

Serpin H1

Gene

Serpinh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei376 – 377Reactive bond homologBy similarity2

GO - Molecular functioni

GO - Biological processi

  • chondrocyte development involved in endochondral bone morphogenesis Source: MGI
  • collagen biosynthetic process Source: MGI
  • collagen fibril organization Source: MGI
  • protein maturation Source: MGI

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes

Protein family/group databases

MEROPSiI04.035

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin H1
Alternative name(s):
47 kDa heat shock protein
Collagen-binding protein
Short name:
Colligin
Serine protease inhibitor J6
Gene namesi
Name:Serpinh1
Synonyms:Cbp1, Hsp47
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88283 Serpinh1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1163113

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000003251718 – 417Serpin H1Add BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93N6-succinyllysineCombined sources1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei140PhosphoserineBy similarity1
Modified residuei206N6-acetyllysineCombined sources1
Modified residuei295N6-succinyllysineCombined sources1
Modified residuei318N6-acetyllysineCombined sources1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP19324
PaxDbiP19324
PeptideAtlasiP19324
PRIDEiP19324
TopDownProteomicsiP19324

2D gel databases

REPRODUCTION-2DPAGEiIPI00114733

PTM databases

iPTMnetiP19324
PhosphoSitePlusiP19324
SwissPalmiP19324

Expressioni

Inductioni

By heat shock and retinoic acid.

Gene expression databases

BgeeiENSMUSG00000070436
ExpressionAtlasiP19324 baseline and differential
GenevisibleiP19324 MM

Interactioni

GO - Molecular functioni

  • unfolded protein binding Source: MGI

Protein-protein interaction databases

BioGridi1985306 interactors.
CORUMiP19324
IntActiP19324 1 interactor.
MINTiP19324
STRINGi10090.ENSMUSP00000091706

Chemistry databases

BindingDBiP19324

Structurei

3D structure databases

ProteinModelPortaliP19324
SMRiP19324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi414 – 417Prevents secretion from ERCurated4

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00900000140788
HOGENOMiHOG000238519
HOVERGENiHBG104930
InParanoidiP19324
KOiK09501
OMAiGVPMMHR
OrthoDBiEOG091G08O0
TreeFamiTF343094

Family and domain databases

CDDicd02046 hsp47, 1 hit
InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR033830 Serpin_H1_domain
IPR036186 Serpin_sf
IPR033547 SERPINH1
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF27 PTHR11461:SF27, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLLLGTLC LLAVALAAEV KKPLEAAAPG TAEKLSSKAT TLAERSTGLA
60 70 80 90 100
FSLYQAMAKD QAVENILLSP LVVASSLGLV SLGGKATTAS QAKAVLSAEK
110 120 130 140 150
LRDEEVHTGL GELLRSLSNS TARNVTWKLG SRLYGPSSVS FADDFVRSSK
160 170 180 190 200
QHYNCEHSKI NFRDKRSALQ SINEWASQTT DGKLPEVTKD VERTDGALLV
210 220 230 240 250
NAMFFKPHWD EKFHHKMVDN RGFMVTRSYT VGVTMMHRTG LYNYYDDEKE
260 270 280 290 300
KLQMVEMPLA HKLSSLIILM PHHVEPLERL EKLLTKEQLK AWMGKMQKKA
310 320 330 340 350
VAISLPKGVV EVTHDLQKHL AGLGLTEAID KNKADLSRMS GKKDLYLASV
360 370 380 390 400
FHATAFEWDT EGNPFDQDIY GREELRSPKL FYADHPFIFL VRDNQSGSLL
410
FIGRLVRPKG DKMRDEL
Length:417
Mass (Da):46,534
Last modified:July 27, 2011 - v3
Checksum:i1124A050A6CC4F67
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176A → P in AAA03200 (PubMed:2394749).Curated1
Sequence conflicti212K → R in CAA43091 (PubMed:1317794).Curated1
Sequence conflicti212K → R in AAA03200 (PubMed:2394749).Curated1
Sequence conflicti216K → R in CAA43091 (PubMed:1317794).Curated1
Sequence conflicti216K → R in AAA03200 (PubMed:2394749).Curated1
Sequence conflicti270 – 271MP → IA in AAA03200 (PubMed:2394749).Curated2
Sequence conflicti277L → S in AAA03200 (PubMed:2394749).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60676 mRNA Translation: CAA43091.1
J05609 mRNA Translation: AAA03200.1 Sequence problems.
D12907 Genomic DNA Translation: BAA02298.1
AK029080 mRNA Translation: BAC26283.1
AK031457 mRNA Translation: BAC27413.1
AK077660 mRNA Translation: BAC36935.1
AK077937 mRNA Translation: BAC37075.1
AK086519 mRNA Translation: BAC39683.1
AK086523 mRNA Translation: BAC39684.1
AK089993 mRNA Translation: BAC41032.1
AK090103 mRNA Translation: BAC41093.1
AK159998 mRNA Translation: BAE35546.1
AK168442 mRNA Translation: BAE40347.1
AK168870 mRNA Translation: BAE40689.1
AC158748 Genomic DNA No translation available.
BC085143 mRNA Translation: AAH85143.1
CCDSiCCDS21480.1
PIRiS23453 A42843
RefSeqiNP_001104513.1, NM_001111043.1
NP_001104514.1, NM_001111044.1
NP_001272705.1, NM_001285776.1
NP_033955.2, NM_009825.2
XP_006507341.1, XM_006507278.3
XP_006507342.1, XM_006507279.3
UniGeneiMm.22708

Genome annotation databases

EnsembliENSMUST00000094154; ENSMUSP00000091706; ENSMUSG00000070436
ENSMUST00000169437; ENSMUSP00000126390; ENSMUSG00000070436
ENSMUST00000207849; ENSMUSP00000147064; ENSMUSG00000070436
ENSMUST00000208119; ENSMUSP00000146969; ENSMUSG00000070436
GeneIDi12406
KEGGimmu:12406
UCSCiuc009ilj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSERPH_MOUSE
AccessioniPrimary (citable) accession number: P19324
Secondary accession number(s): Q5U4D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome