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P19320

- VCAM1_HUMAN

UniProt

P19320 - VCAM1_HUMAN

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Protein

Vascular cell adhesion protein 1

Gene

VCAM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

GO - Molecular functioni

  1. cell adhesion molecule binding Source: BHF-UCL
  2. integrin binding Source: BHF-UCL
  3. primary amine oxidase activity Source: UniProtKB

GO - Biological processi

  1. acute inflammatory response Source: Ensembl
  2. aging Source: Ensembl
  3. amine metabolic process Source: UniProtKB
  4. B cell differentiation Source: BHF-UCL
  5. cell adhesion Source: BHF-UCL
  6. cell chemotaxis Source: Ensembl
  7. cell-matrix adhesion Source: UniProtKB
  8. cellular response to glucose stimulus Source: Ensembl
  9. cellular response to tumor necrosis factor Source: Ensembl
  10. cellular response to vascular endothelial growth factor stimulus Source: Ensembl
  11. chorio-allantoic fusion Source: Ensembl
  12. chronic inflammatory response Source: Ensembl
  13. cytokine-mediated signaling pathway Source: Reactome
  14. extracellular matrix organization Source: Reactome
  15. heart development Source: Ensembl
  16. heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
  17. interferon-gamma-mediated signaling pathway Source: Reactome
  18. leukocyte cell-cell adhesion Source: BHF-UCL
  19. leukocyte tethering or rolling Source: UniProtKB
  20. membrane to membrane docking Source: BHF-UCL
  21. oxidation-reduction process Source: GOC
  22. positive regulation of T cell proliferation Source: BHF-UCL
  23. regulation of immune response Source: Reactome
  24. response to ethanol Source: Ensembl
  25. response to hypoxia Source: Ensembl
  26. response to ionizing radiation Source: Ensembl
  27. response to lipopolysaccharide Source: Ensembl
  28. response to nicotine Source: Ensembl
  29. response to nutrient Source: Ensembl
  30. response to zinc ion Source: Ensembl
  31. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_13552. Integrin cell surface interactions.
REACT_25078. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular cell adhesion protein 1
Short name:
V-CAM 1
Short name:
VCAM-1
Alternative name(s):
INCAM-100
CD_antigen: CD106
Gene namesi
Name:VCAM1
Synonyms:L1CAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:12663. VCAM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 698674ExtracellularSequence AnalysisAdd
BLAST
Transmembranei699 – 72022HelicalSequence AnalysisAdd
BLAST
Topological domaini721 – 73919CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex Source: BHF-UCL
  2. apical part of cell Source: BHF-UCL
  3. cell surface Source: UniProtKB
  4. early endosome Source: UniProtKB
  5. endoplasmic reticulum Source: UniProtKB
  6. external side of plasma membrane Source: BHF-UCL
  7. extracellular space Source: BHF-UCL
  8. extracellular vesicular exosome Source: UniProtKB
  9. filopodium Source: BHF-UCL
  10. Golgi apparatus Source: UniProtKB
  11. integral component of membrane Source: UniProtKB-KW
  12. microvillus Source: BHF-UCL
  13. plasma membrane Source: Reactome
  14. podosome Source: BHF-UCL
  15. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 739715Vascular cell adhesion protein 1PRO_0000014997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 95
Disulfide bondi52 ↔ 99
Disulfide bondi137 ↔ 195
Disulfide bondi246 ↔ 291PROSITE-ProRule annotation
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi335 ↔ 383PROSITE-ProRule annotation
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi534 ↔ 579PROSITE-ProRule annotation
Glycosylationi561 – 5611N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Sialoglycoprotein.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP19320.
PRIDEiP19320.

PTM databases

PhosphoSiteiP19320.

Miscellaneous databases

PMAP-CutDBP19320.

Expressioni

Tissue specificityi

Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.

Inductioni

By cytokines (e.g. IL-1, TNF-alpha).

Gene expression databases

BgeeiP19320.
CleanExiHS_L1CAM.
HS_VCAM1.
ExpressionAtlasiP19320. baseline and differential.
GenevestigatoriP19320.

Organism-specific databases

HPAiCAB005426.

Interactioni

Subunit structurei

Binds to ECMV-D capsid proteins and acts as a receptor for this virus.By similarity

Protein-protein interaction databases

BioGridi113255. 439 interactions.
IntActiP19320. 629 interactions.
STRINGi9606.ENSP00000294728.

Structurei

Secondary structure

1
739
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 3813Combined sources
Beta strandi43 – 519Combined sources
Beta strandi56 – 616Combined sources
Beta strandi68 – 747Combined sources
Beta strandi77 – 848Combined sources
Helixi87 – 893Combined sources
Beta strandi91 – 999Combined sources
Beta strandi102 – 11413Combined sources
Beta strandi120 – 1256Combined sources
Beta strandi133 – 14412Combined sources
Helixi145 – 1473Combined sources
Beta strandi148 – 1547Combined sources
Beta strandi157 – 1637Combined sources
Beta strandi169 – 1713Combined sources
Beta strandi174 – 1829Combined sources
Helixi186 – 1883Combined sources
Beta strandi192 – 1998Combined sources
Beta strandi209 – 2168Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IJ9X-ray3.00A25-220[»]
1VCAX-ray1.80A/B25-226[»]
1VSCX-ray1.90A/B25-219[»]
ProteinModelPortaliP19320.
SMRiP19320. Positions 25-712.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19320.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 10581Ig-like C2-type 1Add
BLAST
Domaini109 – 212104Ig-like C2-type 2Add
BLAST
Domaini223 – 30987Ig-like C2-type 3Add
BLAST
Domaini312 – 39988Ig-like C2-type 4Add
BLAST
Domaini408 – 50699Ig-like C2-type 5Add
BLAST
Domaini511 – 59585Ig-like C2-type 6Add
BLAST
Domaini600 – 68485Ig-like C2-type 7Add
BLAST

Domaini

Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148090.
GeneTreeiENSGT00750000117572.
HOGENOMiHOG000004820.
HOVERGENiHBG053965.
InParanoidiP19320.
KOiK06527.
OMAiENEHSYL.
OrthoDBiEOG7JMGD2.
PhylomeDBiP19320.
TreeFamiTF333571.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR003989. VCAM-1.
[Graphical view]
PfamiPF05790. C2-set. 2 hits.
PF07679. I-set. 3 hits.
PF00047. ig. 1 hit.
[Graphical view]
PRINTSiPR01472. ICAMVCAM1.
PR01474. VCAM1.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P19320-1) [UniParc]FASTAAdd to Basket

Also known as: Long, VCAM-7D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGKMVVILG ASNILWIMFA ASQAFKIETT PESRYLAQIG DSVSLTCSTT
60 70 80 90 100
GCESPFFSWR TQIDSPLNGK VTNEGTTSTL TMNPVSFGNE HSYLCTATCE
110 120 130 140 150
SRKLEKGIQV EIYSFPKDPE IHLSGPLEAG KPITVKCSVA DVYPFDRLEI
160 170 180 190 200
DLLKGDHLMK SQEFLEDADR KSLETKSLEV TFTPVIEDIG KVLVCRAKLH
210 220 230 240 250
IDEMDSVPTV RQAVKELQVY ISPKNTVISV NPSTKLQEGG SVTMTCSSEG
260 270 280 290 300
LPAPEIFWSK KLDNGNLQHL SGNATLTLIA MRMEDSGIYV CEGVNLIGKN
310 320 330 340 350
RKEVELIVQE KPFTVEISPG PRIAAQIGDS VMLTCSVMGC ESPSFSWRTQ
360 370 380 390 400
IDSPLSGKVR SEGTNSTLTL SPVSFENEHS YLCTVTCGHK KLEKGIQVEL
410 420 430 440 450
YSFPRDPEIE MSGGLVNGSS VTVSCKVPSV YPLDRLEIEL LKGETILENI
460 470 480 490 500
EFLEDTDMKS LENKSLEMTF IPTIEDTGKA LVCQAKLHID DMEFEPKQRQ
510 520 530 540 550
STQTLYVNVA PRDTTVLVSP SSILEEGSSV NMTCLSQGFP APKILWSRQL
560 570 580 590 600
PNGELQPLSE NATLTLISTK MEDSGVYLCE GINQAGRSRK EVELIIQVTP
610 620 630 640 650
KDIKLTAFPS ESVKEGDTVI ISCTCGNVPE TWIILKKKAE TGDTVLKSID
660 670 680 690 700
GAYTIRKAQL KDAGVYECES KNKVGSQLRS LTLDVQGREN NKDYFSPELL
710 720 730
VLYFASSLII PAIGMIIYFA RKANMKGSYS LVEAQKSKV

Note: Major isoform.

Length:739
Mass (Da):81,276
Last modified:November 1, 1990 - v1
Checksum:i050E2EBD39AC2FF4
GO
Isoform 2 (identifier: P19320-2) [UniParc]FASTAAdd to Basket

Also known as: Short, VCAM-6D

The sequence of this isoform differs from the canonical sequence as follows:
     310-402: EKPFTVEISP...EKGIQVELYS → A

Show »
Length:647
Mass (Da):71,255
Checksum:i7EA67DB70AC91EF8
GO
Isoform 3 (identifier: P19320-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-113: Missing.

Note: No experimental confirmation available.

Show »
Length:677
Mass (Da):74,346
Checksum:iCA0C2F8A7E51EC83
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1821F → G(PubMed:1377228)Curated
Sequence conflicti402 – 4021S → T(PubMed:1707234)Curated
Sequence conflicti728 – 7281S → P in BAG59286. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181M → I.
Corresponds to variant rs34228330 [ dbSNP | Ensembl ].
VAR_049951
Natural varianti318 – 3181S → F.1 Publication
Corresponds to variant rs3783611 [ dbSNP | Ensembl ].
VAR_014309
Natural varianti384 – 3841T → A.1 Publication
Corresponds to variant rs3783612 [ dbSNP | Ensembl ].
VAR_014310
Natural varianti413 – 4131G → A.1 Publication
Corresponds to variant rs3783613 [ dbSNP | Ensembl ].
VAR_014311
Natural varianti421 – 4211V → I.
Corresponds to variant rs34100871 [ dbSNP | Ensembl ].
VAR_049952
Natural varianti488 – 4881H → R.
Corresponds to variant rs34199378 [ dbSNP | Ensembl ].
VAR_049953
Natural varianti716 – 7161I → L.1 Publication
Corresponds to variant rs3783615 [ dbSNP | Ensembl ].
VAR_014312

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 11362Missing in isoform 3. 1 PublicationVSP_044636Add
BLAST
Alternative sequencei310 – 40293EKPFT…VELYS → A in isoform 2. 1 PublicationVSP_002580Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30257 mRNA. Translation: AAA51917.1.
X53051 mRNA. Translation: CAA37218.1.
M60335 mRNA. Translation: AAA61269.1.
M73255 Genomic DNA. Translation: AAA61270.1.
AF536818 Genomic DNA. Translation: AAM96190.1.
AK291732 mRNA. Translation: BAF84421.1.
AK296692 mRNA. Translation: BAG59286.1.
AC093428 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW72950.1.
BC017276 mRNA. Translation: AAH17276.3.
BC068490 mRNA. Translation: AAH68490.2.
BC085003 mRNA. Translation: AAH85003.1.
M92431 Genomic DNA. No translation available.
CCDSiCCDS55617.1. [P19320-3]
CCDS773.1. [P19320-1]
CCDS774.1. [P19320-2]
PIRiA41288.
B41288.
RefSeqiNP_001069.1. NM_001078.3. [P19320-1]
NP_001186763.1. NM_001199834.1. [P19320-3]
NP_542413.1. NM_080682.2. [P19320-2]
UniGeneiHs.109225.

Genome annotation databases

EnsembliENST00000294728; ENSP00000294728; ENSG00000162692. [P19320-1]
ENST00000347652; ENSP00000304611; ENSG00000162692. [P19320-2]
ENST00000370119; ENSP00000359137; ENSG00000162692. [P19320-3]
GeneIDi7412.
KEGGihsa:7412.
UCSCiuc001dti.3. human. [P19320-1]
uc001dtj.3. human. [P19320-2]

Polymorphism databases

DMDMi137560.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

VCAM1 entry

SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

VCAM-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30257 mRNA. Translation: AAA51917.1 .
X53051 mRNA. Translation: CAA37218.1 .
M60335 mRNA. Translation: AAA61269.1 .
M73255 Genomic DNA. Translation: AAA61270.1 .
AF536818 Genomic DNA. Translation: AAM96190.1 .
AK291732 mRNA. Translation: BAF84421.1 .
AK296692 mRNA. Translation: BAG59286.1 .
AC093428 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW72950.1 .
BC017276 mRNA. Translation: AAH17276.3 .
BC068490 mRNA. Translation: AAH68490.2 .
BC085003 mRNA. Translation: AAH85003.1 .
M92431 Genomic DNA. No translation available.
CCDSi CCDS55617.1. [P19320-3 ]
CCDS773.1. [P19320-1 ]
CCDS774.1. [P19320-2 ]
PIRi A41288.
B41288.
RefSeqi NP_001069.1. NM_001078.3. [P19320-1 ]
NP_001186763.1. NM_001199834.1. [P19320-3 ]
NP_542413.1. NM_080682.2. [P19320-2 ]
UniGenei Hs.109225.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IJ9 X-ray 3.00 A 25-220 [» ]
1VCA X-ray 1.80 A/B 25-226 [» ]
1VSC X-ray 1.90 A/B 25-219 [» ]
ProteinModelPortali P19320.
SMRi P19320. Positions 25-712.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113255. 439 interactions.
IntActi P19320. 629 interactions.
STRINGi 9606.ENSP00000294728.

Chemistry

BindingDBi P19320.
ChEMBLi CHEMBL3735.
DrugBanki DB01136. Carvedilol.

PTM databases

PhosphoSitei P19320.

Polymorphism databases

DMDMi 137560.

Proteomic databases

PaxDbi P19320.
PRIDEi P19320.

Protocols and materials databases

DNASUi 7412.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294728 ; ENSP00000294728 ; ENSG00000162692 . [P19320-1 ]
ENST00000347652 ; ENSP00000304611 ; ENSG00000162692 . [P19320-2 ]
ENST00000370119 ; ENSP00000359137 ; ENSG00000162692 . [P19320-3 ]
GeneIDi 7412.
KEGGi hsa:7412.
UCSCi uc001dti.3. human. [P19320-1 ]
uc001dtj.3. human. [P19320-2 ]

Organism-specific databases

CTDi 7412.
GeneCardsi GC01P101185.
HGNCi HGNC:12663. VCAM1.
HPAi CAB005426.
MIMi 192225. gene.
neXtProti NX_P19320.
PharmGKBi PA37286.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148090.
GeneTreei ENSGT00750000117572.
HOGENOMi HOG000004820.
HOVERGENi HBG053965.
InParanoidi P19320.
KOi K06527.
OMAi ENEHSYL.
OrthoDBi EOG7JMGD2.
PhylomeDBi P19320.
TreeFami TF333571.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_13552. Integrin cell surface interactions.
REACT_25078. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSi VCAM1. human.
EvolutionaryTracei P19320.
GeneWikii VCAM-1.
GenomeRNAii 7412.
NextBioi 29020.
PMAP-CutDB P19320.
PROi P19320.
SOURCEi Search...

Gene expression databases

Bgeei P19320.
CleanExi HS_L1CAM.
HS_VCAM1.
ExpressionAtlasi P19320. baseline and differential.
Genevestigatori P19320.

Family and domain databases

Gene3Di 2.60.40.10. 7 hits.
InterProi IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR003989. VCAM-1.
[Graphical view ]
Pfami PF05790. C2-set. 2 hits.
PF07679. I-set. 3 hits.
PF00047. ig. 1 hit.
[Graphical view ]
PRINTSi PR01472. ICAMVCAM1.
PR01474. VCAM1.
SMARTi SM00409. IG. 2 hits.
SM00408. IGc2. 3 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes."
    Osborn L., Hession C., Tizard R., Vassallo C., Luhowskyj S., Chi-Rosso G., Lobb R.
    Cell 59:1203-1211(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Full length vascular cell adhesion molecule 1 (VCAM-1)."
    Polte T., Newman W., Gopal T.V.
    Nucleic Acids Res. 18:5901-5901(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Umbilical vein.
  3. "Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1)."
    Hession C., Tizard R., Vassallo C., Schiffer S.B., Goff D., Moy P., Chi-Rosso G., Luhowskyj S., Lobb R., Osborn L.
    J. Biol. Chem. 266:6682-6685(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene."
    Cybulsky M.I., Fries J.W.U., Williams A.J., Sultan P., Eddy R., Byers M., Shows T., Gimbrone M.A. Jr., Collins T.
    Proc. Natl. Acad. Sci. U.S.A. 88:7859-7863(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), ALTERNATIVE SPLICING.
  5. SeattleSNPs variation discovery resource
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PHE-318; ALA-384; ALA-413 AND LEU-716.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Placenta and Tongue.
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retinal pigment epithelium.
  10. "Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)."
    Iademarco M.F., McQuillan J.J., Rosen G.D., Dean D.C.
    J. Biol. Chem. 267:16323-16329(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
  11. "Alternative splicing of human VCAM-1 in activated vascular endothelium."
    Cybulsky M.I., Fries J.W., Williams A.J., Sultan P., Davis V.M., Gimbrone M.A. Jr., Collins T.
    Am. J. Pathol. 138:815-820(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 25-686 (ISOFORMS 1 AND 2).
    Tissue: Umbilical vein endothelial cell.
  12. "Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1."
    Osborn L., Vassallo C., Benjamin C.D.
    J. Exp. Med. 176:99-107(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 25-402 (ISOFORMS 1 AND 2), CELL ADHESION DOMAIN.
    Tissue: Endothelial cell.
  13. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-39.
  14. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-561.
    Tissue: Plasma.
  15. "Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8-A resolution."
    Jones E.Y., Harlos K., Bottomley M.J., Robinson R.C., Driscoll P.C., Edwards R.M., Clements J.M., Dudgeon T.J., Stuart D.I.
    Nature 373:539-544(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 25-226.
  16. "The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction."
    Wang J.-H., Pepinsky R.B., Stehle T., Liu J.-H., Karpusas M., Browning B., Osborn L.
    Proc. Natl. Acad. Sci. U.S.A. 92:5714-5718(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 25-220.
  17. "Structure of a functional fragment of VCAM-1 refined at 1.9-A resolution."
    Wang J.-H., Stehle T., Pepinsky R.B., Liu J.-H., Karpusas M., Osborn L.
    Acta Crystallogr. D 52:369-379(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 25-220.

Entry informationi

Entry nameiVCAM1_HUMAN
AccessioniPrimary (citable) accession number: P19320
Secondary accession number(s): A8K6R7
, B4DKS4, E9PDD1, Q6NUP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 26, 2014
This is version 189 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3